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Atherosclerosis is the buildup of fats or other substances such as cholesterol crystals and then macrophages in your artery walls can lead to ______ arteries narrows

plaque

Atherosclerosis is a pattern of the disease arteriosclerosis in which the wall of the artery develops abnormalities, called ______. These lesions may lead to narrowing due to buildup of the atheromatous ______

Endothelium produces NO, causing relaxation of vessels. This process is known as endothelium-mediated ______

vasodilation

In vivo assessment of endothelial dysfunction involves the application of ACh, which makes smooth muscle cells ______.

<p>contract</p> Signup and view all the answers

The recruitment of leukocytes to the vessel wall increases the ______ process.

<p>inflammatory</p> Signup and view all the answers

In hyperlipidemia, monocytes change from a homeostatic phenotype to a ______ phenotype, becoming potent activators of leukocytes.

<p>proinflammatory</p> Signup and view all the answers

Therapy goal: Intervene in the early inflammatory processes when ______ cytokines are produced by macrophages.

<p>proinflammatory</p> Signup and view all the answers

Arterial macrophages express ______ phenotype, which includes the expression of IL-1b, TNFa, and CXCL2.

<p>inflammatory</p> Signup and view all the answers

Clonal hematopoiesis is a new independent risk factor of atherosclerosis, associated with increased ______ formation.

<p>NET</p> Signup and view all the answers

JAK2 mutation is associated with increased ______ formation.

<p>NET</p> Signup and view all the answers

TET2 mutation leads to epigenetic alteration of chemokines, such as IL-6, Cxcl1, 2, 3, and ______.

<p>IL-1b</p> Signup and view all the answers

Canakinumab has been shown to reduce cardiovascular events by 64% in patients with TET2 CH and by 15% in overall patients with CVD and increased ______.

<p>hsCRP</p> Signup and view all the answers

Atherosclerosis is a leading cause of ______

<p>mortality</p> Signup and view all the answers

Atherosclerosis is the buildup of fats or other substances such as cholesterol crystals and then macrophages in your artery walls can lead to plaque ______ arteries narrows

<p>narrows</p> Signup and view all the answers

Atherosclerosis is a pattern of the disease arteriosclerosis in which the wall of the artery develops abnormalities, called ______

<p>lesions</p> Signup and view all the answers

These lesions may lead to narrowing due to buildup of the atheromatous ______

<p>plaque</p> Signup and view all the answers

Risk factors for endothelial dysfunction include Hypertension, Physical inactivity, Aging, Smoking, and ______

<p>Obesity</p> Signup and view all the answers

The endothelium is for ______

<p>vascular homeostasis</p> Signup and view all the answers

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