Lec 14- Skin and Soft Tissue Infections (SSTIs)

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Questions and Answers

What does the acronym SSTI stand for?

  • Severe Systemic Tissue Infection
  • Skin and Soft Tissue Infection (correct)
  • Superficial Skin Tissue Irritation
  • Skin and Surface Tissue Inflammation

Which of the following is a key objective when dealing with SSTIs?

  • To differentiate between purulent and non-purulent infections. (correct)
  • To avoid any diagnostic procedures.
  • To specifically target viral causes of skin infections.
  • To only use oral antibiotics to manage SSTIs.

What is the estimate of how many people are affected by SSTIs each year?

  • 50 million
  • 100,000
  • 1 million
  • 14 million (correct)

SSTIs involve infections located:

<p>In any or all layers of the skin, fascia, and muscle. (D)</p> Signup and view all the answers

What usually causes most SSTIs?

<p>A single pathogen (B)</p> Signup and view all the answers

What is the function of intact skin in the context of infections?

<p>It provides an infection defense (B)</p> Signup and view all the answers

What is a common sign of Impetigo?

<p>Erythematous papules. (B)</p> Signup and view all the answers

How is Impetigo typically diagnosed?

<p>Through clinical presentation (B)</p> Signup and view all the answers

A typical treatment for Impetigo involves:

<p>Topical mupirocin (C)</p> Signup and view all the answers

What is the recommended duration for using topical mupirocin to treat impetigo?

<p>5 days (D)</p> Signup and view all the answers

What is a key characteristic of a purulent SSTI?

<p>It involves the presence of pus. (B)</p> Signup and view all the answers

How are mild purulent SSTIs typically managed?

<p>Through incision and drainage (I&amp;D) (D)</p> Signup and view all the answers

When are systemic antibiotics considered in the treatment of purulent SSTIs?

<p>In moderate-to-severe cases with systemic signs of infection. (B)</p> Signup and view all the answers

What is the first-line management for cutaneous abscesses?

<p>Incision and drainage (I&amp;D) (D)</p> Signup and view all the answers

What organism most commonly causes cutaneous abscesses?

<p><em>Staphylococcus aureus</em> (B)</p> Signup and view all the answers

What is a furuncle?

<p>A superficial infection of the hair follicle (A)</p> Signup and view all the answers

Why are systemic antibiotics often unnecessary for furuncles?

<p>Because furuncles often rupture and drain spontaneously (B)</p> Signup and view all the answers

Where do carbuncles commonly occur on the body?

<p>On the back of the neck (B)</p> Signup and view all the answers

Typical management of carbuncles involves:

<p>I&amp;D +/- C&amp;S (C)</p> Signup and view all the answers

If a patient has recurrent skin abscesses, what might be considered after initial treatment?

<p>To start a 5-day decolonization regimen (A)</p> Signup and view all the answers

What does decolonization typically involve?

<p>Intranasal mupirocin and chlorhexidine washes (D)</p> Signup and view all the answers

Which of the following organisms is the primary concern in purulent SSTIs?

<p><em>Staphylococcus aureus</em> (A)</p> Signup and view all the answers

What is the first-line management of purulent SSTIs?

<p>Incision and drainage (I&amp;D) (C)</p> Signup and view all the answers

Which of the following antibiotics is an option for MSSA infections?

<p>Nafcillin (C)</p> Signup and view all the answers

What is a key difference between cellulitis and erysipelas?

<p>Cellulitis is deep and diffuse, while erysipelas is superficial and spreading. (A)</p> Signup and view all the answers

What kind of breaks do you typically see in the skin in cases of cellulitis?

<p>Clinical unapparent, small (B)</p> Signup and view all the answers

A common symptom in cellulitis includes:

<p>Red, swollen, warm to the touch (D)</p> Signup and view all the answers

What is the most common cause of cellulitis?

<p><em>Streptococcus</em> species (D)</p> Signup and view all the answers

The treatment of cellulitis typically involves:

<p>Antibiotics (B)</p> Signup and view all the answers

Adjunct systemic corticosteroids may be considered with:

<p>Treating cellulitis. (A)</p> Signup and view all the answers

What is often implicated in recurrent cellulitis?

<p>Annual recurrence. (B)</p> Signup and view all the answers

What is a common antibiotic for cellulitis related to Strep?

<p>Penicillin (B)</p> Signup and view all the answers

Necrotizing fasciitis is often described as a:

<p>&quot;Flesh-eating infection&quot; (B)</p> Signup and view all the answers

What is a key initial sign of necrotizing fascitis?

<p>Hard, wooden feeling of tissue. (B)</p> Signup and view all the answers

What is a critical step to take with a patient with necrotizing fascitis?

<p>Surgical Emergency (B)</p> Signup and view all the answers

When clinically assessing necrotizing fascitis, what can CT's show?

<p>Edema/Necrosis (C)</p> Signup and view all the answers

Typical bacteria include for causative organisms for Necrotizing Fasciitis?

<p><em>Staphylococcus aureus</em> (D)</p> Signup and view all the answers

What is the most common cause of skin and soft tissue infections?

