Tardive Dyskinesia and Basal Ganglia Pathways Quiz
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Questions and Answers

Which pathway is associated with the negative symptoms of schizophrenia?

  • Tuberoinfundibular Pathway
  • Nigrostriatal Pathway
  • Mesolimbic Dopamine Pathway
  • Mesocortical Dopamine Pathway (correct)

What effect do first-generation antipsychotics have on negative symptoms of schizophrenia?

  • Reduce negative symptoms
  • Have no effect on negative symptoms
  • Improve negative symptoms
  • Worsen negative symptoms (correct)

Which receptor family is dopamine regulated by in the context of schizophrenia?

  • D3 family
  • D1 family
  • D2 family (D2, D3, D4) (correct)
  • D4 family

What is the biggest predictor of an individual's ability to live independently with schizophrenia?

<p>Negative symptoms (D)</p> Signup and view all the answers

Which pathway is related to emotional behaviors, motivation, and pleasure in the context of schizophrenia?

<p>Mesolimbic Dopamine Pathway (A)</p> Signup and view all the answers

What side effect can occur due to chronic D2 antagonism in the nigrostriatal pathway?

<p>Tardive dyskinesia (D)</p> Signup and view all the answers

Which neurotransmitter pathway is implicated in the negative symptoms of schizophrenia?

<p>Mesocortical pathway (D)</p> Signup and view all the answers

What is the main impact of first-generation antipsychotics on negative symptoms of schizophrenia?

<p>Worsen negative symptoms (B)</p> Signup and view all the answers

What is the primary function of the Dorsolateral prefrontal cortex in the context of schizophrenia?

<p>Regulate cognition and executive function (A)</p> Signup and view all the answers

Which receptor family is targeted by first-generation antipsychotics?

<p>D2 receptor (A)</p> Signup and view all the answers

What symptom is worsened by chronic D2 antagonism in the nigrostriatal pathway?

<p>Tardive dyskinesia (B)</p> Signup and view all the answers

Which part of the brain does the Mesolimbic pathway connect to in the context of schizophrenia?

<p>Ventral striatum (B)</p> Signup and view all the answers

What is the role of the Mesocortical Dopamine Pathway in schizophrenia?

<p>Regulate cognition and executive function (B)</p> Signup and view all the answers

How do first-generation antipsychotics affect positive and negative symptoms of schizophrenia?

<p>Reduce positive symptoms and increase negative symptoms (C)</p> Signup and view all the answers

Atypical antipsychotics have a pharmacological action of:

<p><em>5-HT2A Antagonism</em> (B)</p> Signup and view all the answers

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