Sickle Cell Disease Overview
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Questions and Answers

What is the characteristic shape of red blood cells in sickle cell disorders?

  • Sickle shape (correct)
  • Biconcave disc shape
  • Spherical shape
  • Hexagonal shape
  • What is the severe form of sickle cell disorder known as?

  • Sickle cell anaemia (correct)
  • Sickle cell thalassemia
  • Sickle cell trait
  • HbSC disorder
  • Which type of sickle cell disorder is the heterozygous form of Hb S known as?

  • HbSD disorder
  • Sickle cell thalassemia
  • Sickle cell trait (correct)
  • HbSC disorder
  • Who provided the first written account of sickle cell disease in 1874?

    <p>Africanus Norton</p> Signup and view all the answers

    In which year was the first case of sickle cell disease reported by Drs James Herrick and Ernest Irons?

    <p>1910</p> Signup and view all the answers

    What is the state in which red cells exposed to deoxygenation polymerize and deform into a sickle shape called?

    <p>Sickling state</p> Signup and view all the answers

    What did Linus Pauling and colleagues demonstrate in 1949?

    <p>Molecular differences between various types of hemoglobin</p> Signup and view all the answers

    In what region is Sickle cell anaemia more prevalent?

    <p>Sub-Saharan Africa</p> Signup and view all the answers

    What did Dr. Alan Raper suggest in 1949?

    <p>The survival advantage of the Sickle Cell trait</p> Signup and view all the answers

    What is the estimated carrier rate of Sickle cell disease in Nigeria?

    <p>1 in 4 persons</p> Signup and view all the answers

    What is the mechanism proposed for the overt protection enjoyed in the carrier state of Sickle cell disease?

    <p>Selective sickling of parasitized red cells resulting in more efficient removal by cells of the monocyte-macrophage system</p> Signup and view all the answers

    What did Hahn and Gillespie show in 1927?

    <p>Relationship between low oxygen tension and low pH</p> Signup and view all the answers

    Where is Hb C most prevalent?

    <p>Northern Ghana and Burkina Faso</p> Signup and view all the answers

    What did Sydenstricker and Huck note in 1923?

    <p>'Latent sicklers' among relatives of diagnosed patients</p> Signup and view all the answers

    What was demonstrated by Hunt and Ingram in the late 1950s?

    <p>The sequence of the globin peptide</p> Signup and view all the answers

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