Podcast
Questions and Answers
What is the role of Acetylcholinesterase (AChE) in neuromuscular transmission?
What is the role of Acetylcholinesterase (AChE) in neuromuscular transmission?
- Degradation of ACh in the synaptic cleft (correct)
- Generating the action potential at the neuromuscular junction
- Promoting muscle contraction by releasing calcium into the cytosol
- Converting electrical signals into chemical signals
What occurs when the t-tubules are depolarized?
What occurs when the t-tubules are depolarized?
- Conformational change in the ryanodine receptor (correct)
- Initiation of muscle contraction
- Coupling of electrical activity and calcium release
- Release of ADP stabilizing myosin-actin interaction
Where does coupling of electrical activity and calcium release for muscle contraction occur?
Where does coupling of electrical activity and calcium release for muscle contraction occur?
- T-tubules
- Triads (correct)
- Sarcoplasmic reticulum (SR)
- Myofibrils
What happens when the action potential propagates to the triads?
What happens when the action potential propagates to the triads?
Which component is responsible for converting electrical signals into chemical signals at the triads?
Which component is responsible for converting electrical signals into chemical signals at the triads?
What is the final step in the Power Stroke in Skeletal Muscle and Rigor cycle?
What is the final step in the Power Stroke in Skeletal Muscle and Rigor cycle?
What is the first step in the sequence of events at the neuromuscular junction for skeletal muscle contraction?
What is the first step in the sequence of events at the neuromuscular junction for skeletal muscle contraction?
What occurs when calcium binds to the myofibrils during skeletal muscle contraction?
What occurs when calcium binds to the myofibrils during skeletal muscle contraction?
What happens when the EPP spreads across the muscle fiber at the neuromuscular junction?
What happens when the EPP spreads across the muscle fiber at the neuromuscular junction?
What is the role of nicotinic receptors at the motor-end plate in the neuromuscular junction?
What is the role of nicotinic receptors at the motor-end plate in the neuromuscular junction?
What is the role of calmodulin in smooth muscle contraction?
What is the role of calmodulin in smooth muscle contraction?
How does calcium enter the cytoplasm in smooth muscle?
How does calcium enter the cytoplasm in smooth muscle?
Which neurotransmitters are involved in activating GPCR pathways in the autonomic nervous system?
Which neurotransmitters are involved in activating GPCR pathways in the autonomic nervous system?
What is the main function of myosin light chain kinase (MLCK) in smooth muscle contraction?
What is the main function of myosin light chain kinase (MLCK) in smooth muscle contraction?
What role does Ca2+-CaM play in smooth muscle contraction?
What role does Ca2+-CaM play in smooth muscle contraction?
What role does Myosin light chain phosphatase (MLCP) play in smooth muscle relaxation?
What role does Myosin light chain phosphatase (MLCP) play in smooth muscle relaxation?
Why does smooth muscle have the ability to prolong muscle contraction without using large amounts of ATP?
Why does smooth muscle have the ability to prolong muscle contraction without using large amounts of ATP?
What characteristic of the latch state allows smooth muscle to maintain tone with minimal ATP use?
What characteristic of the latch state allows smooth muscle to maintain tone with minimal ATP use?
How does the latch state contribute to the prolonged tension in smooth muscle?
How does the latch state contribute to the prolonged tension in smooth muscle?
Why does maximal velocity directly depend on cross-bridge phosphorylation in smooth muscle?
Why does maximal velocity directly depend on cross-bridge phosphorylation in smooth muscle?
What mechanism allows smooth muscle to maintain force for long periods without extensive energy utilization?
What mechanism allows smooth muscle to maintain force for long periods without extensive energy utilization?
Why does the heart operate at sarcomere lengths lower than the optimal?
Why does the heart operate at sarcomere lengths lower than the optimal?
Where is smooth muscle located in the body?
Where is smooth muscle located in the body?
What is a characteristic of single-unit smooth muscle?
What is a characteristic of single-unit smooth muscle?
How do thick filaments in smooth muscle differ from skeletal muscle?
How do thick filaments in smooth muscle differ from skeletal muscle?
What is pharmacomechanical coupling in smooth muscle contraction?
What is pharmacomechanical coupling in smooth muscle contraction?
Why do some smooth muscles not require an action potential for contraction?
Why do some smooth muscles not require an action potential for contraction?
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