Staphylococci Overview and Virulence Factors
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Questions and Answers

Which mechanism does S.aureus use to evade phagocytosis effectively?

  • Secretion of myeloperoxidase
  • Production of sulfatase
  • Inhibition of T-cell activation
  • Binding of Protein A to the Fc region of IgG (correct)

    • What role does the polysaccharide capsule of S.aureus play in its pathogenesis?

  • Stimulates leukocyte attraction
  • Enhances resistance to phagocytosis (correct)
  • Increases the production of toxins
  • Facilitates binding to mucosal surfaces

    • What is the primary function of coagulase produced by S.aureus?

  • Promotes immune cell proliferation
  • Degrades extracellular matrix
  • Clots plasma to enhance survival (correct)
  • Converts oxygen to water

    • Which of the following factors is NOT a component of the S.aureus cell wall?

    <p>Pseudomurein</p> Signup and view all the answers

    How does the peptidoglycan of S.aureus contribute to its pathogenicity?

    <p>By stimulating endogenous pyrogen production</p> Signup and view all the answers

    Which statement about the virulence factors of S.aureus is accurate?

    <p>The pathogenesis relies on multiple virulence factors concurrently</p> Signup and view all the answers

    What is a significant source of S.aureus infection among humans?

    <p>Contamination of fomites by carriers</p> Signup and view all the answers

    Which enzyme produced by S.aureus helps neutralize reactive oxygen species?

    <p>Catalase</p> Signup and view all the answers

    What is the primary function of hyaluronidase in bacterial virulence?

    <p>To promote the spread of bacteria</p> Signup and view all the answers

    Which toxin is specifically responsible for causing toxic shock syndrome?

    <p>Toxic shock syndrome toxin (TSST-1)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of superantigen exotoxins?

    <p>They lyse red blood cells.</p> Signup and view all the answers

    What is the role of lipases produced by staphylococci?

    <p>To promote bacterial growth in sebaceous areas</p> Signup and view all the answers

    What effect does exfoliatin (ET) have on the skin?

    <p>It causes desquamation in the stratum granulosum.</p> Signup and view all the answers

    Which of the following describes the primary entry points for staphylococcal infections?

    <p>Skin breaks or respiratory tract</p> Signup and view all the answers

    Cytolytic exotoxins are commonly known to affect which type of cells?

    <p>Mammalian cell membranes including RBCs</p> Signup and view all the answers

    What is a significant effect of the localized host response to staphylococcal infection?

    <p>Formation of pus and tissue necrosis</p> Signup and view all the answers

    What is the primary reason MRSA infections are unresponsive to β-lactam antibiotics?

    <p>MRSA possesses PBP-2a, which has a low affinity for β-lactam antibiotics.</p> Signup and view all the answers

    Which of the following is a common clinical manifestation of community-acquired MRSA (CA-MRSA)?

    <p>Skin and soft tissue infections</p> Signup and view all the answers

    What has been the effect of low-level vancomycin resistance in MRSA since its discovery in 1997?

    <p>Higher mortality rates due to limited treatment options.</p> Signup and view all the answers

    Which of the following is true about Staphylococcus epidermidis?

    <p>It produces polysaccharide intercellular adhesin that aids in adherence to surfaces.</p> Signup and view all the answers

    What are the main preventive measures against S.aureus infections in hospital settings?

    <p>Hand disinfection and environmental cleaning.</p> Signup and view all the answers

    Why have alternative drugs like linezolid and daptomycin been increasingly used against MRSA?

    <p>Resistant strains of MRSA are emerging, limiting treatment options.</p> Signup and view all the answers

    What is a significant challenge posed by coagulase-negative staphylococci (CNS) in hospitals?

    <p>They frequently cause infections associated with prosthetic devices.</p> Signup and view all the answers

    How do MRSA infections impact patient care in hospitals?

    <p>They are linked to longer hospital stays and increased mortality.</p> Signup and view all the answers

    Which of the following statements about Staphylococcus aureus is correct?

    <p>All isolates secrete coagulase.</p> Signup and view all the answers

    What distinguishes staphylococci from catalase-negative streptococci?

    <p>Staphylococci produce catalase.</p> Signup and view all the answers

    Which species of staphylococci is known to cause urinary tract infections, especially cystitis in women?

    <p>Staphylococcus saprophyticus</p> Signup and view all the answers

    What is a common feature of Staphylococci in terms of their morphology?

    <p>They appear as spherical cells in grapelike clusters.</p> Signup and view all the answers

    Which of the following is one of the most common causes of food poisoning?

    <p>Staphylococcus aureus</p> Signup and view all the answers

    Which of the following describes a key characteristic of coagulase-negative staphylococci?

    <p>They lack the enzyme coagulase.</p> Signup and view all the answers

    What role does significant host compromise play in Staphylococcus aureus infections?

    <p>It enhances the virulence of the bacteria.</p> Signup and view all the answers

    Which feature regarding Staphylococci contributes to their ability to persist on surfaces?

    <p>They are resistant to drying and heat.</p> Signup and view all the answers

    What symptom occurs within a short incubation period and is primarily caused by the action of a toxin on the gastrointestinal tract?

    <p>Acute diarrhea</p> Signup and view all the answers

    Which characteristic is used to distinguish Staphylococcus aureus from coagulase-negative staphylococci?

    <p>Coagulase positivity</p> Signup and view all the answers

    What is the primary reason for the shift from penicillin G to β-lactamase-resistant penicillins in treating S.aureus infections?

    <p>Acquisition of antibiotic resistance by S.aureus</p> Signup and view all the answers

    In which of the following types of infections is methicillin-resistant S.aureus (MRSA) predominantly found?

    <p>Hospital-acquired infections primarily</p> Signup and view all the answers

    What is a common laboratory method for identifying Staphylococcus species?

    <p>Catalase test</p> Signup and view all the answers

    Why are strains of S.aureus resistant to methicillin becoming prevalent in hospitals?

    <p>Widespread use of β-lactamase-resistant antibiotics</p> Signup and view all the answers

    What morphological characteristic is typical for Staphylococcus aureus when observed under a microscope?

    <p>Coccoidal clusters</p> Signup and view all the answers

    What is a possible consequence of the widespread resistance of S.aureus to β-lactam antibiotics?

    <p>Higher rates of post-surgical infections</p> Signup and view all the answers

    Staphylococci generally stain gram negative and are oval in shape.

    <p>False</p> Signup and view all the answers

    Staphylococcus epidermidis is primarily associated with causing food poisoning.

