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Questions and Answers

What type of magnetic material is strongly attracted to magnetic fields and can pose safety risks in MRI?

  • Paramagnetic materials
  • Ferromagnetic materials (correct)
  • Diamagnetic materials
  • Superparamagnetic materials

Which property describes a material that is slightly repelled by magnetic fields?

  • Ferromagnetism
  • Diamagnetism (correct)
  • Hexamagnetism
  • Paramagnetism

What happens to hemoglobin when it binds oxygen?

  • It undergoes a conformational change (correct)
  • It turns ferromagnetic
  • It remains unaffected
  • It becomes more paramagnetic

Which of the following substances act as contrast agents in MRI due to their paramagnetic properties?

<p>Gadolinium (C)</p> Signup and view all the answers

What is the primary safety concern regarding ferromagnetic materials in MRI?

<p>They can be attracted into the magnet causing potential injury (C)</p> Signup and view all the answers

Which material is known to exhibit both paramagnetic and diamagnetic properties depending on its oxygen saturation?

<p>Hemoglobin (A)</p> Signup and view all the answers

Why are MRI systems designed to minimize ferromagnetic materials?

<p>To ensure patient safety and equipment integrity (B)</p> Signup and view all the answers

What occurs when biological tissues are subjected to magnetic fields?

<p>They are weakly diamagnetic (A)</p> Signup and view all the answers

What property do paramagnetic substances exhibit that makes them attracted to magnetic fields?

<p>They contain unpaired electrons. (A)</p> Signup and view all the answers

Which of the following materials is considered a diamagnetic substance?

<p>Platinum (C)</p> Signup and view all the answers

How does hemoglobin's binding of oxygen affect its magnetic properties?

<p>It reduces its paramagnetic characteristics. (A)</p> Signup and view all the answers

What enhances MRI images when using gadolinium as a contrast agent?

<p>Altering the relaxation times of nearby protons. (D)</p> Signup and view all the answers

Which safety feature is NOT associated with MR-compatible EEG cap systems?

<p>Metal electrode cables (A)</p> Signup and view all the answers

What is a common characteristic of most biological tissues in relation to magnetism?

<p>They are weakly diamagnetic. (A)</p> Signup and view all the answers

Which component is essential for the MR compatibility of EEG caps?

<p>Shielding against RF interference. (C)</p> Signup and view all the answers

What happens to deoxyhemoglobin's magnetic properties when it is fully oxygenated?

<p>It becomes diamagnetic. (A)</p> Signup and view all the answers

What component is NOT part of a commonly used MR-compatible EEG cap system?

<p>Ferromagnetic material (C)</p> Signup and view all the answers

Which property of materials is relevant for ensuring patient safety during MRI?

<p>Ferromagnetism (C)</p> Signup and view all the answers

What is the primary safety feature of the MR-compatible EEG cap?

<p>Plastic electrode holders (A)</p> Signup and view all the answers

What is the main purpose of RF shielding resistors in EEG caps?

<p>To prevent RF energy interference (A)</p> Signup and view all the answers

Which of the following statements about paramagnetic materials is true?

<p>They improve contrast in MRI images. (C)</p> Signup and view all the answers

What type of magnetic field is primarily generated by gradient switching in MRI?

<p>Rapidly changing variable magnetic field (D)</p> Signup and view all the answers

Which material is considered weakly diamagnetic in the context of MRI?

<p>Deoxyhemoglobin (C)</p> Signup and view all the answers

What is the primary purpose of correcting gradient and cardioballistic artifacts?

<p>To ensure data quality (C)</p> Signup and view all the answers

Which method involves creating an estimate of the gradient artifact to remove it from noisy data?

<p>Template methods (C)</p> Signup and view all the answers

What frequency range is primarily associated with the alpha rhythm identified in EEG recordings?

<p>8-12 Hz (D)</p> Signup and view all the answers

When does the alpha rhythm exhibit the highest amplitude?

<p>When a subject is awake and relaxed with eyes closed (B)</p> Signup and view all the answers

Which of the following techniques is NOT listed as a main method for correcting gradient artifacts?

<p>Wavelet transformation (B)</p> Signup and view all the answers

What is the essential characteristic of the neuronal EEG signal in relation to the gradient artifact?

