14 Questions
Examples of the cell adhesion molecules that Schwann cells release
Cadherins and N-CAMs
Examples of extracellular matrix molecules that Schwann cells release?
Fibronectin and collagen
How does neural regeneration of the PNS work?
Schwann cells of PNS promote axon regeneration by release of various molecules
What are the receptors for neurotrophins on the dynamic growth cone?
TrkA, TrkB, TrkC, p75
What do these receptors commit to through multi signalling?
Neurite outgrowth, cell death/survival
What is not affected by inhibitory signals (only three affect axon growth/proliferation)?
Neurogenin
What is response of CNS injury and regeneration?
Glial scars and inflammation to cell apoptosis
How could PNS help regenerate CNS?
Transfer olfactory ensheathing cells
Where does adult neurogenesis occur in mammals?
Subventricular Zone
Where else does neurogenesis occur?
Hippocampus and the sub-granular zone of the dentate gyrus
What do neural stem cells express (transcription factor)?
Sox 2
What do INPs express?
Neurogenin
What do neuroblasts express?
Neurogenic TFs
What two types of mapping/labelling helped determined if there was neurogenesis in adult humans?
BrdU labelling and 14C mapping
Test your knowledge about neural regeneration in the peripheral nervous system (PNS) and the molecules released by Schwann cells. Explore questions related to cell adhesion molecules, extracellular matrix molecules, neurotrophin receptors, and inhibitory signals in CNS injury/regeneration.
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