Skin Biology Quiz: Melanin and Epidermis
53 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Name the two forms of melanin and briefly describe their respective colors.

Eumelanin (brownish black) and pheomelanin (reddish yellow).

Describe the distribution of melanin granules in keratinocytes of darker-skinned individuals compared to lighter-skinned individuals.

In darker-skinned individuals, melanin granules are more spread out throughout the keratinocytes. In lighter-skinned individuals, melanin is clumped near the keratinocyte nucleus.

Explain why exposure to UV light darkens the skin.

UV light stimulates melanocytes to secrete melanin, which darkens the skin. This color fades as melanin is degraded and old cells are exfoliated.

Besides melanin, list two other pigments that can influence skin color and their sources.

<p>Haemoglobin (from red blood cells) and carotene (from egg yolks and yellow/orange vegetables).</p> Signup and view all the answers

Define cyanosis and albinism, linking each to its underlying cause.

<p>Cyanosis is blueness due to oxygen deficiency in the blood. Albinism is pale skin and blue-gray eyes due to a genetic lack of the melanin synthesizing enzyme.</p> Signup and view all the answers

What is the primary protein found in the cells of the stratum corneum, and what characteristic does it impart to this layer?

<p>Keratin; it makes the layer tough and resistant to abrasion and water loss.</p> Signup and view all the answers

Which epidermal layer is characterized by cells connected by desmosomes and tight junctions, and what causes its 'spiny' appearance in histological preparations?

<p>Stratum spinosum; the preparation process causes the cells to shrink but remain connected at desmosomes.</p> Signup and view all the answers

What two types of cells are found in stratum basale?

<p>Stem cells/keratinocytes and melanocytes.</p> Signup and view all the answers

Name the layer of skin not considered part of the skin, but associated with it.

<p>Hypodermis</p> Signup and view all the answers

What is the main tissue type composing the epidermis?

<p>Keratinized stratified squamous epithelium.</p> Signup and view all the answers

Which layer of the epidermis exists only in thick skin?

<p>Stratum lucidum</p> Signup and view all the answers

What is the role of stem cells in the stratum basale?

<p>They divide and form keratinocytes that migrate to the skin surface to replace lost cells.</p> Signup and view all the answers

What are the main layers of the skin?

<p>Epidermis, dermis and hypodermis.</p> Signup and view all the answers

How do nutrients reach the epidermis, given that it lacks blood vessels?

<p>Diffusion from the underlying connective tissue in the dermis.</p> Signup and view all the answers

Describe the main function of the stratum corneum, relating it to its structure.

<p>Resists abrasion, penetration, and water loss due to its multiple layers of dead, scaly, keratinized cells.</p> Signup and view all the answers

Which epidermal cell type functions as a touch receptor and is associated with dermal nerve fibers?

<p>Tactile cells</p> Signup and view all the answers

What is the primary tissue type composing the reticular layer of the dermis?

<p>Dense irregular connective tissue</p> Signup and view all the answers

What is the name given to the upward, finger-like extensions of the dermis that interlock with the epidermis?

<p>Dermal papillae</p> Signup and view all the answers

What is the name of the condition that results from the inhibited shedding process of the skin?

<p>Ichthyosis</p> Signup and view all the answers

Which layer of the skin is a common site for drug injections due to its abundant blood vessels?

<p>Hypodermis</p> Signup and view all the answers

Which epidermal cell type synthesizes melanin, which shields DNA from UV radiation?

<p>Melanocytes</p> Signup and view all the answers

What are the immune cells found in the stratum spinosum and stratum granulosum that guard against pathogens called?

<p>Dendritic cells</p> Signup and view all the answers

What are 'stretch marks' also known as, caused by tears in collagen fibers due to stretching of the skin?

<p>Striae</p> Signup and view all the answers

Which layer of the epidermis contains stem cells that undergo mitosis to produce new keratinocytes?

<p>Stratum basale</p> Signup and view all the answers

Besides the dermis, where else can you find areolar and adipose tissue?

<p>Hypodermis</p> Signup and view all the answers

What is the immediate response of severed blood vessels when skin is wounded?

<p>Bleeding into the cut.</p> Signup and view all the answers

What is the role of histamine in the initial stages of skin wound healing?

