Sublingual Administration Quiz
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Questions and Answers

Which of the following is a benefit of sublingual or buccal administration of drugs?

  • It results in a more sustained plasma concentration of the drug
  • It bypasses the liver, preventing first-pass metabolism (correct)
  • It allows for first-pass metabolism of the drug
  • It results in a slower onset of drug effect
  • Which drug is an example of the efficacy of sublingual administration?

  • Nitroglycerin (correct)
  • Fentanyl
  • Buprenorphine
  • Scopolamine
  • What are some characteristics of drugs that favor predictable transdermal absorption?

  • Absence of histamine-releasing effects, daily dose requirements of >10 mg, molecular weight of <1,000
  • Combined water and lipid solubility, molecular weight of <1,000, pH 5 to 9 in a saturated aqueous solution (correct)
  • Combined water and lipid solubility, molecular weight of >1,000, pH 3 to 5 in a saturated aqueous solution
  • Presence of histamine-releasing effects, daily dose requirements of <10 mg, molecular weight of <1,000
  • The ______ route of administration permits a rapid onset of drug effect because this blood bypasses the liver

    <p>sublingual or buccal</p> Signup and view all the answers

    Oral transmucosal fentanyl citrate results in a rapid rise in fentanyl concentration for 'breakthrough' cancer pain where rapid onset of pain relief is clinically important because oral fentanyl has an extraction ratio of about ______%

    <p>50</p> Signup and view all the answers

    Transdermal administration of drugs provides sustained therapeutic plasma concentrations of the drug and decreases the likelihood of loss of therapeutic efficacy due to peaks and valleys associated with conventional intermittent drug ______

    <p>injections</p> Signup and view all the answers

    Which cation is the most abundant in blood and intracellular fluids?

    <p>Na+</p> Signup and view all the answers

    Which cation is the most abundant intracellularly?

    <p>K+</p> Signup and view all the answers

    What is the concentration of Na+ and K+ in blood and intracellularly?

    <p>Na+ is 135 meq/L and K+ is 125 meq/L intracellularly, and Na+ is 10meq/L and K+ is 125 meq/L inside the cell</p> Signup and view all the answers

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