Skin Structure and Function Quiz

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Questions and Answers

What type of structures are Krause end bulbs?

  • Complex multi-layered structures
  • Elongated keratinized structures
  • Simple encapsulated, ovoid structures (correct)
  • Collagenous, fusiform structures

Where are Ruffini corpuscles primarily located?

  • Anchored to surrounding connective tissue (correct)
  • In the epidermal invaginations
  • In the glabrous skin of palms and soles
  • In the dermal papillary layer

What do Krause end bulbs primarily sense?

  • Low-frequency vibrations (correct)
  • High-frequency sounds
  • Temperature variations
  • Pressure changes

What primarily affects the color, size, shape, and texture of hairs?

<p>Genetic background and age (D)</p> Signup and view all the answers

Which skin type lacks hair?

<p>Glabrous skin (C)</p> Signup and view all the answers

How is the hair growth cycle characterized?

<p>Periodic growth followed by rest (A)</p> Signup and view all the answers

What is the density of hairs on the face approximately?

<p>600 hairs/cm2 (A)</p> Signup and view all the answers

What happens to the diameter of collagen fibers as they approach the epidermis?

<p>It decreases (B)</p> Signup and view all the answers

What is one consequence of extensive cross-linking of collagen fibers in aging skin?

<p>Wrinkles formation (B)</p> Signup and view all the answers

Which layer of the dermis is primarily composed of loose connective tissue?

<p>Papillary layer (C)</p> Signup and view all the answers

How does solar elastosis affect the skin?

<p>It causes skin to lose its suppleness (B)</p> Signup and view all the answers

What is a common effect of aging on the epidermis?

<p>Thinning and increased transparency (D)</p> Signup and view all the answers

What causes increased extensibility of skin and ligaments in disorders like Ehlers-Danlos syndrome?

<p>Defective collagen-fibril processing (C)</p> Signup and view all the answers

Which type of collagen fibers is primarily found in the papillary layer of the dermis?

<p>Type I and III collagen (C)</p> Signup and view all the answers

What happens to the skin as a result of autoimmune damage to intercellular junctions?

<p>The skin becomes more fragile (B)</p> Signup and view all the answers

Which type of neural components innervate the dermal sweat glands?

<p>Postganglionic fibers of sympathetic ganglia (A)</p> Signup and view all the answers

What role do leukocytes play in the initial phase of wound healing?

<p>They clean the wound. (A)</p> Signup and view all the answers

Which substance is primarily released from cut vessels during the wound healing process?

<p>Polypeptides (D)</p> Signup and view all the answers

In the wound healing process, what is the primary event that occurs immediately after bleeding starts?

<p>Formation of a blood clot. (B)</p> Signup and view all the answers

Which cell type is NOT typically associated with the initial phase of wound healing?

<p>Fibroblasts (C)</p> Signup and view all the answers

During which phase of wound healing does blood from cut vessels begin to coagulate?

<p>Hemostasis phase (A)</p> Signup and view all the answers

What is the function of the dermal papilla in the hair follicle?

<p>To provide a capillary network to sustain the hair follicle (C)</p> Signup and view all the answers

Which structures are involved in the differentiation and formation of hair?

<p>Keratinocytes and melanocytes (D)</p> Signup and view all the answers

What type of keratin is found in hair compared to the stratum corneum?

<p>Hair keratin is harder and more compact (B)</p> Signup and view all the answers

How do melanocytes contribute to hair formation?

<p>By transferring melanosomes into epithelial cells (A)</p> Signup and view all the answers

What is indicated by a reduction in tactile corpuscles during adult life?

<p>Possible skin disorders or aging (D)</p> Signup and view all the answers

Where are lamellated (Pacinian) corpuscles located?

<p>Deep in the skin's dermal layer (C)</p> Signup and view all the answers

What is the primary role of keratinocytes in the hair bulb?

<p>To divide rapidly and contribute to hair root elongation (D)</p> Signup and view all the answers

Which process occurs in keratinocytes surrounding the dermal papilla?

<p>Rapid division followed by keratinization (B)</p> Signup and view all the answers

What percentage of total body weight does the skin typically account for?

<p>15% to 20% (C)</p> Signup and view all the answers

What is the primary function of mechanoreceptors in the skin?

<p>Regulating interactions with physical objects (C)</p> Signup and view all the answers

Which layer of the skin is primarily composed of mesodermal connective tissue?

<p>Dermis (A)</p> Signup and view all the answers

How does the skin contribute to thermoregulation?

<p>Through sweat production and microvasculature (A)</p> Signup and view all the answers

What is the total surface area of skin typically presented by adults?

<p>1.5 m² to 2 m² (D)</p> Signup and view all the answers

What is the epidermis made of?

