Substance Use Disorders Overview
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Questions and Answers

What is the only solution possible for someone who has become addicted to a substance?

  • Social use with restrictions
  • Controlled use of the substance
  • Periodic use under supervision
  • Total abstinence from the substance (correct)
  • What is referred to as a lapse in substance use recovery?

  • A complete return to substance use
  • Using a substance once or for a short period (correct)
  • Completely avoiding triggers and high-risk situations
  • Failing to engage in treatment
  • How are relapse rates for substance use disorders compared to other chronic diseases?

  • Similar to that of diabetes and hypertension (correct)
  • Completely different and not comparable
  • Higher than that of asthma
  • Lower than most other chronic diseases
  • What does the phrase 'once an alcoholic, always an alcoholic' imply?

    <p>Addiction is a chronic condition that cannot be cured, only managed (A)</p> Signup and view all the answers

    What is a common trigger for relapse in individuals recovering from substance use disorders?

    <p>Experiencing high-stress situations (C)</p> Signup and view all the answers

    How is addiction best described in terms of its nature?

    <p>A chronic brain disease that can be treated but not cured (C)</p> Signup and view all the answers

    What is a key characteristic of any chronic disease, including substance use disorder?

    <p>They often involve a relapsing nature (C)</p> Signup and view all the answers

    What is one of the primary purposes of administering oral methadone to persons dependent on heroin?

    <p>To prevent withdrawal symptoms and assist in rehabilitation (C)</p> Signup and view all the answers

    Which of the following is a common route of administration for heroin that enhances its pleasure-inducing effects?

    <p>Inhalation through a pipe or straw (B)</p> Signup and view all the answers

    Why are morphine and similar drugs often injected or smoked by drug dependents?

    <p>They are less effective when administered orally. (A)</p> Signup and view all the answers

    What role does Buprenorphine play in the treatment of heroin dependency?

    <p>It is used as a substitution therapy for heroin dependence. (C)</p> Signup and view all the answers

    How do small amounts of drugs like morphine affect the brain despite poor distribution?

    <p>Minute amounts can be sufficient to cause an effect. (C)</p> Signup and view all the answers

    What is the fastest route for a psychoactive substance to enter the bloodstream?

    <p>Inhaling (B)</p> Signup and view all the answers

    How is alcohol primarily absorbed into the bloodstream?

    <p>Directly from the stomach (B)</p> Signup and view all the answers

    Which route involves the slowest absorption into the bloodstream?

    <p>Topical application (A)</p> Signup and view all the answers

    Which of the following methods is NOT associated with psychoactive substance absorption in a few minutes?

    <p>Intramuscular injection (B)</p> Signup and view all the answers

    What is the primary mechanism of absorption for substances administered via the rectal route?

    <p>Through the rectal wall (C)</p> Signup and view all the answers

    Which route is specifically mentioned for both cocaine and inhalants?

    <p>Snorting (A)</p> Signup and view all the answers

    What absorption route allows a substance to bypass the liver before entering the bloodstream?

    <p>Sublingual administration (A)</p> Signup and view all the answers

    Which inhalation method provides the quickest onset of effects for psychoactive substances?

    <p>Smoking (A)</p> Signup and view all the answers

    What is a characteristic of substances administered through a nicotine patch?

    <p>Absorbs through the skin slowly (C)</p> Signup and view all the answers

    Which neurotransmitter is primarily associated with muscle contraction and memory regulation?

    <p>Acetylcholine (B)</p> Signup and view all the answers

    What impact does GABA have on the body?

    <p>Produces sleep (C)</p> Signup and view all the answers

    How do PAS specifically influence the reward pathway in the brain?

    <p>They increase dopamine levels significantly. (D)</p> Signup and view all the answers

    What is a consequence of prolonged PAS use over time regarding dopamine production?

    <p>Decreased overall dopamine production. (D)</p> Signup and view all the answers

    Which neurotransmitter is primarily linked to mood regulation?

    <p>Serotonin (B)</p> Signup and view all the answers

    What happens when the reward circuit is activated in the brain?

    <p>Pleasurable feelings are experienced and actions are remembered. (D)</p> Signup and view all the answers

    Which neurotransmitter is specifically involved in learning and memory functions?

    <p>Glutamate (D)</p> Signup and view all the answers

    What physiological response does norepinephrine facilitate in the peripheral nervous system?

    <p>Fight or flight response (A)</p> Signup and view all the answers

    How does the body respond to the sustained high levels of dopamine due to PAS use?

    <p>It reduces the number of receptors and dopamine production. (A)</p> Signup and view all the answers

    Which of the following is an effect associated with serotonin?

    <p>Enhancement of sensory perception (D)</p> Signup and view all the answers

    What is the primary effect of the first pass effect on substances taken in the form of tablets or liquids?

    <p>Reduces the pharmacological effect before entering circulation (C)</p> Signup and view all the answers

    Which process allows alcohol to bypass the first pass effect?

    <p>Diffusion directly into the bloodstream (C)</p> Signup and view all the answers

    How is metabolism primarily carried out in the body?

    <p>By the liver converting substances into metabolites (B)</p> Signup and view all the answers

    What does zero order transmission refer to in terms of alcohol metabolism?

    <p>Alcohol is metabolized at a constant rate irrespective of the amount consumed (D)</p> Signup and view all the answers

    What determines the elimination rate of substances other than alcohol?

