Spinal Cord Disorders and Neurologic History
45 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What are some symptoms that may indicate neurological issues during patient assessment?

Symptoms may include vertigo, blurred vision, numbness, and episodes of loss of consciousness.

How does cultural and language diversity affect patient descriptions of neurological symptoms?

Cultural and language differences can complicate the interpretation of symptoms, as patients may use different terms or convey meanings that differ from the clinician's understanding.

Why is corroboration of the patient's history from others significant in neurological assessments?

Corroboration provides valuable insights that may clarify the patient's symptoms and experiences, especially when communication is impaired.

What role does memory loss play in a patient's ability to communicate their neurological issues?

<p>Memory loss can impair the patient’s capacity to accurately describe their symptoms and experiences during the assessment.</p> Signup and view all the answers

What are the essential components of a neurological examination that clinicians should be familiar with?

<p>Clinicians should be familiar with assessing memory, language, insight, and overall neurologic function.</p> Signup and view all the answers

What might the term 'blurred vision' indicate in a neurological context?

<p>'Blurred vision' may indicate unilateral visual loss, transient monocular blindness, or diplopia.</p> Signup and view all the answers

Why is it important for all clinicians to understand the basics of a neurological examination?

<p>Understanding the basics allows clinicians to effectively screen for neurologic dysfunction, which is critical for patient care.</p> Signup and view all the answers

What factors might impair a patient's ability to communicate openly during a neurologic examination?

<p>Factors like intoxication, aphasia, or psychological conditions such as anxiety or depression can impair communication.</p> Signup and view all the answers

What clinical signs may indicate the need for a lumbar puncture in patients with suspected meningitis?

<p>Encephalopathy or other significant clinical signs may indicate a need for a lumbar puncture.</p> Signup and view all the answers

How do antibody tests relate to Sjögren's syndrome diagnosis?

<p>Antibody tests such as anti-SSA and anti-SSB are critical in diagnosing Sjögren's syndrome.</p> Signup and view all the answers

What is the prognosis for patients with severe motor weakness after spinal cord infarction?

<p>Patients with severe motor weakness and persistent areflexia usually have a poor prognosis.</p> Signup and view all the answers

Which factors can influence the prognosis following a spinal cord infarction?

<p>The severity of the deficits at presentation plays a crucial role in determining prognosis.</p> Signup and view all the answers

List some other tests that may be employed if a vitamin deficiency is suspected in a patient.

<p>Tests for vitamin B12, copper, and zinc levels may be performed to investigate deficiencies.</p> Signup and view all the answers

What regions of the CNS are primarily involved in indicating multiple sclerosis (MS) in a young adult?

<p>The cerebral cortex and spinal cord are primarily involved in indicating MS in a young adult.</p> Signup and view all the answers

What symptom associated with warmth or exercise may suggest conduction block in demyelinated axons?

<p>Symptoms that worsen after exposure to heat or exercise may suggest conduction block in demyelinated axons.</p> Signup and view all the answers

In the peripheral nervous system (PNS), what types of nerves could be primarily affected by a disorder?

<p>Both motor and sensory nerves could be primarily affected in a disorder of the PNS.</p> Signup and view all the answers

What condition is characterized by recurrent episodes of diplopia and dysarthria associated with exercise or fatigue?

<p>Myasthenia gravis is characterized by recurrent episodes of diplopia and dysarthria associated with exercise or fatigue.</p> Signup and view all the answers

What visual phenomenon, described as slowly advancing visual scotoma with luminous edges, indicates spreading cortical depression?

<p>The visual phenomenon is termed fortification spectra, indicating spreading cortical depression.</p> Signup and view all the answers

How does the neurologic history aid in diagnosing conditions before examination?

<p>The neurologic history allows for accurate localization and determination of probable cause based on symptoms.</p> Signup and view all the answers

What surgical treatments are indicated for worsening signs of cord compression?

<p>Decompression by laminectomy or a spinal fixation procedure.</p> Signup and view all the answers

Name one neurologic disorder that has a high number of global disability-adjusted life-years (DALYs).

<p>Cerebrovascular diseases have a high number of global DALYs, totaling 143,232,184.</p> Signup and view all the answers

What is the significance of examining symptoms substantiated by family members in neurologic diagnosis?