<p>Dilates blood vessels and increases capillary permeability.</p> Signup and view all the answers

Besides antibodies and clotting proteins, what does blood plasma carry into the wounded area?

<p>Blood plasma carries antibodies and clotting proteins into the wounded area.</p> Signup and view all the answers

What is the primary role of the blood clot that forms in a skin wound?

<p>Knitting the edges of the cut together, inhibiting pathogen spread and forming a scab.</p> Signup and view all the answers

What is the dual function of the scab that forms on a skin wound?

<p>Temporarily seals the wound and blocks infection.</p> Signup and view all the answers

Which cells are responsible for phagocytizing and digesting tissue debris in a healing skin wound?

<p>Macrophages</p> Signup and view all the answers

What cells release histamine to initiate vasodilation and increased capillary permeability at the site of injury?

<p>Mast cells and damaged cells</p> Signup and view all the answers

Besides forming a physical barrier, how else does a blood clot aid in preventing infection during the initial stages of skin wound healing?

<p>By inhibiting the spread of pathogens.</p> Signup and view all the answers

In the context of skin healing, what evolutionary trade-off is suggested by the fact that humans prioritize rapid healing under non-sterile conditions?

<p>Humans sacrifice perfect, scar-free regeneration for speed of healing to prevent infection and wound breakdown.</p> Signup and view all the answers

Compared to lower vertebrates, what specific regenerative capability is notably diminished in adult mammalian skin?

<p>The ability to achieve complete regeneration of skin tissue without scarring.</p> Signup and view all the answers

What is the approximate global annual incidence of patients developing scars and what are two major causes?

<p>Approximately 100 million patients annually, caused by elective operations and trauma.</p> Signup and view all the answers

What is the estimated number of burn scars in children worldwide?

<p>Approximately 4 million.</p> Signup and view all the answers

What characteristic of skin is associated with a higher likelihood of severe scarring?

<p>Increased pigmentation.</p> Signup and view all the answers

What specific type of sweat gland is believed to secrete pheromones, influencing the behavior of others?

<p>Apocrine sweat glands.</p> Signup and view all the answers

What is the name of the body odor caused by bacterial action on sweat from apocrine glands?

<p>Bromhidrosis.</p> Signup and view all the answers

Besides cooling the body, what is another significant function of the perspiration produced by merocrine sweat glands related to bacterial growth?

<p>Inhibiting bacterial growth; the acid mantle.</p> Signup and view all the answers

What specific component of blood plasma is not found in the sweat produced by sweat glands?

<p>Proteins.</p> Signup and view all the answers

What is the term for normal, unnoticeable perspiration, where approximately 500 mL of water is lost daily without visible wetness of the skin?

<p>Insensible perspiration.</p> Signup and view all the answers

What is the name given to the oily secretion of sebaceous glands, and what is its primary function?

<p>Sebum; keeps skin and hair from becoming dry, brittle, and cracked.</p> Signup and view all the answers

Name the type of secretion exhibited by sebaceous glands.

<p>Holocrine secretion.</p> Signup and view all the answers

Mammary glands are modified versions of what type of sweat gland?

<p>Apocrine sweat glands.</p> Signup and view all the answers

What is the term for the presence of more than two nipples on an individual?

<p>Polythelia.</p> Signup and view all the answers

What specific environmental factor is most commonly associated with the DNA damage that leads to skin cancer?

<p>UV rays from the sun.</p> Signup and view all the answers

Which layer of the epidermis do basal cell carcinomas originate from?

<p>Stratum basale.</p> Signup and view all the answers

Name the specific type of epidermal cell from which squamous cell carcinoma arises.

<p>Keratinocytes of the stratum spinosum.</p> Signup and view all the answers

Pattern baldness, influenced by testosterone levels, sees terminal hair replaced by what?

<p>Thin hair.</p> Signup and view all the answers

What is the matrix of the nail, and where is it located?

<p>Growth zone (mitotic) of stratum basale; at proximal end of nail.</p> Signup and view all the answers

What is the role of myoepithelial cells in both apocrine and merocrine sweat glands?