<p>Epithelial tissue of ectodermal origin (C)</p> Signup and view all the answers

Which of the following components is associated with the insulating properties of the skin?

<p>Hair on the head (A)</p> Signup and view all the answers

What is the primary role of the skin within the integumentary system?

<p>To provide a barrier against infection (C)</p> Signup and view all the answers

What comprises an epidermal-melanin unit?

<p>One melanocyte and multiple keratinocytes (A)</p> Signup and view all the answers

How do melanocytes in individuals with ancestry near the equator differ from those in northern Europe?

<p>They produce melanin granules more rapidly (A)</p> Signup and view all the answers

What is the effect of increased UV radiation on melanocytes?

<p>They accelerate melanin synthesis (A)</p> Signup and view all the answers

What is the primary defect causing albinism?

<p>Defect in melanin-producing pathway components (C)</p> Signup and view all the answers

What characterizes the skin of individuals with ancestry in regions of high sunlight?

<p>Increased melanosome accumulation (C)</p> Signup and view all the answers

What is vitiligo primarily associated with?

<p>Skin depigmentation due to melanocyte loss (B)</p> Signup and view all the answers

What occurs during the tanning process after UV exposure?

<p>Darkening of preexisting melanin (B)</p> Signup and view all the answers

What role do paracrine factors from keratinocytes play in response to UV radiation?

<p>They promote melanin synthesis (B)</p> Signup and view all the answers

Flashcards

Epidermis Function

An epithelial layer of ectodermal origin, forming the outermost layer of the skin.

Dermis

A layer of mesodermal connective tissue beneath the epidermis.

Skin Size

The skin is the largest organ, making up 15-20% of body weight and covering 1.5-2 square meters of surface area.

Integument Function

Another name for the skin, meaning "covering".

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Skin's Role in Thermoregulation

The skin helps maintain a stable body temperature by insulating the body and assisting with heat loss (like sweating).

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Mechanoreceptors in Skin

Sensory receptors in the skin that allow for physical interactions with surroundings.

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Skin Composition

The skin consists of the epidermis (ectoderm) and the dermis (mesoderm), with subcutaneous tissue below the dermis.

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Skin's Function in Touch

The skin has mechanoreceptors that help us feel pressure and touch.

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Epidermal-Melanin Unit

A functional unit of the skin composed of one melanocyte transferring melanosomes to surrounding keratinocytes.

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Melanocyte Density

The number of melanocyte units per area of skin is relatively constant across individuals.

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Melanin Production Variation

Individuals with ancestry near the equator produce melanin more rapidly and abundantly due to higher UV exposure.

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Melanin and Vitamin D3

Individuals with ancestry in regions with less sunlight have lighter skin to optimize vitamin D3 synthesis from limited UV radiation.

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Albinism

A congenital disorder where tyrosinase or another component of the melanin pathway is defective, resulting in hypopigmentation.

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Vitiligo

An acquired condition where melanocyte loss or decreased activity causes depigmentation, often in patches.

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Tanning Mechanism

Tanning is a two-step process involving darkening of existing melanin and increased melanin production due to UV exposure.

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UV Wavelength for Tanning

Solar radiation at wavelengths of 290 to 320 nm is responsible for tanning.

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Dermal Papillae

Small, finger-like projections of the dermis that extend into the epidermis, providing a strong connection between the two layers.

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Dermal Layers

The dermis has two sublayers: the papillary layer (thin, loose connective tissue) and the reticular layer (dense, fibrous connective tissue).

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Collagen and Elastin in Aging

In aging, collagen fibers cross-link extensively, and elastic fibers are lost, making the skin less supple and causing wrinkles.

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Solar Elastosis

A condition where excessive sun exposure damages elastic fibers, leading to skin thinning and wrinkles.

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Cutis Laxa & Ehlers-Danlos

These disorders involve defective collagen processing, resulting in excessive skin and ligament extensibility.

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Epidermis Thinning with Age

With age, the epidermis thins and becomes more transparent, making the skin more delicate.

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Sensory Nerve Endings in Skin

Sensory nerves in the skin have endings attached to various receptors, allowing for the sensation of touch, pressure, temperature, and pain.

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Autonomic Innervation of Skin

Sweat glands and smooth muscle in the skin are innervated by postganglionic sympathetic nerves, while parasympathetic innervation is absent.

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Skin's Repair Ability

Skin has a remarkable capacity to heal itself after injuries, a vital process for this constantly exposed organ.

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Wound Healing Stages

The repair process involves multiple overlapping stages: blood clotting, inflammation, tissue formation, and remodeling, lasting longer for larger wounds.

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Blood Clot Formation

When skin is cut, blood vessels bleed, and the leaked blood clots, forming a plug that stops the bleeding and provides a framework for repair.

