Podcast
Questions and Answers
What does the acronym SSTI stand for?
What does the acronym SSTI stand for?
- Severe Systemic Tissue Infection
- Skin and Soft Tissue Infection (correct)
- Superficial Skin Tissue Irritation
- Skin and Surface Tissue Inflammation
Which of the following is a key objective when dealing with SSTIs?
Which of the following is a key objective when dealing with SSTIs?
- To differentiate between purulent and non-purulent infections. (correct)
- To avoid any diagnostic procedures.
- To specifically target viral causes of skin infections.
- To only use oral antibiotics to manage SSTIs.
What is the estimate of how many people are affected by SSTIs each year?
What is the estimate of how many people are affected by SSTIs each year?
- 50 million
- 100,000
- 1 million
- 14 million (correct)
SSTIs involve infections located:
SSTIs involve infections located:
What usually causes most SSTIs?
What usually causes most SSTIs?
What is the function of intact skin in the context of infections?
What is the function of intact skin in the context of infections?
What is a common sign of Impetigo?
What is a common sign of Impetigo?
How is Impetigo typically diagnosed?
How is Impetigo typically diagnosed?
A typical treatment for Impetigo involves:
A typical treatment for Impetigo involves:
What is the recommended duration for using topical mupirocin to treat impetigo?
What is the recommended duration for using topical mupirocin to treat impetigo?
What is a key characteristic of a purulent SSTI?
What is a key characteristic of a purulent SSTI?
How are mild purulent SSTIs typically managed?
How are mild purulent SSTIs typically managed?
When are systemic antibiotics considered in the treatment of purulent SSTIs?
When are systemic antibiotics considered in the treatment of purulent SSTIs?
What is the first-line management for cutaneous abscesses?
What is the first-line management for cutaneous abscesses?
What organism most commonly causes cutaneous abscesses?
What organism most commonly causes cutaneous abscesses?
What is a furuncle?
What is a furuncle?
Why are systemic antibiotics often unnecessary for furuncles?
Why are systemic antibiotics often unnecessary for furuncles?
Where do carbuncles commonly occur on the body?
Where do carbuncles commonly occur on the body?
Typical management of carbuncles involves:
Typical management of carbuncles involves:
If a patient has recurrent skin abscesses, what might be considered after initial treatment?
If a patient has recurrent skin abscesses, what might be considered after initial treatment?
What does decolonization typically involve?
What does decolonization typically involve?
Which of the following organisms is the primary concern in purulent SSTIs?
Which of the following organisms is the primary concern in purulent SSTIs?
What is the first-line management of purulent SSTIs?
What is the first-line management of purulent SSTIs?
Which of the following antibiotics is an option for MSSA infections?
Which of the following antibiotics is an option for MSSA infections?
What is a key difference between cellulitis and erysipelas?
What is a key difference between cellulitis and erysipelas?
What kind of breaks do you typically see in the skin in cases of cellulitis?
What kind of breaks do you typically see in the skin in cases of cellulitis?
A common symptom in cellulitis includes:
A common symptom in cellulitis includes:
What is the most common cause of cellulitis?
What is the most common cause of cellulitis?
The treatment of cellulitis typically involves:
The treatment of cellulitis typically involves:
Adjunct systemic corticosteroids may be considered with:
Adjunct systemic corticosteroids may be considered with:
What is often implicated in recurrent cellulitis?
What is often implicated in recurrent cellulitis?
What is a common antibiotic for cellulitis related to Strep?
What is a common antibiotic for cellulitis related to Strep?
Necrotizing fasciitis is often described as a:
Necrotizing fasciitis is often described as a:
What is a key initial sign of necrotizing fascitis?
What is a key initial sign of necrotizing fascitis?
What is a critical step to take with a patient with necrotizing fascitis?
What is a critical step to take with a patient with necrotizing fascitis?
When clinically assessing necrotizing fascitis, what can CT's show?
When clinically assessing necrotizing fascitis, what can CT's show?
Typical bacteria include for causative organisms for Necrotizing Fasciitis?
Typical bacteria include for causative organisms for Necrotizing Fasciitis?
What is the most common cause of skin and soft tissue infections?
What is the most common cause of skin and soft tissue infections?
The skin's primary role in preventing infections is to act as a:
The skin's primary role in preventing infections is to act as a:
Impetigo is typically characterized by which of the following skin findings?
Impetigo is typically characterized by which of the following skin findings?
In typical cases, how is impetigo diagnosed?
In typical cases, how is impetigo diagnosed?
What is a common topical antibiotic used to treat impetigo?
What is a common topical antibiotic used to treat impetigo?
A key feature of a purulent skin and soft tissue infection is the presence of:
A key feature of a purulent skin and soft tissue infection is the presence of:
For mild purulent SSTIs, the primary management strategy is:
For mild purulent SSTIs, the primary management strategy is:
What is the term for a collection of pus within the skin?
What is the term for a collection of pus within the skin?
The most common bacterial cause of cutaneous abscesses is:
The most common bacterial cause of cutaneous abscesses is:
What is a furuncle commonly known as?
