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Questions and Answers
What is the purpose of the Sickle Solubility Test (SST)?
What is the purpose of the Sickle Solubility Test (SST)?
- To detect the presence of white blood cells
- To identify the total protein content in the blood
- To screen for the presence of sickling Hb (correct)
- To measure the pH of the blood sample
What causes the solution in the Sickle Solubility Test to remain turbid?
What causes the solution in the Sickle Solubility Test to remain turbid?
- Formation of neumatic liquid crystals
- Lysing of RBCs
- Reduced solubility of HbS (correct)
- Presence of HbA
How is the presence of HbA detected in the Sickle Solubility Test?
How is the presence of HbA detected in the Sickle Solubility Test?
- Turbid red solution
- Lysis of RBCs
- Clear red solution (correct)
- Formation of neumatic liquid crystals
Which of the following statements is true about sickle cell trait (Hb-AS)?
Which of the following statements is true about sickle cell trait (Hb-AS)?
What is the typical result of the sickling test after overnight incubation for individuals with sickle cell trait?
What is the typical result of the sickling test after overnight incubation for individuals with sickle cell trait?
Which of the following best describes the appearance of RBCs in individuals with sickle cell trait on the peripheral blood film?
Which of the following best describes the appearance of RBCs in individuals with sickle cell trait on the peripheral blood film?
Which type of thalassemia is characterized by a reduced rate of synthesis of α chains?
Which type of thalassemia is characterized by a reduced rate of synthesis of α chains?
In thalassemias, the condition is classified into α and β types based on the affected:
In thalassemias, the condition is classified into α and β types based on the affected:
What is the main genetic cause of thalassemias?
What is the main genetic cause of thalassemias?
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Study Notes
Sickle Solubility Test (SST)
- Purpose: Detects the presence of hemoglobin S (HbS) in blood samples
- Solution remains turbid due to the presence of hemoglobin S (HbS) or other abnormal hemoglobins
- Presence of HbA is detected by the solution remaining clear or becoming clear after adding a reducing agent
Sickle Cell Trait (Hb-AS)
- Characterized by the presence of both HbA and HbS hemoglobins
- Typical result of the sickling test after overnight incubation: partially sickled or normal red blood cell morphology
- Appearance of RBCs on peripheral blood film: usually normal, but may show rare sickle cells or target cells
Thalassemias
- α-Thalassemia is characterized by a reduced rate of synthesis of α chains
- Classified into α and β types based on the affected globin chain of hemoglobin
- Main genetic cause: mutations leading to reduced or absent synthesis of α or β globin chains
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