<p>Contract to squeeze perspiration up the duct.</p> Signup and view all the answers

Flashcards

Melanin

A pigment produced by melanocytes affecting skin color.

Eumelanin

A form of melanin that is brownish-black in color.

Pheomelanin

A type of melanin with a reddish-yellow hue, containing sulfur.

Effects of UV Light on Skin

UV light exposure stimulates melanin production, darkening the skin.

Signup and view all the flashcards

Cyanosis

A bluish color of the skin due to oxygen deficiency in blood.

Signup and view all the flashcards

Integumentary System

The organ system that includes skin, hair, nails, and glands.

Signup and view all the flashcards

Epidermis

The outermost layer of skin, made of stratified squamous epithelium.

Signup and view all the flashcards

Keratinocytes

The main cell type in the epidermis that produces keratin.

Signup and view all the flashcards

Stratum Basale

The deepest layer of the epidermis containing stem cells and keratinocytes.

Signup and view all the flashcards

Stratum Spinosum

The layer of the epidermis with several keratinocyte layers joined by desmosomes.

Signup and view all the flashcards

Stratum Granulosum

A layer of flat keratinocytes containing keratohyalin granules.

Signup and view all the flashcards

Stratum Lucidum

A thin, pale layer of the epidermis found only in thick skin.

Signup and view all the flashcards

Stratum Corneum

The outermost layer of skin composed of dead, keratinized cells.

Signup and view all the flashcards

Hypodermis

The deep connective tissue layer below the dermis, not part of the skin.

Signup and view all the flashcards

Sweat Glands

Glands that produce sweat; two types are eccrine and apocrine.

Signup and view all the flashcards

Stem cells

Undifferentiated cells in stratum basale that produce keratinocytes.

Signup and view all the flashcards

Melanocytes

Cells in the stratum basale that produce melanin, protecting DNA from UV radiation.

Signup and view all the flashcards

Dendritic cells

Macrophages originating in bone marrow, guarding against pathogens in skin layers.

Signup and view all the flashcards

Tactile cells

Touch receptor cells in the basal layer of the epidermis associated with nerve fibers.

Signup and view all the flashcards

Ichthyosis

Inherited skin disorder inhibiting cell shedding, leading to a buildup of dead skin.

Signup and view all the flashcards

Eczema

Chronic inflammatory skin condition characterized by dry, itching, and reddened areas.

Signup and view all the flashcards

Dermis

Connective tissue layer beneath the epidermis, rich in blood vessels and glands.

Signup and view all the flashcards

Papillary layer

Superficial region of dermis made of thin areolar tissue, allowing cell mobility.

Signup and view all the flashcards

Scarring

The normal outcome of mammalian tissue repair, occurring frequently in humans after injuries or surgeries.

Signup and view all the flashcards

Elective Operations

Planned surgeries performed on patients, contributing to the majority of scars acquired annually.

Signup and view all the flashcards

Keloid Scars

Raised scars that form after an injury, often occurring in individuals with darker skin tones.

Signup and view all the flashcards

Rapid Inflammatory Response

The body's quick biological reaction that helps to heal wounds and prevents infections.

Signup and view all the flashcards

Lower Vertebrate Regeneration

Complete healing without scarring seen in animals like salamanders and some invertebrates.

Signup and view all the flashcards

Bleeding into the wound

Initial response where severed vessels bleed into the cut, facilitating healing.

Signup and view all the flashcards

Histamine release

Mast cells and damaged cells release histamine to aid in healing.

Signup and view all the flashcards

Vasodilation

Histamine causes blood vessels to dilate, increasing blood flow to the wound.

Signup and view all the flashcards

Capillary permeability

Histamine increases capillary permeability, allowing plasma to seep into the wound.

Signup and view all the flashcards

Clot formation

Blood clot forms at the wound site, helping to knit edges together and block pathogens.

Signup and view all the flashcards

Scab formation

A scab forms to temporarily seal the wound and protect against infection.

Signup and view all the flashcards

Macrophage activity

Macrophages digest tissue debris, cleaning the wound area.

Signup and view all the flashcards

Role of antibodies

Blood plasma carries antibodies to fight infection during healing.

Signup and view all the flashcards

Functions of the skin

Skin protects, regulates temperature, and provides sensation.