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Leukocyte Role in Wound Healing

White blood cells, called leukocytes, clean the wound by engulfing bacteria and debris, preparing for tissue regeneration.

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Fibroblast Function in Repair

Fibroblasts are cells that create collagen fibers, forming the connective tissue that strengthens and holds the wound together during healing.

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Krause End Bulbs

Encapsulated, ovoid structures in the skin of the penis and clitoris, sensitive to low-frequency vibrations. They have thin, collagenous capsules penetrated by a sensory fiber.

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Ruffini Corpuscles

Collagenous, fusiform capsules in the skin, firmly anchored to connective tissue. They are sensitive to stretching and twisting.

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Hair Follicles

Invaginations in the epidermis where hair grows, forming elongated keratinized structures.

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Hair Growth

Hair grows in cycles, with periods of growth (anagen) followed by rest (telogen). This growth is not synchronized throughout the body.

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Hair Distribution

All skin has hair, with varying density. Areas like palms, soles, and lips are hairless. The face has the highest, followed by the rest of the body.

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Elastic Fibers in Skin

These fibers are distributed throughout the dermis, providing elasticity and flexibility to the skin. They are darker stained and run among the collagen bundles.

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Dermal Papillary Layer

The uppermost layer of the dermis, containing fine, smaller elastic fibers that connect to the basement membrane.

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Weigert Elastic Stain

A specific staining method that highlights elastic fibers in tissue samples, making them appear darker.

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Hair Bulb

The terminal dilation at the base of a growing hair follicle. It contains a dermal papilla with a capillary network that nourishes the follicle.

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Hair Root Matrix

The layer of cells surrounding the dermal papilla in the hair bulb, responsible for hair growth.

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Hair Shaft

The visible part of the hair that extends beyond the skin surface.

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Keratinization in Hair

The process where hair cells produce keratin, a tough protein, to form the hair shaft.

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Two-Point Discrimination

A test that measures the ability to distinguish two closely spaced points on the skin.

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Tactile Meissner Corpuscles

Small, oval-shaped mechanoreceptors responsible for light touch and pressure.

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Scleroderma

A connective tissue disorder that causes hardening and tightening of the skin.

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Study Notes

Skin Structure and Function

  • The skin is the largest organ of the body, accounting for 15-20% of total body weight in adults. It covers approximately 1.5-2 square meters of surface area.
  • The skin is composed of two primary layers: the epidermis (epithelial layer) and the dermis (connective tissue layer). A subcutaneous layer, or hypodermis, lies beneath the dermis.
  • The epidermis is the outer layer, comprised primarily of keratinocytes. It also contains melanocytes (pigment-producing cells), Langerhans cells (immune function), and Merkel cells (sensory function).
  • The dermis is beneath the epidermis, characterized by a complex network of connective tissue which includes collagen and elastin fibers. It houses blood vessels, nerves, hair follicles, sebaceous glands, and sweat glands.
  • The hypodermis (subcutaneous tissue) is the deepest layer, mostly consisting of adipose tissue, which provides insulation, cushioning, and energy storage.

Epidermal Layers

  • Thick skin is found on the palms and soles and has five layers: stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, and stratum basale.
  • Thin skin has four layers: stratum corneum, stratum granulosum, stratum spinosum, and stratum basale.

Skin Functions

  • Protection: A physical barrier against thermal, mechanical stresses, and pathogens.
  • Thermoregulation: Controls body temperature through sweat production and blood flow.
  • Sensory reception: Detects various stimuli (temperature, pressure, touch).
  • Vitamin D synthesis: UV light in skin plays a role in vitamin D production.
  • Blood regulation: Plays a role in maintaining blood volume.

Skin Appendages

  • Hair Follicles: Complex structures containing the hair shaft, root, and arrector pili muscles.
  • Nails: Keratin plates protecting the tips of fingers and toes.
  • Skin Glands:
    • Sebaceous glands secrete sebum (oily substance).
    • Eccrine sweat glands produce primarily water-based sweat for thermoregulation.
    • Apocrine sweat glands produce a protein-rich sweat and associated with hair follicles.

Skin Repair

  • Wound healing involves overlapping stages: blood clotting, inflammation, and tissue regeneration. The final stage results in scar tissue.

Skin Components

  • Melanocytes: Produce melanin, a pigment that protects against UV radiation.
  • Langerhans Cells: Immune cells that play a role in the body's immune response to antigens.
  • Merkel Cells: Associated with sensory nerve endings, and contribute to touch sensation.

Sensory Receptors

  • Various mechanoreceptors enable interactions with the environment (light touch, pressure, vibration). These also exist within specific tissues located within the skin

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