    <p>The dose dependency of the substance (C)</p> Signup and view all the answers

    What does the term half-life refer to in pharmacology?

    <p>The duration required to eliminate half of the original dose of a substance (D)</p> Signup and view all the answers

    Which statement accurately describes the effect of a short half-life substance?

    <p>The drug effects will be felt for a short duration and leave the body quickly (D)</p> Signup and view all the answers

    Which system is primarily responsible for connecting different parts of the brain and spinal cord?

    <p>Central Nervous System (CNS) (B)</p> Signup and view all the answers

    What is one of the elimination pathways through which substances are moreso discharged from the body?

    <p>Primarily through urine or faeces (A)</p> Signup and view all the answers

    Flashcards

    Substance Use Disorder (SUD)

    A chronic illness characterized by the inability to control substance use despite negative consequences.

    Addiction

    The state of using a substance regularly despite negative consequences, even if it's affecting relationships, work, or health.

    Abstinence

    Complete abstinence from a substance.

    Chronic Disease

    A long-lasting illness that can't be cured but managed with treatment.

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    Relapse

    Returning to substance use after a period of abstinence.

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    Lapse

    A brief return to substance use, often triggered by stress or situations that increase cravings.

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    Relapse Prevention

    The process of preventing relapse through proactive strategies and support.

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    Onset of effect

    The time it takes for a substance to have an effect after it's been taken.

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    Route of administration

    The way a substance enters the body.

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    Absorption

    The process of a substance moving from where it's taken into the bloodstream.

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    Distribution

    The movement of a substance from the blood to the rest of the body.

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    Intravenous (IV) injection

    The quickest route of administration, with the fastest onset of effect, as it bypasses the digestive system.

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    Oral administration

    A slower route of administration, with the substance absorbed from the intestines and processed by the liver before reaching the bloodstream.

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    Sublingual administration

    This method involves placing a substance under the tongue, where it is absorbed directly into the bloodstream.

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    Bucal administration

    A method where a substance is placed between the cheek and gum, allowing it to be absorbed into the bloodstream.

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    Transdermal administration

    A method where a substance is absorbed through the skin into the bloodstream.

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    Metabolism

    The process by which a substance is broken down by the body.

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    Elimination

    The process by which the body removes waste products from its system.

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    Liver

    The primary organ responsible for metabolism.

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    Metabolite

    A substance that results from the breakdown of another substance in the body.

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    Zero-Order Transmission

    The rate at which the body metabolizes a substance is independent of how much is consumed.

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    First-Order Transmission

    The rate at which the body metabolizes a substance depends on the amount consumed.

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    Half-Life

    The time it takes for half of a substance to be eliminated from the body.

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    Central Nervous System (CNS)

    The part of the nervous system that controls the brain and spinal cord.

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    Peripheral Nervous System (PNS)

    The part of the nervous system that connects the CNS to the rest of the body.

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    Nerve Cells

    Billions of nerve cells that transmit signals throughout the nervous system.

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    Heroin: What is it?

    Heroin is a semi-synthetic opioid drug with potent pain-relieving and euphoric effects. It can be snorted, smoked, or injected, with injection being the most common and rapid way to experience its effects.

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    Chasing: What is it?

    Chasing involves placing heroin on a heated surface, inhaling the smoke through a pipe or straw. This method of administration allows for a quicker and more intense high compared to other routes.

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    Methadone: What is it?

    Methadone is a synthetic opioid used in maintenance programs to reduce heroin dependence. It helps prevent withdrawal symptoms, allowing individuals to lead more productive lives.

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    Buprenorphine and Levo-alphaacetylmethadol (LAAM): What are they?

    Buprenorphine and levo-alphaacetylmethadol (LAAM) are synthetic opioids used in substitution programs for heroin dependence. They help reduce cravings and withdrawal symptoms, assisting with recovery.

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    Morphine Absorption: How does it work?

    Morphine and similar drugs are absorbed efficiently when injected or smoked but poorly when taken orally. Absorption from the gastrointestinal tract is affected by the liver, which rapidly breaks down these drugs. Therefore, injection or smoking is preferred for faster, more intense effects.

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    Acetylcholine

    A neurotransmitter that regulates muscle contraction and is involved in memory processes.

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    Dopamine

    A neurotransmitter involved in feelings of pleasure, reward, and motivation.

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    GABA

    A neurotransmitter that inhibits nerve activity, promoting sleep, reducing anxiety, and playing a role in memory formation.

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    Glutamate

    A neurotransmitter crucial for learning and memory.

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    Norepinephrine

    A neurotransmitter that acts as a hormone in the peripheral nervous system (PNS) and plays a role in responses to stress, and regulating blood pressure and calmness in the brain.

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    Serotonin

    A neurotransmitter that regulates mood, sleep, eating, sensory perception, and inhibits pain signals in the spinal cord.

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    Reward Pathway

    A network of brain structures that plays a key role in experiencing pleasure and reward.

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    Tolerance

    The phenomenon where a person needs to take increasingly larger amounts of a substance to achieve the same desired effect.

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    PAS effect on Dopamine Release

    The tendency for a substance to increase the release of dopamine in the synapse.

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    Downregulation of Dopamine Receptors

    The body's response to prolonged exposure to high levels of dopamine, resulting in a decrease in dopamine production and receptor sensitivity.

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