Signup and view all the flashcards

Hair follicle

Structure in skin from which hair grows; contains living cells.

Signup and view all the flashcards

Hair zones

Hair is divided into bulb, root, and shaft.

Signup and view all the flashcards

Alopecia

Condition of hair thinning or baldness.

Signup and view all the flashcards

Keratin

A protein that makes up hair and nails, providing strength.

Signup and view all the flashcards

Types of sweat glands

Two types: apocrine and merocrine, each with different functions.

Signup and view all the flashcards

Apocrine glands

Sweat glands located in armpits and groin, active at puberty.

Signup and view all the flashcards

Merocrine glands

Most numerous sweat glands, produce watery sweat for cooling.

Signup and view all the flashcards

Sebaceous glands

Glands that secrete oil (sebum) to hydrate skin and hair.

Signup and view all the flashcards

Nail matrix

Growth zone of the nail located at the proximal end.

Signup and view all the flashcards

Skin cancer types

Includes basal cell carcinoma, squamous cell carcinoma, and malignant melanoma.

Signup and view all the flashcards

Basal cell carcinoma

Most common type of skin cancer, rarely spreads, forms shiny bumps.

Signup and view all the flashcards

Squamous cell carcinoma

Skin cancer from keratinocytes; can metastasize if untreated.

Signup and view all the flashcards

Study Notes

Integumentary System Overview

  • The integumentary system includes the skin and its accessory organs (hair, nails, and glands).
  • It's the largest and heaviest organ of the body, covering 1.5-2.0 m² and 15% of body weight.
  • Skin thickness ranges from 0.5-6 mm, thinner skin (0.1 mm) covers most of the body, while thick skin (0.5 mm) is on the palms and soles.

Learning Outcomes

  • Students will be able to discuss the major functions of the skin.
  • Students will be able to describe the structures of the integumentary system.
  • Students will be able to outline the structure and cells of the skin layers.
  • Students will be able to describe appendages of skin (hair and nails).
  • Students will be able to name and describe two types of sweat glands.
  • Students will be able to describe cancers involving skin cells.
  • Students will be able to discuss the skin healing process after injury.

Skin Functions

  • Resistance to trauma and infection: keratin, acid mantle
  • Water barrier: prevents water loss, with tight junctions between skin cells. This helps prevent dehydration.
  • UV radiation protection
  • Defense against harmful chemicals:
  • Vitamin D synthesis: a first step, liver & kidneys complete the process.
  • Sensation: extensive sense organ, receptors for temperature, touch, pain, regulating temperature (vasoconstriction/vasodilation), perspiration
  • Nonverbal communication: facial expression and its role in social acceptance and self-image

Skin Structure and Layers

  • Three main layers: epidermis (outer, stratified squamous epithelium), dermis (middle, deeper connective tissue layer), hypodermis (deep, connective tissue layer below the dermis)
  • Epidermis: keratinized stratified squamous epithelium, keratin protein for toughness, layers (strata).
  • Main cell type: keratinocytes
  • Lacks blood vessels, nutrients diffuse from underlying connective tissue, ending in nerve endings & receptors for touch & pain

Layers of the Epidermis

  • Stratum basale: deepest layer, single layer of stem cells and keratinocytes resting on the basement membrane

  • Stem cells: divide and form keratinocytes (migrate to surface to replace lost cells), melanocytes and tactile cells

  • Stratum spinosum: Several layers of keratinocytes connected by desmosomes and tight junctions.

  • Stratum granulosum: Three to five layers of flat keratinocytes, contain dark-staining keratohyalin granules

  • Stratum lucidum: only in thick skin, thin, pale layer of keratinocytes packed with clear protein eleidin (converts to keratin at surface).

  • Stratum corneum: surface layer, several layers of dead scaly keratinized cells that resist abrasion, penetration, and water loss.