What is a furuncle commonly known as?
Carbuncles are best described as:
Carbuncles are best described as:
For recurrent skin abscesses, decolonization strategies typically include:
For recurrent skin abscesses, decolonization strategies typically include:
In purulent SSTIs, the primary bacterial pathogen of concern is generally:
In purulent SSTIs, the primary bacterial pathogen of concern is generally:
What is a key clinical difference between cellulitis and erysipelas?
What is a key clinical difference between cellulitis and erysipelas?
Cellulitis is most commonly caused by which bacteria?
Cellulitis is most commonly caused by which bacteria?
Which type of skin and soft tissue infection (SSTI) typically involves deeper layers, potentially including fascia and muscle?
Which type of skin and soft tissue infection (SSTI) typically involves deeper layers, potentially including fascia and muscle?
In purulent SSTIs, when is it most appropriate to perform a culture and susceptibility test?
In purulent SSTIs, when is it most appropriate to perform a culture and susceptibility test?
What is the primary reason clindamycin may be used as an adjunct treatment in necrotizing fasciitis?
What is the primary reason clindamycin may be used as an adjunct treatment in necrotizing fasciitis?
Which of the following empiric antibiotic regimens would be most appropriate for a severe purulent SSTI, assuming MRSA coverage is necessary?
Which of the following empiric antibiotic regimens would be most appropriate for a severe purulent SSTI, assuming MRSA coverage is necessary?
Which of the following is a key characteristic that differentiates a carbuncle from a furuncle?
Which of the following is a key characteristic that differentiates a carbuncle from a furuncle?
What is the primary goal of decolonization strategies in patients with recurrent skin abscesses?
What is the primary goal of decolonization strategies in patients with recurrent skin abscesses?
What is a typical first-line intervention for managing cutaneous abscesses?
What is a typical first-line intervention for managing cutaneous abscesses?
Why are systemic antibiotics often deemed unnecessary in the management of furuncles unless specific conditions are met?
Why are systemic antibiotics often deemed unnecessary in the management of furuncles unless specific conditions are met?
Which of the following underlying conditions would raise suspicion for considering MRSA coverage in a patient presenting with cellulitis?
Which of the following underlying conditions would raise suspicion for considering MRSA coverage in a patient presenting with cellulitis?
What is a key early sign or symptom that should raise suspicion for necrotizing fasciitis rather than simple cellulitis?
What is a key early sign or symptom that should raise suspicion for necrotizing fasciitis rather than simple cellulitis?
What is the recommended duration of topical mupirocin treatment for impetigo?
What is the recommended duration of topical mupirocin treatment for impetigo?
For cellulitis, which scenario would most warrant consideration of adjunct systemic corticosteroids?
For cellulitis, which scenario would most warrant consideration of adjunct systemic corticosteroids?
A patient with a history of intravenous drug use presents with cellulitis, and MRSA colonization is suspected. Which antibiotic is most appropriate?
A patient with a history of intravenous drug use presents with cellulitis, and MRSA colonization is suspected. Which antibiotic is most appropriate?
What is the most critical first step in managing a patient suspected of having necrotizing fasciitis?
What is the most critical first step in managing a patient suspected of having necrotizing fasciitis?
In managing recurrent cellulitis, what prophylactic antibiotic is commonly considered, assuming no allergies or contraindications?
In managing recurrent cellulitis, what prophylactic antibiotic is commonly considered, assuming no allergies or contraindications?
Which of the following best describes the typical presentation of a patient with Fournier gangrene?
Which of the following best describes the typical presentation of a patient with Fournier gangrene?
Which imaging modality can be used to assess the extent of tissue involvement and confirm the presence of gas in the soft tissues in Necrotizing fasciitis?
Which imaging modality can be used to assess the extent of tissue involvement and confirm the presence of gas in the soft tissues in Necrotizing fasciitis?
Besides Streptococcus pyogenes and Staphylococcus aureus, which organism is increasingly recognized as a potential cause of necrotizing fasciitis, especially in aquatic environments?
Besides Streptococcus pyogenes and Staphylococcus aureus, which organism is increasingly recognized as a potential cause of necrotizing fasciitis, especially in aquatic environments?
Which of the following treatment strategies is essential for patients with necrotizing fasciitis to prevent systemic toxicity caused by bacterial toxins?
Which of the following treatment strategies is essential for patients with necrotizing fasciitis to prevent systemic toxicity caused by bacterial toxins?
Why is the assessment of crepitus important in the evaluation of a patient with a suspected soft tissue infection?
Why is the assessment of crepitus important in the evaluation of a patient with a suspected soft tissue infection?
According to the FDA, what is the minimum lesion size area to define ABSSSI (Acute Bacterial Skin and Skin Structure Infection)?
According to the FDA, what is the minimum lesion size area to define ABSSSI (Acute Bacterial Skin and Skin Structure Infection)?
In a non-purulent SSTI such as cellulitis, what clinical finding would suggest the infection is severe?
