Stereochemical Aspects of Drug Design

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What is of special importance in drug-receptor interaction?

Electronic charge distribution and conformation

What factors does the activity of drugs depend on?

Stereochemistry, distance between atoms or groups, electronic distribution and configuration

What is critical for optimal biological activity in certain drugs?

Distances between the functional groups

What is the receptor usually composed of?

<p>Protein or DNA</p> Signup and view all the answers

What type of substances contain common functional moieties arranged in space in an analogous manner?

<p>Substances with similar pharmacological activity</p> Signup and view all the answers

What is of fundamental importance for the interaction of the drug with the receptor?

<p>Steric arrangement of functional moieties</p> Signup and view all the answers

What are two values of special importance in drug-receptor interaction?

<p>Electronic charge distribution and conformation</p> Signup and view all the answers

What is a limited portion of a macromolecule, usually protein in nature, where a drug interacts?

<p>Receptor</p> Signup and view all the answers

What structural factors does the activity of drugs depend on?

<p>Stereochemistry, distance between atoms or groups, electronic distribution and configuration</p> Signup and view all the answers

What is critical for optimal biological activity in certain drugs?

<p>Interatomic distances between functional groups</p> Signup and view all the answers

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