Symbiosis and Normal Flora

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Questions and Answers

Under normal circumstances, where is a fetus free of microbes?

  • Respiratory tract
  • Skin
  • Intestines
  • In utero (correct)

What event exposes a newborn to microbes?

  • Feeding
  • Sleeping
  • Birth (correct)
  • Vaccinations

What term describes a close relationship between two different species in a community?

  • Competition
  • Symbiosis (correct)
  • Predation
  • Antagonism

Which type of symbiotic relationship benefits both organisms involved?

<p>Mutualism (B)</p> Signup and view all the answers

Which type of symbiotic relationship benefits one organism and neither harms nor helps the other?

<p>Commensalism (C)</p> Signup and view all the answers

Which type of symbiotic relationship benefits one organism while harming the other?

<p>Parasitism (B)</p> Signup and view all the answers

Which type of symbiotic relationship involves one organism inhibiting the growth of another without being affected itself?

<p>Amensalism (B)</p> Signup and view all the answers

Resident flora are microorganisms that:

<p>Are normal flora throughout life (A)</p> Signup and view all the answers

In a healthy person, normal flora are usually:

<p>Protective (B)</p> Signup and view all the answers

When the balance is interrupted, what can normal flora become?

<p>Opportunistic pathogens (D)</p> Signup and view all the answers

A pathogen entering the “wrong” portal of entry will likely result in:

<p>No infection (D)</p> Signup and view all the answers

Which of the following is a portal of entry for pathogens?

<p>Skin (B)</p> Signup and view all the answers

Which of the following can cross the placenta and potentially harm the fetus?

<p>HIV (D)</p> Signup and view all the answers

What term describes the degree of pathogenicity of a specific microbe?

<p>Virulence (B)</p> Signup and view all the answers

What is the first step of infection?

<p>Adhesion (D)</p> Signup and view all the answers

Where does colonization typically occur?

<p>Urogenital tract (D)</p> Signup and view all the answers

What process involves disrupting the host cell membrane and barriers?

<p>Invasion (B)</p> Signup and view all the answers

Which mechanism do pathogens use to avoid host defenses?

<p>Avoid contact with phagocytes (C)</p> Signup and view all the answers

What is the ability of an organism to produce toxins called?

<p>Toxigenesis (C)</p> Signup and view all the answers

What is the normal microbiota also called?

<p>Normal flora (A)</p> Signup and view all the answers

An example of resident flora is:

<p>E. Coli (B)</p> Signup and view all the answers

What is not considered a portal of entry?

<p>Hair (C)</p> Signup and view all the answers

When can normal flora cause disease?

<p>When balance is interrupted (B)</p> Signup and view all the answers

What is symbiosis?

<p>A close relationship between two different species (C)</p> Signup and view all the answers

What is mutualism?

<p>Both members benefit from the interaction (D)</p> Signup and view all the answers

What is commensalism?

<p>One organism benefits and the other is neither harmed nor helped (A)</p> Signup and view all the answers

What is parasitism?

<p>One organism benefits, while the other is harmed (D)</p> Signup and view all the answers

What is virulence?

<p>The degree of pathogenicity of a specific microbe (A)</p> Signup and view all the answers

By what means does Adhesion occur?

<p>By pili &amp; cell membrane proteins (C)</p> Signup and view all the answers

What is Toxigenesis?

<p>Ability of organism to produce toxins (D)</p> Signup and view all the answers

Which of the following is not a way that pathogens avoid the host defense

<p>Attacking the brain (B)</p> Signup and view all the answers

Toxins target sites:

<p>Remote from the original site of infection (A)</p> Signup and view all the answers

What is the role of invasins?

<p>Disrupt host cell membrane &amp; barriers (B)</p> Signup and view all the answers

What type of toxins do bacteria produce?

<p>Bacterial (D)</p> Signup and view all the answers

During what process does a newborn typically first encounter microbes?

<p>During birth (B)</p> Signup and view all the answers

What term describes the general interaction between different species within a shared environment?

<p>Symbiosis (A)</p> Signup and view all the answers

In what type of symbiotic relationship does one organism benefit and the other is harmed?

