Podcast
Questions and Answers
Under normal circumstances, where is a fetus free of microbes?
Under normal circumstances, where is a fetus free of microbes?
- Respiratory tract
- Skin
- Intestines
- In utero (correct)
What event exposes a newborn to microbes?
What event exposes a newborn to microbes?
- Feeding
- Sleeping
- Birth (correct)
- Vaccinations
What term describes a close relationship between two different species in a community?
What term describes a close relationship between two different species in a community?
- Competition
- Symbiosis (correct)
- Predation
- Antagonism
Which type of symbiotic relationship benefits both organisms involved?
Which type of symbiotic relationship benefits both organisms involved?
Which type of symbiotic relationship benefits one organism and neither harms nor helps the other?
Which type of symbiotic relationship benefits one organism and neither harms nor helps the other?
Which type of symbiotic relationship benefits one organism while harming the other?
Which type of symbiotic relationship benefits one organism while harming the other?
Which type of symbiotic relationship involves one organism inhibiting the growth of another without being affected itself?
Which type of symbiotic relationship involves one organism inhibiting the growth of another without being affected itself?
Resident flora are microorganisms that:
Resident flora are microorganisms that:
In a healthy person, normal flora are usually:
In a healthy person, normal flora are usually:
When the balance is interrupted, what can normal flora become?
When the balance is interrupted, what can normal flora become?
A pathogen entering the “wrong” portal of entry will likely result in:
A pathogen entering the “wrong” portal of entry will likely result in:
Which of the following is a portal of entry for pathogens?
Which of the following is a portal of entry for pathogens?
Which of the following can cross the placenta and potentially harm the fetus?
Which of the following can cross the placenta and potentially harm the fetus?
What term describes the degree of pathogenicity of a specific microbe?
What term describes the degree of pathogenicity of a specific microbe?
What is the first step of infection?
What is the first step of infection?
Where does colonization typically occur?
Where does colonization typically occur?
What process involves disrupting the host cell membrane and barriers?
What process involves disrupting the host cell membrane and barriers?
Which mechanism do pathogens use to avoid host defenses?
Which mechanism do pathogens use to avoid host defenses?
What is the ability of an organism to produce toxins called?
What is the ability of an organism to produce toxins called?
What is the normal microbiota also called?
What is the normal microbiota also called?
An example of resident flora is:
An example of resident flora is:
What is not considered a portal of entry?
What is not considered a portal of entry?
When can normal flora cause disease?
When can normal flora cause disease?
What is symbiosis?
What is symbiosis?
What is mutualism?
What is mutualism?
What is commensalism?
What is commensalism?
What is parasitism?
What is parasitism?
What is virulence?
What is virulence?
By what means does Adhesion occur?
By what means does Adhesion occur?
What is Toxigenesis?
What is Toxigenesis?
Which of the following is not a way that pathogens avoid the host defense
Which of the following is not a way that pathogens avoid the host defense
Toxins target sites:
Toxins target sites:
What is the role of invasins?
What is the role of invasins?
What type of toxins do bacteria produce?
What type of toxins do bacteria produce?
During what process does a newborn typically first encounter microbes?
During what process does a newborn typically first encounter microbes?
What term describes the general interaction between different species within a shared environment?
What term describes the general interaction between different species within a shared environment?
In what type of symbiotic relationship does one organism benefit and the other is harmed?
In what type of symbiotic relationship does one organism benefit and the other is harmed?
What term describes normal flora that are present for only a short time?
What term describes normal flora that are present for only a short time?
Under what condition can normal flora cause disease?
Under what condition can normal flora cause disease?
What term describes where pathogens gain entry into the host?
What term describes where pathogens gain entry into the host?
Which of the following is an example of a portal of entry?
Which of the following is an example of a portal of entry?
What structure allows certain microbes to cross to infect a fetus?
What structure allows certain microbes to cross to infect a fetus?
What is the degree of pathogenicity of a specific microbe called?
What is the degree of pathogenicity of a specific microbe called?
What is the initial step of infection?
What is the initial step of infection?
Where does colonization of pathogens usually occur?
Where does colonization of pathogens usually occur?
What is the capacity of an organism to generate toxins called?
What is the capacity of an organism to generate toxins called?
What is the term for the body's normal, permanent microbial inhabitants?
What is the term for the body's normal, permanent microbial inhabitants?
What is the term used to describe the disruption of the host cell membrane by pathogens?
What is the term used to describe the disruption of the host cell membrane by pathogens?
What is a major mechanism used by pathogens to avoid being destroyed by host defenses?
What is a major mechanism used by pathogens to avoid being destroyed by host defenses?
What kind of toxin can bacterial toxins act on?
What kind of toxin can bacterial toxins act on?
What term explains a relationship wherein one organism hinders the growth of another without being directly affected?
What term explains a relationship wherein one organism hinders the growth of another without being directly affected?
What is the expected outcome if a pathogen attempts to enter through a non-preferred portal?
What is the expected outcome if a pathogen attempts to enter through a non-preferred portal?
What benefits do both E. coli andhumans experience in their relationship when E. coli resides in the human GI tract?
What benefits do both E. coli andhumans experience in their relationship when E. coli resides in the human GI tract?
What do pili and cell membrane protiens facilitate during infection?
What do pili and cell membrane protiens facilitate during infection?
Which of the following is most likely to inhabit the ear?
Which of the following is most likely to inhabit the ear?