    <p>False</p> Signup and view all the answers

    The most virulent species of staphylococcus is Staphylococcus saprophyticus.

    <p>False</p> Signup and view all the answers

    Coagulase-negative staphylococci (CNS) lack the enzyme coagulase and do not typically cause serious infections.

    <p>True</p> Signup and view all the answers

    Staphylococcus aureus infections typically require a significant host compromise, like a break in the skin.

    <p>True</p> Signup and view all the answers

    Staphylococci are anaerobic organisms that thrive in environments without oxygen.

    <p>False</p> Signup and view all the answers

    Staphylococcus aureus is known for producing toxins that can lead to toxic shock syndrome.

    <p>True</p> Signup and view all the answers

    All species of staphylococci are highly virulent and cause severe infections.

    <p>False</p> Signup and view all the answers

    MRSA infections can lead to higher mortality rates and longer hospital stays.

    <p>True</p> Signup and view all the answers

    Vancomycin has gained a reputation as the least effective treatment for life-threatening MRSA infections.

    <p>False</p> Signup and view all the answers

    Community-acquired MRSA (CA-MRSA) primarily affects individuals with prior hospital exposure.

    <p>False</p> Signup and view all the answers

    The protein PBP-2a has a high affinity for β-lactam antibiotics.

    <p>False</p> Signup and view all the answers

    Staphylococcus epidermidis is part of the normal skin flora but can also cause infections in prosthetic devices.

    <p>True</p> Signup and view all the answers

    The increasing incidence of vancomycin resistance among MRSA strains has led to the use of alternative drugs such as clindamycin and rifampicin.

    <p>False</p> Signup and view all the answers

    Polysaccharide intercellular adhesin produced by S. epidermidis helps in adherence to bioprosthetic materials.

    <p>True</p> Signup and view all the answers

    Necrotizing pneumonia and osteomyelitis are rare severe manifestations of CA-MRSA infections.

    <p>True</p> Signup and view all the answers

    The presence of a microcapsule in S.aureus is associated with increased sensitivity to phagocytosis.

    <p>False</p> Signup and view all the answers

    Peptidoglycan in S.aureus has no role in stimulating inflammatory responses.

    <p>False</p> Signup and view all the answers

    Coagulase produced by S.aureus initiates fibrin polymerization by binding to thrombin.

    <p>False</p> Signup and view all the answers

    Clumping factor in S.aureus promotes isolation from immune cells by converting fibrinogen to soluble fibrin.

    <p>False</p> Signup and view all the answers

    All S.aureus diseases are a result of both invasive infection and the production of toxins.

    <p>False</p> Signup and view all the answers

    The binding of IgG by Protein A in S.aureus enhances phagocytosis.

    <p>False</p> Signup and view all the answers

    S.aureus is carried by healthy individuals but does not pose a risk for food contamination.

    <p>False</p> Signup and view all the answers

    Catalase produced by S.aureus converts hydrogen peroxide to water and carbon dioxide.

    <p>False</p> Signup and view all the answers

    Localized skin infections caused by S.aureus may include conditions such as folliculitis, furuncles, and carbuncles.

    <p>True</p> Signup and view all the answers

    Toxinoses caused by S.aureus include diseases such as toxic shock syndrome and Staphylococcal gastroenteritis.

    <p>True</p> Signup and view all the answers

    Septicemia is primarily caused by the presence of non-viable bacteria in the bloodstream.

    <p>False</p> Signup and view all the answers

    S.aureus is an uncommon cause of pneumonia in patients with weakened immune systems.

    <p>False</p> Signup and view all the answers

    Carbuncles are small, superficial abscesses that occur around hair follicles.

    <p>False</p> Signup and view all the answers

    Injection of contaminated materials can lead to acute endocarditis caused by S.aureus.

    <p>True</p> Signup and view all the answers

    Staphylococcal gastroenteritis is caused by ingestion of food contaminated with enterotoxins produced by non-viable S.aureus.

    <p>False</p> Signup and view all the answers

    Furuncles are also referred to as boils and can develop around foreign bodies like splinters.

    <p>True</p> Signup and view all the answers

    Hyaluronidase is primarily responsible for degrading hyaluronic acid to promote the spread of bacteria.

    <p>True</p> Signup and view all the answers

    Cytolytic exotoxins are ineffective against mammalian cell membranes.

    <p>False</p> Signup and view all the answers

    The production of Panton-Valentine leukocidin decreases the virulence of staphylococcal strains.

    <p>False</p> Signup and view all the answers

    Enterotoxins produced by Staphylococcus aureus can lead to food poisoning upon ingestion.

    <p>True</p> Signup and view all the answers

    Exfoliatin (ET) is classified as an endotoxin that targets the gastrointestinal tract.

    <p>False</p> Signup and view all the answers

    Toxic shock syndrome toxin (TSST-1) is an example of a superantigen that can induce toxic shock syndrome.

    <p>True</p> Signup and view all the answers

    Lipases produced by staphylococci help to hydrolyze carbohydrates, promoting bacterial survival.

    <p>False</p> Signup and view all the answers

    The localized host response to staphylococcal infection is characterized by tissue necrosis and reduction of pus.

    <p>False</p> Signup and view all the answers

    What is the primary effect of Panton-Valentine leukocidin on polymorphonuclear leukocytes (PMNs)?

    <p>It lyses PMNs, making strains of S.aureus more virulent.</p> Signup and view all the answers

    Describe the action of superantigen exotoxins in relation to T-lymphocyte activation.

    <p>Superantigen exotoxins strongly stimulate T-lymphocyte response, leading to massive cytokine release.</p> Signup and view all the answers

    How does hyaluronidase contribute to the spread of bacterial infections?

    <p>Hyaluronidase hydrolyzes hyaluronic acid, facilitating the spread of bacteria through connective tissues.</p> Signup and view all the answers

    What role do enterotoxins play in food poisoning associated with S.aureus?

    <p>Enterotoxins produced by S.aureus can cause food poisoning upon ingestion of contaminated food.</p> Signup and view all the answers

    Explain the significance of exfoliatin (ET) in staphylococcal infections.

    <p>Exfoliatin causes scalded skin syndrome by attacking intercellular adhesion in the skin, leading to desquamation.</p> Signup and view all the answers

    What outcome results from the localized host response to staphylococcal infection?

    <p>The response is characterized by inflammation, swelling, pus accumulation, and tissue necrosis.</p> Signup and view all the answers

    What is the pathogenic mechanism of fibrinolysin, also known as staphylokinase?

