Podcast
Questions and Answers
What is the primary function of TH1 cells?
What is the primary function of TH1 cells?
- Secrete a large number of cytokines
- Promote class-switching of antibodies
- Activate macrophages and CD8⁺ T cells (correct)
- Activate B cells for antibody production
Which cytokine is NOT associated with TH2 cells?
Which cytokine is NOT associated with TH2 cells?
- IL-4
- IL-2 (correct)
- IL-10
- IL-5
What type of immunity do TH2 cells primarily mediate?
What type of immunity do TH2 cells primarily mediate?
- Humoral (antibody-mediated) immunity (correct)
- Passive immunity
- Innate immunity
- Cell-mediated immunity
Which term refers to naive T-helper cells that have not encountered antigens?
Which term refers to naive T-helper cells that have not encountered antigens?
Which of the following is a consequence of TH1 cell activation?
Which of the following is a consequence of TH1 cell activation?
Flashcards
TH1 Function
TH1 Function
Activates macrophages and CD8⁺ T cells, leading to cell-mediated immunity and delayed hypersensitivity.
TH2 Function
TH2 Function
Activates B cells and promotes antibody class-switching for humoral immunity (antibody-mediated).
Naive TH cell
Naive TH cell
An inactive helper T cell that has not yet encountered an antigen.
Antigen-Presenting Cell (APC)
Antigen-Presenting Cell (APC)
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TH cell Activation
TH cell Activation
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Study Notes
T Cell Subsets
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TH1:
- Immunity: Cell-mediated
- Function: Activates macrophages and CD8+ T cells
- Cytokines: IL-2, IFN-γ, lymphotoxin β
- Result: Cytotoxicity; delayed hypersensitivity
-
TH2:
- Immunity: Humoral (antibody-mediated)
- Function: Activates B cells, promotes class switching
- Cytokines: IL-4, 5, 10, & 13
- Result: Secretion of antibodies
-
Naive T cells (Th0): Helper T cells that haven't encountered antigens yet.
- Characteristics: Have T-cell receptors (TCRs) and CD4 proteins on their surface.
- Activation: An antigen-MHC class II complex on an antigen-presenting cell (e.g., macrophage, dendritic cell) can activate a naive Th cell by interacting with both TCR and CD4.
- Differentiation: The activated T cell differentiates into either a TH1 or TH2 cell.
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Interferon-gamma (IFN-γ): A cytokine involved in TH1 immunity. A significant percentage (78%) of T cells produce this cytokine.
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Description
Test your knowledge on T cell subsets including TH1, TH2, and naive T cells. Understand their functions, cytokines, and roles in immunity. Dive into the intricacies of cell-mediated and humoral responses.
