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Questions and Answers
What is the generic name for Spiriva?
What is the generic name for Spiriva?
tiotropium (tye-o-trope-ee-yum) bromide
What is the trade name of tiotropium bromide?
What is the trade name of tiotropium bromide?
Spiriva
What are the classifications of Spiriva?
What are the classifications of Spiriva?
- Pharmacologic: corticosteroid
- Pharmacologic: anticholinergic (correct)
- Therapeutic: bronchodilator (correct)
- Therapeutic: antibiotic
The mode of action of spiriva involves blocking ACh at the ______ receptor site.
The mode of action of spiriva involves blocking ACh at the ______ receptor site.
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What is Spiriva indicated for?
What is Spiriva indicated for?
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What are the contraindications for using Spiriva?
What are the contraindications for using Spiriva?
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Which of the following are adverse effects of Spiriva? (Select all that apply)
Which of the following are adverse effects of Spiriva? (Select all that apply)
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What is the recommended dosage for Spiriva?
What is the recommended dosage for Spiriva?
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Study Notes
Drug Information
- Generic Name: tiotropium bromide, pronounced as tye-o-trope-ee-yum.
- Trade Name: Spiriva.
Classification
- Pharmacologic Classification: Anticholinergic.
- Therapeutic Classification: Bronchodilator.
Mode of Action
- Mechanism involves blocking acetylcholine (ACh) at muscarinic receptors.
- Prevents conversion of guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP).
- Reduces bronchial smooth muscle constriction.
Indications
- Primarily used for long-term maintenance treatment of bronchospasm associated with Chronic Obstructive Pulmonary Disease (COPD).
Contraindications
- Hypersensitivity to tiotropium or ipratropium is a major contraindication.
- Caution needed for individuals with known hypersensitivity to atropine or milk proteins.
Adverse Effects
- Possible side effects include glaucoma, paradoxical bronchospasm, tachycardia, and dry mouth.
- Concurrent use with ipratropium is not advised due to the risk of increased anticholinergic effects.
Dosage/Administration
- Administered as dry powder capsules through inhalation.
- Typical dosage is 18 mcg once daily; onset of action is approximately 30 minutes, with effects lasting over 24 hours.
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