<p>Examining these symptoms helps focus the neurologic examination and leads to better diagnostic accuracy.</p> Signup and view all the answers

Under what circumstances might a patient not respond positively to therapy?

<p>If the patient has a radioresistant tumor causing high-grade spinal cord compression.</p> Signup and view all the answers

What proportion of patients may experience recovery of motor function after treatment?

<p>Up to one-third of patients may experience recovery of motor function.</p> Signup and view all the answers

What is the relevance of the patient's ability to ambulate at presentation?

<p>A good response to therapy can be expected in individuals who are ambulatory at presentation.</p> Signup and view all the answers

What imaging technique is used to identify thoracic meningiomas?

<p>Magnetic resonance imaging (MRI) is used to identify thoracic meningiomas.</p> Signup and view all the answers

How does a vertebral compression fracture contribute to cord compression?

<p>It can create instability that leads to further compression of the spinal cord.</p> Signup and view all the answers

What is shown in the MRI findings of an intramedullary astrocytoma?

<p>The MRI shows altered signal characteristics within the spinal cord, indicating the presence of a tumor.</p> Signup and view all the answers

What specific MRI feature indicates a spinal epidural abscess due to tuberculosis?

<p>The MRI shows hyperintense areas that indicate an infection or abscess in the spinal epidural space.</p> Signup and view all the answers

What is the role of glucocorticoids in the treatment of transverse myelitis?

<p>High doses of glucocorticoids are administered initially to reduce inflammation and must be tapered slowly while monitoring clinical and MRI signs.</p> Signup and view all the answers

What can be concluded if no underlying cause is identified in a case of myelitis?

<p>Approximately one-quarter of myelitis cases have no identifiable underlying cause, and some may later show symptoms of an immune-mediated disease.</p> Signup and view all the answers

How does transverse myelitis clinically present in patients?

<p>It presents as bilateral sensory symptoms, unilateral or bilateral weakness, and bladder and/or bowel disturbances.</p> Signup and view all the answers

Which imaging technique can be used to assist in the diagnosis of myelitis?

<p>Magnetic resonance imaging (MRI) is the imaging technique used to assist in the diagnosis of myelitis.</p> Signup and view all the answers

What are some potential causes of inflammatory myelopathies?

<p>Possible causes include infections, systemic autoimmune diseases, demyelinating conditions such as MS and NMO, and postinfectious myelitis.</p> Signup and view all the answers

Explain the significance of the erythrocyte sedimentation rate (ESR) in the context of myelitis.

<p>ESR is a laboratory test that may show elevated values in inflammatory conditions but is elevated in only a minority of myelitis cases.</p> Signup and view all the answers

What additional diagnostic test can help in evaluating myelitis cases?

<p>A gallium scan may assist in the diagnosis by detecting inflammation in the spinal cord.</p> Signup and view all the answers

List some viruses associated with myelitis mentioned in the content.

<p>Viruses associated with myelitis include EBV (Epstein-Barr virus), HHV (human herpes virus), HSV (herpes simplex virus), and VZV (varicella-zoster virus).</p> Signup and view all the answers

What are the characteristic imaging findings of an abscess in the upper cervical spine as described?

<p>The imaging shows an irregular hypointense mass replacing the posterior elements of C3 with peripheral enhancement compressing the spinal cord.</p> Signup and view all the answers

What symptoms are commonly associated with an abscess in the cervical spine?

<p>Common symptoms include fever, elevated white blood cell count, and progressive weakness or myelopathy.</p> Signup and view all the answers

Which antibiotic is commonly used empirically before surgery for skin infections that may cause spinal abscess?

<p>Broad-spectrum antibiotics such as vancomycin are typically used empirically.</p> Signup and view all the answers

What role does the sedimentation rate and C-reactive protein play in diagnosing spinal infections?

<p>Elevated sedimentation rate and C-reactive protein indicate inflammation, which can be a sign of an infection.</p> Signup and view all the answers

What risk factors are associated with the development of a spinal abscess?

<p>Risk factors include impaired immune status, IV drug abuse, and infections of the skin or other tissues.</p> Signup and view all the answers

What is the significance of venous congestion and thrombosis in the context of spinal abscesses?

