19 Questions
Which of the following is NOT one of the minimal set of transcription factors required to dedifferentiate an adult cell?
Nanog
Which of the following is an alternative approach for reprogramming cells, compared to using the four transcription factors?
All of the above
Which of the following is a challenge associated with using induced pluripotent stem cells (iPSCs) compared to embryonic stem cells (ESCs)?
All of the above
Which of the following epigenetic modifications is associated with gene activation?
Histone acetylation
What is the biggest challenge in grafting hESC-derived cardiomyocytes in a model of myocardial ischemia?
Achieving sufficient cell numbers for successful grafting
What is a characteristic of umbilical cord blood stem cells?
Rich source of hematopoietic stem cells
Which statement about adult stem cells is true according to the text?
Renew indefinitely in culture
What is a unique property of embryonic stem cells compared to adult stem cells?
Renew indefinitely in the petri dish
Where is the subventricular zone (SVZ) located?
Lateral ventricles
What is the main function of cardiac stem cells according to the text?
Repair heart tissue
Which of the following is a key challenge in using embryonic stem cells (ESCs) for cell replacement therapies?
Potential for teratoma formation
What is the primary advantage of using adult stem cells, such as hematopoietic stem cells (HSCs), for cell replacement therapies?
Adult stem cells can be more easily obtained and used
What is the primary function of mesenchymal stem cells (MSCs) in the body?
Forming cells from the three germ layers
Which of the following is an advantage of transdifferentiation over reprogramming to a pluripotent state?
It avoids the risk of teratoma formation
Which of the following cell types has been successfully generated via transdifferentiation from pancreatic exocrine cells?
Pancreatic beta cells
Which of the following is a potential application of research with embryonic stem cells (ESCs)?
Discovering factors for tissue regeneration and repair
What combination of factors was used to induce transdifferentiation of cardiac fibroblasts into cardiac myocytes?
Tbx5, Mef2C, and Gata4 transcription factors
Which of the following cell types has been generated via transdifferentiation from skin fibroblasts?
Hematopoietic progenitors
Which of the following approaches has been used to induce transdifferentiation of fibroblasts into cardiac myocytes?
Forced expression of Yamanaka factors in serum-free conditions
Test your knowledge on stem cells, including their genetic manipulation, tumorigenic properties, and potential clinical applications. Learn about different types of stem cells, such as umbilical cord blood stem cells, and the importance of proper culture techniques.
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