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Questions and Answers
Name the two forms of melanin and briefly describe their respective colors.
Name the two forms of melanin and briefly describe their respective colors.
Eumelanin (brownish black) and pheomelanin (reddish yellow).
Describe the distribution of melanin granules in keratinocytes of darker-skinned individuals compared to lighter-skinned individuals.
Describe the distribution of melanin granules in keratinocytes of darker-skinned individuals compared to lighter-skinned individuals.
In darker-skinned individuals, melanin granules are more spread out throughout the keratinocytes. In lighter-skinned individuals, melanin is clumped near the keratinocyte nucleus.
Explain why exposure to UV light darkens the skin.
Explain why exposure to UV light darkens the skin.
UV light stimulates melanocytes to secrete melanin, which darkens the skin. This color fades as melanin is degraded and old cells are exfoliated.
Besides melanin, list two other pigments that can influence skin color and their sources.
Besides melanin, list two other pigments that can influence skin color and their sources.
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Define cyanosis and albinism, linking each to its underlying cause.
Define cyanosis and albinism, linking each to its underlying cause.
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What is the primary protein found in the cells of the stratum corneum, and what characteristic does it impart to this layer?
What is the primary protein found in the cells of the stratum corneum, and what characteristic does it impart to this layer?
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Which epidermal layer is characterized by cells connected by desmosomes and tight junctions, and what causes its 'spiny' appearance in histological preparations?
Which epidermal layer is characterized by cells connected by desmosomes and tight junctions, and what causes its 'spiny' appearance in histological preparations?
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What two types of cells are found in stratum basale?
What two types of cells are found in stratum basale?
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Name the layer of skin not considered part of the skin, but associated with it.
Name the layer of skin not considered part of the skin, but associated with it.
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What is the main tissue type composing the epidermis?
What is the main tissue type composing the epidermis?
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Which layer of the epidermis exists only in thick skin?
Which layer of the epidermis exists only in thick skin?
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What is the role of stem cells in the stratum basale?
What is the role of stem cells in the stratum basale?
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What are the main layers of the skin?
What are the main layers of the skin?
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How do nutrients reach the epidermis, given that it lacks blood vessels?
How do nutrients reach the epidermis, given that it lacks blood vessels?
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Describe the main function of the stratum corneum, relating it to its structure.
Describe the main function of the stratum corneum, relating it to its structure.
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Which epidermal cell type functions as a touch receptor and is associated with dermal nerve fibers?
Which epidermal cell type functions as a touch receptor and is associated with dermal nerve fibers?
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What is the primary tissue type composing the reticular layer of the dermis?
What is the primary tissue type composing the reticular layer of the dermis?
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What is the name given to the upward, finger-like extensions of the dermis that interlock with the epidermis?
What is the name given to the upward, finger-like extensions of the dermis that interlock with the epidermis?
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What is the name of the condition that results from the inhibited shedding process of the skin?
What is the name of the condition that results from the inhibited shedding process of the skin?
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Which layer of the skin is a common site for drug injections due to its abundant blood vessels?
Which layer of the skin is a common site for drug injections due to its abundant blood vessels?
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Which epidermal cell type synthesizes melanin, which shields DNA from UV radiation?
Which epidermal cell type synthesizes melanin, which shields DNA from UV radiation?
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What are the immune cells found in the stratum spinosum and stratum granulosum that guard against pathogens called?
What are the immune cells found in the stratum spinosum and stratum granulosum that guard against pathogens called?
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What are 'stretch marks' also known as, caused by tears in collagen fibers due to stretching of the skin?
What are 'stretch marks' also known as, caused by tears in collagen fibers due to stretching of the skin?
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Which layer of the epidermis contains stem cells that undergo mitosis to produce new keratinocytes?
Which layer of the epidermis contains stem cells that undergo mitosis to produce new keratinocytes?
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Besides the dermis, where else can you find areolar and adipose tissue?
Besides the dermis, where else can you find areolar and adipose tissue?
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What is the immediate response of severed blood vessels when skin is wounded?
What is the immediate response of severed blood vessels when skin is wounded?
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What is the role of histamine in the initial stages of skin wound healing?
What is the role of histamine in the initial stages of skin wound healing?
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Besides antibodies and clotting proteins, what does blood plasma carry into the wounded area?