<p>Bacteria (D)</p> Signup and view all the answers

The skin's primary role in preventing infections is to act as a:

<p>Physical barrier (A)</p> Signup and view all the answers

Impetigo is typically characterized by which of the following skin findings?

<p>Honey-colored crusts (C)</p> Signup and view all the answers

In typical cases, how is impetigo diagnosed?

<p>Clinical presentation (C)</p> Signup and view all the answers

What is a common topical antibiotic used to treat impetigo?

<p>Mupirocin (C)</p> Signup and view all the answers

A key feature of a purulent skin and soft tissue infection is the presence of:

<p>Pus (D)</p> Signup and view all the answers

For mild purulent SSTIs, the primary management strategy is:

<p>Incision and drainage (B)</p> Signup and view all the answers

What is the term for a collection of pus within the skin?

<p>Abscess (A)</p> Signup and view all the answers

The most common bacterial cause of cutaneous abscesses is:

<p>Staphylococcus aureus (A)</p> Signup and view all the answers

What is a furuncle commonly known as?

<p>Boil (A)</p> Signup and view all the answers

Carbuncles are best described as:

<p>Multiple interconnected furuncles (C)</p> Signup and view all the answers

For recurrent skin abscesses, decolonization strategies typically include:

<p>Intranasal mupirocin and chlorhexidine washes (D)</p> Signup and view all the answers

In purulent SSTIs, the primary bacterial pathogen of concern is generally:

<p>Staphylococcus aureus (B)</p> Signup and view all the answers

What is a key clinical difference between cellulitis and erysipelas?

<p>Depth of skin involvement (D)</p> Signup and view all the answers

Cellulitis is most commonly caused by which bacteria?

<p>Streptococcus species (D)</p> Signup and view all the answers

Which type of skin and soft tissue infection (SSTI) typically involves deeper layers, potentially including fascia and muscle?

<p>Necrotizing fasciitis (B)</p> Signup and view all the answers

In purulent SSTIs, when is it most appropriate to perform a culture and susceptibility test?

<p>In moderate-to-severe cases to guide antibiotic selection. (D)</p> Signup and view all the answers

What is the primary reason clindamycin may be used as an adjunct treatment in necrotizing fasciitis?

<p>To suppress bacterial toxin and cytokine production. (B)</p> Signup and view all the answers

Which of the following empiric antibiotic regimens would be most appropriate for a severe purulent SSTI, assuming MRSA coverage is necessary?

<p>Vancomycin plus piperacillin/tazobactam (C)</p> Signup and view all the answers

Which of the following is a key characteristic that differentiates a carbuncle from a furuncle?

<p>A carbuncle involves multiple hair follicles and drains through multiple orifices. (C)</p> Signup and view all the answers

What is the primary goal of decolonization strategies in patients with recurrent skin abscesses?

<p>To reduce the risk of future infections by eliminating bacterial reservoirs. (C)</p> Signup and view all the answers

What is a typical first-line intervention for managing cutaneous abscesses?

<p>Incision and drainage (D)</p> Signup and view all the answers

Why are systemic antibiotics often deemed unnecessary in the management of furuncles unless specific conditions are met?

<p>Furuncles often rupture and drain spontaneously, resolving without antibiotics. (D)</p> Signup and view all the answers

Which of the following underlying conditions would raise suspicion for considering MRSA coverage in a patient presenting with cellulitis?

<p>Open wound with known MRSA colonization (B)</p> Signup and view all the answers

What is a key early sign or symptom that should raise suspicion for necrotizing fasciitis rather than simple cellulitis?

<p>Pain out of proportion to clinical findings (C)</p> Signup and view all the answers

What is the recommended duration of topical mupirocin treatment for impetigo?

<p>5 days (A)</p> Signup and view all the answers

For cellulitis, which scenario would most warrant consideration of adjunct systemic corticosteroids?

<p>Cellulitis accompanied by bullae and concern for significant inflammation. (D)</p> Signup and view all the answers

A patient with a history of intravenous drug use presents with cellulitis, and MRSA colonization is suspected. Which antibiotic is most appropriate?

<p>Doxycycline (C)</p> Signup and view all the answers

What is the most critical first step in managing a patient suspected of having necrotizing fasciitis?

<p>Perform immediate surgical consultation. (B)</p> Signup and view all the answers

In managing recurrent cellulitis, what prophylactic antibiotic is commonly considered, assuming no allergies or contraindications?

<p>Penicillin (A)</p> Signup and view all the answers

Which of the following best describes the typical presentation of a patient with Fournier gangrene?

<p>A type of necrotizing soft tissue infection of the scrotum, penis, or vulva. (C)</p> Signup and view all the answers

Which imaging modality can be used to assess the extent of tissue involvement and confirm the presence of gas in the soft tissues in Necrotizing fasciitis?

<p>CT Scan (B)</p> Signup and view all the answers

Besides Streptococcus pyogenes and Staphylococcus aureus, which organism is increasingly recognized as a potential cause of necrotizing fasciitis, especially in aquatic environments?

<p><em>Vibrio vulnificus</em> (D)</p> Signup and view all the answers

Which of the following treatment strategies is essential for patients with necrotizing fasciitis to prevent systemic toxicity caused by bacterial toxins?

