Tardive Dyskinesia and Basal Ganglia Pathways Quiz
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Questions and Answers

Which pathway is associated with the negative symptoms of schizophrenia?

  • Tuberoinfundibular Pathway
  • Nigrostriatal Pathway
  • Mesolimbic Dopamine Pathway
  • Mesocortical Dopamine Pathway (correct)
  • What effect do first-generation antipsychotics have on negative symptoms of schizophrenia?

  • Reduce negative symptoms
  • Have no effect on negative symptoms
  • Improve negative symptoms
  • Worsen negative symptoms (correct)
  • Which receptor family is dopamine regulated by in the context of schizophrenia?

  • D3 family
  • D1 family
  • D2 family (D2, D3, D4) (correct)
  • D4 family
  • What is the biggest predictor of an individual's ability to live independently with schizophrenia?

    <p>Negative symptoms</p> Signup and view all the answers

    Which pathway is related to emotional behaviors, motivation, and pleasure in the context of schizophrenia?

    <p>Mesolimbic Dopamine Pathway</p> Signup and view all the answers

    What side effect can occur due to chronic D2 antagonism in the nigrostriatal pathway?

    <p>Tardive dyskinesia</p> Signup and view all the answers

    Which neurotransmitter pathway is implicated in the negative symptoms of schizophrenia?

    <p>Mesocortical pathway</p> Signup and view all the answers

    What is the main impact of first-generation antipsychotics on negative symptoms of schizophrenia?

    <p>Worsen negative symptoms</p> Signup and view all the answers

    What is the primary function of the Dorsolateral prefrontal cortex in the context of schizophrenia?

    <p>Regulate cognition and executive function</p> Signup and view all the answers

    Which receptor family is targeted by first-generation antipsychotics?

    <p>D2 receptor</p> Signup and view all the answers

    What symptom is worsened by chronic D2 antagonism in the nigrostriatal pathway?

    <p>Tardive dyskinesia</p> Signup and view all the answers

    Which part of the brain does the Mesolimbic pathway connect to in the context of schizophrenia?

    <p>Ventral striatum</p> Signup and view all the answers

    What is the role of the Mesocortical Dopamine Pathway in schizophrenia?

    <p>Regulate cognition and executive function</p> Signup and view all the answers

    How do first-generation antipsychotics affect positive and negative symptoms of schizophrenia?

    <p>Reduce positive symptoms and increase negative symptoms</p> Signup and view all the answers

    Atypical antipsychotics have a pharmacological action of:

    <p><em>5-HT2A Antagonism</em></p> Signup and view all the answers

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