Systematic Virology Summary

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Questions and Answers

What do E1 and E2 each contain?

A pair of transmembrane domains

A short cytoplasmic tail

A single transmembrane domain (correct)

A long extracellular domain

What is a characteristic of E1's cytoplasmic tail?

It is only found in E2

It is essential for function

It is dispensable (correct)

It is very long

What can be said about the cytoplasmic tail of E1?

It is longer than E2's cytoplasmic tail

It is not necessary for the protein's function (correct)

It is essential for the protein's function

It is a characteristic unique to E2

Which of the following statements about E1 and E2 is true?

They each contain a single transmembrane domain Signup and view all the answers

What is true about the transmembrane domains of E1 and E2?

E1 and E2 each have one Signup and view all the answers

Which of the following is a characteristic of E2?

It has a single transmembrane domain Signup and view all the answers

Which statement about E1 is false?

Its cytoplasmic tail is essential Signup and view all the answers

What is a characteristic unique to E1's cytoplasmic tail?

It is dispensable Signup and view all the answers

What do we know about the structure of E1 and E2?

E1 and E2 each have a single transmembrane domain Signup and view all the answers

Which alphavirus structural feature facilitates its budding from the plasma membrane?

Long cytoplasmic domain Signup and view all the answers

Which viral genome replication occurs in the cytoplasm of infected cells?

Alphaviruses Signup and view all the answers

Which statement best describes the cytoplasmic domain of E2 protein in alphaviruses?

Long and hydrophobic Signup and view all the answers

Which statement is true about the transmission of most alphaviruses?

Mosquito-borne Signup and view all the answers

How does E2 interact with the capsid protein in alphaviruses?

Directly with its long cytoplasmic domain Signup and view all the answers

Which of the following best characterizes the budding process of alphaviruses?

Buds from the plasma membrane Signup and view all the answers

Which of the following viruses is most likely to agglutinate goose and chick red blood cells?

Alphaviruses Signup and view all the answers

Which viral protein exhibits a hydrophobic pocket that interacts with the cytoplasmic domain of E2?

Capsid protein Signup and view all the answers

Which process does not occur during the lifecycle of alphaviruses in host cells?

Replication in the host cell nucleus Signup and view all the answers

Which of the following viruses is not a member of the alphavirus genus?

Measles virus Signup and view all the answers

Study Notes

Systematic Virology

Eastern equine encephalitis virus (EEEV), Western equine encephalitis virus (WEEV), Venezuelan equine encephalitis virus (VEEV), Chikungunya virus, Semliki Forest virus, and Sindbis virus are examples of alphaviruses.
The first isolation of an alphavirus was from the brain of a horse in California.
There are two aquatic alphaviruses that infect sea mammals and fish: Southern elephant seal virus and Salmon pancreas disease virus.

Genus Rubivirus

Rubella virus is the only member of this genus and it only infects humans.

Alphavirus General Properties

The particle consists of a nucleocapsid core (icosahedral capsid) surrounded by a lipid bilayer envelope embedded with glycoprotein spikes.
The genome encodes 10 different proteins, divided into nonstructural proteins (NSP1-NSP4) and structural proteins (capsid, E3, E2, 6K/TF, and E1).
Nonstructural proteins are important for replicating the viral genome.
Structural proteins function in virus assembly.
E1 and E2 each contain a single transmembrane domain.
E1 has a short cytoplasmic tail that is dispensable.
E2 has a long (>30 amino acids) cytoplasmic domain that interacts with a hydrophobic pocket in the capsid protein.

Alphavirus Characteristics

Alphaviruses agglutinate goose and chicks RBCs.
They replicate in the cytoplasm.
They bud from the plasma membrane.
Most alphaviruses are mosquito-borne.

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Description

This summary is a guide for the Virology course and supplements the references mentioned during lectures. It is not allowed to copy this summary for third-year veterinary students - Microbiology without citing the author.