Podcast
Questions and Answers
What is the primary function of TH1 cells?
What is the primary function of TH1 cells?
Which cytokine is NOT associated with TH2 cells?
Which cytokine is NOT associated with TH2 cells?
What type of immunity do TH2 cells primarily mediate?
What type of immunity do TH2 cells primarily mediate?
Which term refers to naive T-helper cells that have not encountered antigens?
Which term refers to naive T-helper cells that have not encountered antigens?
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Which of the following is a consequence of TH1 cell activation?
Which of the following is a consequence of TH1 cell activation?
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Study Notes
T Cell Subsets
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TH1:
- Immunity: Cell-mediated
- Function: Activates macrophages and CD8+ T cells
- Cytokines: IL-2, IFN-γ, lymphotoxin β
- Result: Cytotoxicity; delayed hypersensitivity
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TH2:
- Immunity: Humoral (antibody-mediated)
- Function: Activates B cells, promotes class switching
- Cytokines: IL-4, 5, 10, & 13
- Result: Secretion of antibodies
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Naive T cells (Th0): Helper T cells that haven't encountered antigens yet.
- Characteristics: Have T-cell receptors (TCRs) and CD4 proteins on their surface.
- Activation: An antigen-MHC class II complex on an antigen-presenting cell (e.g., macrophage, dendritic cell) can activate a naive Th cell by interacting with both TCR and CD4.
- Differentiation: The activated T cell differentiates into either a TH1 or TH2 cell.
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Interferon-gamma (IFN-γ): A cytokine involved in TH1 immunity. A significant percentage (78%) of T cells produce this cytokine.
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Description
Test your knowledge on T cell subsets including TH1, TH2, and naive T cells. Understand their functions, cytokines, and roles in immunity. Dive into the intricacies of cell-mediated and humoral responses.