In a non-purulent SSTI such as cellulitis, what clinical finding would suggest the infection is severe?
Which of the following predisposing factors is associated with recurrent cellulitis?
Which of the following predisposing factors is associated with recurrent cellulitis?
In patients with cellulitis, why are blood cultures generally not recommended?
In patients with cellulitis, why are blood cultures generally not recommended?
An immunocompromised patient is diagnosed with a severe case of purulent SSTI that failed initial incision and drainage. Which of the following systemic signs would indicate the infection's severity?
An immunocompromised patient is diagnosed with a severe case of purulent SSTI that failed initial incision and drainage. Which of the following systemic signs would indicate the infection's severity?
A patient presents with a painful, tender, red nodule encircled by erythematous swelling, which contains a collection of pus. Which condition is most likely indicated by these symptoms?
A patient presents with a painful, tender, red nodule encircled by erythematous swelling, which contains a collection of pus. Which condition is most likely indicated by these symptoms?
What is a common causative organism for cutaneous abscesses?
What is a common causative organism for cutaneous abscesses?
Which microorganism is commonly associated with cellulitis infections, especially in cases not related to open wounds or MRSA?
Which microorganism is commonly associated with cellulitis infections, especially in cases not related to open wounds or MRSA?
What clinical characteristic is most indicative of severe impetigo requiring oral antibiotics rather than topical treatment?
What clinical characteristic is most indicative of severe impetigo requiring oral antibiotics rather than topical treatment?
Which of the following is a typical symptom associated with cellulitis?
Which of the following is a typical symptom associated with cellulitis?
What type of SSTI is often described as a 'flesh-eating infection'?
What type of SSTI is often described as a 'flesh-eating infection'?
What is the primary management for mild purulent SSTIs?
What is the primary management for mild purulent SSTIs?
What initial interventions are MOST critical for necrotizing fasciitis?
What initial interventions are MOST critical for necrotizing fasciitis?
What is the most common cause of SSTI's?
What is the most common cause of SSTI's?
Which best describes the function of intact skin in the context of preventing infections?
Which best describes the function of intact skin in the context of preventing infections?
What are the typical skin findings for Impetigo?
What are the typical skin findings for Impetigo?
What systemic antibiotic is usually unnecessary for furuncles?
What systemic antibiotic is usually unnecessary for furuncles?
What is the primary factor that differentiates moderate from severe purulent skin and soft tissue infections (SSTIs)?
What is the primary factor that differentiates moderate from severe purulent skin and soft tissue infections (SSTIs)?
In the management of a furuncle, what condition necessitates the use of systemic antibiotics?
In the management of a furuncle, what condition necessitates the use of systemic antibiotics?
Why might an oral agent active against _S. aureus_
be preferred over topical mupirocin in the treatment of impetigo?
Why might an oral agent active against _S. aureus_
be preferred over topical mupirocin in the treatment of impetigo?
What is the MOST important factor when deciding between antibiotics for cellulitis?
What is the MOST important factor when deciding between antibiotics for cellulitis?
What clinical finding would be MOST concerning for necrotizing fasciitis?
What clinical finding would be MOST concerning for necrotizing fasciitis?
What makes managing Fournier gangrene uniquely challenging compared to other causes of necrotizing fasciitis?
What makes managing Fournier gangrene uniquely challenging compared to other causes of necrotizing fasciitis?
What clinical characteristic is most helpful in differentiating between non-purulent cellulitis and erysipelas?
What clinical characteristic is most helpful in differentiating between non-purulent cellulitis and erysipelas?
A patient diagnosed with cellulitis who is allergic to penicillin requires an alternative antibiotic. Which of these would also effectively target _Streptococcus _ species?
A patient diagnosed with cellulitis who is allergic to penicillin requires an alternative antibiotic. Which of these would also effectively target _Streptococcus _ species?
A patient with multiple recurrent cutaneous abscesses is undergoing decolonization. Which measure is MOST important to emphasize for preventing future infections?
A patient with multiple recurrent cutaneous abscesses is undergoing decolonization. Which measure is MOST important to emphasize for preventing future infections?
For a patient with cellulitis being treated with IV antibiotics, what finding would suggest need for adjunct systemic corticosteroids?
For a patient with cellulitis being treated with IV antibiotics, what finding would suggest need for adjunct systemic corticosteroids?
What is the rationale for using clindamycin as an adjunct treatment in necrotizing fasciitis, beyond its direct antibacterial effects?
What is the rationale for using clindamycin as an adjunct treatment in necrotizing fasciitis, beyond its direct antibacterial effects?
What is the MOST appropriate initial step when a patient exhibits signs of necrotizing fasciitis?
What is the MOST appropriate initial step when a patient exhibits signs of necrotizing fasciitis?
A patient with a moderate, non-purulent cellulitis is being discharged on oral antibiotics. Which would be MOST appropriate?
A patient with a moderate, non-purulent cellulitis is being discharged on oral antibiotics. Which would be MOST appropriate?