<p>Venous congestion and thrombosis can lead to further spinal cord damage and worsening myelopathy.</p> Signup and view all the answers

Why might patients experience irreversible deficits after several days of myelopathy symptoms?

<p>After several days, irreversible deficits may occur due to extensive damage to the spinal cord.</p> Signup and view all the answers

How long is antibiotic treatment generally continued in cases of spinal abscess?

<p>Antibiotic treatment is typically continued for 6 to 8 weeks.</p> Signup and view all the answers

Flashcards

MS in young adults

Multiple sclerosis (MS) is a disorder affecting the central nervous system (CNS), potentially causing problems with the cerebral cortex, basal ganglia, brainstem, cerebellum, or spinal cord.

Compressive cervical spondylosis

A condition primarily affecting the cervical spine in older adults, potentially leading to neurological issues.

Symptoms worsening with heat/exercise

Suggests a conduction block in demyelinated axons, a potential sign of MS.

Diplopia and dysarthria with exercise

May point towards a neuromuscular transmission disorder, like myasthenia gravis.

Signup and view all the flashcards

Fortification spectra

Visual scotoma with luminous edges, suggesting spreading cortical depression, possibly from migraine.

Signup and view all the flashcards

Neurologic History

Important for accurately localizing problems and determining possible causes, often before the examination.

Signup and view all the flashcards

Cerebrovascular Diseases DALYs (2019)

High impact on health, with a large number of Disability-Adjusted Life Years (DALYs) and deaths.

Signup and view all the flashcards

Meningitis/Encephalitis DALYs (2019)

Significant impact on health, with substantial DALYs and deaths.

Signup and view all the flashcards

Neurologic examination components

The neurologic evaluation includes various skills mastered through practice on many patients, with and without neurologic issues.

Signup and view all the flashcards

Patient history corroboration

Gathering information from family, friends, or observers to confirm or expand on a patient's description of symptoms.

Signup and view all the flashcards

Symptom interpretation complexity

Understanding patient descriptions of symptoms becomes harder with language differences and cultural variations.

Signup and view all the flashcards

Neurological assessment

A systematic evaluation of the nervous system for signs of dysfunction, starting from initial contact with a patient.

Signup and view all the flashcards

Communicating symptoms

The patient's ability to communicate openly about health issues can be affected by memory loss, aphasia, or other factors.

Signup and view all the flashcards

Loss of consciousness

Episodes of unconsciousness require details from witnesses for precise evaluation of the event.

Signup and view all the flashcards

Neurological dysfunction screening

Basic skills in the neurologic exam are essential for all clinicians to identify potential signs of nervous system problems.

Signup and view all the flashcards

Symptom description variations

How symptoms are described can range from a complete loss of feeling to tingling sensations or weakness; similar with visual issues, this can be monocular blindness or double vision.

Signup and view all the flashcards

Lumbar puncture

A procedure to collect cerebrospinal fluid (CSF) from the spinal canal to assess the presence of infection, inflammation, or other abnormalities.

Signup and view all the flashcards

Encephalopathy

A brain dysfunction that affects cognition, behavior, and other mental functions.

Signup and view all the flashcards

Paraneoplastic disorders

Neurological disorders triggered by the body's immune response to a cancer.

Signup and view all the flashcards

Spinal cord infarction

A blood clot in a spinal artery obstructing blood flow, causing tissue death in the spinal cord.

Signup and view all the flashcards

Anti-SSA and anti-SSB antibodies

Antibodies associated with Sjögren's syndrome, an autoimmune disorder affecting salivary and lacrimal glands.

Signup and view all the flashcards

Epidural Abscess

Infection that forms in the space between the spinal cord and the vertebrae, compressing the spinal cord and causing neurological problems.

Signup and view all the flashcards

Cervicomedullary Junction

The area where the spinal cord joins the brain stem.

Signup and view all the flashcards

Symptoms of Epidural Abscess

Fever, elevated white blood cell count, sedimentation rate, and C-reactive protein. Weakness, paralysis, and other neurological deficits.

Signup and view all the flashcards

Risk Factors for Epidural Abscess

Weakened immune system (HIV, diabetes, kidney problems, alcoholism, cancer), IV drug abuse, infections of the skin.

