18 Questions
What is the primary function of negative selection in the thymus gland during T cell maturation?
To delete T cells that do not recognize self-antigens
What is the primary difference between CD4+ T helper cells and CD8+ cytotoxic T cells in terms of their MHC restriction?
CD4+ T cells are restricted to MHC class II, while CD8+ T cells are restricted to MHC class I
Which of the following is a key function of T helper cells (CD4+ T cells) in the immune response?
Activation of B cells to produce antibodies
What is the role of cytokines in the differentiation and maturation of T cells?
Cytokines induce the expression of specific transcription factors that drive T cell lineage commitment
Which of the following is a key function of regulatory T cells (Tregs) in the immune system?
Suppression of immune responses to prevent autoimmunity
Which of the following is a key difference between the maturation of T cells in the thymus and B cells in the bone marrow?
T cells undergo positive selection, while B cells undergo negative selection
Which of the following is NOT a function of Th1 helper T cells?
Stimulation of IgE antibody production
What is the primary function of T regulatory cells (Treg)?
Regulate and suppress the immune response
Which cytokine is responsible for the differentiation of naive T helper cells (Th0) into Th17 cells?
IL-6 and TGF-β
Which of the following is a function of Th2 helper T cells?
Activation of eosinophils and IgE production
What is the primary function of Th17 cells?
Recruitment of leukocytes, mainly neutrophils, to infection sites
Which of the following cytokines is produced by naive T helper cells (Th0)?
IL-4 and IFN-α
What is the main function of T helper cells when stimulated by IL2?
Maintain peripheral self-tolerance
Which of the following is NOT a function of T cytotoxic cells (CD8)?
Inducing apoptosis in B cells
What is the main mechanism through which T cytotoxic cells kill infected cells?
Release of perforins and granzymes
What is the approximate ratio of T helper cells to T cytotoxic cells?
2:1
Which of the following cytokines are secreted by T cytotoxic cells during their killing mechanism?
TNF and IFN-
What forms the T cell receptor (TCR) complex that helps transduce signals received by TCR to T cell activation?
$\alpha/\beta$ TCR and CD3 chains
Test your knowledge on the origin and maturation of T cells in the immune system. Learn about T cell progenitors, development in the thymus glands, acquisition of specific receptors (TCR), CD3, CD4, and CD8, and the transition from immature to mature T cells.
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