For a patient with recurrent cellulitis despite addressing all predisposing factors, which prophylactic measure is advised?
For a patient with recurrent cellulitis despite addressing all predisposing factors, which prophylactic measure is advised?
Abscesses commonly involve which pathogen?
Abscesses commonly involve which pathogen?
In the context of SSTIs, which of the following scenarios would most likely lead to a polymicrobial infection?
In the context of SSTIs, which of the following scenarios would most likely lead to a polymicrobial infection?
A patient presents with a suspected SSTI. Initial assessment reveals an area of redness and swelling with no purulent drainage. What is the MOST important next step in determining the appropriate antibiotic therapy?
A patient presents with a suspected SSTI. Initial assessment reveals an area of redness and swelling with no purulent drainage. What is the MOST important next step in determining the appropriate antibiotic therapy?
A patient is diagnosed with cellulitis of the lower extremity. Despite 48 hours of IV nafcillin, the patient remains febrile. The area of erythema and swelling has not decreased and patient is complaining of increased pain. Which of the following would be MOST appropriate?
A patient is diagnosed with cellulitis of the lower extremity. Despite 48 hours of IV nafcillin, the patient remains febrile. The area of erythema and swelling has not decreased and patient is complaining of increased pain. Which of the following would be MOST appropriate?
Which of the following factors MOST strongly suggests that an SSTI is necrotizing fasciitis rather than severe cellulitis?
Which of the following factors MOST strongly suggests that an SSTI is necrotizing fasciitis rather than severe cellulitis?
In a patient with necrotizing fasciitis, which of the following is the MOST important determinant of survival?
In a patient with necrotizing fasciitis, which of the following is the MOST important determinant of survival?
A patient with a history of injection drug use presents with a carbuncle. After incision and drainage, cultures grow MRSA. Which oral antibiotic would be MOST appropriate for outpatient treatment?
A patient with a history of injection drug use presents with a carbuncle. After incision and drainage, cultures grow MRSA. Which oral antibiotic would be MOST appropriate for outpatient treatment?
A young child presents with honey-colored crusted lesions around the nose and mouth. Topical mupirocin is prescribed. What is the MOST important instruction to give the parents regarding the application of the medication?
A young child presents with honey-colored crusted lesions around the nose and mouth. Topical mupirocin is prescribed. What is the MOST important instruction to give the parents regarding the application of the medication?
A patient is being treated for recurrent furuncles. After incision and drainage of a recent lesion, decolonization strategies are being considered. Which regimen is the MOST comprehensive approach for decolonization?
A patient is being treated for recurrent furuncles. After incision and drainage of a recent lesion, decolonization strategies are being considered. Which regimen is the MOST comprehensive approach for decolonization?
In managing cellulitis, which of the following patient characteristics would MOST warrant empiric coverage for MRSA in addition to typical streptococcal coverage?
In managing cellulitis, which of the following patient characteristics would MOST warrant empiric coverage for MRSA in addition to typical streptococcal coverage?
A patient with cellulitis is being discharged on oral cephalexin. Which sign or symptom should the patient be instructed to monitor closely and return immediately if it develops, suggesting the antibiotic is not effective or the infection is worsening?
A patient with cellulitis is being discharged on oral cephalexin. Which sign or symptom should the patient be instructed to monitor closely and return immediately if it develops, suggesting the antibiotic is not effective or the infection is worsening?
Which of the following clinical findings would definitively indicate that a patient's skin and soft tissue infection (SSTI) should be classified as severe?
Which of the following clinical findings would definitively indicate that a patient's skin and soft tissue infection (SSTI) should be classified as severe?
A patient with recurrent cellulitis, despite addressing predisposing factors, is being considered for prophylactic antibiotics. Which of the following is the MOST important consideration before initiating long-term antibiotic prophylaxis?
A patient with recurrent cellulitis, despite addressing predisposing factors, is being considered for prophylactic antibiotics. Which of the following is the MOST important consideration before initiating long-term antibiotic prophylaxis?
Patients with Fournier gangrene typically require broad-spectrum antibiotics. What is the MOST critical initial intervention alongside antibiotic therapy?
Patients with Fournier gangrene typically require broad-spectrum antibiotics. What is the MOST critical initial intervention alongside antibiotic therapy?
When managing necrotizing fasciitis, which of the following is the MOST important rationale for using clindamycin in addition to other broad-spectrum antibiotics?
When managing necrotizing fasciitis, which of the following is the MOST important rationale for using clindamycin in addition to other broad-spectrum antibiotics?
What is the primary reason Gram stain and culture are typically deemed unnecessary in uncomplicated cases of impetigo?
What is the primary reason Gram stain and culture are typically deemed unnecessary in uncomplicated cases of impetigo?
A patient has a large carbuncle on their neck with signs of systemic infection. After incision and drainage, cultures are sent. Empirically, what is the MOST appropriate initial antibiotic regimen while awaiting culture results?
A patient has a large carbuncle on their neck with signs of systemic infection. After incision and drainage, cultures are sent. Empirically, what is the MOST appropriate initial antibiotic regimen while awaiting culture results?