    <p>Fibrinolysin dissolves fibrin clots, which can facilitate the spread of staphylococcal infections.</p> Signup and view all the answers

    Discuss the impact of superantigen-driven cytokine release in toxic shock syndrome.

    <p>The massive cytokine release leads to widespread inflammation and potentially fatal complications.</p> Signup and view all the answers

    What are the typical symptoms associated with a toxin-mediated gastrointestinal disturbance caused by S.aureus?

    <p>Nausea, vomiting, and diarrhea are typical symptoms.</p> Signup and view all the answers

    How can Staphylococcus aureus be distinguished from coagulase-negative staphylococci in the laboratory?

    <p>S.aureus is distinguished by its coagulase positivity and its ability to ferment mannitol.</p> Signup and view all the answers

    What treatment approach is required for serious S.aureus infections, particularly when they are resistant to common antibiotics?

    <p>Aggressive treatment including incision, drainage, and systemic antibiotics is required.</p> Signup and view all the answers

    What effect do penicillinase-encoding plasmids have on the treatment of S.aureus infections?

    <p>They make virtually all S.aureus strains resistant to penicillin G.</p> Signup and view all the answers

    What laboratory tests can be used to confirm the presence of S.aureus?

    <p>Tests for catalase and coagulase positivity are used for confirmation.</p> Signup and view all the answers

    What has been the trend regarding hospital-acquired methicillin-resistant S.aureus (MRSA) in recent decades?

    <p>Around 50 percent of hospital S.aureus isolates are now resistant to methicillin or oxacillin.</p> Signup and view all the answers

    What is the significance of the exfoliative toxin produced by some strains of S.aureus?

    <p>It leads to scalded skin syndrome by causing marked epithelial desquamation.</p> Signup and view all the answers

    How has the increased use of methicillin changed the landscape of bacterial resistance in S.aureus?

    <p>Increased use of methicillin has led to the emergence of methicillin-resistant S.aureus (MRSA).</p> Signup and view all the answers

    What distinguishes Staphylococcus aureus from other staphylococcal species in terms of virulence?

    <p>Staphylococcus aureus is distinguished by its ability to secrete coagulase, which enables it to clot plasma and is linked to its high virulence.</p> Signup and view all the answers

    Name two clinical implications of Staphylococcus epidermidis infections.

    <p>Staphylococcus epidermidis is associated with prosthetic implant infections and is a common cause of bacteremia in immunocompromised patients.</p> Signup and view all the answers

    How do the morphological characteristics of staphylococci assist in their identification?

    <p>Staphylococci are generally Gram-positive, spherical, and appear in grape-like clusters, aiding in their identification under the microscope.</p> Signup and view all the answers

    What role does the catalase enzyme play in distinguishing staphylococci from other bacteria?

    <p>Catalase production in staphylococci allows them to break down hydrogen peroxide, differentiating them from catalase-negative streptococci.</p> Signup and view all the answers

    What is the significance of Staphylococcus saprophyticus in urinary tract infections?

    <p>Staphylococcus saprophyticus is particularly recognized for causing urinary tract infections, especially cystitis in younger women.</p> Signup and view all the answers

    Explain how Staphylococcus aureus can contribute to food poisoning.

    <p>Staphylococcus aureus can produce enterotoxins that contaminate food, leading to food poisoning when ingested.</p> Signup and view all the answers

    Why are staphylococci considered hardy organisms in their environment?

    <p>Staphylococci are resistant to heat and drying, allowing them to persist on fomites for extended periods.</p> Signup and view all the answers

    What is the general impact of host compromise on Staphylococcus aureus infections?

    <p>Significant host compromise, such as skin breaks or foreign body presence, increases susceptibility to Staphylococcus aureus infections.</p> Signup and view all the answers

    What does the gene for PBP-2a contribute to in MRSA infections?

    <p>It encodes a new peptidoglycan transpeptidase with low affinity for β-lactam antibiotics.</p> Signup and view all the answers

    Identify one severe disease condition that CA-MRSA can cause apart from skin infections.

    <p>Necrotizing pneumonia.</p> Signup and view all the answers

    What has been a recent trend regarding vancomycin resistance in MRSA since 1997?

    <p>The incidence of vancomycin resistance has increased steadily.</p> Signup and view all the answers

    What role does polysaccharide intercellular adhesin play in infections caused by Staphylococcus epidermidis?

    <p>It facilitates adherence to bioprosthetic materials and acts as a barrier to antimicrobials.</p> Signup and view all the answers

    How have alternative treatments like linezolid and daptomycin become important against MRSA?

    <p>They have shown good in vitro activity against MRSA and various clinically significant gram-positive bacteria.</p> Signup and view all the answers

    What is a major strategy for controlling nosocomial S.aureus epidemics in healthcare settings?

    <p>Implementing stringent infection control procedures, including hand disinfection.</p> Signup and view all the answers

    What is a common clinical manifestation of skin infections caused by CA-MRSA?

    <p>Abscesses.</p> Signup and view all the answers

    What challenges does the presence of coagulase-negative staphylococci (CNS) pose in hospitals?

    <p>They are important agents of hospital-acquired infections, particularly in patients with implanted devices.</p> Signup and view all the answers

    What are the potential serious consequences of staphylococcal infections that invade the bloodstream?

    <p>The potential serious consequences include septicemia and the risk of internal abscesses or infections in organs such as the lungs or heart.</p> Signup and view all the answers

    How do carbuncles differ from furuncles in terms of their characteristics?

    <p>Carbuncles are larger, deeper, and multiloculated skin infections, while furuncles (boils) are subcutaneous abscesses that typically form around foreign bodies.</p> Signup and view all the answers

    What is acute endocarditis and how is it commonly caused?

    <p>Acute endocarditis is an infection of the heart's inner lining and is commonly caused by injections using contaminated needles or preparations.</p> Signup and view all the answers

    In what way can staphylococcal gastroenteritis occur, and what type of toxin is involved?

    <p>Staphylococcal gastroenteritis occurs from ingestion of food contaminated with enterotoxin-producing Staphylococcus aureus.</p> Signup and view all the answers

    What are toxinoses and what significant condition is caused by S.aureus related to toxinoses?

    <p>Toxinoses are diseases caused by toxins, and a significant condition caused by S.aureus is Toxic Shock Syndrome (TSS).</p> Signup and view all the answers

    What role does Staphylococcus aureus play in nosocomial infections?

    <p>Staphylococcus aureus is one of the most common causes of hospital-associated infections, often resulting from wound infections or bacteremia related to catheters.</p> Signup and view all the answers

    Describe the process through which S.aureus can cause pneumonia.

