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Questions and Answers
Which of the following is NOT a risk factor for developing a substance use disorder?
Which of the following is NOT a risk factor for developing a substance use disorder?
What is the primary neurotransmitter involved in the initial pleasurable effects of substance use?
What is the primary neurotransmitter involved in the initial pleasurable effects of substance use?
Which of the following brain regions is primarily responsible for impaired decision-making and inability to resist cravings in Stage 3 of addiction?
Which of the following brain regions is primarily responsible for impaired decision-making and inability to resist cravings in Stage 3 of addiction?
Which of these statements accurately describes the changes in dopamine receptors after repeated drug use?
Which of these statements accurately describes the changes in dopamine receptors after repeated drug use?
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Which of the following demographics is NOT typically associated with a higher prevalence of substance use disorders?
Which of the following demographics is NOT typically associated with a higher prevalence of substance use disorders?
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Which of the following is NOT a characteristic of the epidemiology of substance use disorders?
Which of the following is NOT a characteristic of the epidemiology of substance use disorders?
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What is a key characteristic of Stage 2 of addiction?
What is a key characteristic of Stage 2 of addiction?
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Which of the following BEST describes the pathophysiology of substance use disorders?
Which of the following BEST describes the pathophysiology of substance use disorders?
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Which genetic factor is NOT associated with increased risk for substance use disorders?
Which genetic factor is NOT associated with increased risk for substance use disorders?
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How does early-life exposure to stressors influence risk for substance use disorders?
How does early-life exposure to stressors influence risk for substance use disorders?
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Which of the following psychological factors can increase vulnerability to substance use disorders?
Which of the following psychological factors can increase vulnerability to substance use disorders?
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What role does peer pressure play in the risk of developing substance use disorders?
What role does peer pressure play in the risk of developing substance use disorders?
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Which neurobiological alteration significantly contributes to drug-seeking behavior?
Which neurobiological alteration significantly contributes to drug-seeking behavior?
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Which socioeconomic factor is correlated with higher rates of substance misuse?
Which socioeconomic factor is correlated with higher rates of substance misuse?
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Which neurotransmitter is primarily associated with the reward sensation in addiction?
Which neurotransmitter is primarily associated with the reward sensation in addiction?
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What effect does adolescent use of substances have on the brain?
What effect does adolescent use of substances have on the brain?
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What is one consequence of downregulation of dopamine receptors due to persistent substance use?
What is one consequence of downregulation of dopamine receptors due to persistent substance use?
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Which of the following behaviors by parents can increase the risk of substance use in children?
Which of the following behaviors by parents can increase the risk of substance use in children?
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How does the prefrontal cortex contribute to substance use disorders?
How does the prefrontal cortex contribute to substance use disorders?
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What role does glutamate play in the context of addiction?
What role does glutamate play in the context of addiction?
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Genetic predisposition to substance use disorders can involve variants in which types of genes?
Genetic predisposition to substance use disorders can involve variants in which types of genes?
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Which phase of addiction is characterized by increased stress and anxiety during withdrawal?
Which phase of addiction is characterized by increased stress and anxiety during withdrawal?
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What is a potential effect of epigenetic changes due to chronic substance use?
What is a potential effect of epigenetic changes due to chronic substance use?
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Which structure of the brain, when dysregulated, is associated with processing emotions and negative affect during withdrawal?
Which structure of the brain, when dysregulated, is associated with processing emotions and negative affect during withdrawal?
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Flashcards
Binge/intoxication phase
Binge/intoxication phase
The initial phase of substance use where dopamine spikes create a feeling of reward.
Dopamine release
Dopamine release
The process by which dopamine is increased in the nucleus accumbens, affecting reward sensations.
Sensitization
Sensitization
Heightened responsiveness in reward circuits due to repeated substance exposure.
