9 Questions
What is the purpose of the Sickle Solubility Test (SST)?
To screen for the presence of sickling Hb
What causes the solution in the Sickle Solubility Test to remain turbid?
Reduced solubility of HbS
How is the presence of HbA detected in the Sickle Solubility Test?
Clear red solution
Which of the following statements is true about sickle cell trait (Hb-AS)?
It can lead to hematuria due to kidney papillae necrosis.
What is the typical result of the sickling test after overnight incubation for individuals with sickle cell trait?
Positive
Which of the following best describes the appearance of RBCs in individuals with sickle cell trait on the peripheral blood film?
Normal appearance of RBCs with few target cells.
Which type of thalassemia is characterized by a reduced rate of synthesis of α chains?
Alpha thalassemia
In thalassemias, the condition is classified into α and β types based on the affected:
Globin chain type
What is the main genetic cause of thalassemias?
Reduced rate of synthesis α or β chains
Learn about the Sickle Solubility Test (SST) used to screen for the presence of sickling Hb. Understand the procedure that involves lysing RBCs and reducing Hb using sodium saponin hydrosulfite in a phosphate buffer.
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