A patient presents with an SSTI characterized by a painful, rapidly spreading area of redness and swelling on their lower leg. They also report a fever and chills. Which of the following findings would be MOST concerning for necrotizing fasciitis?
A patient presents with an SSTI characterized by a painful, rapidly spreading area of redness and swelling on their lower leg. They also report a fever and chills. Which of the following findings would be MOST concerning for necrotizing fasciitis?
An immunocompromised patient develops a severe purulent SSTI that does not respond to initial incision and drainage. Systemic signs of infection include a temperature above 38°C, a heart rate above 90 bpm, a respiratory rate above 24, and an abnormal WBC. Which antibiotic would be the MOST adequate choice to combat the infection?
An immunocompromised patient develops a severe purulent SSTI that does not respond to initial incision and drainage. Systemic signs of infection include a temperature above 38°C, a heart rate above 90 bpm, a respiratory rate above 24, and an abnormal WBC. Which antibiotic would be the MOST adequate choice to combat the infection?
In cases of recurrent skin abscesses, what is the MOST crucial aspect of decolonization strategies to preventing future infections?
In cases of recurrent skin abscesses, what is the MOST crucial aspect of decolonization strategies to preventing future infections?
What clinical finding would MOST likely warrant initiation of systemic antibiotics in a patient presenting with a furuncle?
What clinical finding would MOST likely warrant initiation of systemic antibiotics in a patient presenting with a furuncle?
In a patient diagnosed with cellulitis who is allergic to penicillin, which agent effectively targets Streptococcus species while considering potential allergies?
In a patient diagnosed with cellulitis who is allergic to penicillin, which agent effectively targets Streptococcus species while considering potential allergies?
For a patient with multiple recurrent cutaneous abscesses undergoing decolonization, what is the MOST crucial measure to emphasize for the prevention of future infections?
For a patient with multiple recurrent cutaneous abscesses undergoing decolonization, what is the MOST crucial measure to emphasize for the prevention of future infections?
For a patient with cellulitis being treated with IV antibiotics, what finding would MOST strongly indicate the need for adjunct systemic corticosteroids?
For a patient with cellulitis being treated with IV antibiotics, what finding would MOST strongly indicate the need for adjunct systemic corticosteroids?
What action should the healthcare provider need to take when a patient exhibits signs of necrotizing fasciitis?
What action should the healthcare provider need to take when a patient exhibits signs of necrotizing fasciitis?
A patient with a moderate, non-purulent cellulitis exhibits is being discharged. What antibiotic should they discharge with?
A patient with a moderate, non-purulent cellulitis exhibits is being discharged. What antibiotic should they discharge with?
What clinical feature is MOST helpful in differentiating between non-purulent cellulitis and erysipelas upon initial examination?
What clinical feature is MOST helpful in differentiating between non-purulent cellulitis and erysipelas upon initial examination?
Which of the following factors is MOST critical for determining the need for systemic antibiotics in the management of a furuncle?
Which of the following factors is MOST critical for determining the need for systemic antibiotics in the management of a furuncle?
Which of the organism is MOST suggestive for Necrotizing Fasciitis?
Which of the organism is MOST suggestive for Necrotizing Fasciitis?
What is the purpose when administering clindamycin as an adjunct in treating Necrotizing Fasciitis?
What is the purpose when administering clindamycin as an adjunct in treating Necrotizing Fasciitis?
What is the significance level of a skin lesion to define ABSSSI (Acute Bacterial Skin and Skin Structure Infection)?
What is the significance level of a skin lesion to define ABSSSI (Acute Bacterial Skin and Skin Structure Infection)?
In Cellulitis. what clinical finding would suggest this would represent a severe infection?
In Cellulitis. what clinical finding would suggest this would represent a severe infection?
In dealing with Recurrent Cellulitis, what would be a re-occuring predisposing factor?
In dealing with Recurrent Cellulitis, what would be a re-occuring predisposing factor?
Why are blood cultures not recommended in Celullitis?
Why are blood cultures not recommended in Celullitis?
Why is the evaluation critical for assessing a patient when it comes to soft tissue infection?
Why is the evaluation critical for assessing a patient when it comes to soft tissue infection?
A patient displays the following sypmtoms on his skin: painful, tender, red nodule. What condition would likely fall under this?
A patient displays the following sypmtoms on his skin: painful, tender, red nodule. What condition would likely fall under this?
In the terms of severity for Non-Purulent SSTI's, define what characterizies severe?
In the terms of severity for Non-Purulent SSTI's, define what characterizies severe?
When evaluating patients for Necrotizing faciitis, what can be expected from signs and findings?
When evaluating patients for Necrotizing faciitis, what can be expected from signs and findings?
If the signs are similar to cellulitis, what is key symptoms that are common with Necrotizing Fasciitis?
If the signs are similar to cellulitis, what is key symptoms that are common with Necrotizing Fasciitis?