<p>Surgical debridement to remove the infected tissue (B)</p> Signup and view all the answers

Why is the assessment of crepitus important in the evaluation of a patient with a suspected soft tissue infection?

<p>Crepitus suggests the presence of gas in the tissues, which may indicate necrotizing infection. (C)</p> Signup and view all the answers

According to the FDA, what is the minimum lesion size area to define ABSSSI (Acute Bacterial Skin and Skin Structure Infection)?

<p>75 cm² (B)</p> Signup and view all the answers

In a non-purulent SSTI such as cellulitis, what clinical finding would suggest the infection is severe?

<p>Signs of deeper infection like skin sloughing or hypotension. (B)</p> Signup and view all the answers

Which of the following predisposing factors is associated with recurrent cellulitis?

<p>Obesity (A)</p> Signup and view all the answers

In patients with cellulitis, why are blood cultures generally not recommended?

<p>Blood cultures are positive in less than 5% of cases (B)</p> Signup and view all the answers

An immunocompromised patient is diagnosed with a severe case of purulent SSTI that failed initial incision and drainage. Which of the following systemic signs would indicate the infection's severity?

<p>A fever of &gt;38°C, heart rate &gt;90 bpm, and an abnormal WBC count. (A)</p> Signup and view all the answers

A patient presents with a painful, tender, red nodule encircled by erythematous swelling, which contains a collection of pus. Which condition is most likely indicated by these symptoms?

<p>Cutaneous Abscess (C)</p> Signup and view all the answers

What is a common causative organism for cutaneous abscesses?

<p>Staphylococcus aureus (B)</p> Signup and view all the answers

Which microorganism is commonly associated with cellulitis infections, especially in cases not related to open wounds or MRSA?

<p>Streptococcus species (D)</p> Signup and view all the answers

What clinical characteristic is most indicative of severe impetigo requiring oral antibiotics rather than topical treatment?

<p>Numerous lesions across multiple body areas or an outbreak affecting multiple people. (D)</p> Signup and view all the answers

Which of the following is a typical symptom associated with cellulitis?

<p>Localized pain, swelling, warmth, and redness (C)</p> Signup and view all the answers

What type of SSTI is often described as a 'flesh-eating infection'?

<p>Necrotizing fasciitis (B)</p> Signup and view all the answers

What is the primary management for mild purulent SSTIs?

<p>Incision and drainage (C)</p> Signup and view all the answers

What initial interventions are MOST critical for necrotizing fasciitis?

<p>Prompt surgical evaluation and debridement in conjunction with broad-spectrum antibiotics (C)</p> Signup and view all the answers

What is the most common cause of SSTI's?

<p>Bacteria (B)</p> Signup and view all the answers

Which best describes the function of intact skin in the context of preventing infections?

<p>Serves as a physical barrier against pathogens (B)</p> Signup and view all the answers

What are the typical skin findings for Impetigo?

<p>Honey-colored crusted lesions (C)</p> Signup and view all the answers

What systemic antibiotic is usually unnecessary for furuncles?

<p>Only if moderate to severe (B)</p> Signup and view all the answers

What is the primary factor that differentiates moderate from severe purulent skin and soft tissue infections (SSTIs)?

<p>The failure of incision and drainage, coupled with systemic signs of infection. (A)</p> Signup and view all the answers

In the management of a furuncle, what condition necessitates the use of systemic antibiotics?

<p>Presence of fever or other signs of systemic infection. (A)</p> Signup and view all the answers

Why might an oral agent active against _S. aureus_ be preferred over topical mupirocin in the treatment of impetigo?

<p>In cases with numerous lesions or outbreaks affecting multiple people. (A)</p> Signup and view all the answers

What is the MOST important factor when deciding between antibiotics for cellulitis?

<p>Knowledge of specific bacterial species (D)</p> Signup and view all the answers

What clinical finding would be MOST concerning for necrotizing fasciitis?

<p>Pain out of proportion to exam findings (D)</p> Signup and view all the answers

What makes managing Fournier gangrene uniquely challenging compared to other causes of necrotizing fasciitis?

<p>Commonality to have underlying diseases such as diabetes (D)</p> Signup and view all the answers

What clinical characteristic is most helpful in differentiating between non-purulent cellulitis and erysipelas?

<p>Depth of the infection (B)</p> Signup and view all the answers

A patient diagnosed with cellulitis who is allergic to penicillin requires an alternative antibiotic. Which of these would also effectively target _Streptococcus _ species?

<p>Azithromycin (A)</p> Signup and view all the answers

A patient with multiple recurrent cutaneous abscesses is undergoing decolonization. Which measure is MOST important to emphasize for preventing future infections?

<p>Regularly changing bed linens and towels. (A)</p> Signup and view all the answers

For a patient with cellulitis being treated with IV antibiotics, what finding would suggest need for adjunct systemic corticosteroids?

<p>Dramatic inflammatory response (A)</p> Signup and view all the answers

What is the rationale for using clindamycin as an adjunct treatment in necrotizing fasciitis, beyond its direct antibacterial effects?

<p>Suppress bacterial toxin and cytokine production. (B)</p> Signup and view all the answers

What is the MOST appropriate initial step when a patient exhibits signs of necrotizing fasciitis?