Signup and view all the flashcards

Treatment for Epidural Abscess

Broad-spectrum antibiotics to target various bacteria. Surgery in some cases to drain the abscess.

Signup and view all the flashcards

Progression of Epidural Abscess

Can worsen rapidly leading to irreversible neurological damage. May become chronic and granulomatous after initial treatment.

Signup and view all the flashcards

Impact of Epidural Abscess

Can lead to paralysis and other neurologic deficits that may be irreversible. Requires prompt diagnosis and treatment.

Signup and view all the flashcards

What is a granulomatous abscess?

A chronic, sterile form of an abscess that often appears after the treatment of an acute epidural infection. It features granulomas, which are collections of immune cells.

Signup and view all the flashcards

When is surgery indicated for spinal cord compression?

Surgery, either decompression by laminectomy or spinal fixation, is considered when radiotherapy fails to improve symptoms, maximum tolerated radiotherapy has been given, a vertebral compression fracture or spinal instability contributes to compression, or for high-grade compression from a radioresistant tumor.

Signup and view all the flashcards

What is a good predictor of response to therapy?

Patients who are ambulatory (able to walk) at the time of diagnosis tend to respond well to treatment.

Signup and view all the flashcards

What is the typical outcome of treatment?

Treatment usually prevents further weakness, and some recovery of motor function is observed in a significant portion of patients.

Signup and view all the flashcards

Describe the appearance of a thoracic meningioma on MRI.

A well-defined, extramedullary mass (outside the spinal cord) that intensely enhances after contrast injection, displacing the spinal cord.

Signup and view all the flashcards

What is an intramedullary astrocytoma?

A type of tumor that grows within the spinal cord, often visualized on MRI as an enhancing mass within the spinal cord itself.

Signup and view all the flashcards

How does a spinal epidural abscess appear on T2-weighted MRI?

A spinal epidural abscess, often caused by tuberculosis, appears as a high-signal intensity area on T2-weighted MRI, indicating fluid buildup.

Signup and view all the flashcards

What is the significance of spinal cord compression?

Compression of the spinal cord can lead to various neurological deficits, including weakness, paralysis, and sensory disturbances.

Signup and view all the flashcards

Why is understanding the cause of spinal cord compression important?

Determining the cause of compression guides treatment strategies, as different conditions require different approaches.

Signup and view all the flashcards

What is transverse myelitis?

A condition where the spinal cord is extensively injured, often causing bilateral sensory problems, weakness, and bladder/bowel issues.

Signup and view all the flashcards

What causes transverse myelitis?

The cause can be unknown in about 25% of cases, but may be linked to immune-mediated diseases, infections, or autoimmune disorders.

Signup and view all the flashcards

What are some common symptoms of transverse myelitis?

Common symptoms include bilateral sensory changes (numbness, tingling), weakness on one or both sides, and problems with bladder and/or bowel control.

Signup and view all the flashcards

How is transverse myelitis diagnosed?

Diagnosis often involves a combination of MRI scans, spinal fluid analysis, and blood tests. Specific tests like those for antibodies and infections may be used as well.

Signup and view all the flashcards

What is the initial treatment for transverse myelitis?

High doses of corticosteroids are the primary treatment, given over a prolonged period and gradually reduced while monitoring the patient's progress.

Signup and view all the flashcards

What other tests might be helpful in diagnosing transverse myelitis?

Besides the standard tests, additional investigations may include serum calcium levels and a gallium scan to identify potential underlying causes.

Signup and view all the flashcards

Why is monitoring important in transverse myelitis treatment?

Monitoring is crucial to ensure the inflammation is decreasing, the patient's clinical condition is improving, and to adjust treatment accordingly.

Signup and view all the flashcards

What does transverse myelitis mean for the patient?

Recovery can be unpredictable, with some individuals experiencing full or near-full improvement, while others have long-term disabilities, depending on the severity and underlying cause.