What key factor distinguishes severe non-purulent SSTIs from moderate cases?
What key factor distinguishes severe non-purulent SSTIs from moderate cases?
In managing a patient with necrotizing fasciitis, why is prompt surgical intervention considered a critical step?
In managing a patient with necrotizing fasciitis, why is prompt surgical intervention considered a critical step?
For a patient with recurrent furuncles, what is the MOST effective strategy for decolonization to prevent future infections, considering both the patient and their environment?
For a patient with recurrent furuncles, what is the MOST effective strategy for decolonization to prevent future infections, considering both the patient and their environment?
A patient is diagnosed with cellulitis and is allergic to penicillin. Considering the need to effectively target Streptococcus species while minimizing the risk of adverse reactions, which of the following would be MOST appropriate?
A patient is diagnosed with cellulitis and is allergic to penicillin. Considering the need to effectively target Streptococcus species while minimizing the risk of adverse reactions, which of the following would be MOST appropriate?
What is the underlying rationale for using clindamycin as an adjunct treatment in necrotizing fasciitis, beyond its direct antibacterial effects?
What is the underlying rationale for using clindamycin as an adjunct treatment in necrotizing fasciitis, beyond its direct antibacterial effects?
A 62-year-old male with a history of diabetes presents with a painful, rapidly spreading soft tissue infection in his groin area. Physical exam reveals crepitus and a foul odor. What is the MOST likely diagnosis and the FIRST critical step in management?
A 62-year-old male with a history of diabetes presents with a painful, rapidly spreading soft tissue infection in his groin area. Physical exam reveals crepitus and a foul odor. What is the MOST likely diagnosis and the FIRST critical step in management?
Which clinical indicator is MOST suggestive of necrotizing fasciitis, requiring immediate and aggressive intervention, rather than severe cellulitis?
Which clinical indicator is MOST suggestive of necrotizing fasciitis, requiring immediate and aggressive intervention, rather than severe cellulitis?
According to the FDA, what would be the criteria to define ABSSSI in SSTI’s?
According to the FDA, what would be the criteria to define ABSSSI in SSTI’s?
Patients with Fournier gangrene often require broad-spectrum antibiotics and may have underlying medical conditions. What is the MOST critical initial intervention?
Patients with Fournier gangrene often require broad-spectrum antibiotics and may have underlying medical conditions. What is the MOST critical initial intervention?
For a patient without systemic illness who is diagnosed with cellulitis and is to be treated as an outpatient, what oral antibiotic would be MOST appropriate?
For a patient without systemic illness who is diagnosed with cellulitis and is to be treated as an outpatient, what oral antibiotic would be MOST appropriate?
Which of the following factors MOST strongly suggests that a skin and soft tissue infection is necrotizing fasciitis rather than severe cellulitis?
Which of the following factors MOST strongly suggests that a skin and soft tissue infection is necrotizing fasciitis rather than severe cellulitis?
Why are Gram stain and culture typically deemed unnecessary in uncomplicated cases of impetigo?
Why are Gram stain and culture typically deemed unnecessary in uncomplicated cases of impetigo?
In cases of recurrent skin abscesses, what is the MOST crucial aspect of prevention?
In cases of recurrent skin abscesses, what is the MOST crucial aspect of prevention?
Flashcards
SSTIs
SSTIs
Infections involving any or all layers of the skin, fascia, and muscle.
Purulent vs. Non-Purulent SSTIs
Purulent vs. Non-Purulent SSTIs
Distinguishing between infections with pus (purulent) and those without (non-purulent) to guide appropriate treatment strategies.
SSTI: Key Aspects
SSTI: Key Aspects
Understanding the distribution, causes, disease mechanisms, common germs, signs, diagnosis, and care for both types of SSTIs and a severe form called necrotizing fasciitis.
