32 Questions
What is the function of cytokines in the production of erythroid progenitor cells?
Cytokines induce stem cell differentiation to produce committed erythroid progenitor cells.
What is the first step in red cell production?
Differentiation of erythroid progenitor cells
What is the first step in red cell production?
Hematopoietic stem cell differentiation
Red cell production begins with the ______ stem cell (HSC).
hematopoietic
What are the two populations of committed erythroid progenitor cells?
BFU-E and CFU-E
Stem cell differentiation is induced by ______ in specialized microenvironment to produce a committed erythroid progenitor cell.
cytokines
What are the two populations of committed erythroid progenitor cells in the unipotential progenitor cell compartment?
The two populations are burst-forming unit-erythroid (BFU-E) and colony-forming unit-erythroid (CFU-E).
Which two populations make up the committed erythroid progenitor cell compartment?
BFU-E and CFU-E
What are nucleated erythrocyte precursors in the bone marrow called?
Normoblasts
What is the name of nucleated erythrocyte precursors in the bone marrow?
Normoblasts
What are erythroblasts?
Erythroblasts are nucleated erythrocyte precursors in the bone marrow.
The committed ( unipotential) progenitor cell compartment consists of two populations : ______ and colony-forming unit-erythroid(CFU-E).
burst-forming unit-erythroid(BFU-E)
How many morphologically defined stages are involved in the formation of erythroid maturing cells?
There are six morphologically defined stages.
Nucleated erythrocyte precursors in the bone marrow called ______.
erythroblast
How long do normoblasts spend in the proliferating and maturing compartment of the bone marrow?
5-7 days
How many morphologically defined stages are involved in the process of erythroid maturing cells formation?
6
What is the stage before mature RBCs?
Reticulocytes
How long do normoblasts spend in the proliferating and maturing compartment of the bone marrow?
Normoblasts spend from 5 to 7 days in the proliferating and maturing compartment of the bone marrow.
The process of erythroid maturing cells formation includes ______ morphologically defined stages.
six
How long does it take for a reticulocyte to mature before it is released to the peripheral blood?
1-2 days
The normoblasts spend from 5 to 7 days in the proliferating and maturing compartment of the bone marrow. After reaching the reticulocyte stage, there is an additional ______ days of maturation.
2-3
What is the reticulocyte stage?
The reticulocyte stage is the stage of erythroid maturing cells before the release to the peripheral blood.
What induces stem cell differentiation to produce a committed erythroid progenitor cell?
Cytokines in specialized microenvironment
How long do normoblasts spend in the proliferating and maturing compartment of the bone marrow?
5-7 days
How many additional days of maturation occur after the reticulocyte stage?
There is an additional 2-3 days of maturation.
What is the normal range of reticulocytes?
0.5-2.5%
Which stage of erythroblast is the last before it becomes a reticulocyte?
Orthochromatic normoblast
The first 1-2 days of erythroid maturing cell maturation after reaching the reticulocyte stage are spent in the ______ befor is released to the peripheral blood.
bone marrow
What is the name of the committed erythroid progenitor cell that has the ability to form colonies?
CFU-E
Where do normoblasts spend the first 1-2 days of the additional maturation period?
Normoblasts spend the first 1-2 days of the additional maturation period in the bone marrow before being released to the peripheral blood.
Stem cell differentiation is induced by cytokines in a specialized ______ to produce a committed erythroid progenitor cell.
microenvironment
What do reticulocytes lack that mature RBCs have?
Nucleus
Study Notes
Are you familiar with erythroid progenitor cells and their role in red cell production? Test your knowledge with our quiz! From hematopoietic stem cell differentiation to the two populations of committed progenitor cells, BFU-E and CFU-E, this quiz will challenge your understanding of erythroid progenitor cells. Don't forget to brush up on your knowledge of cytokines and their role in inducing stem cell differentiation. Take the quiz now!
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