Systematic Virology Summary
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Questions and Answers

What do E1 and E2 each contain?

  • A pair of transmembrane domains
  • A short cytoplasmic tail
  • A single transmembrane domain (correct)
  • A long extracellular domain

What is a characteristic of E1's cytoplasmic tail?

  • It is only found in E2
  • It is essential for function
  • It is dispensable (correct)
  • It is very long

What can be said about the cytoplasmic tail of E1?

  • It is longer than E2's cytoplasmic tail
  • It is not necessary for the protein's function (correct)
  • It is essential for the protein's function
  • It is a characteristic unique to E2

Which of the following statements about E1 and E2 is true?

<p>They each contain a single transmembrane domain (C)</p> Signup and view all the answers

What is true about the transmembrane domains of E1 and E2?

<p>E1 and E2 each have one (A)</p> Signup and view all the answers

Which of the following is a characteristic of E2?

<p>It has a single transmembrane domain (B)</p> Signup and view all the answers

Which statement about E1 is false?

<p>Its cytoplasmic tail is essential (C)</p> Signup and view all the answers

What is a characteristic unique to E1's cytoplasmic tail?

<p>It is dispensable (A)</p> Signup and view all the answers

What do we know about the structure of E1 and E2?

<p>E1 and E2 each have a single transmembrane domain (C)</p> Signup and view all the answers

Which alphavirus structural feature facilitates its budding from the plasma membrane?

<p>Long cytoplasmic domain (D)</p> Signup and view all the answers

Which viral genome replication occurs in the cytoplasm of infected cells?

<p>Alphaviruses (A)</p> Signup and view all the answers

Which statement best describes the cytoplasmic domain of E2 protein in alphaviruses?

<p>Long and hydrophobic (A)</p> Signup and view all the answers

Which statement is true about the transmission of most alphaviruses?

<p>Mosquito-borne (A)</p> Signup and view all the answers

How does E2 interact with the capsid protein in alphaviruses?

<p>Directly with its long cytoplasmic domain (C)</p> Signup and view all the answers

Which of the following best characterizes the budding process of alphaviruses?

<p>Buds from the plasma membrane (D)</p> Signup and view all the answers

Which of the following viruses is most likely to agglutinate goose and chick red blood cells?

<p>Alphaviruses (B)</p> Signup and view all the answers

Which viral protein exhibits a hydrophobic pocket that interacts with the cytoplasmic domain of E2?

<p>Capsid protein (D)</p> Signup and view all the answers

Which process does not occur during the lifecycle of alphaviruses in host cells?

<p>Replication in the host cell nucleus (D)</p> Signup and view all the answers

Which of the following viruses is not a member of the alphavirus genus?

<p>Measles virus (B)</p> Signup and view all the answers

Study Notes

Systematic Virology

  • Eastern equine encephalitis virus (EEEV), Western equine encephalitis virus (WEEV), Venezuelan equine encephalitis virus (VEEV), Chikungunya virus, Semliki Forest virus, and Sindbis virus are examples of alphaviruses.
  • The first isolation of an alphavirus was from the brain of a horse in California.
  • There are two aquatic alphaviruses that infect sea mammals and fish: Southern elephant seal virus and Salmon pancreas disease virus.

Genus Rubivirus

  • Rubella virus is the only member of this genus and it only infects humans.

Alphavirus General Properties

  • The particle consists of a nucleocapsid core (icosahedral capsid) surrounded by a lipid bilayer envelope embedded with glycoprotein spikes.
  • The genome encodes 10 different proteins, divided into nonstructural proteins (NSP1-NSP4) and structural proteins (capsid, E3, E2, 6K/TF, and E1).
  • Nonstructural proteins are important for replicating the viral genome.
  • Structural proteins function in virus assembly.
  • E1 and E2 each contain a single transmembrane domain.
  • E1 has a short cytoplasmic tail that is dispensable.
  • E2 has a long (>30 amino acids) cytoplasmic domain that interacts with a hydrophobic pocket in the capsid protein.

Alphavirus Characteristics

  • Alphaviruses agglutinate goose and chicks RBCs.
  • They replicate in the cytoplasm.
  • They bud from the plasma membrane.
  • Most alphaviruses are mosquito-borne.

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Description

This summary is a guide for the Virology course and supplements the references mentioned during lectures. It is not allowed to copy this summary for third-year veterinary students - Microbiology without citing the author.

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