Besides antibodies and clotting proteins, what does blood plasma carry into the wounded area?
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What is the primary role of the blood clot that forms in a skin wound?
What is the primary role of the blood clot that forms in a skin wound?
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What is the dual function of the scab that forms on a skin wound?
What is the dual function of the scab that forms on a skin wound?
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Which cells are responsible for phagocytizing and digesting tissue debris in a healing skin wound?
Which cells are responsible for phagocytizing and digesting tissue debris in a healing skin wound?
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What cells release histamine to initiate vasodilation and increased capillary permeability at the site of injury?
What cells release histamine to initiate vasodilation and increased capillary permeability at the site of injury?
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Besides forming a physical barrier, how else does a blood clot aid in preventing infection during the initial stages of skin wound healing?
Besides forming a physical barrier, how else does a blood clot aid in preventing infection during the initial stages of skin wound healing?
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In the context of skin healing, what evolutionary trade-off is suggested by the fact that humans prioritize rapid healing under non-sterile conditions?
In the context of skin healing, what evolutionary trade-off is suggested by the fact that humans prioritize rapid healing under non-sterile conditions?
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Compared to lower vertebrates, what specific regenerative capability is notably diminished in adult mammalian skin?
Compared to lower vertebrates, what specific regenerative capability is notably diminished in adult mammalian skin?
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What is the approximate global annual incidence of patients developing scars and what are two major causes?
What is the approximate global annual incidence of patients developing scars and what are two major causes?
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What is the estimated number of burn scars in children worldwide?
What is the estimated number of burn scars in children worldwide?
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What characteristic of skin is associated with a higher likelihood of severe scarring?
What characteristic of skin is associated with a higher likelihood of severe scarring?
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What specific type of sweat gland is believed to secrete pheromones, influencing the behavior of others?
What specific type of sweat gland is believed to secrete pheromones, influencing the behavior of others?
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What is the name of the body odor caused by bacterial action on sweat from apocrine glands?
What is the name of the body odor caused by bacterial action on sweat from apocrine glands?
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Besides cooling the body, what is another significant function of the perspiration produced by merocrine sweat glands related to bacterial growth?
Besides cooling the body, what is another significant function of the perspiration produced by merocrine sweat glands related to bacterial growth?
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What specific component of blood plasma is not found in the sweat produced by sweat glands?
What specific component of blood plasma is not found in the sweat produced by sweat glands?
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What is the term for normal, unnoticeable perspiration, where approximately 500 mL of water is lost daily without visible wetness of the skin?
What is the term for normal, unnoticeable perspiration, where approximately 500 mL of water is lost daily without visible wetness of the skin?
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What is the name given to the oily secretion of sebaceous glands, and what is its primary function?
What is the name given to the oily secretion of sebaceous glands, and what is its primary function?
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Name the type of secretion exhibited by sebaceous glands.
Name the type of secretion exhibited by sebaceous glands.
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Mammary glands are modified versions of what type of sweat gland?
Mammary glands are modified versions of what type of sweat gland?
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What is the term for the presence of more than two nipples on an individual?
What is the term for the presence of more than two nipples on an individual?
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What specific environmental factor is most commonly associated with the DNA damage that leads to skin cancer?
What specific environmental factor is most commonly associated with the DNA damage that leads to skin cancer?
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Which layer of the epidermis do basal cell carcinomas originate from?
Which layer of the epidermis do basal cell carcinomas originate from?
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Name the specific type of epidermal cell from which squamous cell carcinoma arises.
Name the specific type of epidermal cell from which squamous cell carcinoma arises.
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Pattern baldness, influenced by testosterone levels, sees terminal hair replaced by what?
Pattern baldness, influenced by testosterone levels, sees terminal hair replaced by what?
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What is the matrix of the nail, and where is it located?
What is the matrix of the nail, and where is it located?
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What is the role of myoepithelial cells in both apocrine and merocrine sweat glands?
What is the role of myoepithelial cells in both apocrine and merocrine sweat glands?
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Flashcards
Melanin
Melanin
A pigment produced by melanocytes affecting skin color.
Eumelanin
Eumelanin
A form of melanin that is brownish-black in color.
Pheomelanin
Pheomelanin
A type of melanin with a reddish-yellow hue, containing sulfur.
