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Questions and Answers
What is the primary function of a wetting agent in the preparation of a suspension?
What is the primary function of a wetting agent in the preparation of a suspension?
What is the primary function of aluminum hydroxide in the antacid suspension?
What is the primary function of aluminum hydroxide in the antacid suspension?
What is the purpose of including parabens (methylparaben and propylparaben) in the aluminum hydroxide antacid suspension?
What is the purpose of including parabens (methylparaben and propylparaben) in the aluminum hydroxide antacid suspension?
Which of the following ingredients in the calcium carbonate antacid suspension acts as a source of carbon dioxide?
Which of the following ingredients in the calcium carbonate antacid suspension acts as a source of carbon dioxide?
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What is the primary function of syrup in the calcium carbonate antacid suspension?
What is the primary function of syrup in the calcium carbonate antacid suspension?
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What is the purpose of using chloroform water in the calcium carbonate antacid suspension?
What is the purpose of using chloroform water in the calcium carbonate antacid suspension?
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Which of the following techniques is mentioned for homogenization of the aluminum hydroxide antacid suspension?
Which of the following techniques is mentioned for homogenization of the aluminum hydroxide antacid suspension?
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What is the primary function of light magnesium carbonate in the calcium carbonate antacid suspension?
What is the primary function of light magnesium carbonate in the calcium carbonate antacid suspension?
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Which ingredient in the aluminum hydroxide antacid suspension is responsible for providing viscosity?
Which ingredient in the aluminum hydroxide antacid suspension is responsible for providing viscosity?
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What is the purpose of using a porcelain mortar in the preparation of the calcium carbonate antacid suspension?
What is the purpose of using a porcelain mortar in the preparation of the calcium carbonate antacid suspension?
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Study Notes
Mixtures Containing Diffusible Solids
- Diffusible solids are substances that are insoluble in aqueous vehicles but can be uniformly distributed by simple shaking.
- Examples of diffusible solids include rhubarb, light magnesium carbonate, light kaolin, and magnesium trisilicate.
Method of Preparation of Mixtures Containing Diffusible Solids
- Dissolve soluble ingredients in about 3/4 of the vehicle volume to form a clear solution.
- Mix insoluble powder ingredients with a viscous liquid (if any) in a clean mortar.
- Gradually add the clear solution to the powder mixture to form a paste, then a milky suspension.
- Transfer the mixture to a measuring cylinder, washing the mixing equipment with a portion of the vehicle.
- Add liquid ingredients and adjust the volume with the rest of the vehicle.
- Close the bottle and label it, including an additional label stating "Shake the bottle before use."
Notes on Preparation
- Some dispersed phases have an affinity for the vehicle and can be easily wetted.
- Other drugs may not be easily penetrated by the vehicle and may clump or float on top.
- Suspending agents increase the viscosity of the liquid to hold indiffusible solids in suspension.
Suspending Agents
Compound Powder of Tragacanth B.P.
- Consists of 15% Tragacanth, 20% Acacia, 20% Starch, and 45% Sucrose.
- Store in airtight containers.
- Use 2% W/V of the total mixture volume (2g per 100ml).
Mucilage of Tragacanth
- Consists of 12.5g Tragacanth, 25ml Alcohol, and Chloroform water to 1000ml.
- Use 25% V/V of the total mixture volume (25ml per 100ml).
Powdered Acacia
- Use 6-10% W/V of the total mixture volume (6-10g per 100ml).
Acacia Mucilage
- Consists of 400g Acacia and 600ml Chloroform water.
- Use 25% V/V of the total mixture volume (25ml per 100ml).
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Description
Learn about substances that are insoluble in aqueous vehicles but can be diffused into them through shaking. Explore examples like rhubarb, light magnesium carbonate, light kaolin, and magnesium trisilicate. Understand the method of preparation for mixtures containing diffusible solids.