<p>Parasitism (C)</p> Signup and view all the answers

What term describes normal flora that are present for only a short time?

<p>Transient flora (A)</p> Signup and view all the answers

Under what condition can normal flora cause disease?

<p>When balance is interrupted (A)</p> Signup and view all the answers

What term describes where pathogens gain entry into the host?

<p>Portal of entry (A)</p> Signup and view all the answers

Which of the following is an example of a portal of entry?

<p>Skin (C)</p> Signup and view all the answers

What structure allows certain microbes to cross to infect a fetus?

<p>The placenta (C)</p> Signup and view all the answers

What is the degree of pathogenicity of a specific microbe called?

<p>Virulence (A)</p> Signup and view all the answers

What is the initial step of infection?

<p>Adhesion (D)</p> Signup and view all the answers

Where does colonization of pathogens usually occur?

<p>Urogenital tract (C)</p> Signup and view all the answers

What is the capacity of an organism to generate toxins called?

<p>Toxigenesis (D)</p> Signup and view all the answers

What is the term for the body's normal, permanent microbial inhabitants?

<p>Resident flora (A)</p> Signup and view all the answers

What is the term used to describe the disruption of the host cell membrane by pathogens?

<p>Invasion (B)</p> Signup and view all the answers

What is a major mechanism used by pathogens to avoid being destroyed by host defenses?

<p>Avoid contact with phagocytes (B)</p> Signup and view all the answers

What kind of toxin can bacterial toxins act on?

<p>Sites remote from the original site of infection (D)</p> Signup and view all the answers

What term explains a relationship wherein one organism hinders the growth of another without being directly affected?

<p>Amensalism (A)</p> Signup and view all the answers

What is the expected outcome if a pathogen attempts to enter through a non-preferred portal?

<p>The infection may not occur (B)</p> Signup and view all the answers

What benefits do both E. coli andhumans experience in their relationship when E. coli resides in the human GI tract?

<p>Mutualism (D)</p> Signup and view all the answers

What do pili and cell membrane protiens facilitate during infection?

<p>Adhesion (C)</p> Signup and view all the answers

Which of the following is most likely to inhabit the ear?

<p>Mycobacteria (D)</p> Signup and view all the answers

Which of the following keeps the normal flora from causing diseases?

<p>all of the above (D)</p> Signup and view all the answers

What is the name of the microbes that cause spontaneous abortions?

<p>all of the above (D)</p> Signup and view all the answers

What keeps pathogens from being consumed?

<p>all of the above (D)</p> Signup and view all the answers

A microbe gains access to the body through the skin. What portal of entry would that be considered?

<p>exogenous (D)</p> Signup and view all the answers

If a person gets T.B., what category of symbiosis caused this disease?

<p>parasitism (C)</p> Signup and view all the answers

If Bacillus Laterosporus prevent the grown of candida, what symbiotic relationship would that be?

<p>amensalism (D)</p> Signup and view all the answers

A microbe inhibits phagocytic engulfment, so that it is harder to consume the bacteria. This would be under what general virulence factor category?

<p>Evasion of Host Defense (A)</p> Signup and view all the answers

What is the virulence factor associated with pili?

<p>Adhesion (B)</p> Signup and view all the answers

What does Rubivirus cause when it crosses the placenta?

<p>all of the above (D)</p> Signup and view all the answers

If a microbe produces products that kill or damage phagocytes before or after ingestion. That would be under what type of virulence factor?

<p>Evasion of Host Defense (A)</p> Signup and view all the answers

Which of the following is likely to be classified as transient flora?

<p>Bacillus Laterosporus (C)</p> Signup and view all the answers

The digestive tract is in contact with the external environment. What virulence factor is best represented by this statement?

<p>Colonization (B)</p> Signup and view all the answers

Which virulence factor refers to disrupting the host cell membrane and barriers?

<p>Invasion (B)</p> Signup and view all the answers

What relationship describes the interaction where one species benefits while the other remains unaffected?

<p>Commensalism (D)</p> Signup and view all the answers

Flashcards

Fetus in Utero

The fetus is normally free of microbes in utero.

Symbiosis

A close relationship between two different species of organisms in a community.