<p>Surgical consult (B)</p> Signup and view all the answers

A patient with a moderate, non-purulent cellulitis is being discharged on oral antibiotics. Which would be MOST appropriate?

<p>Cephalexin (C)</p> Signup and view all the answers

For a patient with recurrent cellulitis despite addressing all predisposing factors, which prophylactic measure is advised?

<p>Prophylactic antibiotics (A)</p> Signup and view all the answers

Abscesses commonly involve which pathogen?

<p>Staph aureus (C)</p> Signup and view all the answers

In the context of SSTIs, which of the following scenarios would most likely lead to a polymicrobial infection?

<p>An infection arising from a decubitus ulcer in a long-term care patient. (C)</p> Signup and view all the answers

A patient presents with a suspected SSTI. Initial assessment reveals an area of redness and swelling with no purulent drainage. What is the MOST important next step in determining the appropriate antibiotic therapy?

<p>Determine if the infection is cellulitis, erysipelas, or necrotizing infection. (C)</p> Signup and view all the answers

A patient is diagnosed with cellulitis of the lower extremity. Despite 48 hours of IV nafcillin, the patient remains febrile. The area of erythema and swelling has not decreased and patient is complaining of increased pain. Which of the following would be MOST appropriate?

<p>Obtain surgical consult and consider imaging to rule out necrotizing fasciitis. (B)</p> Signup and view all the answers

Which of the following factors MOST strongly suggests that an SSTI is necrotizing fasciitis rather than severe cellulitis?

<p>Pain that is disproportionate to physical exam findings. (B)</p> Signup and view all the answers

In a patient with necrotizing fasciitis, which of the following is the MOST important determinant of survival?

<p>Prompt and aggressive surgical debridement. (B)</p> Signup and view all the answers

A patient with a history of injection drug use presents with a carbuncle. After incision and drainage, cultures grow MRSA. Which oral antibiotic would be MOST appropriate for outpatient treatment?

<p>Doxycycline. (D)</p> Signup and view all the answers

A young child presents with honey-colored crusted lesions around the nose and mouth. Topical mupirocin is prescribed. What is the MOST important instruction to give the parents regarding the application of the medication?

<p>Ensure the area is gently cleaned before application and apply twice daily, avoiding excessive use. (C)</p> Signup and view all the answers

A patient is being treated for recurrent furuncles. After incision and drainage of a recent lesion, decolonization strategies are being considered. Which regimen is the MOST comprehensive approach for decolonization?

<p>Intranasal mupirocin, chlorhexidine washes, and decontamination of personal items. (D)</p> Signup and view all the answers

In managing cellulitis, which of the following patient characteristics would MOST warrant empiric coverage for MRSA in addition to typical streptococcal coverage?

<p>Recent hospitalization and known MRSA colonization. (C)</p> Signup and view all the answers

A patient with cellulitis is being discharged on oral cephalexin. Which sign or symptom should the patient be instructed to monitor closely and return immediately if it develops, suggesting the antibiotic is not effective or the infection is worsening?

<p>Development of hemorrhagic bullae or skin sloughing. (B)</p> Signup and view all the answers

Which of the following clinical findings would definitively indicate that a patient's skin and soft tissue infection (SSTI) should be classified as severe?

<p>Failure to respond to appropriate oral antibiotics and the absence of purulence. (A)</p> Signup and view all the answers

A patient with recurrent cellulitis, despite addressing predisposing factors, is being considered for prophylactic antibiotics. Which of the following is the MOST important consideration before initiating long-term antibiotic prophylaxis?

<p>Potential for antibiotic resistance and adverse effects. (D)</p> Signup and view all the answers

Patients with Fournier gangrene typically require broad-spectrum antibiotics. What is the MOST critical initial intervention alongside antibiotic therapy?

<p>Surgical debridement of necrotic tissue. (C)</p> Signup and view all the answers

When managing necrotizing fasciitis, which of the following is the MOST important rationale for using clindamycin in addition to other broad-spectrum antibiotics?

<p>Its ability to suppress bacterial toxin production, thereby reducing systemic toxicity. (B)</p> Signup and view all the answers

What is the primary reason Gram stain and culture are typically deemed unnecessary in uncomplicated cases of impetigo?

<p>The causative pathogens of impetigo are predictable, and empiric treatment is typically effective. (A)</p> Signup and view all the answers

A patient has a large carbuncle on their neck with signs of systemic infection. After incision and drainage, cultures are sent. Empirically, what is the MOST appropriate initial antibiotic regimen while awaiting culture results?

<p>Intravenous vancomycin. (C)</p> Signup and view all the answers

A patient presents with an SSTI characterized by a painful, rapidly spreading area of redness and swelling on their lower leg. They also report a fever and chills. Which of the following findings would be MOST concerning for necrotizing fasciitis?

<p>The presence of crepitus upon palpation of the affected area. (A)</p> Signup and view all the answers

An immunocompromised patient develops a severe purulent SSTI that does not respond to initial incision and drainage. Systemic signs of infection include a temperature above 38°C, a heart rate above 90 bpm, a respiratory rate above 24, and an abnormal WBC. Which antibiotic would be the MOST adequate choice to combat the infection?

