Podcast
Questions and Answers
Which of the following is a benefit of sublingual or buccal administration of drugs?
Which of the following is a benefit of sublingual or buccal administration of drugs?
- It results in a more sustained plasma concentration of the drug
- It bypasses the liver, preventing first-pass metabolism (correct)
- It allows for first-pass metabolism of the drug
- It results in a slower onset of drug effect
Which drug is an example of the efficacy of sublingual administration?
Which drug is an example of the efficacy of sublingual administration?
- Nitroglycerin (correct)
- Fentanyl
- Buprenorphine
- Scopolamine
What are some characteristics of drugs that favor predictable transdermal absorption?
What are some characteristics of drugs that favor predictable transdermal absorption?
- Absence of histamine-releasing effects, daily dose requirements of >10 mg, molecular weight of <1,000
- Combined water and lipid solubility, molecular weight of <1,000, pH 5 to 9 in a saturated aqueous solution (correct)
- Combined water and lipid solubility, molecular weight of >1,000, pH 3 to 5 in a saturated aqueous solution
- Presence of histamine-releasing effects, daily dose requirements of <10 mg, molecular weight of <1,000
The ______ route of administration permits a rapid onset of drug effect because this blood bypasses the liver
The ______ route of administration permits a rapid onset of drug effect because this blood bypasses the liver
Oral transmucosal fentanyl citrate results in a rapid rise in fentanyl concentration for 'breakthrough' cancer pain where rapid onset of pain relief is clinically important because oral fentanyl has an extraction ratio of about ______%
Oral transmucosal fentanyl citrate results in a rapid rise in fentanyl concentration for 'breakthrough' cancer pain where rapid onset of pain relief is clinically important because oral fentanyl has an extraction ratio of about ______%
Transdermal administration of drugs provides sustained therapeutic plasma concentrations of the drug and decreases the likelihood of loss of therapeutic efficacy due to peaks and valleys associated with conventional intermittent drug ______
Transdermal administration of drugs provides sustained therapeutic plasma concentrations of the drug and decreases the likelihood of loss of therapeutic efficacy due to peaks and valleys associated with conventional intermittent drug ______
Which cation is the most abundant in blood and intracellular fluids?
Which cation is the most abundant in blood and intracellular fluids?
Which cation is the most abundant intracellularly?
Which cation is the most abundant intracellularly?
What is the concentration of Na+ and K+ in blood and intracellularly?
What is the concentration of Na+ and K+ in blood and intracellularly?
