Stem Cells and Genetic Manipulation Quiz
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Questions and Answers

Which of the following is NOT one of the minimal set of transcription factors required to dedifferentiate an adult cell?

  • Nanog (correct)
  • Oct3/4
  • c-myc
  • Sox2

    • Which of the following is an alternative approach for reprogramming cells, compared to using the four transcription factors?

  • Using small molecules
  • Using modified-RNA
  • Using proteins
  • All of the above (correct)

    • Which of the following is a challenge associated with using induced pluripotent stem cells (iPSCs) compared to embryonic stem cells (ESCs)?

  • Tumors associated with c-myc re-expression
  • Differentiation potential and variation from colony to colony
  • Low efficiency of reprogramming
  • All of the above (correct)

    • Which of the following epigenetic modifications is associated with gene activation?

    <p>Histone acetylation (C)</p> Signup and view all the answers

    What is the biggest challenge in grafting hESC-derived cardiomyocytes in a model of myocardial ischemia?

    <p>Achieving sufficient cell numbers for successful grafting (C)</p> Signup and view all the answers

    What is a characteristic of umbilical cord blood stem cells?

    <p>Rich source of hematopoietic stem cells (A)</p> Signup and view all the answers

    Which statement about adult stem cells is true according to the text?

    <p>Renew indefinitely in culture (D)</p> Signup and view all the answers

    What is a unique property of embryonic stem cells compared to adult stem cells?

    <p>Renew indefinitely in the petri dish (A)</p> Signup and view all the answers

    Where is the subventricular zone (SVZ) located?

    <p>Lateral ventricles (D)</p> Signup and view all the answers

    What is the main function of cardiac stem cells according to the text?

    <p>Repair heart tissue (D)</p> Signup and view all the answers

    Which of the following is a key challenge in using embryonic stem cells (ESCs) for cell replacement therapies?

    <p>Potential for teratoma formation (C)</p> Signup and view all the answers

    What is the primary advantage of using adult stem cells, such as hematopoietic stem cells (HSCs), for cell replacement therapies?

    <p>Adult stem cells can be more easily obtained and used (B)</p> Signup and view all the answers

    What is the primary function of mesenchymal stem cells (MSCs) in the body?

    <p>Forming cells from the three germ layers (B)</p> Signup and view all the answers

    Which of the following is an advantage of transdifferentiation over reprogramming to a pluripotent state?

    <p>It avoids the risk of teratoma formation (C)</p> Signup and view all the answers

    Which of the following cell types has been successfully generated via transdifferentiation from pancreatic exocrine cells?

    <p>Pancreatic beta cells (C)</p> Signup and view all the answers

    Which of the following is a potential application of research with embryonic stem cells (ESCs)?

    <p>Discovering factors for tissue regeneration and repair (B)</p> Signup and view all the answers

    What combination of factors was used to induce transdifferentiation of cardiac fibroblasts into cardiac myocytes?

    <p>Tbx5, Mef2C, and Gata4 transcription factors (D)</p> Signup and view all the answers

    Which of the following cell types has been generated via transdifferentiation from skin fibroblasts?

    <p>Hematopoietic progenitors (A)</p> Signup and view all the answers

    Which of the following approaches has been used to induce transdifferentiation of fibroblasts into cardiac myocytes?

    <p>Forced expression of Yamanaka factors in serum-free conditions (A)</p> Signup and view all the answers

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