Solid Organ Transplant Overview
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Questions and Answers

What is the primary characteristic of embryonic stem cells?

  • Can develop into any cell type (correct)
  • Only exist in the adult body
  • Can only differentiate into specific tissues
  • Are less versatile than adult stem cells

In tumor staging, what does a T stage of '2' indicate?

  • Tumor size greater than 5 cm
  • Tumor has broken through the skin
  • Tumor size between 0-2 cm
  • Tumor size between 2-5 cm (correct)

Which of the following is a major characteristic of neutropenic fever in oncology patients?

  • Increased platelet production
  • Improved immunity
  • Low white blood cell count (correct)
  • Reduced risk of infections

Which option best describes a primary side effect of chemotherapy?

<p>It inhibits the division of rapidly dividing cells (A)</p> Signup and view all the answers

What is the significance of a normal white blood cell count range of 4500-11,000?

<p>Indicates a healthy immune response (C)</p> Signup and view all the answers

What is a common characteristic of fatigue related to cancer treatment?

<p>Affects cognitive function (C)</p> Signup and view all the answers

Which of the following statements about adult/somatic stem cells is accurate?

<p>They can only differentiate into specific tissue types (C)</p> Signup and view all the answers

What does a main side effect of using peripheral blood stem cells include?

<p>More rapid engraftment (A)</p> Signup and view all the answers

What type of transplant involves donor tissue being placed in a normal anatomical site?

<p>Orthotopic transplant (D)</p> Signup and view all the answers

Which of the following is not a type of anti-rejection drug concerned with preventing rejection of the transplanted organ?

<p>Antibiotics (A)</p> Signup and view all the answers

What is the primary concern associated with lymphatic buildup in lymphedema compared to regular edema?

<p>It has a chronic buildup of lymph (D)</p> Signup and view all the answers

Which of the following scenarios best illustrates a heterotopic transplant?

<p>A pancreas is placed in a different location than its normal site (B)</p> Signup and view all the answers

What is one of the significant complications of ionizing radiation treatment?

<p>Destruction of all tissue integrity (A)</p> Signup and view all the answers

In terms of energy, what describes the fractional method of radiation treatment?

<p>Radiation dose spreads over several sessions (A)</p> Signup and view all the answers

Which of the following statements about graft-versus-host disease (GVHD) is accurate?

<p>It involves donor T lymphocytes attacking the host tissue (B)</p> Signup and view all the answers

Which condition is typically characterized by bone pain and originates from plasma cells in the bone marrow?

<p>Multiple myeloma (A)</p> Signup and view all the answers

Flashcards

Embryonic stem cells

Stem cells that can differentiate into any cell type in the body.

Adult stem cells

Stem cells that can only differentiate into specific cell types within that tissue.

Neutropenic fever

A serious complication of cancer treatment, a leading cause of death in oncology patients.

Tumor staging

Classifying tumors based on size, spread to lymph nodes, and metastasis.

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Chemotherapy effects

Side effects of chemotherapy targeting rapidly dividing cells resulting in various body systems issues.

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CA-related fatigue

A common, debilitating symptom experienced during and after cancer treatment, often lasting for years.

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Normal WBC range

A white blood cell count between 4500 and 11,000 per microliter of blood.

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Thrombocytopenia

A condition characterized by an abnormally low platelet count (less than 150,000 platelets/uL).

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Solid Organ Transplant (SOT) Testing

Organ donors are tested for communicable diseases like CMV, VRE, Hepatitis B&C, and HIV to prevent transmission to the recipient.

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Orthotopic Transplant

The donor tissue is placed into the original anatomical location of the organ in a recipient.

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Anti-rejection Drugs Concerns

Immunosuppressants prevent organ rejection but increase the risk of infections and inflammation.

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Lymphedema vs. Edema

Lymphedema is chronic lymph fluid buildup; edema is general swelling.

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Heart Transplant Rehab Safety

Post-transplant rehab is generally safe, but with sternal precautions e.g., no heavy lifting, and gradual increases in activity.

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Graft-Versus-Host Disease (GVHD)

T-lymphocytes from donor tissue attack the recipient's tissues.

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Multiple Myeloma

A cancer of plasma cells in the bone marrow, causing bone pain and kidney problems.

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Radiation Therapy Concerns

Radiation therapy's effects include tissue damage, fibrosis, osteoporosis, and mucositis.

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Study Notes

Solid Organ Transplant

  • Organ testing for communicable diseases is crucial to prevent transmission of infectious agents such as CMV, VRE, HIV, and Hep B/C.
  • Transplant types
    • Allograft: Tissue from one individual to another of the same species.
    • Autologous: Tissue from the same individual, for example, identical twins.
    • Syngenic: Tissue from genetically identical individuals.
    • Xenogenic: Tissue from a different species.
    • Orthotopic: Donor tissue (as in heart transplant) is placed in the same location as the original tissue.
    • Heterotopic: Donor tissue is placed in a different location from the original tissue.
  • Anti-rejection drugs can cause complications such as rejection, infection, inflammation, and immunosuppression. This commonly results in lymphedema which is not the same as edema as it represents a chronic buildup of lymph.

Additional Concerns (Cancer, etc.)

  • Cancer Assessment and Treatment
    • Cancer is assessed through physical examination, imaging (like X-rays), and biopsies.
    • Tumour staging involves determining size and location of the primary tumour, as well as spread to lymph nodes.
    • Radiation, and chemotherapeutic drugs are used to target rapidly dividing cells.
    • Chemotherapy can cause side effects like hair loss, nausea, and immune suppression.
  • Adverse Effects of Cancer Treatment
    • Patient fatigue and related complications, lasting years or even months, can be common.
    • Long-term health impacts like chronic pain can hinder quality of life.
    • Increased infection risk during treatment and aftercare.
  • Peripheral Neuropathy
    • Radiation and cancer affect sensory nerves.
    • Symptoms may include decreased pain sensation, reduced nerve conduction, sensory or motor deficits, and impaired balance.
  • Other Health Factors
    • Graft-Versus-Host Disease (GVHD)
    • Heart transplant-related concerns (including recovery times and activities).
    • Effects of radiation on different parts of the body, and different considerations of patients with respect to the effects of ionizing radiation.

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Description

This quiz covers essential concepts related to solid organ transplants, including types of grafts, the importance of organ testing for diseases, and the complications from anti-rejection medications. Participants will learn about various transplant methods such as allograft, autologous, and xenogenic, as well as the implications of lymphedema.

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