    <p>S.aureus can lead to severe, necrotizing pneumonia through its virulence factors and ability to invade body tissues.</p> Signup and view all the answers

    How do localized skin infections manifest with S.aureus and what types are most common?

    <p>Localized skin infections with S.aureus often present as superficial abscesses like folliculitis, furuncles, and impetigo.</p> Signup and view all the answers

    Match the following Staphylococcus species with their clinical significance:

    <p>Staphylococcus aureus = Primary cause of food poisoning Staphylococcus epidermidis = Common in prosthetic infections Staphylococcus saprophyticus = Causes urinary tract infections in women Staphylococcus hominis = Associated with skin flora</p> Signup and view all the answers

    Match the following virulence factors with their descriptions:

    <p>Coagulase = Enzyme that clots plasma Exfoliatin = Causes skin peeling Hyaluronidase = Aids tissue penetration Toxins = Can lead to toxic shock syndrome</p> Signup and view all the answers

    Match the following characteristics of Staphylococci with their descriptions:

    <p>Gram-positive = Stains purple under Gram stain Facultatively anaerobic = Can grow with or without oxygen Catalase positive = Produces catalase enzyme Grapelike clusters = Characteristic arrangement under microscope</p> Signup and view all the answers

    Match the following treatments with their targets:

    <p>Beta-lactam antibiotics = Target bacterial cell wall synthesis Vancomycin = Effective against MRSA Linezolid = Used for resistant Gram-positive infections Daptomycin = Disrupts bacterial membrane function</p> Signup and view all the answers

    Match the following Staphylococcus species with their unique features:

    <p>Staphylococcus aureus = Secretes coagulase Staphylococcus epidermidis = Often found in skin flora Staphylococcus saprophyticus = Associated with female urinary tract infections Staphylococcus lugdunensis = Can cause severe skin infections</p> Signup and view all the answers

    Match the following symptoms with their respective Staphylococcus-related conditions:

    <p>Food poisoning = Gastrointestinal symptoms within hours Toxic shock syndrome = Rapid onset fever and rash Folliculitis = Infection of hair follicles Septicemia = Bloodstream infection leading to systemic issues</p> Signup and view all the answers

    Match the following laboratory diagnosis methods with the target organism:

    <p>Culture on mannitol salt agar = Identifies Staphylococcus aureus Coagulase test = Differentiates S.aureus from CNS Gram staining = Determines Gram-positive cocci Oxacillin resistance testing = Identifies MRSA strains</p> Signup and view all the answers

    Match the following host factors with their role in Staphylococcus infection susceptibility:

    <p>Break in the skin = Entry point for pathogens Insertion of foreign body = Increases risk of infection Obstructed hair follicle = Can lead to folliculitis Compromised immune system = Heightened risk of severe infections</p> Signup and view all the answers

    Match the virulence factors with their descriptions:

    <p>Capsule = Increases resistance to phagocytosis Teichoic acid = Binds to fibronectin Clumping factor = Binds to fibrinogen and promotes clumping Peptidoglycan = Stimulates production of pyrogen and inhibits phagocytosis</p> Signup and view all the answers

    Match the S.aureus enzymes with their functions:

    <p>Coagulase = Clots plasma and helps evade phagocytosis Catalase = Converts H2O2 to water and oxygen Hyaluronidase = Promotes tissue invasion by breaking down connective tissue Nuclease = Degrades DNA in necrotic tissue</p> Signup and view all the answers

    Match the types of S.aureus infections with their causes:

    <p>Toxic Shock Syndrome = Toxin-mediated effect Food Poisoning = Result of toxin in contaminated food Skin Infections = Caused by direct contact with carriers Bacteremia = Invasive infection leading to bacteria in the bloodstream</p> Signup and view all the answers

    Match the S.aureus exotoxins with their effects:

    <p>Exfoliatin = Causes exfoliation of the skin Enterotoxin = Leads to gastrointestinal symptoms like vomiting Pyrogenic Toxin = Induces fever and shock Hemolysin = Lyses red blood cells</p> Signup and view all the answers

    Match the clinical manifestations with their associated factors:

    <p>Osteomyelitis = Invasive infection affecting bone Endocarditis = Infection of the heart valves Pneumonia = Infections resulting from S.aureus aspiration Cellulitis = Caused by skin breaches leading to bacterial invasion</p> Signup and view all the answers

    Match the sources of S.aureus infection with their descriptions:

    <p>Fomites = Inanimate objects that can become contaminated Healthy Carriers = Individuals that harbor S.aureus without symptoms Food Contamination = Transfer of S.aureus from individuals via food Direct Contact = Transference from skin to skin interaction</p> Signup and view all the answers

    Match the host defense mechanisms with their roles against S.aureus infections:

    <p>Phagocytosis = Engulfs and destroys pathogens Antibodies = Neutralize toxins and opsonize bacteria Complement System = Facilitates opsonization and lysis of bacteria Inflammatory Response = Increases blood flow and immune cell recruitment</p> Signup and view all the answers

    Match the S.aureus virulence factors with their effects on pathogenesis:

    <p>Protein A = Prevents opsonization by binding to IgG Fibronectin-binding protein = Facilitates adherence to host tissues Capsule = Protects against phagocytosis Coagulase = Promotes fibrin formation to shield bacteria from immune responses</p> Signup and view all the answers

    Match the localized skin infections with their descriptions:

    <p>Folliculitis = Small, superficial abscesses involving hair follicles. Furuncles = Subcutaneous abscesses often formed around foreign bodies. Carbuncles = Larger, deeper, multiloculated skin infections. Impetigo = Localized, superficial, spreading crusty skin lesion in children.</p> Signup and view all the answers

    Match the type of infection with its relevant characteristic:

    <p>Septicemia = Generalized infection causing sepsis. Acute endocarditis = Caused by contaminated needles or injections. Pneumonia = Severe, necrotizing lung infection. Deep localized infections = May arise from trauma or superficial infections.</p> Signup and view all the answers

    Match the toxinoses caused by S.aureus with their effects:

    <p>Toxic shock syndrome = High fever, rash, multiorgan damage. Staphylococcal gastroenteritis = Caused by ingestion of contaminated food. Bacteremia = Presence of viable bacteria circulating in the bloodstream. Septic arthritis = Acute infection of joint space, especially in children.</p> Signup and view all the answers

    Match the S.aureus-related conditions with their potential outcomes:

