Teratogens and Congenital Defects
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Questions and Answers

What is the primary focus of the sub-discipline of teratology in medical genetics?

  • identifying teratogenic substances
  • developing treatments for congenital disabilities
  • classifying congenital abnormalities in dysmorphology (correct)
  • studying the causes of miscarriage

What is a teratogen?

  • a medical condition that causes congenital abnormalities
  • a substance that interferes with normal fetal development (correct)
  • a type of congenital disability
  • a substance that promotes normal fetal development

What is a key factor that determines susceptibility to teratogenesis?

  • age of the mother
  • duration of exposure to the teratogen (correct)
  • type of teratogen
  • all of the above

During which stage of development is the embryo most susceptible to teratogens?

<p>embryonic stage (B)</p> Signup and view all the answers

What is a possible effect of teratogens on the embryo during the pre-differentiation stage?

<p>it may cause death of the embryo by killing all or most of the cells (C)</p> Signup and view all the answers

What are the two types of anomalies that can be caused by teratogens?

<p>Visible deviations of structure and other (A)</p> Signup and view all the answers

What is a congenital birth defect characterized by a baby being born without parts of the brain and skull?

<p>Anencephaly (B)</p> Signup and view all the answers

What is the effect of ionizing radiation on a fetus?

<p>All of the above (D)</p> Signup and view all the answers

What is the effect of lead on a fetus?

<p>All of the above (D)</p> Signup and view all the answers

What is the result of the neural tube not closing all the way?

<p>Spina bifida (A)</p> Signup and view all the answers

What is characterized by shorter than normal skeletal growth?

<p>Dwarfism (C)</p> Signup and view all the answers

What is the result of hyperthermia on a fetus?

<p>All of the above (D)</p> Signup and view all the answers

What is the result of an enzyme deficiency?

<p>Abnormal chemical functions (C)</p> Signup and view all the answers

What is the term for the failure of an organ to develop during embryonic growth and development?

<p>Failure of Development (C)</p> Signup and view all the answers

Which of the following is an example of a Physical Agent teratogen?

<p>X-rays (D)</p> Signup and view all the answers

What is the term for a tissue found in an abnormal place or position?

<p>Misplacement (C)</p> Signup and view all the answers

What is the condition caused by alcohol exposure during pregnancy?

<p>Fetal Alcoholic Syndrome (FAS) (A)</p> Signup and view all the answers

What is a characteristic of Fetal Alcoholic Syndrome (FAS)?

<p>Limb and Face malformation (C)</p> Signup and view all the answers

What was the first human teratogen identified in 1941?

<p>Maternal rubella infection during pregnancy (A)</p> Signup and view all the answers

What was the outcome for children born to mothers who took thalidomide during pregnancy?

<p>Severe and debilitating malformations (D)</p> Signup and view all the answers

What period of pregnancy is crucial for the development of vital organs and systems?

<p>First trimester (C)</p> Signup and view all the answers

What is the consequence of maternal influenza exposure during the first trimester?

<p>Raised risk of non-chromosomal congenital anomalies (B)</p> Signup and view all the answers

When does brain development commence during pregnancy?

<p>Around the third week (C)</p> Signup and view all the answers

What is the current use of thalidomide?

<p>Treating various adult conditions, including multiple myeloma and complications of leprosy (B)</p> Signup and view all the answers

What is the primary focus of the study of teratology?

<p>Safeguarding embryonic development and preventing abnormalities (A)</p> Signup and view all the answers

What is the significance of teratogenic effects in understanding human health?

<p>They help in understanding the essence of existence (A)</p> Signup and view all the answers

What is a major contributor to the threat of teratogenic effects on developing fetuses?

<p>Environmental contamination from released chemicals (C)</p> Signup and view all the answers

What was the outcome of the experiment involving pregnant pigs fed a vitamin A-deficient diet in the 1930s?

<p>Piglets with various malformations, including the absence of eyes (C)</p> Signup and view all the answers

What is the primary goal of understanding the mechanisms behind teratogenic effects?

<p>Safeguarding human health and preventing developmental abnormalities (D)</p> Signup and view all the answers

What is the term used to describe the study of abnormal development?

<p>Teratology (C)</p> Signup and view all the answers

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