<p>Vancomycin. (A)</p> Signup and view all the answers

In cases of recurrent skin abscesses, what is the MOST crucial aspect of decolonization strategies to preventing future infections?

<p>Use of intranasal mupirocin, coupled with chlorhexidine washes and sanitary practices. (C)</p> Signup and view all the answers

What clinical finding would MOST likely warrant initiation of systemic antibiotics in a patient presenting with a furuncle?

<p>Development of a fever and chills. (D)</p> Signup and view all the answers

In a patient diagnosed with cellulitis who is allergic to penicillin, which agent effectively targets Streptococcus species while considering potential allergies?

<p>Azithromycin. (B)</p> Signup and view all the answers

For a patient with multiple recurrent cutaneous abscesses undergoing decolonization, what is the MOST crucial measure to emphasize for the prevention of future infections?

<p>Maintaining meticulous personal hygiene, including regular handwashing. (D)</p> Signup and view all the answers

For a patient with cellulitis being treated with IV antibiotics, what finding would MOST strongly indicate the need for adjunct systemic corticosteroids?

<p>Persistent elevations in inflammatory markers despite antibiotic usage. (A)</p> Signup and view all the answers

What action should the healthcare provider need to take when a patient exhibits signs of necrotizing fasciitis?

<p>Obtain immediate surgical consultation for possible debridement. (A)</p> Signup and view all the answers

A patient with a moderate, non-purulent cellulitis exhibits is being discharged. What antibiotic should they discharge with?

<p>Cephalexin. (D)</p> Signup and view all the answers

What clinical feature is MOST helpful in differentiating between non-purulent cellulitis and erysipelas upon initial examination?

<p>The sharpness of the skin. (D)</p> Signup and view all the answers

Which of the following factors is MOST critical for determining the need for systemic antibiotics in the management of a furuncle?

<p>The presence of systemic signs of infection. (D)</p> Signup and view all the answers

Which of the organism is MOST suggestive for Necrotizing Fasciitis?

<p>Vibrio vulnificus. (C)</p> Signup and view all the answers

What is the purpose when administering clindamycin as an adjunct in treating Necrotizing Fasciitis?

<p>Inhibits bacterial toxin production to reduce systemic toxicity. (B)</p> Signup and view all the answers

What is the significance level of a skin lesion to define ABSSSI (Acute Bacterial Skin and Skin Structure Infection)?

<p>75 cm^2 (D)</p> Signup and view all the answers

In Cellulitis. what clinical finding would suggest this would represent a severe infection?

<p>Sign of deeper infection (skin sloughing). (C)</p> Signup and view all the answers

In dealing with Recurrent Cellulitis, what would be a re-occuring predisposing factor?

<p>Toe abnormalities. (B)</p> Signup and view all the answers

Why are blood cultures not recommended in Celullitis?

<p>Low benefits to the culture. (B)</p> Signup and view all the answers

Why is the evaluation critical for assessing a patient when it comes to soft tissue infection?

<p>To help evaluate any sort of crepitus. (C)</p> Signup and view all the answers

A patient displays the following sypmtoms on his skin: painful, tender, red nodule. What condition would likely fall under this?

<p>Cutaneous abscesses (C)</p> Signup and view all the answers

In the terms of severity for Non-Purulent SSTI's, define what characterizies severe?

<p>Signs of deeper infection. (D)</p> Signup and view all the answers

When evaluating patients for Necrotizing faciitis, what can be expected from signs and findings?

<p>Fascia swollen and grey (B)</p> Signup and view all the answers

If the signs are similar to cellulitis, what is key symptoms that are common with Necrotizing Fasciitis?

<p>Hard, wooden feeling tissue. (D)</p> Signup and view all the answers

What key factor distinguishes severe non-purulent SSTIs from moderate cases?

<p>Failure of antibiotic treatment with signs of deeper infection (e.g., skin sloughing, hypotension, organ dysfunction). (B)</p> Signup and view all the answers

In managing a patient with necrotizing fasciitis, why is prompt surgical intervention considered a critical step?

<p>To debride necrotic tissue and control the spread of infection, which antibiotics alone cannot achieve. (C)</p> Signup and view all the answers

For a patient with recurrent furuncles, what is the MOST effective strategy for decolonization to prevent future infections, considering both the patient and their environment?

<p>Twice-daily intranasal mupirocin, daily chlorhexidine washes, and decontamination of towels, sheets, and clothes. (C)</p> Signup and view all the answers

A patient is diagnosed with cellulitis and is allergic to penicillin. Considering the need to effectively target Streptococcus species while minimizing the risk of adverse reactions, which of the following would be MOST appropriate?

<p>Clindamycin (B)</p> Signup and view all the answers

What is the underlying rationale for using clindamycin as an adjunct treatment in necrotizing fasciitis, beyond its direct antibacterial effects?

<p>To inhibit protein synthesis, suppressing the production of bacterial toxins and cytokines. (C)</p> Signup and view all the answers

A 62-year-old male with a history of diabetes presents with a painful, rapidly spreading soft tissue infection in his groin area. Physical exam reveals crepitus and a foul odor. What is the MOST likely diagnosis and the FIRST critical step in management?