    <p>Localized skin infections = Can lead to abscess formation. Nosocomial infections = Common cause of hospital-associated bacteremia. Furuncles = Can progress to septicemia. Carbuncles = May require antibiotic therapy and debridement.</p> Signup and view all the answers

    Match the infection type with its risk factor:

    <p>Septic arthritis = Most common in children. Pneumonia = Associated with lung infections. Endocarditis = Linked to contaminated injections. Septicemia = Presence of pathogenic microorganisms in the blood.</p> Signup and view all the answers

    Match the specific effects or characteristics to the type of S.aureus infection:

    <p>Toxic shock syndrome = Results in hypotension and multiorgan involvement. Furuncles = Commonly form around foreign bodies. Carbuncles = Result in deeper infections that may require surgical interventions. Pneumonia = Causes severe necrotizing damage to lung tissue.</p> Signup and view all the answers

    Match the type of abscess with its description:

    <p>Folliculitis = Involves hair follicles. Furuncles = Typically associated with splinters. Carbuncles = Multiloculated and larger than furuncles. Impetigo = Spreading crusty lesions generally seen in children.</p> Signup and view all the answers

    Match the disease caused by toxins with the corresponding symptoms:

    <p>Toxic shock syndrome = Hypotension and rash. Staphylococcal gastroenteritis = Vomiting and diarrhea. Septicemia = Prolonged presence of toxins in the blood. Pneumonia = Severe respiratory distress.</p> Signup and view all the answers

    Match the following characteristics with their corresponding descriptions relating to Staphylococcus aureus:

    <p>Coagulase positivity = Distinguishes S.aureus from coagulase-negative staphylococci Mannitol positivity = S.aureus ability to ferment mannitol resulting in yellow colonies Hemolytic colonies = S.aureus colonies tend to be yellow and hemolytic Grapelike clusters = Typical microscopic appearance of staphylococci</p> Signup and view all the answers

    Match the following treatments with their indications for Staphylococcus aureus infections:

    <p>Systemic antibiotics = Used for serious S.aureus infections Incision and drainage = Necessary for localized lesions β-lactamase-resistant penicillins = Replacement for penicillin G due to resistance Vancomycin = Often used for MRSA infections</p> Signup and view all the answers

    Match the following tests with their specific Staphylococcus identification methods:

    <p>Catalase test = Used to demonstrate positive catalase activity Coagulase test = Differentiates S.aureus from coagulase-negative staphylococci Microscopic morphology = Initial step in identifying staphylococci Automated systems like VITEK = Rapid identification of isolates</p> Signup and view all the answers

    Match the following symptoms with their trigger related to Staphylococcus aureus:

    <p>Nausea = Acute symptom caused by toxin action on GI tract Vomiting = Occurs within less than 6 hours post toxin exposure Diarrhea = Symptom reflecting irritation of the gastrointestinal system Scalded skin syndrome = Results from exfoliative toxin affecting the skin</p> Signup and view all the answers

    Match the following antibiotic resistance concepts with their respective implications in treating S.aureus infections:

    <p>MRSA = Strains resistant to methicillin and related antibiotics Penicillin G resistance = Due to penicillinase-encoding plasmids or transposons Acquired resistance determinants = Complicate the choice of antibiotics for treatment Community-acquired MRSA = A significant source of infections in non-hospital settings</p> Signup and view all the answers

    Match the following laboratory identification characteristics with their relevance to Staphylococcus aureus:

    <p>Gram-positive staining = Staphylococci appear purple under the microscope Colony morphology = Yellow colonies indicate S.aureus presence Formation in clusters = Grapelike arrangement observable in samples Hemolysis patterns = Differentiates S.aureus from coagulase-negative strains</p> Signup and view all the answers

    Match the following strains with their associated features regarding Staphylococcus aureus:

    <p>Hospital-acquired MRSA = Often shows resistance to multiple antibiotics Community-acquired MRSA = Can manifest with different clinical presentations Methicillin-sensitive S.aureus = Responsive to β-lactam antibiotics Vancomycin-resistant S.aureus = Emerging concern in the treatment landscape</p> Signup and view all the answers

    Match the following antibiotic classes with their relevance to Staphylococcus aureus treatment challenges:

    <p>Penicillin = First-line treatment largely ineffective due to resistance Methicillin = Replaced by vancomycin for MRSA infections Oxacillin = Another β-lactam class facing resistance issues Linezolid = Alternative treatment for resistant S.aureus strains</p> Signup and view all the answers

    Match the following terms related to MRSA with their descriptions:

    <p>PBP-2a = Penicillin binding protein associated with antibiotic resistance CA-MRSA = Community-acquired Methicillin-resistant Staphylococcus aureus Vancomycin = First-line treatment for life-threatening MRSA infections Polysaccharide intercellular adhesin = Facilitates adherence to bioprosthetic materials</p> Signup and view all the answers

    Match the following MRSA complications with their common forms:

    <p>Abscesses = Common skin and soft tissue infection Septicemia = Severe systemic infection Necrotizing pneumonia = Severe lung infection Osteomyelitis = Infection of the bone</p> Signup and view all the answers

    Match the following antibiotics with their usage against MRSA:

    <p>Linezolid = Alternative treatment for MRSA Daptomycin = Used for resistant Gram-positive bacteria Vancomycin = Primary drug for MRSA infections β-lactams = Ineffective against MRSA due to resistance</p> Signup and view all the answers

    Match the following types of Staphylococcus to their virulence characteristics:

    <p>Staphylococcus aureus = Causes toxic shock syndrome and soft tissue infections Staphylococcus epidermidis = Commonly infects implanted devices Coagulase-negative staphylococci = Typically low virulence but can cause hospital infections Methicillin-resistant Staphylococcus aureus = Known for high antibiotic resistance</p> Signup and view all the answers

    Match the following factors to their impacts on MRSA infection outcomes:

    <p>Longer hospital stays = Associated with MRSA infections Higher mortality rates = Resulting from serious MRSA complications No effective vaccine = Challenge in preventing MRSA spread Increased incidence of resistance = Complicates treatment options</p> Signup and view all the answers

    Match the following descriptions to the specific strains or types of MRSA:

    <p>Community-acquired MRSA = Infects individuals without prior MRSA exposure Hospital-acquired MRSA = Infections linked to health care environments Vancomycin-resistant MRSA = Strains showing low-level resistance to vancomycin Coagulase-negative staphylococci = Common in nosocomial infections but lower virulence</p> Signup and view all the answers

    Match the following prevention methods for S.aureus infections with their descriptions:

