Podcast
Questions and Answers
What do E1 and E2 each contain?
What do E1 and E2 each contain?
What is a characteristic of E1's cytoplasmic tail?
What is a characteristic of E1's cytoplasmic tail?
What can be said about the cytoplasmic tail of E1?
What can be said about the cytoplasmic tail of E1?
Which of the following statements about E1 and E2 is true?
Which of the following statements about E1 and E2 is true?
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What is true about the transmembrane domains of E1 and E2?
What is true about the transmembrane domains of E1 and E2?
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Which of the following is a characteristic of E2?
Which of the following is a characteristic of E2?
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Which statement about E1 is false?
Which statement about E1 is false?
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What is a characteristic unique to E1's cytoplasmic tail?
What is a characteristic unique to E1's cytoplasmic tail?
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What do we know about the structure of E1 and E2?
What do we know about the structure of E1 and E2?
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Which alphavirus structural feature facilitates its budding from the plasma membrane?
Which alphavirus structural feature facilitates its budding from the plasma membrane?
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Which viral genome replication occurs in the cytoplasm of infected cells?
Which viral genome replication occurs in the cytoplasm of infected cells?
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Which statement best describes the cytoplasmic domain of E2 protein in alphaviruses?
Which statement best describes the cytoplasmic domain of E2 protein in alphaviruses?
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Which statement is true about the transmission of most alphaviruses?
Which statement is true about the transmission of most alphaviruses?
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How does E2 interact with the capsid protein in alphaviruses?
How does E2 interact with the capsid protein in alphaviruses?
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Which of the following best characterizes the budding process of alphaviruses?
Which of the following best characterizes the budding process of alphaviruses?
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Which of the following viruses is most likely to agglutinate goose and chick red blood cells?
Which of the following viruses is most likely to agglutinate goose and chick red blood cells?
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Which viral protein exhibits a hydrophobic pocket that interacts with the cytoplasmic domain of E2?
Which viral protein exhibits a hydrophobic pocket that interacts with the cytoplasmic domain of E2?
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Which process does not occur during the lifecycle of alphaviruses in host cells?
Which process does not occur during the lifecycle of alphaviruses in host cells?
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Which of the following viruses is not a member of the alphavirus genus?
Which of the following viruses is not a member of the alphavirus genus?
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Study Notes
Systematic Virology
- Eastern equine encephalitis virus (EEEV), Western equine encephalitis virus (WEEV), Venezuelan equine encephalitis virus (VEEV), Chikungunya virus, Semliki Forest virus, and Sindbis virus are examples of alphaviruses.
- The first isolation of an alphavirus was from the brain of a horse in California.
- There are two aquatic alphaviruses that infect sea mammals and fish: Southern elephant seal virus and Salmon pancreas disease virus.
Genus Rubivirus
- Rubella virus is the only member of this genus and it only infects humans.
Alphavirus General Properties
- The particle consists of a nucleocapsid core (icosahedral capsid) surrounded by a lipid bilayer envelope embedded with glycoprotein spikes.
- The genome encodes 10 different proteins, divided into nonstructural proteins (NSP1-NSP4) and structural proteins (capsid, E3, E2, 6K/TF, and E1).
- Nonstructural proteins are important for replicating the viral genome.
- Structural proteins function in virus assembly.
- E1 and E2 each contain a single transmembrane domain.
- E1 has a short cytoplasmic tail that is dispensable.
- E2 has a long (>30 amino acids) cytoplasmic domain that interacts with a hydrophobic pocket in the capsid protein.
Alphavirus Characteristics
- Alphaviruses agglutinate goose and chicks RBCs.
- They replicate in the cytoplasm.
- They bud from the plasma membrane.
- Most alphaviruses are mosquito-borne.
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Description
This summary is a guide for the Virology course and supplements the references mentioned during lectures. It is not allowed to copy this summary for third-year veterinary students - Microbiology without citing the author.