<p>Fournier gangrene; Immediate surgical consultation for debridement. (C)</p> Signup and view all the answers

Which clinical indicator is MOST suggestive of necrotizing fasciitis, requiring immediate and aggressive intervention, rather than severe cellulitis?

<p>Localized, intense pain that is disproportionate to clinical findings, accompanied by systemic toxicity. (D)</p> Signup and view all the answers

According to the FDA, what would be the criteria to define ABSSSI in SSTI’s?

<p>Lesion Size over 75cm (A)</p> Signup and view all the answers

Patients with Fournier gangrene often require broad-spectrum antibiotics and may have underlying medical conditions. What is the MOST critical initial intervention?

<p>Emergent surgical debridement. (C)</p> Signup and view all the answers

For a patient without systemic illness who is diagnosed with cellulitis and is to be treated as an outpatient, what oral antibiotic would be MOST appropriate?

<p>Cephalexin (A)</p> Signup and view all the answers

Which of the following factors MOST strongly suggests that a skin and soft tissue infection is necrotizing fasciitis rather than severe cellulitis?

<p>Pain is disproportionate to physical findings (C)</p> Signup and view all the answers

Why are Gram stain and culture typically deemed unnecessary in uncomplicated cases of impetigo?

<p>The causative organisms are predictable, and treatment is empiric. (C)</p> Signup and view all the answers

In cases of recurrent skin abscesses, what is the MOST crucial aspect of prevention?

<p>Chlorhexidine and Mupirocin (D)</p> Signup and view all the answers

Flashcards

SSTIs

Infections involving any or all layers of the skin, fascia, and muscle.

Purulent vs. Non-Purulent SSTIs

Distinguishing between infections with pus (purulent) and those without (non-purulent) to guide appropriate treatment strategies.

SSTI: Key Aspects

Understanding the distribution, causes, disease mechanisms, common germs, signs, diagnosis, and care for both types of SSTIs and a severe form called necrotizing fasciitis.

Impetigo

A common skin infection presenting with erythematous papules evolving into vesicles and pustules, leading to honey-colored dry discharge.

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Diagnosing Impetigo

Based on clinical presentation, gram stains and cultures are not necessary in typical cases.

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Treating Impetigo

Involves topical mupirocin or oral agents like S. aureus for 7 days, especially in outbreaks.

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Purulent SSTI Severity

Severity of purulent SSTIs are determined by systemic signs of infection based on mild, moderate and severe.

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Cutaneous Abscesses Management

First line treatment of Cutaneous Abscesses, consider cultures for moderate-to-severe cases.

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Furuncle Management

Rupture and drain spontaneously or with moist heat. Large furuncles may require I&D +/- C&S. Systemic antibiotics usually unnecessary.

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Carbuncle Management

First line is I&D +/- C&S. Systemic antibiotics usually unnecessary. Unless fever or other signs of systemic infection (moderate-to-severe)

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Recurrent Skin Abscesses

Drain and culture early. Treat against identified pathogen. Evaluate/consider other causes. 5-day decolonization regimen?

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Decolonization

Twice daily intranasal mupirocin, Daily chlorhexidine washes, and Decontamination of towels, sheets, clothes.

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Non-Purulent SSTI - Severity

Mild, Moderate, or Severe; Failed antibiotics; Systemic signs of infection; Immunocompromised; Signs of deeper infection (skin sloughing, hypotension, organ dysfunction)

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Cellulitis Management

Elevate, Cultures typically unnecessary, Treatment with antibiotics x5 days, Consider adjunct systemic corticosteroids

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Necrotizing Fasciitis

Prompt surgical intervention, Frequent repeat surgeries, Broad empiric antibiotic treatment, Narrow as appropriate

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SSTI Review

Review common skin and soft tissue infections.

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SSTI Differentiation

Differentiate between purulent and non-purulent SSTIs to guide management.

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SSTI: Comprehensive analysis

Discuss disease spread, causes, germs, signs, diagnosis, and treatment of purulent and non-purulent SSTIs, along with necrotizing fasciitis.

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Cutaneous Abscesses

Bacterial collections of pus within the skin.

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Furuncles

Superficial infections of the hair follicle, inflammatory nodules with overlying pustules, commonly S. aureus

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Carbuncles

Several adjacent furuncles, inflammatory mass with pus draining from multiple orifices

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Impetigo Treatment

Management involves topical mupirocin BID for 5 days.

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ABSSSI

Acute bacterial skin and skin structure infections.

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Skin's Role in Infection

Intact skin provides defense against infection

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SSTI Risk Factors

Skin puncture, abrasion, etc., disrupt normal host defenses.

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Impetigo Organisms

Staphylococcus aureus and Streptococcus species

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Abscesses Definition

Collections of pus.

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Non-purulent ABSSSI

Superficial infections that are Diffuse, Superficial, and Spreading

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Cellulitis Risks

Fragile skin, trauma, ulceration, and/or edema from venous insufficiency.

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Cellulitis Cause

Streptococcus species

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Necrotizing Fasciitis Definition

Flesh eating infection with a deep, aggressive infection and is a Surgical emergency .

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Necrotizing Fasciitis Findings

Initial presentation is similar to cellulitis with Pain out of proportion, Hard, wooden feeling of tissue, Crepitus, and Fascia that is swollen and grey.

