Statins and SLCO1B1 Gene Interaction
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Questions and Answers

How can your DNA affect drug response according to the text?

  • By affecting the targeted drug development process
  • By influencing the rate of drug uptake into cells
  • By controlling drug metabolism within the body
  • By determining the type of drug receptors you have (correct)

    • In pharmacogenomics, what does the CYP2D6 gene primarily affect?

  • Drug uptake
  • Drug receptors
  • Targeted drug development
  • Drug metabolism (correct)

    • How can decreased drug uptake into cells affect drug efficacy?

  • It causes the drug to accumulate in tissues (correct)
  • It enhances targeted drug development
  • It increases the drug's effectiveness
  • It accelerates the drug's action

    • What is the role of the SLCO1B1 gene in pharmacogenomics?

    <p>Influencing drug uptake</p> Signup and view all the answers

    How does T-DM1 work in treating HER2-positive breast cancer?

    <p>By attaching to HER2 on cancerous cells and killing them</p> Signup and view all the answers

    Which factor can indicate that T-DM1 is not suitable for treating breast cancer?

    <p>Low expression of HER2 receptors</p> Signup and view all the answers

    What happens if drugs are removed from cells too quickly?

    <p>They may cause side effects</p> Signup and view all the answers

    What is the significance of the amount of HER2 in breast cancer treatment with T-DM1?

    <p>T-DM1 works better with low HER2 expression</p> Signup and view all the answers

    What does T-DM1 attach to in breast cancer cells to exert its effects?

    <p>HER2 receptors</p> Signup and view all the answers

    What is the impact of taking a smaller dose or changing the drug if amitriptyline is broken down very slowly?

    <p>To avoid a bad reaction</p> Signup and view all the answers

    How do drugs developed based on mutations in genes work?

    <p>They target specific changes in proteins affected by mutations</p> Signup and view all the answers

    In pharmacogenomics, drugs created based on mutations in genes will only work for:

    <p>Specific type of mutation</p> Signup and view all the answers

    For individuals with cystic fibrosis whose mutations result in a closed channel, how does ivacaftor work?

    <p>Forcing the channel open</p> Signup and view all the answers

    Which type of mutation in cystic fibrosis makes ivacaftor ineffective?

    <p>Mutation causing the channel not to be made at all</p> Signup and view all the answers

    What is the main function of the CFTR protein in cystic fibrosis?

    <p>Forming a channel for particle movement</p> Signup and view all the answers

    How does amitriptyline metabolism relate to drug dosage?

    <p>Slow metabolism may require a smaller dose</p> Signup and view all the answers

    In pharmacogenomics, how do mutations affect drug responses?

    <p>Mutations lead to varied drug responses</p> Signup and view all the answers

    What characteristic of gene mutations can determine the effectiveness of drugs based on them?

    <p>Specific type of mutation</p> Signup and view all the answers

    How does ivacaftor act on specific types of CFTR gene mutations in cystic fibrosis?

    <p>By forcing the channel open</p> Signup and view all the answers

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