Impetigo
Impetigo
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Diagnosing Impetigo
Diagnosing Impetigo
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Treating Impetigo
Treating Impetigo
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Purulent SSTI Severity
Purulent SSTI Severity
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Cutaneous Abscesses Management
Cutaneous Abscesses Management
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Furuncle Management
Furuncle Management
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Carbuncle Management
Carbuncle Management
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Recurrent Skin Abscesses
Recurrent Skin Abscesses
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Decolonization
Decolonization
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Non-Purulent SSTI - Severity
Non-Purulent SSTI - Severity
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Cellulitis Management
Cellulitis Management
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Necrotizing Fasciitis
Necrotizing Fasciitis
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SSTI Review
SSTI Review
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SSTI Differentiation
SSTI Differentiation
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SSTI: Comprehensive analysis
SSTI: Comprehensive analysis
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Cutaneous Abscesses
Cutaneous Abscesses
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Furuncles
Furuncles
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Carbuncles
Carbuncles
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Impetigo Treatment
Impetigo Treatment
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ABSSSI
ABSSSI
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Skin's Role in Infection
Skin's Role in Infection
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SSTI Risk Factors
SSTI Risk Factors
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Impetigo Organisms
Impetigo Organisms
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Abscesses Definition
Abscesses Definition
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Non-purulent ABSSSI
Non-purulent ABSSSI
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Cellulitis Risks
Cellulitis Risks
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Cellulitis Cause
Cellulitis Cause
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Necrotizing Fasciitis Definition
Necrotizing Fasciitis Definition
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Necrotizing Fasciitis Findings
Necrotizing Fasciitis Findings
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Debridement
Debridement
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Fournier Gangrene
Fournier Gangrene
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Recurrent Cellulitis
Recurrent Cellulitis
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FDA: ABSSSI
FDA: ABSSSI
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SSTI Culprit
SSTI Culprit
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Decolonization Method
Decolonization Method
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Furuncles/Carbuncles Tx
Furuncles/Carbuncles Tx
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Cellulitis Treatment
Cellulitis Treatment
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Necrotizing Fasciitis Sign
Necrotizing Fasciitis Sign
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Study Notes
Objectives
- This lecture reviews common skin and soft tissue infections (SSTIs)
- It differentiates between purulent and non-purulent SSTIs, detailing the appropriate management strategies for each type
- The lecture will cover the epidemiology, pathogenesis, microbiology, clinical manifestations, diagnosis, and treatment of both purulent and non-purulent SSTIs, as well as necrotizing fasciitis
Relevant Terminology
- SSTI refers to skin and soft tissue infection
- SSI refers to skin and skin structure infection
- ABSSSI refers to acute bacterial skin and skin structure infections
Epidemiology of SSTIs
- Approximately 14 million people are affected by SSTIs each year
- Inpatient admissions and outpatient visits for SSTIs increased by 65% in the early 2000s over a 9-year period
- SSTIs account for 2% of all hospitalizations
- There are 6.3 million physician office visits annually due to SSTIs
General Information on SSTIs
- SSTIs involve any or all layers of the skin, fascia, and muscle
- They are generally caused by a single pathogen
- Exceptions include diabetic foot infections, bite wounds, and burn wounds which may have multiple pathogens
Pathophysiology of SSTIs
- The intact skin serves as a defense against infection
- SSTIs typically arise from disruptions to normal host defenses, such as skin punctures or abrasions
- The majority of SSTIs are caused by organisms already present on the skin surface
Impetigo
- Begins with erythematous papules that evolve into vesicles and pustules
- After rupturing, vesicles and pustules develop a honey-colored dry discharge over an erythematous base
- Clinical presentation is the means of diagnosis
- Gram stains and cultures are unnecessary in typical cases
- Staphylococcus aureus and Streptococcus species are the most common causative organisms
- Treatment includes topical mupirocin applied twice daily for 5 days, which is as effective as oral antimicrobials for impetigo
- Oral agents active against S. aureus are used for 7 days, typically for methicillin-susceptible organisms
- Oral treatment is preferred for numerous lesions or when outbreaks affect multiple people
Purulent SSTI Severity
- Mild: None of the listed criteria for moderate or severe infections are present
- Moderate: Systemic signs of infection are observed
- Severe: Characterized by failed incision and drainage plus antibiotics, systemic signs of infection (temperature >38°C, heart rate >90 bpm, respiratory rate >24, abnormal WBC count), or the patient is immunocompromised
Cutaneous Abscesses
- Characterized by collections of pus
- Present as painful, tender, red nodules encircled by erythematous swelling
- Staphylococcus aureus is the most common causative agent
- Incision and drainage (I&D) is the first-line management
- Culture and susceptibilities testing (C&S) is recommended for moderate-to-severe cases
