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Questions and Answers
What is the formula to calculate channel density?
What is the formula to calculate channel density?
- Macroscopic conductance / Surface area
- Single-channel conductance / Macroscopic conductance (correct)
- Surface area / Gating current
- Single-channel conductance / Membrane capacitance
In the context of channel density, what does the term 'gating current measurements' refer to?
In the context of channel density, what does the term 'gating current measurements' refer to?
- Calculating the number of channels per unit area
- Measuring the current associated with channel opening and closing (correct)
- Estimating channel density based on membrane capacitance
- Measuring the conductance of each channel
Considering the data provided, which type of channel has the highest conductance?
Considering the data provided, which type of channel has the highest conductance?
- Squid giant axon sodium channel
- Frog skeletal potassium channel
- Rat node sodium channel
- Mammalian BK potassium channel (correct)
What is the lower limit for channel density in excitable cells based on membrane charging during action potentials?
What is the lower limit for channel density in excitable cells based on membrane charging during action potentials?
How is the number of channels per unit area estimated in terms of channel density calculations?
How is the number of channels per unit area estimated in terms of channel density calculations?
Based on the given data, which type of preparation channel has the highest number per μm^2?
Based on the given data, which type of preparation channel has the highest number per μm^2?
What is the lower limit of channel density per μm2 based on the information provided?
What is the lower limit of channel density per μm2 based on the information provided?
In single channel current measurements, what does 'ip = gp (Vm-Ep)' represent?
In single channel current measurements, what does 'ip = gp (Vm-Ep)' represent?
What is the significance of the duration of an action potential in relation to ion movement through channels?
What is the significance of the duration of an action potential in relation to ion movement through channels?
Which patch clamp configuration involves recording while fixing the membrane potential?
Which patch clamp configuration involves recording while fixing the membrane potential?
What does 'stochastic in opening and closing but unitary in amplitude' refer to in single channel currents?
What does 'stochastic in opening and closing but unitary in amplitude' refer to in single channel currents?
What is the conductance value calculated for the channel pore with a radius of 0.5nm and a length of 5nm?
What is the conductance value calculated for the channel pore with a radius of 0.5nm and a length of 5nm?
What is the impact of access resistance on single channel conductance in the example discussed?
What is the impact of access resistance on single channel conductance in the example discussed?
How does unequal ion distributions affect the current-voltage relationship in the context of single channel recording?
How does unequal ion distributions affect the current-voltage relationship in the context of single channel recording?
What does the slope of an I-V curve represent in the context of single channel current-voltage relation?
What does the slope of an I-V curve represent in the context of single channel current-voltage relation?
What can be inferred about the single potassium channel's conductance when compared with the calculated conductance of the channel pore?
What can be inferred about the single potassium channel's conductance when compared with the calculated conductance of the channel pore?
What happens at around -76mV based on the discussion in single channel current-voltage relation?
What happens at around -76mV based on the discussion in single channel current-voltage relation?
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