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Questions and Answers
What is the primary requirement for the precise application of clinical laboratory testing?
What is the primary requirement for the precise application of clinical laboratory testing?
Which criterion defines normality for establishing reference intervals for laboratory analytes?
Which criterion defines normality for establishing reference intervals for laboratory analytes?
What type of tube is used for collecting whole blood for serum?
What type of tube is used for collecting whole blood for serum?
In specimen collection, what happens to heavy and light components of blood after spinning in a centrifuge?
In specimen collection, what happens to heavy and light components of blood after spinning in a centrifuge?
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What does the Sonoclot Analyzer measure?
What does the Sonoclot Analyzer measure?
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What does the Sonoclot Analyzer differentiate between?
What does the Sonoclot Analyzer differentiate between?
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What is the purpose of Thromboelastography with platelet mapping (TEG-PM)?
What is the purpose of Thromboelastography with platelet mapping (TEG-PM)?
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What does Platelet aggregometry measure?
What does Platelet aggregometry measure?
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What does the Sonoclot Analyzer provide in addition to a qualitative graph?
What does the Sonoclot Analyzer provide in addition to a qualitative graph?
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What is the purpose of the Onset and Clot RATE results in the Sonoclot Analyzer?
What is the purpose of the Onset and Clot RATE results in the Sonoclot Analyzer?
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What is the main function of Arachidonic acid (AA) in Thromboelastography with platelet mapping (TEG-PM)?
What is the main function of Arachidonic acid (AA) in Thromboelastography with platelet mapping (TEG-PM)?
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What is the primary sensitivity of Adenosine diphosphate (ADP) in Thromboelastography with platelet mapping (TEG-PM)?
What is the primary sensitivity of Adenosine diphosphate (ADP) in Thromboelastography with platelet mapping (TEG-PM)?
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What does LQC stand for in the context of clinical laboratory quality control?
What does LQC stand for in the context of clinical laboratory quality control?
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What is the purpose of EQC in clinical laboratory quality control?
What is the purpose of EQC in clinical laboratory quality control?
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What does Thromboelastography (TEG) measure?
What does Thromboelastography (TEG) measure?
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What is the purpose of Calibration in clinical laboratory quality control?
What is the purpose of Calibration in clinical laboratory quality control?
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What can lead to unreliable readings from Glucometers/ketone meters?
What can lead to unreliable readings from Glucometers/ketone meters?
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What does ROTEM measure?
What does ROTEM measure?
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What does the Dose Response Cartridge predict?
What does the Dose Response Cartridge predict?
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What does HMS Plus technology monitor?
What does HMS Plus technology monitor?
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What is the purpose of Quantitative heparin tests in clinical laboratory analysis?
What is the purpose of Quantitative heparin tests in clinical laboratory analysis?
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What can cause heparin resistance?
What can cause heparin resistance?
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What does EQC verify in clinical laboratory quality control?
What does EQC verify in clinical laboratory quality control?
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What does Reference Interval refer to in clinical laboratory quality control?
What does Reference Interval refer to in clinical laboratory quality control?
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What is the purpose of using purple top tubes containing EDTA for blood collection?
What is the purpose of using purple top tubes containing EDTA for blood collection?
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What can cause hemolysis in a blood sample?
What can cause hemolysis in a blood sample?
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What is the role of the Point of Care Coordinator in a clinical laboratory?
What is the role of the Point of Care Coordinator in a clinical laboratory?
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What does analytical sensitivity refer to in laboratory testing?
What does analytical sensitivity refer to in laboratory testing?
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What is the purpose of the Centers for Medicare & Medicaid Services (CMS) Clinical Laboratory Improvement Amendments (CLIA)?
What is the purpose of the Centers for Medicare & Medicaid Services (CMS) Clinical Laboratory Improvement Amendments (CLIA)?
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What is the responsibility of the Medical Director in a clinical laboratory?
What is the responsibility of the Medical Director in a clinical laboratory?
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What does clinical specificity measure in laboratory testing?
What does clinical specificity measure in laboratory testing?
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What can lead to false positives and false negatives in laboratory testing?
What can lead to false positives and false negatives in laboratory testing?