Mutualism

Both organisms benefit from the interaction

Commensalism

One organism benefits and the other is neither harmed nor helped.

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Parasitism

One organism benefits, while the other is harmed.

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Amensalism

One organism inhibits another's growth without being affected itself.

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Resident Flora

Microbes that colonize a person throughout life

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Transient Flora

Microbes that remain for hours, days, or months before disappearing.

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Opportunistic Pathogens

Normal flora that can cause disease when balance is disrupted.

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Portal of Entry

The specific route a pathogen uses to enter the host.

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Exogenous

From outside source

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Endogenous

From inside the body

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Placenta

Some microbes cross this barrier causing spontaneous abortions, birth defects, or premature births.

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Virulence

The degree of pathogenicity or disease-provoking power of a microbe.

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Adhesion

Attachment of a pathogen to host cells

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Colonization

Establishment of pathogens at the site of entry

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Invasion

Disrupts host cell membrane & barriers

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Evasion of Host Defense

Mechanisms used by pathogens to avoid or suppress the host's immune response.

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Toxigenesis

The ability of an organism to produce toxins.

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Normal Flora are Protective

Normal flora are usually protective and do not cause diseases in their normal habitat in a healthy person.

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Skin as Portal of Entry

The skin is a common entry point for pathogens.

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Mucous Membranes as Portal

Mucous membranes are a common entry point for pathogens.

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Multiple Portals of Entry

Some infectious agents can enter via multiple routes.

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Remote Action of Toxins

Bacterial toxins can exert their effects far from the original infection site.

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Evasion of Phagocytes

Avoid contact with phagocytes, inhibition of phagocytic engulfment. Survival inside the phagocytes, production of products that kill or damage phagocytes before or after ingestion.

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Study Notes

  • A fetus is normally free of microbes while in utero
  • During birth, a newborn gets exposed to microbes, starting the colonization of the infant’s intestine

Symbiosis

  • A close relationship between two different species of organisms in a community
  • Mutualism: Both organisms benefit, e.g., E. coli in the human GI tract
  • Commensalism: One organism benefits, the other is neither harmed nor helped, e.g., some mycobacteria in the ear, living on secretions and dead cells
  • Parasitism: One organism benefits, while the other is harmed, e.g., Tuberculosis, helminths & protozoa
  • Amensalism: One organism hampers the growth/survival of another without being affected, e.g., penicillium

Normal Flora (Microbiota)

  • Resident flora: normal flora throughout life, e.g., S. epidermidis & E. Coli
  • Transient flora: remain for hours, days, or months before vanishing, e.g., Bacillus Laterosporus, sometimes lives in intestine to limit growth of Candida
  • Normal flora are usually protective, not causing diseases in their normal habitat in a healthy person
  • When balance is interrupted, normal flora can become opportunistic pathogens

Portal of Entry

  • Exogenous
  • Endogenous
  • Most pathogens have a preferred portal of entry
  • Infection may not occur if a pathogen enters the "wrong" portal
  • Some infectious agents enter via multiple portals, e.g., Streptococcus and Staphylococcus

Portals of Entry Include

  • Skin
  • Mucous membranes
  • Placenta: some microbes cross the placenta causing spontaneous abortions, birth defects, or premature births, e.g., HIV, Rubivirus, Cytomegalovirus, Parvovirus B-19, Treponema pallidum, Listeria monocytogenes, Toxoplasma gondii

Virulence

  • Degree of pathogenicity or disease-provoking power of a specific microbe

Virulence Factors

  • Adhesion: first step of infection, accomplished via pili & cell membrane proteins
  • Colonization: of tissues in contact with the external environment, such as the:
    • Urogenital tract
    • Digestive tract
    • Respiratory tract
    • Conjunctiva
  • Invasion: disrupts host cell membrane & barriers (Invasins)
  • Evasion of Host Defense:
    • Avoid contact with phagocytes
    • Inhibition of phagocytic engulfment
    • Survival inside the phagocytes
    • Production of products that kill or damage phagocytes before or after ingestion
  • Toxins: major virulence factor
  • Toxigenesis: the ability of an organism to produce toxins
  • Bacterial toxins can act on sites remote from the original site of infection

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