<p>It averages out to zero across many TRs. (A)</p> Signup and view all the answers

What physiological activity is the alpha rhythm potentially an index of?

<p>Cortical inactivity (B)</p> Signup and view all the answers

What is the primary cause of an action potential in a neuron?

<p>Sudden flow of ions in and out of the neuron (D)</p> Signup and view all the answers

Which of the following is a marker of N2 light sleep in EEG readings?

<p>Spindles (A)</p> Signup and view all the answers

How do postsynaptic potentials (PSPs) differ from action potentials?

<p>PSPs last longer than action potentials (D)</p> Signup and view all the answers

Which of the following accurately describes a postsynaptic potential?

<p>It involves changes in membrane potential due to neurotransmitter binding (B)</p> Signup and view all the answers

What is a significant factor for ensuring compatibility in simultaneous EEG-fMRI procedures?

<p>Limiting the introduction of ferrous materials (A)</p> Signup and view all the answers

What is the primary nature of an action potential compared to a postsynaptic potential?

<p>Action potentials are all-or-nothing events, while PSPs are graded (D)</p> Signup and view all the answers

Which of the following best describes the duration of a postsynaptic potential?

<p>It can last for tens to hundreds of milliseconds (B)</p> Signup and view all the answers

What is a consequence of neurotransmitter binding at synapses?

<p>It can create a change in the postsynaptic membrane potential (B)</p> Signup and view all the answers

Which statement is true regarding the changes in membrane potential during an action potential?

<p>There is a temporary shift from negative to positive voltage (D)</p> Signup and view all the answers

What does an increased P300 amplitude generally indicate?

<p>Greater significance of the event (A)</p> Signup and view all the answers

What do shorter P300 latencies typically suggest about mental performance?

<p>They indicate superior mental performance (B)</p> Signup and view all the answers

Which disorder is associated with a decrease in P300 amplitude?

<p>Schizophrenia (B)</p> Signup and view all the answers

What effect does caffeine have on P300 amplitude and processing?

<p>It facilitates quicker mental processing and less attention demand (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic of the P300 wave in individuals with schizophrenia?

<p>Increased P300 amplitude (B)</p> Signup and view all the answers

What does the latency prolongation of P300 suggest about cognitive processes?

<p>Deficits in attentional or working memory systems (C)</p> Signup and view all the answers

Which of the following psychiatric disorders has been noted for P300 amplitude reduction during manic psychosis?

<p>Bipolar disorder (A)</p> Signup and view all the answers

In terms of P300, what does an increase in the cognitive resources demand imply?

<p>An increase in P300 amplitude (A)</p> Signup and view all the answers

Flashcards

Action Potential

A rapid change in neuron's membrane voltage, from negative to positive, caused by ion flow.

Postsynaptic Potential (PSP)

A temporary change in a neuron's membrane potential at a synapse, as a result of neurotransmitters.

PSP duration

PSPs last tens or hundreds of milliseconds, longer than action potentials.

EEG

Electroencephalography, a technique that measures brain activity through electrical signals.

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fMRI

Functional Magnetic Resonance Imaging, a technique to visualize brain activity by measuring blood flow.

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Electrocorticography (ECoG)

A technique that records electrical activity from the brain's surface using electrodes.

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iEEG

Intracranial EEG, a technique that measures brain electrical activity from inside the brain using electrodes.

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Simultaneous EEG-fMRI

A technique to measure both electrical and blood flow brain activity simultaneously.

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Ferromagnetic Material in MRI

Materials strongly attracted to magnetic fields, posing safety risks in MRI due to potential for pulling into the magnet.

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Paramagnetic Substance in MRI

Substances, like gadolinium, used as contrast agents in MRI, altering relaxation times of nearby protons to enhance image contrast.

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Diamagnetic Material in MRI

Materials slightly repelled by magnetic fields; pose no safety risk in MRI.

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EEG-fMRI Compatibility Challenge

Simultaneously recording EEG (brainwaves) and fMRI (brain activity) is challenging due to the strong and rapidly changing magnetic fields in an MRI machine, which can interfere with EEG recordings.

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MRI-compatible EEG cap's safety features

Protect the scalp from direct contact with the electrode and employ RF shielding to reduce interference within the magnetic environment.

