Telomerase and Telomere DNA Repeats Quiz
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Questions and Answers

What is the role of telomerase in DNA replication?

  • Synthesizes telomere DNA repeat at the 5' end of the leading strand (correct)
  • Fills the gaps in the lagging strand
  • Removes RNA primers from the lagging strand
  • Seals the DNA fragments

    • What is the directionality of polymerase when adding nucleotides to DNA?

  • 5'-3' (correct)
  • 3'-3'
  • 3'-5'
  • 5'-5'

    • In which type of cells does telomerase synthesize telomeric repeats continuously?

  • Prokaryotic cells
  • Eukaryotic germ cells (correct)
  • Somatic cells
  • Plant cells

    • What is the role of polymerase a (primase) in DNA replication?

    <p>Synthesizes a RNA primer complementary to the leading strand</p> Signup and view all the answers

    Which polymerase fills the gap till it hits the 5’ end of the lagging strand?

    <p>DNA Polymerase d (pol d)</p> Signup and view all the answers

    What is the role of ligase in DNA replication?

    <p>Seals the DNA fragments</p> Signup and view all the answers

    What is the consequence of removing RNA primers from the lagging strand?

    <p>Creates a permanent gap at the 5' end of the lagging strand</p> Signup and view all the answers

    What is the sequence of the telomere DNA repeat synthesized by telomerase?

    <p>AGGGTT</p> Signup and view all the answers

    What is the directionality of polymerase a (primase) when synthesizing a RNA primer?

    <p>5'-3'</p> Signup and view all the answers

    What is the consequence of telomerase synthesizing telomeric repeats continuously?

    <p>Reaches a significant length &amp; stops</p> Signup and view all the answers

    What is the role of RNase H & FEN1 in DNA replication?

    <p>Remove RNA primers from the lagging strand</p> Signup and view all the answers

    Why is it better for telomerase to synthesize telomeric repeats and lose a few bases?

    <p>Creates a permanent gap again at the 5' end of the lagging strand</p> Signup and view all the answers

    What is the role of telomerase in DNA replication?

    <p>Synthesizes telomere DNA repeat at the 5' end of the leading strand</p> Signup and view all the answers

    What is the directionality of polymerase when adding nucleotides to DNA?

    <p>5'-3'</p> Signup and view all the answers

    In which type of cells does telomerase synthesize telomeric repeats continuously?

    <p>Eukaryotic germ cells</p> Signup and view all the answers

    What is the role of polymerase a (primase) in DNA replication?

    <p>Synthesizes a RNA primer complementary to the leading strand</p> Signup and view all the answers

    Which polymerase fills the gap till it hits the 5’ end of the lagging strand?

    <p>DNA Polymerase d (pol d)</p> Signup and view all the answers

    What is the role of ligase in DNA replication?

    <p>Seals the DNA fragments</p> Signup and view all the answers

    What is the consequence of removing RNA primers from the lagging strand?

    <p>Creates a permanent gap at the 5' end of the lagging strand</p> Signup and view all the answers

    What is the sequence of the telomere DNA repeat synthesized by telomerase?

    <p>AGGGTT</p> Signup and view all the answers

    What is the directionality of polymerase a (primase) when synthesizing a RNA primer?

    <p>5'-3'</p> Signup and view all the answers

    What is the consequence of telomerase synthesizing telomeric repeats continuously?

    <p>Reaches a significant length &amp; stops</p> Signup and view all the answers

    What is the role of RNase H & FEN1 in DNA replication?

    <p>Remove RNA primers from the lagging strand</p> Signup and view all the answers

    Why is it better for telomerase to synthesize telomeric repeats and lose a few bases?

    <p>Creates a permanent gap again at the 5' end of the lagging strand</p> Signup and view all the answers

    What is the function of telomerase?

    <p>To synthesize telomere DNA repeat at the 3' end of the leading strand</p> Signup and view all the answers

    What is the direction in which polymerase can add nucleotides?

    <p>5'-3'</p> Signup and view all the answers

    What is the role of Polymerase a (primase) in telomere synthesis?

    <p>It synthesizes a RNA primer complementary to the leading strand</p> Signup and view all the answers

    What is the role of DNA Polymerase d (pol d) in telomere synthesis?

    <p>It fills the gap till it hits the 5' end of the lagging strand</p> Signup and view all the answers

    What is the role of Ligase in telomere synthesis?

    <p>It seals DNA fragments</p> Signup and view all the answers

    What is the reason for telomerase to synthesize telomeric repeats continuously in eukaryotic germ cells?

    <p>To reach a significant length and stop</p> Signup and view all the answers

    What happens to the RNA primer after the gap in the lagging strand is filled by Polymerase d?

    <p>It is removed by RNase H and FEN1</p> Signup and view all the answers

    Why does telomerase synthesize telomeric repeats at the 3' end of the leading strand instead of filling the gap in the lagging strand?

    <p>Because Polymerase can only add nts in the 5'-3' direction</p> Signup and view all the answers

    What is the consequence of telomerase synthesizing telomeric repeats instead of filling the gap in the lagging strand?

    <p>It creates a permanent gap at the 5' end of the lagging strand</p> Signup and view all the answers

    What is the direction of nucleotide addition during telomere synthesis?

    <p>5'-3'</p> Signup and view all the answers

    What is the function of RNase H in telomere synthesis?

    <p>It removes RNA primer</p> Signup and view all the answers

    What is the function of FEN1 in telomere synthesis?

    <p>It removes RNA primer</p> Signup and view all the answers

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