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Questions and Answers
What is the purpose of anticoagulants, preservatives, and additives in blood component storage?
What are the different types of anticoagulants currently available for blood component storage?
What is the purpose of additive solutions such as Adsol, Nutricel, and Optisol in blood component storage?
What are storage lesions?
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What are the label requirements for blood components?
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What is the storage duration of leukoreduced RBCs?
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What are cryoprecipitate, plasma, platelets, granulocytes, FVIII concentrate, FIX concentrate, and NovoSeven?
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What is the purpose of leukoreduced RBCs?
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Study Notes
Blood Components and Hemotherapy
- Anticoagulants, preservatives, and additives are used in blood component storage to maintain the viability of red blood cells (RBCs).
- Anticoagulants currently available include ACD, CPD, and CPDA-1, which have different compositions and storage durations.
- The action of ingredients in anticoagulant solutions includes supporting ATP generation, synthesizing ATP, preventing coagulation, and preventing a fall in pH.
- Additive solutions such as Adsol, Nutricel, and Optisol enhance the level of ATP and extend the shelf-life of RBCs to 42 days.
- Storage lesions occur during blood component storage, resulting in biochemical changes that affect RBC function.
- Components must be stored at specific temperatures, and the temperature must be recorded and monitored continuously.
- Allogeneic blood must undergo testing for ABO, Rh, ABSC, syphilis, HIV, HBV, and HCV.
- Label requirements for components include the component name, donor unit number, required storage temperature, expiration date/time, and amount of blood collected/amount of anticoagulant.
- Component administration requires aseptic technique, and components stored at 1-6°C expire within 24 hours of a broken seal.
- Whole blood can be split into components, including RBCs, plasma, cryoprecipitate, and platelets, which have different storage durations and indications.
- Leukoreduced RBCs are prepared by filtration and are used to prevent recurrent febrile nonhemolytic reactions, HLA sensitization, infection, and TRALI.
- Cryoprecipitate, plasma, platelets, granulocytes, FVIII concentrate, FIX concentrate, and NovoSeven are other blood components used for specific indications and require different storage and administration methods.
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Description
Do you know the ins and outs of blood component storage and hemotherapy? Test your knowledge with this quiz! Learn about the different anticoagulants, additives, and preservatives used to maintain the viability of red blood cells, as well as the storage lesions that can occur during storage. Discover the proper storage temperatures and labeling requirements for blood components, and understand the different indications for components such as RBCs, plasma, cryoprecipitate, and platelets. Take this quiz to