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MR Bore Environment

The internal space of an MRI machine. It presents a challenging environment for EEG recording due to strong magnetic fields(static and variable).

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Deoxyhemoglobin Properties

Deoxyhemoglobin has unpaired electrons, exhibiting paramagnetic properties. This is important in MRI contrast.

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Radio Frequency (RF) Energy in MRI

High-frequency electromagnetic energy emitted during MRI scanning, which can affect sensors used to measure brain activity.

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Paramagnetism

A property where a material is weakly attracted to a magnetic field due to unpaired electrons.

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Diamagnetism

A property where a material is weakly repelled by a magnetic field.

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Contrast Agent in MRI

A substance used in MRI to enhance the contrast of images by altering the relaxation times of nearby protons.

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Gadolinium

A paramagnetic element used as a contrast agent in MRI.

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Deoxyhemoglobin & Paramagnetism

The form of hemoglobin without bound oxygen is paramagnetic, making it attracted to magnetic fields.

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Oxyhemoglobin & Diamagnetism

When hemoglobin binds oxygen, it becomes diamagnetic, meaning it is weakly repelled by magnetic fields.

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MR-compatible EEG Cap

A special EEG cap designed to be safe to use during MRI scans.

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Ferromagnetism

Ferromagnetic materials are strongly attracted to magnetic fields. They pose a safety risk in MRI as they can be pulled into the magnet.

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Hemoglobin and Oxygen

When hemoglobin binds oxygen, it becomes less attracted to magnetic fields (diamagnetic). This is significant for understanding MRI signals.

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MRI safety risks

Ferromagnetic materials (like iron) can be dangerous in MRI because they are strongly attracted to the magnetic field, potentially causing injury.

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MRI contrast agents

Paramagnetic substances, like gadolinium, are used as contrast agents in MRI to enhance the contrast of images by altering the relaxation times of nearby protons.

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MRI design and ferromagnetism

MRI machines are designed to minimize the presence of ferromagnetic materials to ensure patient safety and equipment integrity.

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Biological tissues and diamagnetism

Most biological tissues are weakly diamagnetic, meaning they are slightly repelled by magnetic fields. This makes them safe for MRI.

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Gradient Artifact (GA)

A distortion in EEG recordings caused by magnetic field gradients in the fMRI scanner.

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Template Methods for GA Correction

Techniques that estimate and remove the artifact based on its repetitive pattern, assuming it's time-locked to the fMRI imaging sequence.

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Blind Source Separation (BSS)

A method that identifies and separates different signal sources in the EEG data, including artifacts.

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Alpha Rhythm

Prominent brainwave pattern (8-12 Hz) observed in EEG during relaxed wakefulness, decreasing during mental effort or sleep.

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Alpha Rhythm and Cortical Inactivity

Alpha rhythm is a potential indicator of low cortical activity, possibly originating in the thalamus.

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Event Related Potentials (ERPs)

Brainwave patterns in EEG that are time-locked to specific events or stimuli, reflecting brain responses.

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fMRI & EEG Alpha

EEG alpha activity can be used as a marker of brain state (e.g., relaxation) in conjunction with fMRI, providing insights into brain function.

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P300 component

A positive-going event-related potential (ERP) occurring around 300 milliseconds after a stimulus, associated with cognitive processes like memory updating and classification.

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P300 amplitude

The strength or intensity of the P300 wave, reflecting the level of cognitive resources allocated to a stimulus.

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P300 latency

The time delay between the stimulus and the peak of the P300 wave, reflecting the speed of cognitive processing.

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P300 in Schizophrenia

Schizophrenia is characterized by a reduction in P300 amplitude and an increase in P300 latency, suggesting impairments in cognitive processing.

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P300 in Bipolar Disorder

Patients with bipolar disorder show reduced P300 amplitude and prolonged P300 latency, similar to schizophrenia but with less pronounced early auditory processing deficits.

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Caffeine's Effect on P300

Caffeine enhances cognitive processing by potentially reducing the demand on attention resources and allocating more resources for task performance.

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P300 and Mental Performance

P300 latency is inversely related to cognitive speed, with shorter latencies indicating faster and more efficient processing.

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P300 and Cognitive Load

P300 amplitude increases when more cognitive resources are required to process a stimulus, reflecting the mental effort involved.