Withdrawal phase
Withdrawal phase
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Preoccupation/anticipation phase
Preoccupation/anticipation phase
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Glutamate
Glutamate
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Epigenetic changes
Epigenetic changes
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Corticotropin-releasing factor (CRF)
Corticotropin-releasing factor (CRF)
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Dopamine Receptor Downregulation
Dopamine Receptor Downregulation
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Increased Sensitization
Increased Sensitization
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Substance Use Disorders (SUDs)
Substance Use Disorders (SUDs)
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Addiction
Addiction
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Risk Factors for SUDs
Risk Factors for SUDs
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Stages of Addiction
Stages of Addiction
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Neurotransmitter Imbalances
Neurotransmitter Imbalances
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Brain Circuit Disruption
Brain Circuit Disruption
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Genetic Risk Factors
Genetic Risk Factors
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Dopamine System
Dopamine System
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Impulsivity
Impulsivity
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Mental Health Disorders
Mental Health Disorders
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Peer Pressure
Peer Pressure
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Socioeconomic Factors
Socioeconomic Factors
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Early Exposure to Substances
Early Exposure to Substances
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Trauma History
Trauma History
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Study Notes
Substance Use Disorders (SUD) Risk Factors
- Biological/Genetic:
- Genetics play a significant role in SUD, impacting how individuals metabolize substances and their sensitivity.
- Family history of SUD increases risk.
- Variants in dopamine-related genes can influence vulnerability.
- Neurobiological alterations in dopamine and glutamate systems are key.
- Dysregulated reward systems can enhance drug-seeking behavior and impair decision-making (prefrontal cortex).
Psychological/Behavioral Risk Factors
- Mental Health:
- Co-occurring conditions like depression, anxiety, PTSD, and schizophrenia increase risk.
- Self-medication with substances is a common coping mechanism for emotional distress.
- Impulsivity/Poor Self-Control:
- Impaired prefrontal cortex function hinders resisting urges and controlling behavior, leading to substance misuse.
- Trauma/Abuse History:
- Exposure to trauma (physical, sexual, emotional) significantly increases SUD risk.
- Early-life stressors alter HPA axis function, making individuals more susceptible to addiction.
Social and Environmental Risk Factors
- Peer Pressure/Social Networks:
- Exposure to peers who use substances increases risk.
- Social settings normalizing drug use promote habitual use.
- Socioeconomic Factors:
- Lower socioeconomic status is associated with higher rates of substance misuse.
- Unemployment, lack of education, and unstable housing exacerbate stress and increase vulnerability.
Early Exposure and Addiction
- Adolescent Use: Prefrontal cortex development is incomplete during adolescence, making early substance use risky.
- Parental Modeling: Children exposed to parental substance use are more likely to normalize this behavior.
- Drug Availability: Easier access to substances increases the likelihood of use and dependence.
Neuroplasticity and Chronic Use
- Neuroplastic Changes: Chronic use downregulates dopamine receptors, decreasing sensitivity to rewards, and requiring more substance for the same effect.
- Increased Sensitization: Repeated use enhances neural responses to conditioned cues, leading to cravings and compulsion.
Epidemiology of Substance Use Disorders
- Prevalence/Impact: SUDs involve recurrent substance use (e.g., alcohol, opioids, stimulants) leading to significant impairment.
- Demographics/Risk Factors: Adolescents, young adults, and those with mental health disorders are at higher risk.
- Genetics, Environment, & Psychology: These factors interact to increase vulnerability to SUDs.
Clinical Manifestations
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Physical Manifestations: Withdrawal symptoms include tremors, sweating, anxiety, nausea, headaches; and tolerance development requiring higher doses for the same effect.
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Psychological Manifestations: Mood swings, anxiety, depression, impaired cognitive function, cravings.
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Behavioral Manifestations: Compulsive drug-seeking, neglect of responsibilities, social withdrawal, risky behaviors.
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Social/Occupational Impairments: Relationship conflicts, financial problems, legal issues.
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Neurocircuitry of Addiction: Substance use overstimulates the mesolimbic dopamine pathway causing intense reward sensations.
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Withdrawal/Negative Affect: Changes in stress regulation circuits causing dysphoric feelings and withdrawal symptoms, creating negative reinforcement.
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Stages of Addiction: Initial pleasure (Stage 1), substance use for withdrawal avoidance (Stage 2), and impaired decision-making/cravings due to prefrontal cortex dysfunction (Stage 3)
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Preoccupation/Anticipation: Cravings, compulsive drug-seeking, due to prefrontal cortex dysfunction
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Psychological Co-morbidities: Co-existent conditions including mood disorders (e.g., depression, bipolar), anxiety disorders, and schizophrenia.
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Long-Term Consequences: Cognitive decline, physical complications (e.g., liver damage, cardiovascular diseases), and infectious diseases.
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Description
This quiz explores the various risk factors associated with Substance Use Disorders (SUD). It covers biological, psychological, and behavioral influences that can predispose individuals to SUD, including genetics, mental health conditions, and personal history of trauma. Understanding these factors is crucial for prevention and intervention strategies.