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What is the trade name of Sodium Nitroprusside?
What is the trade name of Sodium Nitroprusside?
- Nitrofast
- Nitrostat
- Nitropress (correct)
- Nitromed
What classes does Sodium Nitroprusside belong to?
What classes does Sodium Nitroprusside belong to?
- Beta-blockers
- Diuretics
- Vasodilator (correct)
- Antihypertensives (correct)
What is the mechanism of action of Sodium Nitroprusside?
What is the mechanism of action of Sodium Nitroprusside?
Produces peripheral vasodilation through direct action on smooth muscle of the blood vessels.
How quickly does Sodium Nitroprusside onset occur?
How quickly does Sodium Nitroprusside onset occur?
What is the half-life of Sodium Nitroprusside?
What is the half-life of Sodium Nitroprusside?
What happens to the effects of Sodium Nitroprusside when the infusion stops?
What happens to the effects of Sodium Nitroprusside when the infusion stops?
What are the indications for using Sodium Nitroprusside?
What are the indications for using Sodium Nitroprusside?
What are the contraindications for Sodium Nitroprusside?
What are the contraindications for Sodium Nitroprusside?
What are the adverse reactions associated with Sodium Nitroprusside?
What are the adverse reactions associated with Sodium Nitroprusside?
What is the usual dose of Sodium Nitroprusside?
What is the usual dose of Sodium Nitroprusside?
What is the pregnancy safety category of Sodium Nitroprusside?
What is the pregnancy safety category of Sodium Nitroprusside?
What special considerations should be taken when using Sodium Nitroprusside?
What special considerations should be taken when using Sodium Nitroprusside?
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Study Notes
Sodium Nitroprusside Overview
- Trade name: Nitropress
- Classification: Antihypertensive and vasodilator
Mechanism of Action
- Induces peripheral vasodilation by directly acting on blood vessel smooth muscle
- Can lower diastolic blood pressure by 30% to 40% below pretreatment levels
Pharmacokinetics
- Rapid onset of action
- Half-life: 1 to 2 minutes
- Duration of effect ceases once infusion stops
Indications
- Used for hypertensive emergencies
- Effective in treating acute congestive heart failure (CHF)
Contraindications
- Not recommended for patients with hypotension
- Avoid use in bradycardic patients
Adverse Reactions
- Potential side effects include hypotension and bradycardia
Drug Interactions
- Can interact with virtually all medications; caution is advised
Dosage Information
- Average effective dose: 3 mcg/kg/min
- Acceptable dosing range: 1-5 mcg/kg/min
- Maximum allowable dose: never exceed 10 mcg/kg/min
Pregnancy Safety
- Classified as category C, indicating risks cannot be ruled out
Special Considerations
- Blood pressure should not fall below 60 mmHg systolic
- Risk of cyanide toxicity may arise starting at doses as low as 2 mcg/kg/min, especially after 10 minutes at maximum dosing; requires medical oversight
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