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Debridement

Surgical removal of dead tissue.

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Fournier Gangrene

Involves scrotum, penis or vulva and treats as with other necrotizing fasciitis infections.

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Recurrent Cellulitis

Annual recurrence rates of 8-20% and consider prophylactic antibiotics if 3-4 episodes/year.

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FDA: ABSSSI

A guide for assessing treatment effectiveness in acute bacterial skin and skin structure infections.

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SSTI Culprit

Staphylococcus aureus.

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Decolonization Method

Twice daily intranasal mupirocin and Daily chlorhexidine washes

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Furuncles/Carbuncles Tx

Systemic antibiotics usually unnecessary unless there is fever or other signs of systemic infection.

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Cellulitis Treatment

Oral antibiotics for five days: Penicillin VK or Cephalexin

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Necrotizing Fasciitis Sign

The initial presentation is similar to cellulitis, however Pain is out of proportion.

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Study Notes

Objectives

  • This lecture reviews common skin and soft tissue infections (SSTIs)
  • It differentiates between purulent and non-purulent SSTIs, detailing the appropriate management strategies for each type
  • The lecture will cover the epidemiology, pathogenesis, microbiology, clinical manifestations, diagnosis, and treatment of both purulent and non-purulent SSTIs, as well as necrotizing fasciitis

Relevant Terminology

  • SSTI refers to skin and soft tissue infection
  • SSI refers to skin and skin structure infection
  • ABSSSI refers to acute bacterial skin and skin structure infections

Epidemiology of SSTIs

  • Approximately 14 million people are affected by SSTIs each year
  • Inpatient admissions and outpatient visits for SSTIs increased by 65% in the early 2000s over a 9-year period
  • SSTIs account for 2% of all hospitalizations
  • There are 6.3 million physician office visits annually due to SSTIs

General Information on SSTIs

  • SSTIs involve any or all layers of the skin, fascia, and muscle
  • They are generally caused by a single pathogen
  • Exceptions include diabetic foot infections, bite wounds, and burn wounds which may have multiple pathogens

Pathophysiology of SSTIs

  • The intact skin serves as a defense against infection
  • SSTIs typically arise from disruptions to normal host defenses, such as skin punctures or abrasions
  • The majority of SSTIs are caused by organisms already present on the skin surface

Impetigo

  • Begins with erythematous papules that evolve into vesicles and pustules
  • After rupturing, vesicles and pustules develop a honey-colored dry discharge over an erythematous base
  • Clinical presentation is the means of diagnosis
  • Gram stains and cultures are unnecessary in typical cases
  • Staphylococcus aureus and Streptococcus species are the most common causative organisms
  • Treatment includes topical mupirocin applied twice daily for 5 days, which is as effective as oral antimicrobials for impetigo
  • Oral agents active against S. aureus are used for 7 days, typically for methicillin-susceptible organisms
  • Oral treatment is preferred for numerous lesions or when outbreaks affect multiple people

Purulent SSTI Severity

  • Mild: None of the listed criteria for moderate or severe infections are present
  • Moderate: Systemic signs of infection are observed
  • Severe: Characterized by failed incision and drainage plus antibiotics, systemic signs of infection (temperature >38°C, heart rate >90 bpm, respiratory rate >24, abnormal WBC count), or the patient is immunocompromised

Cutaneous Abscesses

  • Characterized by collections of pus
  • Present as painful, tender, red nodules encircled by erythematous swelling
  • Staphylococcus aureus is the most common causative agent
  • Incision and drainage (I&D) is the first-line management
  • Culture and susceptibilities testing (C&S) is recommended for moderate-to-severe cases
  • Systemic antibiotics typically don't improve cure rates for mild infections, but should be considered for moderate-to-severe cases, significant systemic infection, extremes of age, multiple abscesses, impaired host defenses, or lack of response to I&D

Furuncles

  • Superficial infections of the hair follicle
  • Manifest as inflammatory nodules with overlying pustules
  • Most commonly caused by S. aureus
  • Often rupture and drain spontaneously or with moist heat
  • Larger furuncles may require I&D +/- C&S
  • Systemic antibiotics are usually unnecessary unless there is fever or other signs of systemic infection indicative of moderate-to-severe infection

Carbuncles

  • Several adjacent furuncles
  • Characterized by an inflammatory mass with pus draining from multiple orifices
  • Commonly found on the back of the neck
  • First-line management is I&D +/- C&S
  • Systemic antibiotics are usually unnecessary unless fever or other signs of systemic infection are present (moderate-to-severe)

Recurrent Skin Abscesses

  • A strategy includes draining and culturing early, treating against the identified pathogen, considering other possible causes, and implementing a 5-day decolonization regimen
  • Decolonization involves twice-daily intranasal mupirocin, daily chlorhexidine washes, and decontamination of towels, sheets, and clothes

Purulent SSTI Summary

  • First-line management involves incision and drainage (I&D)
  • Cultures and susceptibilities are needed if the infection is moderate/severe
  • Antibiotics may or may not be necessary
  • Think Staphylococcus aureus

