19 Questions
How can your DNA affect drug response according to the text?
By determining the type of drug receptors you have
In pharmacogenomics, what does the CYP2D6 gene primarily affect?
Drug metabolism
How can decreased drug uptake into cells affect drug efficacy?
It causes the drug to accumulate in tissues
What is the role of the SLCO1B1 gene in pharmacogenomics?
Influencing drug uptake
How does T-DM1 work in treating HER2-positive breast cancer?
By attaching to HER2 on cancerous cells and killing them
Which factor can indicate that T-DM1 is not suitable for treating breast cancer?
Low expression of HER2 receptors
What happens if drugs are removed from cells too quickly?
They may cause side effects
What is the significance of the amount of HER2 in breast cancer treatment with T-DM1?
T-DM1 works better with low HER2 expression
What does T-DM1 attach to in breast cancer cells to exert its effects?
HER2 receptors
What is the impact of taking a smaller dose or changing the drug if amitriptyline is broken down very slowly?
To avoid a bad reaction
How do drugs developed based on mutations in genes work?
They target specific changes in proteins affected by mutations
In pharmacogenomics, drugs created based on mutations in genes will only work for:
Specific type of mutation
For individuals with cystic fibrosis whose mutations result in a closed channel, how does ivacaftor work?
Forcing the channel open
Which type of mutation in cystic fibrosis makes ivacaftor ineffective?
Mutation causing the channel not to be made at all
What is the main function of the CFTR protein in cystic fibrosis?
Forming a channel for particle movement
How does amitriptyline metabolism relate to drug dosage?
Slow metabolism may require a smaller dose
In pharmacogenomics, how do mutations affect drug responses?
Mutations lead to varied drug responses
What characteristic of gene mutations can determine the effectiveness of drugs based on them?
Specific type of mutation
How does ivacaftor act on specific types of CFTR gene mutations in cystic fibrosis?
By forcing the channel open
Explore how statins are transported into the liver by a protein encoded by the SLCO1B1 gene. Learn about the impact of specific genetic changes on simvastatin levels in the liver and potential muscle problems associated with high doses of the drug.
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