    <p>Hand disinfection = Critical for controlling infection spread Fomites disinfection = Cleans surfaces to reduce contamination Use of alternative antibiotics = Necessary due to resistance issues Vaccine development = Currently ineffectual for MRSA</p> Signup and view all the answers

    Match the following statements about antibiotic resistance in MRSA with their implications:

    <p>PBP-2a acquisition = Decreases sensitivity to β-lactam antibiotics Increased vancomycin resistance = Limits treatment options for severe infections Use of linezolid and daptomycin = Introduced for resistant strains Polysaccharide intercellular adhesin = Enhances adherence and biofilm formation on implants</p> Signup and view all the answers

    Study Notes

    Staphylococci

    • Staphylococci are gram-positive, spherical bacteria that often appear in grape-like clusters.
    • They are facultative anaerobes, meaning they can thrive in the presence or absence of oxygen.
    • They are resistant to heat and drying, making them capable of surviving for long periods on surfaces.
    • Staphylococcus aureus is the most virulent species and is responsible for various infections, including food poisoning, toxic shock syndrome, and abscess formation.
    • Staphylococcus epidermidis is less virulent and is often a cause of infections associated with implanted medical devices, such as catheters and prosthetics.
    • Staphylococcus saprophyticus is known to cause urinary tract infections, particularly cystitis, in women.

    Virulence Factors of Staphylococcus aureus

    • Cell Wall Virulence Factors:

      • Capsule: Provides protection against phagocytosis.
      • Peptidoglycan: Plays a role in osmotic stability, triggers immune responses, and hinders phagocytosis.
      • Teichoic acid: Binds to fibronectin, promoting adherence.
      • Protein A: Binds to the Fc region of IgG, blocking opsonization and decreasing phagocytosis.
      • Fibronectin-binding protein (FnBP): Facilitates binding to mucosal cells and tissue matrix.
      • Clumping factor: Binds to fibrinogen, leading to coagulation and clumping.

    • Enzymes:

      • Coagulase: Causes plasma to clot, potentially hindering phagocytosis.
      • Catalase: Converts hydrogen peroxide to water and oxygen, which helps neutralize reactive oxygen species.
      • Hyaluronidase: Degrades hyaluronic acid in connective tissues, facilitating bacterial spread.
      • Fibrinolysin (Staphylokinase): Dissolves fibrin clots, assisting in bacterial dissemination.
      • Lipases: Break down lipids, supporting survival in sebaceous areas.
      • Nuclease (DNAase): Degrades DNA, possibly aiding in bacterial spread and evasion of the host's immune response.

    • Toxins:

      • Cytolytic exotoxins (α, β, γ, δ Toxins): Damage cell membranes, often referred to as hemolysins.
      • Panton-Valentine leukocidin: Lyses polymorphonuclear leukocytes (PMNs), contributing to virulence.
      • Superantigen exotoxins: Stimulate excessive T-cell activation, causing cytokine release and potentially leading to toxic shock syndrome.
        • Enterotoxins: Cause food poisoning upon ingestion.
        • Toxic shock syndrome toxin (TSST-1): The primary cause of toxic shock syndrome.
        • Exfoliatin (ET): Causes scalded skin syndrome in children by disrupting intercellular adhesion.

    Clinical Significance of Staphylococcus aureus

    • Infections often result from entry points such as skin breaks, wounds, and the respiratory tract.
    • Localized infections typically present with inflammation, swelling, pus formation, and tissue necrosis.
    • Food poisoning: Associated with the ingestion of enterotoxins produced by S. aureus.
    • Toxic shock syndrome (TSS): Caused by the release of TSST-1, leading to systemic inflammation and multi-organ dysfunction.
    • Scalded skin syndrome: Characterized by superficial blistering due to the action of exfoliatin, which disrupts skin layers.

    Laboratory Identification of Staphylococci

    • Gram stain: S. aureus appears as gram-positive cocci in clusters.
    • Catalase test: Positive reaction (produces bubbles) distinguishes staphylococci from streptococci.
    • Coagulase test: Positive for S. aureus, indicating the presence of coagulase.
    • Mannitol salt agar (MSA): S. aureus ferments mannitol, producing yellow colonies, while other staphylococci typically form white colonies.
    • Automated systems: Can provide rapid identification of staphylococcal species.

    Treatment

    • Serious infections: Require incision and drainage of localized lesions, plus systemic antibiotics.

    Antibiotic Resistance and Methicillin-Resistant Staphylococcus aureus (MRSA)

    • Penicillin resistance: Common due to staphylococcal production of penicillinase.
    • Methicillin and oxacillin resistance (MRSA): Develops due to the acquisition of a gene coding for a new penicillin-binding protein (PBP-2a), rendering the bacteria resistant to beta-lactam antibiotics.
    • Hospital-acquired MRSA (HA-MRSA): Frequently seen in healthcare settings, associated with longer hospital stays and higher mortality rates.
    • Community-acquired MRSA (CA-MRSA): Increasingly reported in individuals without prior healthcare exposure.
    • Vancomycin resistance: Emerged as a significant threat, leading to the use of alternative therapies like linezolid and daptomycin.

    Prevention

    • Infection control measures: Disinfection of hands and surfaces is crucial for limiting transmission.

    Coagulase-Negative Staphylococci (CNS)

    • Staphylococcus epidermidis: Primarily a component of the skin flora, but can cause infections associated with implanted devices, often due to its ability to form biofilms.
    • Polysaccharide intracellular adhesin (PIA): Produced by S. epidermidis, facilitates adherence to implanted materials and forms a protective barrier against antimicrobial agents.

    Staphylococci

    • Gram-positive spherical bacteria, usually arranged in grapelike clusters
    • Grow on various media, ferment carbohydrates, produce pigments (white to deep yellow)
    • Found in human skin and mucous membranes
    • Cause abscess formation, pyogenic infections, and septicemia

    Staphylococcus aureus

    • One of the most common causes of bacterial infections
    • Responsible for food poisoning, toxic shock syndrome
    • Virulence factors include capsule, peptidoglycan, teichoic acid, protein A, fibronectin-binding protein, clumping factor, enzymes, and toxins

    Staphylococcus epidermidis

    • Found in human skin
    • Common cause of prosthetic implant infections

    Staphylococcus saprophyticus

    • Causes urinary tract infections, particularly cystitis in women
    • Often referred to as Coagulase Negative Staphylococci (CNS)

