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Questions and Answers
What classification does Sumatriptan [Imitrex] belong to?
What are the indications for using Sumatriptan [Imitrex]?
Acute treatment of migraine headaches with or without an aura in adults.
What is the mechanism of action (MOA) of Sumatriptan [Imitrex]?
Relieves migraines by stimulating serotonin receptors in the brain, causing blood vessels to contract and reducing pain signal transmission.
What are the administration routes for Sumatriptan [Imitrex]?
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Which of the following are common side effects of Sumatriptan [Imitrex]?
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What are some rare side effects of Sumatriptan [Imitrex]?
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What should be noted regarding drug interactions with Sumatriptan [Imitrex]?
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What additional information is important to know about Sumatriptan [Imitrex]?
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Study Notes
Classification
- Sumatriptan, marketed as Imitrex, is classified as a selective serotonin receptor agonist.
Indications
- Used for the acute treatment of migraine headaches in adults, applicable with or without an aura.
Mechanism of Action (MOA)
- Relieves migraines by stimulating serotonin receptors in the brain.
- Causes the muscles surrounding cerebral blood vessels to contract, narrowing the vessels.
- Reduces pain signal transmission from nerves to the brain.
Administration
- Available routes include oral (PO), intranasal, and subcutaneous (SC) injections.
Side Effects
- Common side effects are generally transient and may include:
- Chest or throat pain/tightness
- Tingling sensations
- Flushing and sweating
- Weakness and dizziness
- Abdominal discomfort and nasal irritation
- Injection site reactions
- May elevate blood pressure, particularly in individuals with uncontrolled hypertension.
Rare Side Effects
- Associated with serious conditions such as:
- Coronary artery spasms
- Heart attacks
- Stroke
- Abnormal heart rhythms
- Seizures
Drug Interactions
- Caution with monoamine oxidase inhibitors (MAOIs) like:
- Isocarboxazid (Marplan)
- Phenelzine (Nardil)
- Tranylcypromine (Parnate)
- Procarbazine (Matulane)
- These may inhibit sumatriptan breakdown in the liver, leading to increased blood levels and side effects.
Additional Information
- Primarily used to manage migraine symptoms such as headache, nausea, vomiting, and sensitivity to light/sound.
- Helps patients return to normal activities and may reduce reliance on other pain medications.
- Sumatriptan does not prevent future migraines or reduce frequency of attacks.
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Description
Test your knowledge on Sumatriptan, commonly known as Imitrex, and its classification, indications, and mechanism of action. These flashcards provide critical information for understanding how this medication works in treating migraines.