Signup and view all the flashcards

Study Notes

Spinal Cord Disorders

  • Causes in Young Adults: May be associated with Multiple Sclerosis (MS).
  • Causes in Older Adults: May be related to Compressive Cervical Spondylosis.
  • Symptom Clues: Pain worsening after heat or exercise may indicate conduction block in demyelinated axons (like MS). Symptoms like diplopia (double vision) and dysarthria (difficulty speaking) worsened by exertion suggest neuromuscular junction disorders (e.g., myasthenia gravis).
  • Visual Symptoms: Slowly progressing visual scotoma (blind spot) with luminous edges (fortification spectra) may indicate spreading cortical depression, often with migraine.

Neurologic History

  • Importance: Patient description and corroborated by others is crucial for localization and cause determination.
  • Key Questions: Investigate potential for syncope (fainting), disequilibrium (loss of balance), vertigo (spinning sensation), anxiety, depression, hypochondriasis. Look for clues related to language, memory, insight, behavior.
  • Symptom Descriptions: Clarify ambiguous terms like "numbness" (complete loss of feeling, tingling, or weakness) and "blurred vision".
  • Cultural Considerations: Differences in primary languages and cultures can complicate symptom interpretation.

Neurologic Examination

  • Complexity: A skilled examination utilizes various techniques honed through experience and repetition.
  • Importance of Corroboration: Get information from family/friends to corroborate patient's claims.
  • Expertise: Complete neurologic examination is primarily for neurologists, but generalists need basic examination skills for screening. Emphasis is placed on efficient screening.

Spinal Cord Compression

  • Treatment: Surgical intervention (laminectomy or spinal fixation) in cases of worsening cord compression despite radiotherapy, vertebral compression fractures or instability, or high-grade tumors.
  • Outcome: Patients who are ambulatory pre-treatment may see significant improvement in motor function with treatment.

Imaging and Diagnostics

  • MRI (Thoracic Meningioma): Shows intense, well-defined extramedullary mass displacing the spinal cord.
  • MRI (Intramedullary Astrocytoma): Shows expansion of the upper cervical spine by a mass originating within the spinal cord.
  • MRI (Spinal Epidural Abscess): Shows a hypointense mass compressing the spinal cord and diffuse epidural enhancement after contrast, frequently due to tuberculosis.
  • Acute Epidural Abscess: Fever, elevated WBC count, sedimentation rate, CRP may be present; treatment with broad-spectrum antibiotics (vancomycin, ceftriaxone, metronidazole) initially, then based on culture results, for 6-8 weeks. Impaired immunity is a risk factor.
  • Chronic Sterile Granulomatous Form: Often seen after treating acute infection, possibly related to clotting disorders.
  • Lumbar Puncture: Only when encephalopathy or meningitis is suspected.

Myelopathy

  • Spinal Cord Infarction: Prognosis relates to severity of presentation; motor weakness and areflexia may have poorer outcomes, though some recovery is possible.
  • Treatment for Myelopathy (e.g., after Spinal Cord Infarction): No specific medical intervention is mentioned, but surgery and or other approaches may be considered.

Inflammatory and Immune Myelopathies (Myelitis)

  • Uncommon Underlying Cause: About one-quarter of multiple sclerosis (MS), neuromyelitis optica (NMO), post-infectious myelitis, and other cases can't have a specific cause identified.
  • Transverse Myelitis: Extensive spinal cord injury with bilateral sensory symptoms, unilateral or bilateral weakness, bladder and/or bowel disturbance.
  • Diagnosis: No direct cause for myelitis indicated. Treatment usually initial high-dosage glucocorticoids, needing long-term treatment with tapering. Monitoring of resolution is key
  • Further Diagnostics: Elevated inflammatory markers, serum calcium levels, or a gallium scan may help in diagnosis

Associated Conditions

  • Paraneoplastic Disorders: Antibodies (e.g., for amphiphysin, CRMP5, Hu) may be indicative.
  • Other Diagnostic Tests: Vitamin B12, copper, zinc levels can be helpful in assessment.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Description

This quiz covers the causes of spinal cord disorders in young and older adults, focusing on conditions such as Multiple Sclerosis and Compressive Cervical Spondylosis. It also discusses the importance of a thorough neurologic history, including key questions to understand patients' symptoms and conditions better.

More Like This

Spinal Cord Disorders Overview
40 questions
Spinal Cord Disorders Overview
31 questions
Spinal Cord Lesions and Disorders Overview
13 questions
Use Quizgecko on...
Browser
Browser