Staphylococcal Infections: Introduction and Classification
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Questions and Answers

What is the main difference between Micrococcaceae and Streptococcaceae?

  • Catalase positive vs. catalase negative
  • Associated with human infections vs. not
  • Produce coagulase vs. do not
  • Arrangement in tetrads vs. pairs or chains (correct)
  • Which enzyme is responsible for the basis of the coagulase test?

  • Amylase
  • Coagulase (correct)
  • Catalase
  • Protease
  • Which Staphylococcus species is considered the most pathogenic?

  • S. aureus (correct)
  • S. epidermidis
  • S. schleiferi
  • S. saprophyticus
  • What do non-coagulase producing Staphylococci species refer to as?

    <p>Coagulase-negative Staphylococci (CoNS)</p> Signup and view all the answers

    Who named Staphylococcus and what does the name mean?

    <p>Sir Alexander Ogston, 'a bunch of grapes'</p> Signup and view all the answers

    Which of the following Staphylococcus species is most commonly associated with human infections?

    <p>S. epidermidis</p> Signup and view all the answers

    What characteristic pigmentation led to the naming of the species Staphylococcus aureus by Rosenbach?

    <p>Golden yellow pigmentation</p> Signup and view all the answers

    Which of the following is NOT a feature of Staphylococcus aureus as mentioned in the text?

    <p>Sporing</p> Signup and view all the answers

    Why is Staphylococcus aureus of importance as a human pathogen, especially in hospital environments?

    <p>It produces infections that range from local to life-threatening systemic infections</p> Signup and view all the answers

    Which factor is NOT associated with the cell wall of Staphylococcus aureus according to the text?

    <p>Lipopolysaccharides</p> Signup and view all the answers

    What is the typical arrangement of Staphylococcus aureus cells?

    <p>Grape-like clusters</p> Signup and view all the answers

    Which type of infections can Staphylococcus aureus produce according to the text?

    <p>Infections that range from local to life-threatening systemic infections</p> Signup and view all the answers

    Study Notes

    Classification of Gram-Positive Cocci

    • Gram-positive cocci are classified into two families: Micrococcaceae and Streptococcaceae, differentiated by the catalase test.
    • Micrococcaceae includes genera Micrococcus and Staphylococcu.
    • Staphylococcus species are arranged in clusters.
    • Micrococcus species are skin commensals, usually not associated with human infections, and are arranged in tetrads.

    Staphylococcus aureus

    • Staphylococcus aureus is catalase positive, coagulase positive, facultative anaerobe, non-motile, non-sporing, and occasionally capsulated.
    • It produces golden yellow pigmentation on blood agar and alpha-hemolytic colonies.
    • S. aureus is the most pathogenic species and produces an enzyme coagulase, which forms the basis of coagulase test.

    Virulence Factors of Staphylococcus aureus

    • Cell wall-associated factors: peptidoglycan, teichoic acid, protein A, and clumping factor.
    • Membrane active toxins: hemolysins, leukocidin (or Panton-Valentine toxin), epidermolytic toxin (exfoliative toxin), and toxic shock syndrome toxin.
    • Extracellular enzymes: coagulase, deybonuclease, and heat-stable thermolysin.

    Coagulase-Negative Staphylococci (CoNS)

    • CoNS are rarely pathogenic to humans, but may cause infections in immunocompromised patients.
    • Examples of CoNS include S. epidermidis, S. saprophyticus, S. lugdunensis, S. schleiferi, S. haemolyticus, and S. warneri.

    History of Staphylococcus

    • Staphylococcus was named after the Greek word "Staphyle" meaning "a bunch of grapes" and "kokkos" meaning "berry-shaped" by Sir Alexander Ogston in 1880.
    • Rosenbach named the species S. aureus in 1884 based on the characteristic golden yellow pigmentation of its colonies.

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    Description

    Learn about Staphylococcal infections and the classification of gram-positive cocci into Micrococcaceae and Streptococcaceae families based on the catalase test. Explore the characteristics of Micrococcaceae and Streptococcaceae, including their arrangement and genera.

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