Antibiotic Treatment Options for Purulent SSTIs

  • MRSA IV antibiotics include Vancomycin, Daptomycin, Ceftaroline, Telavancin, Dalbavancin, Oritavancin, and Delafloxacin
  • MRSA oral antibiotics include Linezolid, tedizolid, Clindamycin, Doxycycline, minocycline, and Trimethoprim-sulfamethoxazole
  • MSSA (IV/PO) antibiotics include Nafcillin, oxacillin, dicloxacillin, Cephalexin, and Cefazolin

Severity of Non-Purulent SSTI

  • Mild: None of the below criteria for moderate or severe infection are present
  • Moderate: Exhibits signs or symptoms of systemic infection
  • Severe: Characterized by failed antibiotics; systemic signs of infection (temperature >38°C, heart rate >90 bpm, respiratory rate >24, abnormal WBC count); immunocompromised status; or signs of deeper infection such as skin sloughing, hypotension, or organ dysfunction

Cellulitis

  • Cellulitis is linked to fragile skin, trauma, ulceration, or edema from venous insufficiency
  • It is also frequently caused by breaks in the skin that are clinical unapparent and small
  • The lower legs are the most common site
  • Affected areas are typically red, swollen, and warm to the touch
  • The most common causative organism are Streptococcus species, including group A Strep
  • If moderate infection, consider MSSA
  • Other considerations: Gynecologic cancer with surgery/radiation, consider Group B Strep and open wound, penetrating trauma, known MRSA colonization, SIRS, IVDU; consider MRSA
  • Management includes elevation of the affected limb
  • Cultures are typically unnecessary, with blood cultures positive in <5% of cases
    • Exceptions: On chemotherapy, severe systemic features, animal bites, water immersion injuries, neutropenia, and severe cell-mediated immunodeficiency
  • Treatment is with antibiotics for 5 days
  • Antibiotics targeting Streptococcus species are typically initiated
  • Many patients can receive oral therapy
  • Adjunct systemic corticosteroids may also be considered

Antibiotics for Strep Skin Infections

  • IV antibiotics include Penicillin 2-4 million units q4-6h, Clindamycin 600-900 mg q8h, Nafcillin 1-2g q4-6h, and Cefazolin 1g q8h
  • Oral antibiotics include Penicillin VK 250-500 mg q6h and Cephalexin 500 mg q6h

Recurrent Cellulitis

  • Annual recurrence rates range from 8-20%
  • Predisposing factors include edema, obesity, eczema, venous insufficiency, toe web abnormalities, tobacco use, and homelessness
  • Prophylactic antibiotics should be considered for patients who experience 3-4 episodes per year despite controlling predisposing factors
  • Penicillin (PO/IM) and erythromycin can be used

Treatment for Nonpurulent SSTIs

  • Severe: Requires emergent surgical inspection/debridement to rule out necrotizing process
    • Give empiric Rx; Vancomycin PLUS Piperacillin/Tazobactam, and C & S
  • Moderate: Give intravenous Rx Penicillin or Ceftriaxone or Cefazolin or Clindamycin
  • Mild: Give oral Rx: Penicillin VK or Cephalosporin or Dicloxacillin or Clindamycin

Necrotizing Fasciitis

  • Serious "flesh eating infection”
  • Deep, aggressive infection that can lead to major tissue destruction and death
  • May develop from an initial break in the skin or from non-penetrating trauma with no known portal of entry
  • It is a surgical emergency
  • Presentation/Findings: Initial presentation similar to cellulitis, pain out of proportion, hard, wooden feeling of tissue, Crepitus – cracking/crunching sound due to air, CT/MRI may show edema/necrosis, and Fascia is swollen and gray, brownish exudate, no true pus
  • Causative Organisms: Streptococcus pyogenes, Staphylococcus aureus, Aeromonas hydrophila, Vibrio vulnificus, and Polymicrobial (Perianal abscesses, decubitus ulcers, injection sites in IVDU and Spread from genital site

Treatment of Necrotizing Fasciitis

  • Treatment approach includes prompt surgical intervention, frequent repeat surgeries, broad empiric antibiotic treatment (covering MRSA, aerobes, and anaerobes), and duration until debridement is no longer deemed necessary, with clinical improvement and the patient being fever-free for 48-72 hours. A narrow antibiotic directed towards infection can be used, as needed
  • Commonly used drugs include Vancomycin, Linezolid, or Daptomycin, combined with either Piperacillin/Tazobactam, a carbapenem, Ceftriaxone + Metronidazole, or a fluoroquinolone + Metronidazole
  • Clindamycin should also be given
  • Bacterial toxins may result in organ failure, shock, tissue destruction
  • Adjunct clindamycin is used for suppression of toxin and cytokine production
  • IVIG and Linezolid

Fournier Gangrene

  • Type of necrotizing soft tissue infection that affects the scrotum, penis, or vulva
  • Onset commonly occurs between ages 50-60
  • 80% present with underlying diseases, commonly diabetes
  • Most often polymicrobial
  • Treatment mirrors other necrotizing fasciitis infections

FDA Guidance

  • The FDA defines acute bacterial skin and skin structure infection (ABSSSI) as a bacterial infection of the skin with a lesion size area of at least 75 cm²

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