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Questions and Answers
What classification does Sumatriptan [Imitrex] belong to?
What classification does Sumatriptan [Imitrex] belong to?
- Antidepressants
- Non-steroidal anti-inflammatory drugs
- Opioid analgesics
- Selective serotonin receptor agonists (correct)
What are the indications for using Sumatriptan [Imitrex]?
What are the indications for using Sumatriptan [Imitrex]?
Acute treatment of migraine headaches with or without an aura in adults.
What is the mechanism of action (MOA) of Sumatriptan [Imitrex]?
What is the mechanism of action (MOA) of Sumatriptan [Imitrex]?
Relieves migraines by stimulating serotonin receptors in the brain, causing blood vessels to contract and reducing pain signal transmission.
What are the administration routes for Sumatriptan [Imitrex]?
What are the administration routes for Sumatriptan [Imitrex]?
Which of the following are common side effects of Sumatriptan [Imitrex]?
Which of the following are common side effects of Sumatriptan [Imitrex]?
What are some rare side effects of Sumatriptan [Imitrex]?
What are some rare side effects of Sumatriptan [Imitrex]?
What should be noted regarding drug interactions with Sumatriptan [Imitrex]?
What should be noted regarding drug interactions with Sumatriptan [Imitrex]?
What additional information is important to know about Sumatriptan [Imitrex]?
What additional information is important to know about Sumatriptan [Imitrex]?
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Study Notes
Classification
- Sumatriptan, marketed as Imitrex, is classified as a selective serotonin receptor agonist.
Indications
- Used for the acute treatment of migraine headaches in adults, applicable with or without an aura.
Mechanism of Action (MOA)
- Relieves migraines by stimulating serotonin receptors in the brain.
- Causes the muscles surrounding cerebral blood vessels to contract, narrowing the vessels.
- Reduces pain signal transmission from nerves to the brain.
Administration
- Available routes include oral (PO), intranasal, and subcutaneous (SC) injections.
Side Effects
- Common side effects are generally transient and may include:
- Chest or throat pain/tightness
- Tingling sensations
- Flushing and sweating
- Weakness and dizziness
- Abdominal discomfort and nasal irritation
- Injection site reactions
- May elevate blood pressure, particularly in individuals with uncontrolled hypertension.
Rare Side Effects
- Associated with serious conditions such as:
- Coronary artery spasms
- Heart attacks
- Stroke
- Abnormal heart rhythms
- Seizures
Drug Interactions
- Caution with monoamine oxidase inhibitors (MAOIs) like:
- Isocarboxazid (Marplan)
- Phenelzine (Nardil)
- Tranylcypromine (Parnate)
- Procarbazine (Matulane)
- These may inhibit sumatriptan breakdown in the liver, leading to increased blood levels and side effects.
Additional Information
- Primarily used to manage migraine symptoms such as headache, nausea, vomiting, and sensitivity to light/sound.
- Helps patients return to normal activities and may reduce reliance on other pain medications.
- Sumatriptan does not prevent future migraines or reduce frequency of attacks.
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