Cells of the Epidermis

  • Keratinocytes: majority, synthesize keratin, produced by mitosis in stratum basale.
  • Melanocytes: synthesize pigment melanin, shields DNA from UV radiation, occur in stratum basale.
  • Dendritic cells: macrophages, originate in bone marrow, guard against pathogens, in stratum spinosum and stratum granulosum
  • Tactile cells: touch receptor cells, associated with dermal nerve fibers, basala layer

Skin Disorders

  • Ichthyosis: Genetically inherited (or acquired), shedding process inhibited, build-up of dead cells, can result in overheating
  • Eczema: Chronic, inherited inflammatory skin condition, symptoms include dry, itchy, and reddened skin
  • Exfoliative dermatitis: Excessive shedding of skin

Dermis

  • Connective tissue layer below epidermis, 0.2 mm (eyelids) to 4 mm (palms, soles), mainly collagen, rich in blood vessels, sweat glands, sebaceous glands, nerve endings, hair follicles & nail roots, skeletal muscles of facial expression.
  • Two layers: -Papillary layer: superficial, thin areolar tissue near the dermal papillae; allows mobility of leukocytes. -Reticular layer: deeper, thicker, dense, irregular connective tissue, stretch marks (striae) due to tears in collagen fibers from stretching.

Hypodermis

  • Subcutaneous tissue, more areolar and adipose tissue than in the dermis, pads body & binds skin to underlying tissues, abundant blood vessels (site of drug injection).
  • subcutaneous fat: energy reservoir, thermal insulation, thicker in women, thinner in infants and elderly

Skin Appendages: Hair and Nails

  • Hair: slender filament of keratinized cells growth from follicle.
  • covers most of body, 100,000 hairs on scalp, 55-70 hairs per cm² on limbs & trunk, 10x on face.
  • Three zones:
  • Bulb: swelling at base, living cells.
  • Root: remainder in follicle.
  • Shaft: portion above skin surface
  • Nail: finger/toe nails - clear, hard derivatives of stratum corneum, composed of thin, dead cells packed with hard keratin. -Functions: Grooming, food manipulation, sensitivity enhancement. (nail plate, free edge, nail body, nail root)

Skin Cancer

  • Most cases caused by UV radiation.
  • Common sites: head, neck, hands.
  • Common in fair skin people & elderly.
  • Three main types: basal cell carcinoma, squamous cell carcinoma, malignant melanoma

Skin Healing

  • Stages of a wound healing:
    • Bleeding into the wound.
    • Scab formation (macrophages, fibroblasts, clotting).
    • Granulation tissue formation (new capillaries, fibroblasts).
    • Epithelial regeneration/remodeling (scarring, weeks to years).

Glands of the Skin

  • Sweat glands: Two main kinds: apocrine and merocrine
    • Apocrine: found in groin, anal area, armpits, secretions milky, contain fatty acids, become active during puberty.
    • Merocrine: most numerous, especially on palms, soles, and forehead, simple tubular glands, watery sweat helps cool the body, have myoepithelial cells which squeeze secretions.
  • Sebaceous glands: flask-shaped, short ducts to hair follicles, secrete sebum, oily secretion, keeps skin/hair from becoming dry/brittle/cracked (lanolin).

Other Information

  • Skin color variations determined by melanin production and distribution.
  • Environmental factors (sun exposure) affect melanin production, pigmentation.
  • Other pigments (hemoglobin, carotene) also contribute to skin color (e.g., jaundice=bilirubin in blood).
  • Conditions affecting nails: different potential issues (not elaborated).

Burns

  • Leading causes of accidental deaths, Fires, spills, sunlight, ionization, strong acids/bases, electrical shocks.
  • Can result in primary fluid loss, infection & toxic effects of eschar.
  • Debridement is removing the eschar.
  • Different degrees of burns (first, second, third-degree) are categorized by tissue involvement, symptom differences, and treatment requirements.

Stages in the Healing Process

  • Defined stages leading to full wound healing.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

Description

Test your knowledge on skin biology, focusing on melanin forms, their colors, and distribution in different skin tones. Explore the effects of UV light on skin darkening, as well as other pigments influencing skin color. Additionally, delve into the anatomy and function of the epidermis and its layers.

More Like This

Melanin and UV Radiation Quiz
5 questions

Melanin and UV Radiation Quiz

MagicalMoldavite2235 avatar
MagicalMoldavite2235
Melanin and Melanocytes in Human Skin
8 questions
Use Quizgecko on...
Browser
Browser