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Study Notes

BM402: Engineering in Medicine

  • Course name: BM402: Engineering in Medicine
  • Date: 24th October 2024
  • Location: M 2170 - South Campus

MRI

  • Functional MRI
  • Applications of MRI and fMRI
  • EEG
  • Applications of EEG
  • Multimodal Imaging

EEG Basics

  • Electro-encephalo-gram (EEG): Measurement of electrical patterns on the scalp reflecting cortical activity (brainwaves).
  • Electrical: EEG measures electrical potentials from the brain.
  • Electrode: Electrodes are placed on the scalp to measure the electrical potentials.
  • EEG cap: A cap containing electrodes to measure electrical signals from the brain.
  • Amplifier: An amplifier boosts the weak electrical signals from the electrodes.
  • Processing: Processing the amplified signals to understand patterns and activity.
  • Picture/Record: Visual display and recording of the measured brainwaves.
  • Brainwave types:
  • Delta (1.0-4.0 Hz): Sleep, dreaming
  • Theta (4.0-8.0 Hz): Drowsiness
  • Alpha (8.0-12.0 Hz): Reflective, restful
  • Beta (12.0-25.0 Hz): Busy, active mind
  • Gamma (>35 Hz): Problem-solving, concentration

International 10-20 System

  • System for electrode placement on the head for EEG recordings.
  • Standardized placement locations on the scalp.
  • Numerical percentages for defining locations, e.g., 10%, 20%

Electrocorticography (ECOG)

  • ECOG, IEEG
  • Intracortical microelectrode: An electrode that is inserted directly into the brain.
  • Grid and stick electrodes: Used in intracortical recordings.
  • Dr. Kareem Zaghloul: Researcher associated with neural signatures of memory and information in the human brain.

EEG History

  • Detailed history of EEG, including significant developments and key researchers like Hans Berger.
  • Timeline of Technological Advancements:
  • Equipment recordings
  • Evoked potentials
  • Event-related potentials
  • Topographic analyses
  • Computer-aided signal processing
  • Brain-computer interfaces
  • Brain-controlled therapies
  • Personalized medicine
  • Key areas: technology, findings, and applications (1929-1938, 1950, 1960,...1980,.., 1990, 2000, 2010, 2020)

EEG - Brain Rhythms & Frequency Bands

  • Different brainwave frequencies correlate with different mental states, categorized:
  • Gamma: Problem solving, concentration (Frequency>35Hz)
  • Beta: Busy, active mind (frequency 12-35Hz)
  • Alpha: Reflective, restful (frequency 8-12Hz)
  • Theta: Drowsiness (Frequency 4–8Hz)
  • Delta: Sleep, dreaming (Frequency 0.5–4Hz)

EEG Recordings During Sleep

  • EEG stages during sleep: Wake, Stage 1, Stage 2, Stage 3, REM, and their characteristic frequency bands

Recording the Electrical Activity of the Brain

  • Definition of action potential
  • Local field potential
  • Electroencephalogram

Postsynaptic Potentials (PSPs)

  • Definition of Postsynaptic potentials
  • Relation to chemical transmission at the synapse
  • Duration of PSPs

Simultaneous EEG-fMRI

  • Advantages and disadvantages of simultaneous EEG and fMRI.
  • Compatibility issues (magnetic fields, RF emissions, materials).
  • Techniques and components for compatibility: electrode cap, connector box, resistors, battery pack, EEG amplifier/digitizer.
  • Main artifacts: gradient, ballistocardiogram (BCG)
  • Artefact correction methods: template, blind source separation, filtering

Magnetic Properties Relevant to MRI

  • Ferromagnetism: Strongly attracted to magnetic fields (iron).
  • Paramagnetism: Slightly attracted to magnetic fields (gadolinium, deoxyhemoglobin).
  • Diamagnetism: Slightly repelled by magnetic fields (biological tissues).
  • Importance of these properties for device design and interpreting results
  • Definition: neural response associated with a specific sensory, cognitive or motor event.
  • Recording: Average change in voltage over time, starting at stimulus onset, multiple trials
  • Identification of ERP components (e.g., P100, N100, P200, P300) related to sensory properties, selective attention, and endogenous cognitive activity
  • Latency and amplitude as indicators of mental performance and neurobiological vulnerability.

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