Statistical Inference: Point Estimation

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Questions and Answers

What type of cells are destroyed in Acute Inflammatory Demyelinating Polyneuropathy?

  • Astrocytes
  • Oligodendrocytes
  • Neurons
  • Schwann cells (correct)

What is a common cause of Osmotic Demyelination Syndrome?

  • Rapid correction of hyponatremia (correct)
  • Rapid correction of hypernatremia
  • Slow correction of hypernatremia
  • Slow correction of hyponatremia

Which of the following is a common presentation of Charcot-Marie-Tooth Disease?

  • Foot deformities (correct)
  • Cognitive decline
  • Hearing loss
  • Vision loss

Progressive Multifocal Leukoencephalopathy (PML) involves demyelination of what?

<p>Central nervous system (CNS) (C)</p>
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What is a potential trigger for Acute Disseminated Encephalomyelitis (ADEM)?

<p>Infection or vaccination (B)</p>
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What is a typical symptom of Osmotic Demyelination Syndrome?

<p>Acute paralysis (C)</p>
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Which of the following is associated with Progressive Multifocal Leukoencephalopathy?

<p>Severe immunosuppression (D)</p>
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What part of the body is primarily affected in Charcot-Marie-Tooth disease?

<p>Peripheral nerves (C)</p>
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Which of the following describes the muscle weakness seen in Acute Inflammatory Demyelinating Polyneuropathy?

<p>Symmetric ascending (C)</p>
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Following an infection or vaccination, which condition involves multifocal inflammation and demyelination?

<p>Acute Disseminated Encephalomyelitis (A)</p>
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What is the underlying cause of Charcot-Marie-Tooth disease?

<p>Genetic mutation (B)</p>
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Which virus is associated with Progressive Multifocal Leukoencephalopathy (PML)?

<p>JC Virus (A)</p>
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What condition features albuminocytologic dissociation in the cerebrospinal fluid?

<p>Acute Inflammatory Demyelinating Polyneuropathy (B)</p>
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What is the typical outcome for patients with Progressive Multifocal Leukoencephalopathy?

<p>Rapidly progressive and usually fatal (D)</p>
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What is a potential cause of Acute Inflammatory Demyelinating Polyneuropathy?

<p>Bacterial infection (A)</p>
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Rapid changes in which of the following can lead to Osmotic Demyelination Syndrome?

<p>Electrolytes (B)</p>
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Which of the following is a risk factor for Progressive Multifocal Leukoencephalopathy (PML)?

<p>Natalizumab use (D)</p>
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What gene duplication is implicated in Charcot-Marie-Tooth disease?

<p>PMP22 (C)</p>
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Which of the following is a key symptom of Acute Disseminated Encephalomyelitis (ADEM)?

<p>Altered mental status (B)</p>
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What is the primary treatment focus in Acute Inflammatory Demyelinating Polyneuropathy?

<p>Respiratory support (D)</p>
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Flashcards

Osmotic Demyelination Syndrome

Massive axonal demyelination in the pons, often due to rapid osmotic changes.

Acute Inflammatory Demyelinating Polyneuropathy (AIDP)

Autoimmune condition causing inflammation and demyelination, affecting motor, sensory, and peripheral nerves.

Acute Disseminated Encephalomyelitis (ADEM)

Multifocal inflammation and demyelination following infection or vaccination.

Charcot-Marie-Tooth Disease

Progressive hereditary nerve disorders due to defective proteins affecting peripheral nerves or myelin sheath.

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PMP22 gene duplication

Cause of Charcot-Marie-Tooth Disease, common type.

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Progressive Multifocal Leukoencephalopathy (PML)

Demyelination of the central nervous system (CNS) due to destruction of oligodendrocytes.

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Natalizumab

A risk factor for Progressive Multifocal Leukoencephalopathy (PML).

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Osmotic Demyelination Syndrome (Rapid Sodium Correction)

Correction from low to high sodium levels can lead to this condition.

