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Questions and Answers
Which of the following diseases can result in retinal changes and are considered in the text?
Which of the following diseases can result in retinal changes and are considered in the text?
- Dystrophic changes in the choriocapillaris
- Mucopolysaccharidosis
- Areas of geographic atrophy
- Neuronal ceroid lipofuscinosis (correct)
What type of changes were observed in the choriocapillaris?
What type of changes were observed in the choriocapillaris?
- Geographic changes
- Dystrophic changes (correct)
- Atrophic changes
- Peripheral changes
Where were the areas of geographic atrophy found?
Where were the areas of geographic atrophy found?
- Midperipheral and peripheral fundus (correct)
- Macula
- Optic nerve
- Central fundus
What is the mode of inheritance for the defect?
What is the mode of inheritance for the defect?
Which of the following diseases are NOT considered in the text?
Which of the following diseases are NOT considered in the text?
Which retinopathy is characterized by multifocal red or brown tapetal discoloration and no vision loss?
Which retinopathy is characterized by multifocal red or brown tapetal discoloration and no vision loss?
What is the prevalence of Swedish Vallhund retinopathy in the breed?
What is the prevalence of Swedish Vallhund retinopathy in the breed?
Which gene is associated with increased levels of mRNA in affected retina of Swedish Vallhunds with retinopathy?
Which gene is associated with increased levels of mRNA in affected retina of Swedish Vallhunds with retinopathy?
Which retinopathy is characterized by a rapid nystagmus, reduced PLRs, and accumulation of inclusion bodies in the RPE cells?
Which retinopathy is characterized by a rapid nystagmus, reduced PLRs, and accumulation of inclusion bodies in the RPE cells?
Which retinopathy shows retinal thinning, night blindness, severe daytime vision problems, and a severe reduction in ERG amplitudes in its most advanced stage?
Which retinopathy shows retinal thinning, night blindness, severe daytime vision problems, and a severe reduction in ERG amplitudes in its most advanced stage?
Which term is commonly used to describe the retinopathy caused by RPE65 mutation in Briards?
Which term is commonly used to describe the retinopathy caused by RPE65 mutation in Briards?
What is the main role of RPE65 in the visual cycle?
What is the main role of RPE65 in the visual cycle?
What is the consequence of a lack of functional RPE65?
What is the consequence of a lack of functional RPE65?
Which mutation is most commonly associated with Leber congenital amaurosis in humans?
Which mutation is most commonly associated with Leber congenital amaurosis in humans?
What has been approved as a treatment for Leber congenital amaurosis due to RPE65 mutations in the United States?
What has been approved as a treatment for Leber congenital amaurosis due to RPE65 mutations in the United States?
Which breed of dog was found to have a missense mutation (c.C1270T; p.Arg424Trp) in the CNGA3 gene causing day blindness?
Which breed of dog was found to have a missense mutation (c.C1270T; p.Arg424Trp) in the CNGA3 gene causing day blindness?
What amino acid is changed by the missense mutation (c.C1270T; p.Arg424Trp) in the CNGA3 gene in German Shepherd Dogs?
What amino acid is changed by the missense mutation (c.C1270T; p.Arg424Trp) in the CNGA3 gene in German Shepherd Dogs?
What type of mutation was found in the Labrador Retrievers with day blindness?
What type of mutation was found in the Labrador Retrievers with day blindness?
What amino acid is removed by the 3 bp deletion (c.1931_ 1933delTGG) in the CNGA3 gene in Labrador Retrievers?
What amino acid is removed by the 3 bp deletion (c.1931_ 1933delTGG) in the CNGA3 gene in Labrador Retrievers?
In which breed of dog was a recessively inherited congenital stationary night blindness (CSNB) reported?
In which breed of dog was a recessively inherited congenital stationary night blindness (CSNB) reported?
Which breed has been reported to have an unusually high frequency of Retinal Pigment Epithelial Dystrophy (RPED)?
Which breed has been reported to have an unusually high frequency of Retinal Pigment Epithelial Dystrophy (RPED)?
What is the initial visual impairment experienced by dogs with RPED?
What is the initial visual impairment experienced by dogs with RPED?
Which breed has a breed-related condition consisting of RPED and neurologic dysfunction associated with low circulatory levels of vitamin E?
Which breed has a breed-related condition consisting of RPED and neurologic dysfunction associated with low circulatory levels of vitamin E?
What is the recommended oral tocopherol supplementation for English Cocker Spaniels diagnosed with vitamin E deficiency?
What is the recommended oral tocopherol supplementation for English Cocker Spaniels diagnosed with vitamin E deficiency?
What is the characteristic appearance of retinal lesions in the Chinese Crested Dog with pigmentary chorioretinopathy?
What is the characteristic appearance of retinal lesions in the Chinese Crested Dog with pigmentary chorioretinopathy?
Which gene is responsible for the late-onset retinopathy in Labrador Retrievers?
Which gene is responsible for the late-onset retinopathy in Labrador Retrievers?
What is the function of ABCA4 in the visual cycle?
What is the function of ABCA4 in the visual cycle?
Which subunits make up the cGMP-gated channel in the outer segment cell membrane of cone photoreceptors?
Which subunits make up the cGMP-gated channel in the outer segment cell membrane of cone photoreceptors?
Which breed of dog has the CNGB3 mutation that causes achromatopsia?
Which breed of dog has the CNGB3 mutation that causes achromatopsia?
What treatment has been successful in restoring cone function in younger dogs with achromatopsia?
What treatment has been successful in restoring cone function in younger dogs with achromatopsia?
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