lecture 10 multiple chocie quiz- immunology
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Questions and Answers

What is the main role of MHC cell surface proteins in the immune system?

  • Inhibiting cytokine production
  • Presenting peptide antigens to T cell receptors (correct)
  • Producing antibodies against pathogens
  • Activating B cells directly

    • Which type of T cells primarily recognize peptides presented by Class I MHC molecules?

  • Regulatory T cells
  • Natural killer cells
  • CD8+ cytotoxic T cells (correct)
  • CD4+ helper T cells

    • What role do T cell receptors (TCRs) play in recognizing antigens?

  • Producing cytokines upon interaction
  • Inhibiting antigen presentation by MHC molecules
  • Binding specifically to peptide-MHC complexes (correct)
  • Activating macrophages directly

    • Where do Class II MHC molecules present peptides derived from?

    <p>Extracellular proteins</p> Signup and view all the answers

    What is the specificity of the interaction between TCRs and the peptide-MHC complex?

    <p>Highly specific</p> Signup and view all the answers

    What is the role of immunodominant peptides in the context of T cell activation?

    <p>They trigger a strong response from T cells</p> Signup and view all the answers

    Which of the following factors influences the selection of immunodominant peptides during antigen processing?

    <p>MHC allele expression</p> Signup and view all the answers

    What is the primary function of Class I MHC molecules in the antigen processing pathway?

    <p>Present peptides to CD8+ CTLs</p> Signup and view all the answers

    What is the significance of T cell receptors in recognizing antigens?

    <p>They recognize both peptides and MHC molecules</p> Signup and view all the answers

    Which statement accurately describes the antigen processing pathway for Class II MHC molecules?

    <p>Loads peptides onto newly synthesized Class II MHC molecules</p> Signup and view all the answers

    What is the main origin of peptide antigens presented by Class I MHC molecules?

    <p>Viral proteins synthesized by infected cells</p> Signup and view all the answers

    What is responsible for transporting peptide fragments from the cytosol into the endoplasmic reticulum (ER) in antigen processing for Class I MHC molecules?

    <p>TAP complex</p> Signup and view all the answers

    What is the key component that makes up Class I MHC molecules along with the heavy chain and β2 microglobulin?

    <p>Peptide-binding cleft</p> Signup and view all the answers

    Which type of proteins are NOT a source of peptide antigens for Class I MHC molecules?

    <p>Ribosomal proteins</p> Signup and view all the answers

    During antigen processing for Class I MHC molecules, what degrades intracellular proteins within the cytosol?

    <p>Proteasome</p> Signup and view all the answers

    Which process ensures that only peptides capable of stable binding to Class I MHC molecules are presented on the cell surface?

    <p>Peptide-MHC Association</p> Signup and view all the answers

    Where are peptide antigens loaded onto Class I MHC molecules during biosynthesis?

    <p>Endoplasmic reticulum</p> Signup and view all the answers

    What is the main function of CD8+ cytotoxic T lymphocytes (CTLs) in response to peptide-MHC complexes on the cell surface?

    <p>Recognize and eliminate cells presenting specific peptide antigens</p> Signup and view all the answers

    Which molecule specifically recognizes and binds to the peptide-MHC complex on the cell surface?

    <p>TCR (T cell receptor)</p> Signup and view all the answers

    During which stage does the activation of CD8+ CTLs by the peptide-MHC complex occur?

    <p>ER-to-Golgi transport</p> Signup and view all the answers

    Where do peptide antigens originate for Class II MHC molecules?

    <p>From microbial proteins through phagocytosis</p> Signup and view all the answers

    What is the role of Class I MHC molecules in the immune system?

    <p>Presentation of peptides to CD8+ cytotoxic T lymphocytes</p> Signup and view all the answers

    Which cells are responsible for recognizing peptide-MHC complexes on the cell surface?

    <p>CD8+ cytotoxic T lymphocytes</p> Signup and view all the answers

    What is the function of the Ii protein in the antigen processing pathway?

    <p>Prevents loading of cytosolic peptides onto Class II MHC molecules</p> Signup and view all the answers

    Which statement accurately describes the origin of peptide antigens for Class I MHC molecules?

    <p>They can include misfolded host proteins</p> Signup and view all the answers

    Which type of cells express Class II MHC molecules?

    <p>B cells</p> Signup and view all the answers

    What is the primary role of CD4+ helper T cells?

    <p>Produce antibodies</p> Signup and view all the answers

    Which cells recognize antigens presented by MHC molecules?

    <p>CD4+ helper T cells</p> Signup and view all the answers

    What is the main function of CD8+ cytotoxic T lymphocytes?

    <p>Destroy infected or abnormal cells</p> Signup and view all the answers

    Where do Class I MHC molecules primarily present peptides from?

    <p>Intracellular proteins</p> Signup and view all the answers

    Which types of T cells recognize peptides presented by MHC Class I molecules?

    <p>CD8+ cytotoxic T lymphocytes</p> Signup and view all the answers

    Which cells express Class I MHC molecules?

    <p>Most nucleated cells</p> Signup and view all the answers

    What is the main function of CD4+ T cells in immune responses?

    <p>Cytokine release and coordination of immune responses</p> Signup and view all the answers

    Which of the following is a characteristic of Class II MHC molecules?

    <p>Expressed primarily by antigen-presenting cells (APCs)</p> Signup and view all the answers

    What is the specific function of CD8+ cytotoxic T lymphocytes upon recognizing peptide-MHC class I complexes?

    <p>Initiate responses against infected or abnormal cells leading to their destruction</p> Signup and view all the answers

    What ensures the specificity and fidelity of T cell responses to antigenic peptides presented by MHC molecules?

    <p>Dual recognition of the peptide antigen and the MHC molecule by the TCR</p> Signup and view all the answers

    Where are protein antigens processed and degraded to generate peptide fragments for presentation to T cells?

    <p>In the cytoplasm</p> Signup and view all the answers

    What is the role of MHC cell surface proteins in the immune system?

    <p>Presenting peptide antigens to T cells for recognition</p> Signup and view all the answers

    What is the significance of TCR recognition of both the peptide antigen and the MHC molecule?

    <p>It ensures the specificity and fidelity of T cell responses</p> Signup and view all the answers

    In T cell recognition, what do the variable regions of the TCR specifically bind to?

    <p>Peptide antigens</p> Signup and view all the answers

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