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AIDP Presentation

Symmetric ascending muscle weakness and absent DTRs are common signs.

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AIDP Causes

Likely facilitated by molecular mimicry and triggered by inoculations or stress.

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Albuminocytologic Dissociation

Increased CSF protein with normal cell count.

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AIDP Pathogens

Campylobacter jejuni and viruses (e.g., Zika).

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ADEM Presentation

Rapidly progressive multifocal neurologic symptoms and altered mental status.

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PML Demyelination

Demyelination of central nervous system (CNS)

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PML Location

Parietal and occipital areas

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Study Notes

  • Statistical inference involves drawing conclusions about a population based on a sample.

Point Estimation

  • A point estimator, denoted as $\hat{\Theta}$, is a statistic used to estimate a parameter $\theta$ of a probability distribution.
  • $\hat{\Theta}$ is a function of the random sample $X_1, X_2,..., X_n$, expressed as $\hat{\Theta} = g(X_1, X_2,..., X_n)$.

Methods for Finding Estimators

  • Two common methods are the Method of Moments and Maximum Likelihood Estimation (MLE).

Method of Moments

  • This method is used when estimating parameters $\theta_1, \theta_2,..., \theta_k$ of a probability distribution.
  • First, the i-th population moment $\mu_i = E(X_i)$ is expressed in terms of $\theta_1, \theta_2,..., \theta_k$.
  • Second, the i-th sample moment is calculated as $\hat{\mu_i} = \frac{1}{n}\sum_{i=1}^{n} X_i$.
  • Finally, a system of equations ($\mu_i = \hat{\mu_i}$) is solved for $\theta_1, \theta_2,..., \theta_k$.

Maximum Likelihood Estimation (MLE)

  • This method is used when parameters $\theta$ of a probability distribution.
  • First, the likelihood function $L(\theta; x_1, x_2,..., x_n) = f(x_1, x_2,..., x_n;\theta) = \prod_{i=1}^{n} f(x_i;\theta)$ is found.
  • Then, the log-likelihood function is computed as $l(\theta; x_1, x_2,..., x_n) = ln(L(\theta; x_1, x_2,..., x_n))$.
  • Next, $l(\theta; x_1, x_2,..., x_n)$ is differentiated with respect to $\theta$ and set equal to 0.
  • Finally, the equation is solved for $\theta$ to obtain the MLE.

Properties of Estimators

  • Important properties include bias, variance, and mean squared error (MSE).

Bias

  • The bias of an estimator $\hat{\Theta}$ is defined as $B(\hat{\Theta}) = E(\hat{\Theta}) - \theta$.
  • An estimator is unbiased if its bias is zero: $B(\hat{\Theta}) = 0$.
  • An estimator is biased if its bias is not zero: $B(\hat{\Theta}) \neq 0$.

Variance

  • The variance of an estimator $\hat{\Theta}$ is defined as $Var(\hat{\Theta}) = E[(\hat{\Theta} - E(\hat{\Theta}))^2]$.

Mean Squared Error (MSE)

  • The MSE of an estimator $\hat{\Theta}$ is defined as $MSE(\hat{\Theta}) = E[(\hat{\Theta} - \theta)^2]$, which can be decomposed into $Var(\hat{\Theta}) + [B(\hat{\Theta})]^2$.

Example: Unbiased Estimator of Variance

  • Given a random sample $X_1, X_2,..., X_n$ from a population with mean $\mu$ and variance $\sigma^2$, the sample variance $S^2 = \frac{1}{n-1}\sum_{i=1}^{n} (X_i - \bar{X})^2$ is an unbiased estimator of $\sigma^2$ because $E(S^2) = \sigma^2$.

Theorem: Minimum Variance Unbiased Estimator of the Mean

  • For a random sample $X_1, X_2,..., X_n$ from a population with mean $\mu$ and variance $\sigma^2$, the sample mean $\bar{X}$ is the minimum variance unbiased estimator of $\mu$.

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