- Systemic antibiotics typically don't improve cure rates for mild infections, but should be considered for moderate-to-severe cases, significant systemic infection, extremes of age, multiple abscesses, impaired host defenses, or lack of response to I&D
Furuncles
- Superficial infections of the hair follicle
- Manifest as inflammatory nodules with overlying pustules
- Most commonly caused by S. aureus
- Often rupture and drain spontaneously or with moist heat
- Larger furuncles may require I&D +/- C&S
- Systemic antibiotics are usually unnecessary unless there is fever or other signs of systemic infection indicative of moderate-to-severe infection
Carbuncles
- Several adjacent furuncles
- Characterized by an inflammatory mass with pus draining from multiple orifices
- Commonly found on the back of the neck
- First-line management is I&D +/- C&S
- Systemic antibiotics are usually unnecessary unless fever or other signs of systemic infection are present (moderate-to-severe)
Recurrent Skin Abscesses
- A strategy includes draining and culturing early, treating against the identified pathogen, considering other possible causes, and implementing a 5-day decolonization regimen
- Decolonization involves twice-daily intranasal mupirocin, daily chlorhexidine washes, and decontamination of towels, sheets, and clothes
Purulent SSTI Summary
- First-line management involves incision and drainage (I&D)
- Cultures and susceptibilities are needed if the infection is moderate/severe
- Antibiotics may or may not be necessary
- Think Staphylococcus aureus
Antibiotic Treatment Options for Purulent SSTIs
- MRSA IV antibiotics include Vancomycin, Daptomycin, Ceftaroline, Telavancin, Dalbavancin, Oritavancin, and Delafloxacin
- MRSA oral antibiotics include Linezolid, tedizolid, Clindamycin, Doxycycline, minocycline, and Trimethoprim-sulfamethoxazole
- MSSA (IV/PO) antibiotics include Nafcillin, oxacillin, dicloxacillin, Cephalexin, and Cefazolin
Severity of Non-Purulent SSTI
- Mild: None of the below criteria for moderate or severe infection are present
- Moderate: Exhibits signs or symptoms of systemic infection
- Severe: Characterized by failed antibiotics; systemic signs of infection (temperature >38°C, heart rate >90 bpm, respiratory rate >24, abnormal WBC count); immunocompromised status; or signs of deeper infection such as skin sloughing, hypotension, or organ dysfunction
Cellulitis
- Cellulitis is linked to fragile skin, trauma, ulceration, or edema from venous insufficiency
- It is also frequently caused by breaks in the skin that are clinical unapparent and small
- The lower legs are the most common site
- Affected areas are typically red, swollen, and warm to the touch
- The most common causative organism are Streptococcus species, including group A Strep
- If moderate infection, consider MSSA
- Other considerations: Gynecologic cancer with surgery/radiation, consider Group B Strep and open wound, penetrating trauma, known MRSA colonization, SIRS, IVDU; consider MRSA
- Management includes elevation of the affected limb
- Cultures are typically unnecessary, with blood cultures positive in <5% of cases
- Exceptions: On chemotherapy, severe systemic features, animal bites, water immersion injuries, neutropenia, and severe cell-mediated immunodeficiency
- Treatment is with antibiotics for 5 days
- Antibiotics targeting Streptococcus species are typically initiated
- Many patients can receive oral therapy
- Adjunct systemic corticosteroids may also be considered
Antibiotics for Strep Skin Infections
- IV antibiotics include Penicillin 2-4 million units q4-6h, Clindamycin 600-900 mg q8h, Nafcillin 1-2g q4-6h, and Cefazolin 1g q8h
- Oral antibiotics include Penicillin VK 250-500 mg q6h and Cephalexin 500 mg q6h
Recurrent Cellulitis
- Annual recurrence rates range from 8-20%
- Predisposing factors include edema, obesity, eczema, venous insufficiency, toe web abnormalities, tobacco use, and homelessness
- Prophylactic antibiotics should be considered for patients who experience 3-4 episodes per year despite controlling predisposing factors
- Penicillin (PO/IM) and erythromycin can be used
Treatment for Nonpurulent SSTIs
- Severe: Requires emergent surgical inspection/debridement to rule out necrotizing process
- Give empiric Rx; Vancomycin PLUS Piperacillin/Tazobactam, and C & S
- Moderate: Give intravenous Rx Penicillin or Ceftriaxone or Cefazolin or Clindamycin
- Mild: Give oral Rx: Penicillin VK or Cephalosporin or Dicloxacillin or Clindamycin
Necrotizing Fasciitis
- Serious "flesh eating infection”
- Deep, aggressive infection that can lead to major tissue destruction and death
- May develop from an initial break in the skin or from non-penetrating trauma with no known portal of entry
- It is a surgical emergency
- Presentation/Findings: Initial presentation similar to cellulitis, pain out of proportion, hard, wooden feeling of tissue, Crepitus – cracking/crunching sound due to air, CT/MRI may show edema/necrosis, and Fascia is swollen and gray, brownish exudate, no true pus
- Causative Organisms: Streptococcus pyogenes, Staphylococcus aureus, Aeromonas hydrophila, Vibrio vulnificus, and Polymicrobial (Perianal abscesses, decubitus ulcers, injection sites in IVDU and Spread from genital site
Treatment of Necrotizing Fasciitis
- Treatment approach includes prompt surgical intervention, frequent repeat surgeries, broad empiric antibiotic treatment (covering MRSA, aerobes, and anaerobes), and duration until debridement is no longer deemed necessary, with clinical improvement and the patient being fever-free for 48-72 hours. A narrow antibiotic directed towards infection can be used, as needed
- Commonly used drugs include Vancomycin, Linezolid, or Daptomycin, combined with either Piperacillin/Tazobactam, a carbapenem, Ceftriaxone + Metronidazole, or a fluoroquinolone + Metronidazole
- Clindamycin should also be given
- Bacterial toxins may result in organ failure, shock, tissue destruction
- Adjunct clindamycin is used for suppression of toxin and cytokine production
- IVIG and Linezolid
Fournier Gangrene
- Type of necrotizing soft tissue infection that affects the scrotum, penis, or vulva
- Onset commonly occurs between ages 50-60
- 80% present with underlying diseases, commonly diabetes
- Most often polymicrobial
- Treatment mirrors other necrotizing fasciitis infections
FDA Guidance
- The FDA defines acute bacterial skin and skin structure infection (ABSSSI) as a bacterial infection of the skin with a lesion size area of at least 75 cm²
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