    Virulence Factors of Staphylococcus aureus

    • Capsule: Helps bacteria resist phagocytosis
    • Peptidoglycan: Induces inflammation, attracts leukocytes, inhibits phagocytosis
    • Teichoic acid: Binds to fibronectin
    • Protein A: Binds to IgG, hindering phagocytosis
    • Fibronectin-binding protein: Promotes binding to mucosal cells and tissue matrix
    • Clumping factor: Binds to fibrinogen, causing bacteria to clump

    Enzymes of Staphylococcus aureus

    • Coagulase: Causes plasma to clot by activating prothrombin
    • Catalase: Converts hydrogen peroxide to water and oxygen
    • Hyaluronidase: Breaks down hyaluronic acid, allowing bacteria to spread
    • Fibrinolysin: Dissolves fibrin clots
    • Lipases: Hydrolyze lipids, enabling bacteria to survive in sebaceous areas
    • Nuclease (DNAase): Degrades DNA, which is implicated in its virulence

    Toxins of Staphylococcus aureus

    • Cytolytic exotoxins (α, β, γ, δ Toxins): Damage cell membranes, including red blood cells
    • Panton-Valentine leukocidin:: Lyses leukocytes, increasing strain virulence
    • Superantigen exotoxins: Bind to T-cell receptors, causing enhanced T-cell response
    • Enterotoxins: Contaminate food and cause staphylococcal gastroenteritis
    • Toxic shock syndrome toxin (TSST-1): Cause of toxic shock syndrome
    • Exfoliatin (ET): Causes scalded skin syndrome in children, disrupting skin cohesion

    Clinical Significance of Staphylococcus aureus Infections

    • Localized Skin Infections: Folliculitis, furuncles (boils), carbuncles, impetigo
    • Deep Localized Infections: Osteomyelitis, septic arthritis
    • Septicemia: Presence of bacteria in the bloodstream
    • Acute Endocarditis: Caused by contaminated injections or needles
    • Pneumonia: Can be severe and necrotizing
    • Nosocomial Infections: Common in hospitals, affecting wounds and catheters
    • Toxinoses: Diseases caused by bacterial toxins (Toxic shock syndrome, staphylococcal gastroenteritis)

    Antibiotic Resistance in Staphylococcus aureus

    • Methicillin-resistant Staphylococcus aureus (MRSA): Resistant to beta-lactam antibiotics (penicillin, methicillin) due to altered penicillin-binding protein (PBP-2a)

    Community-Acquired MRSA (CA-MRSA)

    • Occurs in individuals without previous risk factors for MRSA infections
    • Causes skin and soft tissue infections (abscesses, cellulitis)

    Vancomycin Resistance

    • Vancomycin was a treatment for MRSA but resistance has emerged

    Prevention of Staphylococcus aureus Infections

    • No effective vaccine
    • Disinfection of hands and fomites to control nosocomial outbreaks

    Coagulase-Negative Staphylococci (CNS)

    • Staphylococcus epidermidis
    • Important cause of hospital-acquired infections associated with implanted devices and catheters
    • Produces polysaccharide intercellular adhesin, aiding adherence to bioprosthetic materials.

    Staphylococcus

    • Gram-positive spherical bacteria
    • Occur in grape-like clusters
    • Facultatively anaerobic
    • Produce catalase
    • Common in skin and mucous membranes

    Staphylococcus aureus

    • Most virulent species of Staphylococcus
    • Produces coagulase, an enzyme that clots plasma
    • Common cause of bacterial infections
    • Causes food poisoning and toxic shock syndrome

    Staphylococcus epidermidis

    • Less virulent than S. aureus
    • Common cause of prosthetic implant infections

    Staphylococcus saprophyticus

    • Less virulent than S. aureus
    • Causes urinary tract infections, especially cystitis in women

    Virulence Factors of S. aureus

    • Hyaluronidase (spreading factor): Degrades hyaluronic acid in connective tissues, promoting spread of bacteria
    • Fibrinolysin (staphylokinase): Dissolves fibrin clots
    • Lipases: Hydrolyze lipids, aiding survival in sebaceous areas
    • Nuclease (DNAase): Degrades DNA

    Toxins of S. aureus

    • Cytolytic Exotoxins (α, β, γ, δ): Damage mammalian cell membranes, including red blood cells
    • Panton-Valentine Leukocidin: Lyses neutrophils (PMNs), increasing virulence
    • Superantigen Exotoxins: Bind to T-cell receptors and MHC Class II, triggering excessive T-cell activation
      • Toxic shock syndrome toxin (TSST-1): Causes toxic shock syndrome (TSS), leading to high fever, rash, vomiting, diarrhea, hypotension, and organ damage
      • Exfoliatin (ET): Causes scalded skin syndrome in children, destroying skin intercellular adhesive
    • Enterotoxins: Produced by around half of S. aureus isolates
      • Contaminate food and cause food poisoning upon ingestion, leading to nausea, vomiting, and diarrhea

    Clinical Significance of S. aureus

    • Infection causes inflammation, pus formation, and tissue necrosis
    • Can invade bloodstream, causing bacteremia and septicemia
    • May result in internal abscesses, skin lesions, and infections in various organs

    Localized S. aureus Infections

    • Folliculitis: Small abscesses involving hair follicles
    • Furuncles (boils): Subcutaneous abscesses forming around foreign bodies
    • Carbuncles: Large, deep, multiloculated skin infections
    • Impetigo: Superficial, spreading, crusty skin lesions, common in children

    Other S. aureus Infections

    • Deep, localized infections: May be metastatic from superficial infections or result from trauma
    • Acute endocarditis: Caused by contaminated injections or needles
    • Septicemia: Generalized infection
    • Pneumonia: Can cause severe, necrotizing pneumonia
    • Healthcare-associated infections (nosocomial): Significant cause of hospital-acquired infections

    Laboratory Identification

    • Gram staining: Strongly gram-positive bacteria, often in clusters
    • Catalase test: Positive
    • Coagulase test: Positive in S. aureus, negative in coagulase-negative staphylococci (CNS)
    • Mannitol fermentation: Positive in S. aureus

    Treatment

    • Incision and drainage: for localized lesions
    • Systemic antibiotics: Choice is complex due to frequent antibiotic resistance
    • Penicillin G: No longer the first-line treatment due to widespread penicillinase resistance
    • β-Lactamase-resistant penicillins: Methicillin or oxacillin
    • Methicillin-resistant S. aureus (MRSA): Resistant to many β-lactam antibiotics

    MRSA

    • Hospital-acquired MRSA (HA-MRSA): Common in hospital settings
    • Community-acquired MRSA (CA-MRSA): Infections occur independent of hospital exposure
    • Vancomycin resistance: Emergence of vancomycin-resistant MRSA strains, prompting alternative therapies

    Coagulase-Negative Staphylococci (CNS)

    • Important agents of healthcare-associated infections
    • Infections associated with implanted prosthetic devices and catheters

    Staphylococcus epidermidis

    • Part of normal skin flora
    • Common cause of infections of implants, such as heart valves and catheters
    • Produces polysaccharide intercellular adhesin (PIA), facilitating adherence to biomaterials

    Prevention

    • No effective S. aureus vaccine
    • Infection control measures: Hand washing, disinfection of surfaces, and fomites

    Staphylococci

    • Staphylococci are Gram-positive spherical bacteria, often arranged in grape-like clusters.
    • They are commonly found on skin and mucous membranes.
    • Staphylococci can cause a range of infections, from minor skin infections to life-threatening sepsis.