Which of the following keeps the normal flora from causing diseases?
Which of the following keeps the normal flora from causing diseases?
What is the name of the microbes that cause spontaneous abortions?
What is the name of the microbes that cause spontaneous abortions?
What keeps pathogens from being consumed?
What keeps pathogens from being consumed?
A microbe gains access to the body through the skin. What portal of entry would that be considered?
A microbe gains access to the body through the skin. What portal of entry would that be considered?
If a person gets T.B., what category of symbiosis caused this disease?
If a person gets T.B., what category of symbiosis caused this disease?
If Bacillus Laterosporus prevent the grown of candida, what symbiotic relationship would that be?
If Bacillus Laterosporus prevent the grown of candida, what symbiotic relationship would that be?
A microbe inhibits phagocytic engulfment, so that it is harder to consume the bacteria. This would be under what general virulence factor category?
A microbe inhibits phagocytic engulfment, so that it is harder to consume the bacteria. This would be under what general virulence factor category?
What is the virulence factor associated with pili?
What is the virulence factor associated with pili?
What does Rubivirus cause when it crosses the placenta?
What does Rubivirus cause when it crosses the placenta?
If a microbe produces products that kill or damage phagocytes before or after ingestion. That would be under what type of virulence factor?
If a microbe produces products that kill or damage phagocytes before or after ingestion. That would be under what type of virulence factor?
Which of the following is likely to be classified as transient flora?
Which of the following is likely to be classified as transient flora?
The digestive tract is in contact with the external environment. What virulence factor is best represented by this statement?
The digestive tract is in contact with the external environment. What virulence factor is best represented by this statement?
Which virulence factor refers to disrupting the host cell membrane and barriers?
Which virulence factor refers to disrupting the host cell membrane and barriers?
What relationship describes the interaction where one species benefits while the other remains unaffected?
What relationship describes the interaction where one species benefits while the other remains unaffected?
Flashcards
Fetus in Utero
Fetus in Utero
The fetus is normally free of microbes in utero.
Symbiosis
Symbiosis
A close relationship between two different species of organisms in a community.
Mutualism
Mutualism
Both organisms benefit from the interaction
Commensalism
Commensalism
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Parasitism
Parasitism
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Amensalism
Amensalism
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Resident Flora
Resident Flora
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Transient Flora
Transient Flora
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Opportunistic Pathogens
Opportunistic Pathogens
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Portal of Entry
Portal of Entry
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Exogenous
Exogenous
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Endogenous
Endogenous
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Placenta
Placenta
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Virulence
Virulence
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Adhesion
Adhesion
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Colonization
Colonization
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Invasion
Invasion
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Evasion of Host Defense
Evasion of Host Defense
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Toxigenesis
Toxigenesis
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Normal Flora are Protective
Normal Flora are Protective
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Skin as Portal of Entry
Skin as Portal of Entry
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Mucous Membranes as Portal
Mucous Membranes as Portal
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Multiple Portals of Entry
Multiple Portals of Entry
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Remote Action of Toxins
Remote Action of Toxins
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Evasion of Phagocytes
Evasion of Phagocytes
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Study Notes
- A fetus is normally free of microbes while in utero
- During birth, a newborn gets exposed to microbes, starting the colonization of the infant’s intestine
Symbiosis
- A close relationship between two different species of organisms in a community
- Mutualism: Both organisms benefit, e.g., E. coli in the human GI tract
- Commensalism: One organism benefits, the other is neither harmed nor helped, e.g., some mycobacteria in the ear, living on secretions and dead cells
- Parasitism: One organism benefits, while the other is harmed, e.g., Tuberculosis, helminths & protozoa
- Amensalism: One organism hampers the growth/survival of another without being affected, e.g., penicillium
Normal Flora (Microbiota)
- Resident flora: normal flora throughout life, e.g., S. epidermidis & E. Coli
- Transient flora: remain for hours, days, or months before vanishing, e.g., Bacillus Laterosporus, sometimes lives in intestine to limit growth of Candida
- Normal flora are usually protective, not causing diseases in their normal habitat in a healthy person
- When balance is interrupted, normal flora can become opportunistic pathogens
Portal of Entry
- Exogenous
- Endogenous
- Most pathogens have a preferred portal of entry
- Infection may not occur if a pathogen enters the "wrong" portal
- Some infectious agents enter via multiple portals, e.g., Streptococcus and Staphylococcus
Portals of Entry Include
- Skin
- Mucous membranes
- Placenta: some microbes cross the placenta causing spontaneous abortions, birth defects, or premature births, e.g., HIV, Rubivirus, Cytomegalovirus, Parvovirus B-19, Treponema pallidum, Listeria monocytogenes, Toxoplasma gondii
Virulence
- Degree of pathogenicity or disease-provoking power of a specific microbe
Virulence Factors
- Adhesion: first step of infection, accomplished via pili & cell membrane proteins
- Colonization: of tissues in contact with the external environment, such as the:
- Urogenital tract
- Digestive tract
- Respiratory tract
- Conjunctiva
- Invasion: disrupts host cell membrane & barriers (Invasins)
- Evasion of Host Defense:
- Avoid contact with phagocytes
- Inhibition of phagocytic engulfment
- Survival inside the phagocytes
- Production of products that kill or damage phagocytes before or after ingestion
- Toxins: major virulence factor
- Toxigenesis: the ability of an organism to produce toxins
- Bacterial toxins can act on sites remote from the original site of infection
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