20 Questions
Which patients are eligible for a shorter all-oral regimen for multidrug- or rifampin-resistant tuberculosis (MDR/RR TB)?
Patients with confirmed fluoroquinolone-susceptible disease
What is the main toxicity associated with the novel regimen BPaL?
Peripheral neuropathy
How long was the course of treatment with the BPaL regimen in the study?
6 months
What percentage of patients in the study achieved cure with the BPaL regimen?
90%
What is the purpose of lobectomy or wedge resection in the treatment of tuberculosis?
To improve pulmonary reserve
What is the role of bedaquiline in the BPaL regimen?
To improve cure rate
Which of the following is a criterion for offering a shorter all-oral regimen to patients with MDR/RR TB?
Availability of all drugs in the regimen
What is the main adverse effect of linezolid in the BPaL regimen?
Myelosuppression
What is the purpose of the shorter MDR-TB regimen?
To reduce treatment duration
How many patients were enrolled in the study of the BPaL regimen?
109
Which drug was approved by the FDA in August 2019 for the treatment of a population of patients with MDR-TB caused by a strain with additional resistance to a fluoroquinolone or a second-line injectable drug?
Pretomanid
What did the WHO suggest about the use of the new 6-9 month pretomanid regimen in late 2019?
It should not be used until more information is available on safety and efficacy.
Which drug was used at a reduced daily dose and/or for a shorter period of time in a dose-blinded study reported in 2021?
Linezolid
What is the name of the regimen being tested by the Global Alliance that is composed of bedaquiline, pretomanid, moxifloxacin, and pyrazinamide?
BPaMZ
In a phase 2B trial, MDR-TB patients treated with the BPaMZ regimen became culture-negative within 8 weeks of treatment how many times faster than drug-sensitive TB patients treated with the standard regimen?
3 times
What is the aim of testing the BPaMZ regimen for both MDR-TB and drug-susceptible TB?
To reduce treatment duration to 2 months for MDR-TB and 4 months for drug-susceptible TB
Where is the ideal setting for providing care to seriously ill MDR-TB patients?
Specialized centers
When should hospitalization be considered for MDR-TB patients?
When patients are in critical condition
What is associated with significant reductions in mortality risk and AIDS-related events in HIV-associated TB patients?
Treatment of HIV-associated TB with anti-TB drugs and simultaneous use of ART
What is the reduction in mortality rates associated with early initiation of ART during anti-TB treatment?
34-68%
"Criteria for Offering a Shorter All-Oral Regimen for Multidrug-Resistant Tuberculosis (MDR-TB)" - Test your knowledge on the criteria for offering a shorter all-oral regimen to patients with confirmed MDR-TB. Learn about the absence of resistance to specific drugs, history of exposure to second-line drugs, and more.
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