    Important Species

    • The most clinically significant species are Staphylococcus aureus, Staphylococcus epidermidis, and Staphylococcus saprophyticus.
    • S. aureus is a major cause of bacterial infections, food poisoning, and toxic shock syndrome.
    • S. epidermidis is often involved in prosthetic implant infections.
    • S. saprophyticus is a frequent cause of urinary tract infections, particularly in women.

    General Features

    • Staphylococci are facultatively anaerobic, meaning they can grow with or without oxygen.
    • They are catalase-positive, which distinguishes them from streptococci.
    • S. aureus is the most virulent species and almost always produces coagulase, an enzyme that clots plasma.
    • Coagulase-negative staphylococci (CNS) are less virulent and lack coagulase.

    Staphylococcus aureus

    • S. aureus infections often require a compromised host, like a skin break, foreign body insertion, or weakened immune system.
    • S. aureus can cause infections through direct invasion, toxin production, or a combination of both.

    Epidemiology

    • S. aureus is commonly carried by healthy individuals on their skin and mucous membranes, making them potential carriers.
    • Transmission can occur through direct contact, contaminated fomites, or contaminated food.

    Pathogenesis

    • S. aureus virulence depends on various factors that contribute to its ability to cause disease.
    • Virulence factors include:

    Cell Wall Virulence Factors

    • Capsule: A thin polysaccharide layer that can hinder phagocytosis.
    • Peptidoglycan: Provides structural support, stimulates inflammation, attracts leukocytes (contributes to abscess formation), and can inhibit phagocytosis.
    • Teichoic acid: Binds to fibronectin, a protein found in connective tissue.
    • Protein A: Binds to the Fc region of IgG antibodies, interfering with opsonization and phagocytosis.
    • Fibronectin-binding protein: Promotes attachment to mucosal cells and tissue matrix.
    • Clumping factor: Binds to fibrinogen, converting it to fibrin and causing staphylococci to clump together.

    Enzymes

    • Coagulase: Clots plasma by activating prothrombin, potentially aiding in evading phagocytosis.
    • Catalase: Converts hydrogen peroxide (H2O2) to water and oxygen, detoxifying reactive oxygen species.

    Infections Caused by Staphylococcus aureus

    • Localized Skin Infections:

      • Folliculitis: Small abscesses in hair follicles.
      • Furuncles (Boils): Subcutaneous abscesses often forming around foreign bodies (e.g., splinters).
      • Carbuncles: Larger, deeper, multiloculated skin infections that can lead to bacteremia.
      • Impetigo: Superficial, spreading, crusty skin lesions often seen in children.

    • Deep, Localized Infections:

      • Osteomyelitis: Infection of bone marrow.
      • Septic Arthritis: Acute infection of joint space, particularly in children.

    • Acute Endocarditis: Infection of the heart valves, often caused by contaminated injections or needles.

    • Septicemia: Generalized infection with sepsis, potentially fatal.

    • Pneumonia: Severe, necrotizing pneumonia.

    • Nosocomial Infections: Hospital-acquired infections, frequently associated with wounds or catheters.

    • Toxinoses: Disease caused by toxins:

      • Toxic Shock Syndrome (TSS): High fever, rash, vomiting, diarrhea, hypotension, and multiorgan damage.
      • Staphylococcal Gastroenteritis: Food poisoning caused by ingesting enterotoxin-producing S. aureus. Symptoms include nausea, vomiting, and diarrhea, onset within hours of ingestion.
      • Scalded Skin Syndrome: Superficial blistering caused by an exfoliative toxin that disrupts skin layers, resulting in peeling.

    Laboratory Identification

    • Microscopically, S. aureus appears as Gram-positive cocci in grape-like clusters.
    • Catalase Test: Positive (distinguishes from streptococci).
    • Coagulase Test: Positive (distinguishes from most coagulase-negative staphylococci).
    • Mannitol Fermentation: Positive (distinguishes from most coagulase-negative staphylococci).
    • Automated systems like VITEK can aid in rapid identification.

    Treatment

    • Serious S. aureus infections: Require aggressive management with incision and drainage of abscesses and systemic antibiotics.
    • Antibiotic Resistance: S. aureus frequently develops antibiotic resistance, including penicillinase production, methicillin resistance, and vancomycin resistance.

    Methicillin-Resistant Staphylococcus aureus (MRSA)

    • Hospital-Acquired MRSA (HA-MRSA): Common in hospitals, often resistant to many antibiotics, including methicillin and oxacillin.
    • Community-Acquired MRSA (CA-MRSA): Emerged in the mid-1990s, occurring in individuals with no previous hospital exposure. Most often causes skin and soft tissue infections, but can cause severe diseases like pneumonia, osteomyelitis, and septicemia.

    Vancomycin Resistance

    • Vancomycin-Resistant S. aureus (VRSA): Emerged in 1997, prompting the use of alternative antibiotics like linezolid and daptomycin.

    Prevention

    • No effective vaccine against S. aureus.
    • Infection control procedures like hand hygiene and disinfection of fomites are critical for preventing the spread of S. aureus.

    Coagulase-Negative Staphylococci (CNS)

    • CNS are often involved in hospital-acquired infections, primarily related to implanted prosthetic devices and catheters.
    • Staphylococcus epidermidis: Commonly found on skin and can cause infections like prosthetic valve and catheter infections.
    • Polysaccharide Intercellular Adhesin: Produced by S. epidermidis, facilitating adherence to prosthetic surfaces and acting as a barrier to antibiotics.

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    Staphylococci PDF - Microbiology Lecture Notes 2024-2025

    Description

    This quiz delves into the characteristics and virulence factors of Staphylococci, particularly focusing on Staphylococcus aureus and its role in various infections. Test your knowledge on the different species and their implications in medical contexts.

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