Systemic Review and Meta-analysis

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Questions and Answers

What is the purpose of a Systemic Review?

To provide a comprehensive survey of a topic using all primary studies of the highest level of evidence (correct)

To conduct a statistical analysis of primary studies

To combine results from several primary studies

To develop clinical practice guidelines based on primary studies

What is the significance of a Systemic Review?

To provide evidence for policy makers to judge risks, benefits, and harms of health care interventions (correct)

To summarize evidence relating to efficacy and safety of health care interventions

To conduct a statistical analysis of primary studies

To develop clinical practice guidelines based on primary studies

What are the steps underlying the reviewing process in a Systemic Review explicitly and clearly defined?

Yes (correct)

Not mentioned in the text

Only partially

What is the term used to describe the statistical method that combines results from several primary studies?

Meta-analysis Signup and view all the answers

What do clinicians use Systemic Reviews for?

To keep up-to-date with evidence on health care interventions Signup and view all the answers

What does the PICO framework stand for in defining a research question for a Systemic Review?

Population, Intervention, Comparator, Outcomes Signup and view all the answers

What are the most important electronic medical databases to perform a comprehensive search?

MEDLINE, EMBASE, and CENTRAL Signup and view all the answers

What does 'MeSH' terms refer to?

A controlled vocabulary used for indexing and searching biomedical information Signup and view all the answers

How many investigators should be involved in the selection process according to the text?

At least two Signup and view all the answers

What is the purpose of data extraction in systematic reviews?

To establish reliability and avoid data entry errors Signup and view all the answers

What is the purpose of assessing study quality in systematic reviews?

To better assess the quality of each study included Signup and view all the answers

What is the preferred form of presentation for multiple studies to answer a clinical question?

Quantitative analysis (Metaanalysis) Signup and view all the answers

What is 'Metaanalysis' used for in systematic reviews?

Combining the samples statistically Signup and view all the answers

'MeSH' stands for:

"Medical Subject Headings" Signup and view all the answers

Which scale is NOT mentioned as a tool for assessing study quality?

"Etc." (No specific scales mentioned) Signup and view all the answers

Study Notes

Purpose and Significance of Systemic Review

The purpose of a Systemic Review is to provide a comprehensive and unbiased summary of existing research on a specific topic.
The significance of a Systemic Review lies in its ability to synthesize all relevant studies, providing a clear understanding of the topic and informing evidence-based decision-making.

Steps Underlying the Reviewing Process

The reviewing process in a Systemic Review involves explicitly and clearly defined steps to ensure transparency and reproducibility.
These steps include defining a research question, identifying relevant studies, selecting studies, assessing study quality, extracting data, and synthesizing results.

Statistical Method and Clinicians' Use

The term used to describe the statistical method that combines results from several primary studies is 'Meta-analysis'.
Clinicians use Systemic Reviews to inform their practice, as they provide a comprehensive and up-to-date summary of the best available evidence on a specific topic.

PICO Framework

The PICO framework stands for Population, Intervention, Comparison, and Outcome, and is used to define a research question for a Systemic Review.

Electronic Medical Databases and MeSH Terms

The most important electronic medical databases to perform a comprehensive search include PubMed, Embase, and Cochrane Library.
'MeSH' terms refer to Medical Subject Headings, a controlled vocabulary used to index and retrieve biomedical literature.

Selection Process and Data Extraction

At least two investigators should be involved in the selection process to minimize bias and ensure consistency.
The purpose of data extraction in systematic reviews is to collect and organize the data from each study in a structured and standardized way.

Assessing Study Quality and Presentation

The purpose of assessing study quality in systematic reviews is to evaluate the risk of bias and methodological quality of each study.
The preferred form of presentation for multiple studies to answer a clinical question is a forest plot, which visually displays the results of each study.

Meta-analysis

Meta-analysis is used in systematic reviews to combine the results of multiple studies, providing a more precise estimate of the effect size and increasing the power to detect significant differences.

MeSH Terms and Scale

'MeSH' stands for Medical Subject Headings.
The Newcastle-Ottawa Scale is not mentioned as a tool for assessing study quality.

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Description

Explore the concepts of Systemic Review and Meta-analysis with this quiz. Learn about the comprehensive survey of topics and the statistical method used to combine results from primary studies for more precise and valid results.