Effects of UV Light on Skin
Effects of UV Light on Skin
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Cyanosis
Cyanosis
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Integumentary System
Integumentary System
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Epidermis
Epidermis
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Keratinocytes
Keratinocytes
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Stratum Basale
Stratum Basale
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Stratum Spinosum
Stratum Spinosum
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Stratum Granulosum
Stratum Granulosum
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Stratum Lucidum
Stratum Lucidum
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Stratum Corneum
Stratum Corneum
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Hypodermis
Hypodermis
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Sweat Glands
Sweat Glands
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Stem cells
Stem cells
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Melanocytes
Melanocytes
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Dendritic cells
Dendritic cells
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Tactile cells
Tactile cells
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Ichthyosis
Ichthyosis
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Eczema
Eczema
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Dermis
Dermis
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Papillary layer
Papillary layer
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Scarring
Scarring
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Elective Operations
Elective Operations
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Keloid Scars
Keloid Scars
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Rapid Inflammatory Response
Rapid Inflammatory Response
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Lower Vertebrate Regeneration
Lower Vertebrate Regeneration
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Bleeding into the wound
Bleeding into the wound
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Histamine release
Histamine release
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Vasodilation
Vasodilation
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Capillary permeability
Capillary permeability
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Clot formation
Clot formation
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Scab formation
Scab formation
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Macrophage activity
Macrophage activity
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Role of antibodies
Role of antibodies
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Functions of the skin
Functions of the skin
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Hair follicle
Hair follicle
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Hair zones
Hair zones
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Alopecia
Alopecia
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Keratin
Keratin
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Types of sweat glands
Types of sweat glands
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Apocrine glands
Apocrine glands
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Merocrine glands
Merocrine glands
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Sebaceous glands
Sebaceous glands
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Nail matrix
Nail matrix
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Skin cancer types
Skin cancer types
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Basal cell carcinoma
Basal cell carcinoma
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Squamous cell carcinoma
Squamous cell carcinoma
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Study Notes
Integumentary System Overview
- The integumentary system includes the skin and its accessory organs (hair, nails, and glands).
- It's the largest and heaviest organ of the body, covering 1.5-2.0 m² and 15% of body weight.
- Skin thickness ranges from 0.5-6 mm, thinner skin (0.1 mm) covers most of the body, while thick skin (0.5 mm) is on the palms and soles.
Learning Outcomes
- Students will be able to discuss the major functions of the skin.
- Students will be able to describe the structures of the integumentary system.
- Students will be able to outline the structure and cells of the skin layers.
- Students will be able to describe appendages of skin (hair and nails).
- Students will be able to name and describe two types of sweat glands.
- Students will be able to describe cancers involving skin cells.
- Students will be able to discuss the skin healing process after injury.
Skin Functions
- Resistance to trauma and infection: keratin, acid mantle
- Water barrier: prevents water loss, with tight junctions between skin cells. This helps prevent dehydration.
- UV radiation protection
- Defense against harmful chemicals:
- Vitamin D synthesis: a first step, liver & kidneys complete the process.
- Sensation: extensive sense organ, receptors for temperature, touch, pain, regulating temperature (vasoconstriction/vasodilation), perspiration
- Nonverbal communication: facial expression and its role in social acceptance and self-image
Skin Structure and Layers
- Three main layers: epidermis (outer, stratified squamous epithelium), dermis (middle, deeper connective tissue layer), hypodermis (deep, connective tissue layer below the dermis)
- Epidermis: keratinized stratified squamous epithelium, keratin protein for toughness, layers (strata).
- Main cell type: keratinocytes
- Lacks blood vessels, nutrients diffuse from underlying connective tissue, ending in nerve endings & receptors for touch & pain
Layers of the Epidermis
-
Stratum basale: deepest layer, single layer of stem cells and keratinocytes resting on the basement membrane
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Stem cells: divide and form keratinocytes (migrate to surface to replace lost cells), melanocytes and tactile cells
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Stratum spinosum: Several layers of keratinocytes connected by desmosomes and tight junctions.
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Stratum granulosum: Three to five layers of flat keratinocytes, contain dark-staining keratohyalin granules
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Stratum lucidum: only in thick skin, thin, pale layer of keratinocytes packed with clear protein eleidin (converts to keratin at surface).