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What is the purpose of using red top tubes for blood collection?
What is the purpose of using red top tubes for blood collection?
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What is the responsibility of the laboratory in ensuring reliable test results?
What is the responsibility of the laboratory in ensuring reliable test results?
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What is the role of the Medical Director in managing laboratory testing?
What is the role of the Medical Director in managing laboratory testing?
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What does specificity ensure in laboratory testing?
What does specificity ensure in laboratory testing?
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What is the primary difference between TEG® and ROTEM®?
What is the primary difference between TEG® and ROTEM®?
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What is the function of RapidTEG®?
What is the function of RapidTEG®?
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What can TEG® evaluate using functional fibrinogen and platelet mapping tests?
What can TEG® evaluate using functional fibrinogen and platelet mapping tests?
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What is the role of TEG® in assessing Antiplatelet (clopidegrel)?
What is the role of TEG® in assessing Antiplatelet (clopidegrel)?
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What do TEG® machines with resonance technology use instead of the traditional pin-in-cup technique?
What do TEG® machines with resonance technology use instead of the traditional pin-in-cup technique?
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What measurements does TEG® provide to assess clot formation and stability?
What measurements does TEG® provide to assess clot formation and stability?
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How can TEG® guide treatment decisions based on the measured parameters?
How can TEG® guide treatment decisions based on the measured parameters?
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What are equivalent variables in ROTEM® to TEG®'s reaction time (R value) and maximum amplitude (MA)?
What are equivalent variables in ROTEM® to TEG®'s reaction time (R value) and maximum amplitude (MA)?
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What are the initial processes of platelet aggregation regulated by?
What are the initial processes of platelet aggregation regulated by?
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What is the mechanism of action of major antiplatelet drugs such as clopidogrel and aspirin?
What is the mechanism of action of major antiplatelet drugs such as clopidogrel and aspirin?
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Study Notes
Thromboelastography (TEG®) and ROTEM® Viscoelastic Hemostatic Assays Overview
- Thromboelastography (TEG®) and rotational thromboelastogram (ROTEM®) are viscoelastic hemostatic assays that measure physical clot properties in whole blood.
- TEG® predominantly measures clot properties with a pin suspended in a cup, while ROTEM® is an alternative assay widely available commercially.
- TEG® involves placing whole blood in a citrated tube, transferring it to a tube containing kaolin (activator), and measuring the physical properties of the clot.
- RapidTEG® uses kaolin and tissue factor as activators, triggering the extrinsic pathway and enabling faster testing, suitable for managing massive transfusions in trauma patients.
- TEG® offers functional fibrinogen and platelet mapping tests to evaluate platelet function and clot formation with or without heparin.
- Antiplat (clopidegrel) can be assessed using TEG® to evaluate bleeding risk, and newer TEG® machines use resonance technology instead of the traditional pin-in-cup technique.
- TEG® provides various measurements such as reaction time (R value), kinetics (K value), angle (α-angle), and maximum amplitude (MA) to assess clot formation and stability.
- TEG® can guide treatment decisions based on the measured parameters, such as recommending fresh frozen plasma, cryoprecipitate, platelets, or fibrinolytic agents.
- TEG® and ROTEM® have differences in diagnostic nomenclature and operation, with TEG® involving cup movement and ROTEM® using an immobile cup, making their results not directly comparable.
- Equivalent variables in ROTEM® include clotting time (CT), α-angle, clot formation time (CFT), maximum clot firmness (MCF), and clot lysis (CL).
- The initial processes of platelet aggregation involve interactions between subendothelial macromolecules, glycoprotein receptors, and platelet-derived substances, regulated by antiplatelet drugs such as clopidogrel and aspirin.
- Major antiplatelet drugs act to block platelet activation and inhibit the upregulation of glycoprotein GPIIb/IIIa receptors, essential for platelet aggregation, providing insights into their mechanisms of action.
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Description
Test your knowledge of Thromboelastography (TEG®) and ROTEM® viscoelastic hemostatic assays with this quiz. Explore the differences between TEG® and ROTEM®, understand the measurements they provide, and learn about their clinical applications in guiding treatment decisions.