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Injury and Regeneration in the PNS and CNS

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Injury and Regeneration in the PNS and CNS

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Questions and Answers

Examples of the cell adhesion molecules that Schwann cells release

Fibronectin and collagen

Cadherins and N-CAMs (correct)

NGF, BDNF

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Examples of extracellular matrix molecules that Schwann cells release?

Fibronectin and collagen (correct)

NGF, BDNF

Cadherins and N-CAMS

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How does neural regeneration of the PNS work?

Schwann cells of PNS promote axon regeneration by release of various molecules

What are the receptors for neurotrophins on the dynamic growth cone?

TrkA, TrkB, TrkC, p75 Signup and view all the answers

What do these receptors commit to through multi signalling?

Neurite outgrowth, cell death/survival Signup and view all the answers

What is not affected by inhibitory signals (only three affect axon growth/proliferation)?

Neurogenin Signup and view all the answers

What is response of CNS injury and regeneration?

Glial scars and inflammation to cell apoptosis Signup and view all the answers

How could PNS help regenerate CNS?

Transfer olfactory ensheathing cells Signup and view all the answers

Where does adult neurogenesis occur in mammals?

Subventricular Zone Signup and view all the answers

Where else does neurogenesis occur?

Hippocampus and the sub-granular zone of the dentate gyrus Signup and view all the answers

What do neural stem cells express (transcription factor)?

Sox 2 Signup and view all the answers

What do INPs express?

Neurogenin Signup and view all the answers

What do neuroblasts express?

Neurogenic TFs Signup and view all the answers

What two types of mapping/labelling helped determined if there was neurogenesis in adult humans?

BrdU labelling and 14C mapping Signup and view all the answers