T Cells Origin and Maturation Quiz

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What is the primary function of negative selection in the thymus gland during T cell maturation?

To delete T cells that do not recognize self-antigens (correct)

To ensure that T cells can recognize a wide range of foreign antigens

To promote the development of self-reactive T cells

To induce positive selection of T cells with high affinity for self-antigens

What is the primary difference between CD4+ T helper cells and CD8+ cytotoxic T cells in terms of their MHC restriction?

CD4+ T cells are not restricted to any MHC class, while CD8+ T cells are restricted to both MHC class I and II

CD4+ T cells are restricted to MHC class I, while CD8+ T cells are restricted to MHC class II

CD4+ T cells and CD8+ T cells have the same MHC class restrictions

CD4+ T cells are restricted to MHC class II, while CD8+ T cells are restricted to MHC class I (correct)

Which of the following is a key function of T helper cells (CD4+ T cells) in the immune response?

Recruitment of neutrophils and other innate immune cells

Phagocytosis of pathogens and cellular debris

Direct killing of infected or cancerous cells

Activation of B cells to produce antibodies (correct)

What is the role of cytokines in the differentiation and maturation of T cells?

Cytokines induce the expression of specific transcription factors that drive T cell lineage commitment Signup and view all the answers

Which of the following is a key function of regulatory T cells (Tregs) in the immune system?

Suppression of immune responses to prevent autoimmunity Signup and view all the answers

Which of the following is a key difference between the maturation of T cells in the thymus and B cells in the bone marrow?

T cells undergo positive selection, while B cells undergo negative selection Signup and view all the answers

Which of the following is NOT a function of Th1 helper T cells?

Stimulation of IgE antibody production Signup and view all the answers

What is the primary function of T regulatory cells (Treg)?

Regulate and suppress the immune response Signup and view all the answers

Which cytokine is responsible for the differentiation of naive T helper cells (Th0) into Th17 cells?

IL-6 and TGF-β Signup and view all the answers

Which of the following is a function of Th2 helper T cells?

Activation of eosinophils and IgE production Signup and view all the answers

What is the primary function of Th17 cells?

Recruitment of leukocytes, mainly neutrophils, to infection sites Signup and view all the answers

Which of the following cytokines is produced by naive T helper cells (Th0)?

IL-4 and IFN-α Signup and view all the answers

What is the main function of T helper cells when stimulated by IL2?

Maintain peripheral self-tolerance Signup and view all the answers

Which of the following is NOT a function of T cytotoxic cells (CD8)?

Inducing apoptosis in B cells Signup and view all the answers

What is the main mechanism through which T cytotoxic cells kill infected cells?

Release of perforins and granzymes Signup and view all the answers

What is the approximate ratio of T helper cells to T cytotoxic cells?

2:1 Signup and view all the answers

Which of the following cytokines are secreted by T cytotoxic cells during their killing mechanism?

TNF and IFN- Signup and view all the answers

What forms the T cell receptor (TCR) complex that helps transduce signals received by TCR to T cell activation?

$\alpha/\beta$ TCR and CD3 chains Signup and view all the answers