Podcast
Questions and Answers
Sickle cell anemia is a genetic blood disorder that primarily affects the ______ of red blood cells.
Sickle cell anemia is a genetic blood disorder that primarily affects the ______ of red blood cells.
shape
In sickle cell anemia, the blockage of blood flow by sickle-shaped cells can result in pain and damage to organs such as the liver, heart, and ______.
In sickle cell anemia, the blockage of blood flow by sickle-shaped cells can result in pain and damage to organs such as the liver, heart, and ______.
kidneys
A common symptom of anemia is ______, which results from low oxygen levels in the body.
A common symptom of anemia is ______, which results from low oxygen levels in the body.
fatigue
Sickle cell anemia is classified as an autosomal ______ genetic disorder.
Sickle cell anemia is classified as an autosomal ______ genetic disorder.
In Brazil, sickle cell anemia is more common in the areas of Bahia, Rio de Janeiro, and São ______.
In Brazil, sickle cell anemia is more common in the areas of Bahia, Rio de Janeiro, and São ______.
Individuals with sickle cell trait, who carry one gene for sickle cell anemia, are protected from ______.
Individuals with sickle cell trait, who carry one gene for sickle cell anemia, are protected from ______.
Sickle cell anemia leads to the polymerization of abnormal ______, distorting the red blood cell shape.
Sickle cell anemia leads to the polymerization of abnormal ______, distorting the red blood cell shape.
The lack of enough red blood cells in the body is a condition known as ______.
The lack of enough red blood cells in the body is a condition known as ______.
In the genetic inheritance of sickle cell anemia, individuals who carry only one affected gene are referred to as ______.
In the genetic inheritance of sickle cell anemia, individuals who carry only one affected gene are referred to as ______.
The primary cause of anemia is a condition of low ______ levels within the body.
The primary cause of anemia is a condition of low ______ levels within the body.
A symptom of sickle cell anemia is recurring episodes of intense ______ throughout the body, especially in the chest, arms, and legs.
A symptom of sickle cell anemia is recurring episodes of intense ______ throughout the body, especially in the chest, arms, and legs.
The altered shape of red blood cells in sickle cell anemia can impede blood flow, causing damage in the liver, heart, eyes, and ______.
The altered shape of red blood cells in sickle cell anemia can impede blood flow, causing damage in the liver, heart, eyes, and ______.
People with sickle cell anemia often face a heightened ______ of infection because of spleen damage.
People with sickle cell anemia often face a heightened ______ of infection because of spleen damage.
To inherit sickle cell anemia, a child must inherit the affected gene from ______ parents.
To inherit sickle cell anemia, a child must inherit the affected gene from ______ parents.
In Brazil, the sickle cell trait is more common among Afro-______.
In Brazil, the sickle cell trait is more common among Afro-______.
One advantage for carriers of sickle cell anemia is that they have lower ______ counts.
One advantage for carriers of sickle cell anemia is that they have lower ______ counts.
The presence of the sickle cell allele provides a degree of protection against ______, prevalent in certain regions.
The presence of the sickle cell allele provides a degree of protection against ______, prevalent in certain regions.
Sickle cell anemia is marked by a defect in ______ within red blood cells, causing them to assume an abnormal shape.
Sickle cell anemia is marked by a defect in ______ within red blood cells, causing them to assume an abnormal shape.
Due to the polymerization of hemoglobin, the ______ sickle cells block blood flow.
Due to the polymerization of hemoglobin, the ______ sickle cells block blood flow.
The sickled cells lead to damage in the eyes and ______.
The sickled cells lead to damage in the eyes and ______.
Flashcards
Sickle Cell Anemia
Sickle Cell Anemia
A genetic blood disorder where red blood cells become sickle-shaped, blocking blood flow and causing pain and organ damage.
Anemia
Anemia
A condition characterized by a deficiency of red blood cells, leading to low oxygen levels in the body, fatigue, weakness, dizziness, and pale skin.
Pain Crises
Pain Crises
A set of painful episodes that occur when sickle-shaped red blood cells block blood flow to organs and tissues.
Inheritance Pattern of Sickle Cell Anemia
Inheritance Pattern of Sickle Cell Anemia
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Sickle Cell Anemia Carriers
Sickle Cell Anemia Carriers
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Prevalence of Sickle Cell Anemia in Brazil
Prevalence of Sickle Cell Anemia in Brazil
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Advantage of Sickle Cell Anemia Trait
Advantage of Sickle Cell Anemia Trait
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Study Notes
Sickle Cell Anemia Overview
- Genetic blood disorder alters red blood cell shape
- Sickle-shaped cells obstruct blood flow and can cause pain in the chest, arms, and legs
- Can damage the liver, heart, kidneys, gallbladder, eyes, bones, and joints
- Results in anemia, fatigue, and heightened infection risk
- Prevalent in people of African descent and Brazilians
What is Anemia
- Condition with insufficient red blood cells in the body
- Results in reduced oxygen levels
- Causes fatigue, weakness, dizziness, and pale skin
- Typically caused by blood loss, iron deficiency, or genetic disorders like sickle cell anemia
Disease Effects on Humans
- Can cause pain crises
- Causes fatigue or anemia
- Can cause increased infections
- Can cause organ damage
Genetic Inheritance
- Autosomal recessive, requiring both parents to pass on the gene
- Carriers with one gene may have mild symptoms or no symptoms at all
Commonness in Brazil
- Affects 1 in 1,000 Brazilians
- 1 in 17 Afro-Brazilians carry the trait
- Most common in Bahia, Rio de Janeiro, and São Paulo
Advantages of Sickle Cell Anemia
- Can protect against malaria (parasite-caused disease)
- There is a lower likelihood of getting the disease
- Lower parasite counts occur
- Lower mortality rate
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