-
Stratum corneum: surface layer, several layers of dead scaly keratinized cells that resist abrasion, penetration, and water loss.
Cells of the Epidermis
- Keratinocytes: majority, synthesize keratin, produced by mitosis in stratum basale.
- Melanocytes: synthesize pigment melanin, shields DNA from UV radiation, occur in stratum basale.
- Dendritic cells: macrophages, originate in bone marrow, guard against pathogens, in stratum spinosum and stratum granulosum
- Tactile cells: touch receptor cells, associated with dermal nerve fibers, basala layer
Skin Disorders
- Ichthyosis: Genetically inherited (or acquired), shedding process inhibited, build-up of dead cells, can result in overheating
- Eczema: Chronic, inherited inflammatory skin condition, symptoms include dry, itchy, and reddened skin
- Exfoliative dermatitis: Excessive shedding of skin
Dermis
- Connective tissue layer below epidermis, 0.2 mm (eyelids) to 4 mm (palms, soles), mainly collagen, rich in blood vessels, sweat glands, sebaceous glands, nerve endings, hair follicles & nail roots, skeletal muscles of facial expression.
- Two layers: -Papillary layer: superficial, thin areolar tissue near the dermal papillae; allows mobility of leukocytes. -Reticular layer: deeper, thicker, dense, irregular connective tissue, stretch marks (striae) due to tears in collagen fibers from stretching.
Hypodermis
- Subcutaneous tissue, more areolar and adipose tissue than in the dermis, pads body & binds skin to underlying tissues, abundant blood vessels (site of drug injection).
- subcutaneous fat: energy reservoir, thermal insulation, thicker in women, thinner in infants and elderly
Skin Appendages: Hair and Nails
- Hair: slender filament of keratinized cells growth from follicle.
- covers most of body, 100,000 hairs on scalp, 55-70 hairs per cm² on limbs & trunk, 10x on face.
- Three zones:
- Bulb: swelling at base, living cells.
- Root: remainder in follicle.
- Shaft: portion above skin surface
- Nail: finger/toe nails - clear, hard derivatives of stratum corneum, composed of thin, dead cells packed with hard keratin. -Functions: Grooming, food manipulation, sensitivity enhancement. (nail plate, free edge, nail body, nail root)
Skin Cancer
- Most cases caused by UV radiation.
- Common sites: head, neck, hands.
- Common in fair skin people & elderly.
- Three main types: basal cell carcinoma, squamous cell carcinoma, malignant melanoma
Skin Healing
- Stages of a wound healing:
- Bleeding into the wound.
- Scab formation (macrophages, fibroblasts, clotting).
- Granulation tissue formation (new capillaries, fibroblasts).
- Epithelial regeneration/remodeling (scarring, weeks to years).
Glands of the Skin
- Sweat glands: Two main kinds: apocrine and merocrine
- Apocrine: found in groin, anal area, armpits, secretions milky, contain fatty acids, become active during puberty.
- Merocrine: most numerous, especially on palms, soles, and forehead, simple tubular glands, watery sweat helps cool the body, have myoepithelial cells which squeeze secretions.
- Sebaceous glands: flask-shaped, short ducts to hair follicles, secrete sebum, oily secretion, keeps skin/hair from becoming dry/brittle/cracked (lanolin).
Other Information
- Skin color variations determined by melanin production and distribution.
- Environmental factors (sun exposure) affect melanin production, pigmentation.
- Other pigments (hemoglobin, carotene) also contribute to skin color (e.g., jaundice=bilirubin in blood).
- Conditions affecting nails: different potential issues (not elaborated).
Burns
- Leading causes of accidental deaths, Fires, spills, sunlight, ionization, strong acids/bases, electrical shocks.
- Can result in primary fluid loss, infection & toxic effects of eschar.
- Debridement is removing the eschar.
- Different degrees of burns (first, second, third-degree) are categorized by tissue involvement, symptom differences, and treatment requirements.
Stages in the Healing Process
- Defined stages leading to full wound healing.
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Description
Test your knowledge on skin biology, focusing on melanin forms, their colors, and distribution in different skin tones. Explore the effects of UV light on skin darkening, as well as other pigments influencing skin color. Additionally, delve into the anatomy and function of the epidermis and its layers.