Sickle Cell Disease Overview
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Questions and Answers

What is the characteristic shape of red blood cells in sickle cell disorders?

  • Sickle shape (correct)
  • Biconcave disc shape
  • Spherical shape
  • Hexagonal shape

What is the severe form of sickle cell disorder known as?

  • Sickle cell anaemia (correct)
  • Sickle cell thalassemia
  • Sickle cell trait
  • HbSC disorder

Which type of sickle cell disorder is the heterozygous form of Hb S known as?

  • HbSD disorder
  • Sickle cell thalassemia
  • Sickle cell trait (correct)
  • HbSC disorder

Who provided the first written account of sickle cell disease in 1874?

<p>Africanus Norton (C)</p> Signup and view all the answers

In which year was the first case of sickle cell disease reported by Drs James Herrick and Ernest Irons?

<p>1910 (C)</p> Signup and view all the answers

What is the state in which red cells exposed to deoxygenation polymerize and deform into a sickle shape called?

<p>Sickling state (D)</p> Signup and view all the answers

What did Linus Pauling and colleagues demonstrate in 1949?

<p>Molecular differences between various types of hemoglobin (C)</p> Signup and view all the answers

In what region is Sickle cell anaemia more prevalent?

<p>Sub-Saharan Africa (D)</p> Signup and view all the answers

What did Dr. Alan Raper suggest in 1949?

<p>The survival advantage of the Sickle Cell trait (D)</p> Signup and view all the answers

What is the estimated carrier rate of Sickle cell disease in Nigeria?

<p>1 in 4 persons (B)</p> Signup and view all the answers

What is the mechanism proposed for the overt protection enjoyed in the carrier state of Sickle cell disease?

<p>Selective sickling of parasitized red cells resulting in more efficient removal by cells of the monocyte-macrophage system (C)</p> Signup and view all the answers

What did Hahn and Gillespie show in 1927?

<p>Relationship between low oxygen tension and low pH (C)</p> Signup and view all the answers

Where is Hb C most prevalent?

<p>Northern Ghana and Burkina Faso (B)</p> Signup and view all the answers

What did Sydenstricker and Huck note in 1923?

<p>'Latent sicklers' among relatives of diagnosed patients (C)</p> Signup and view all the answers

What was demonstrated by Hunt and Ingram in the late 1950s?

<p>The sequence of the globin peptide (B)</p> Signup and view all the answers

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