Podcast
Questions and Answers
Which of the following statements best explains the mechanism of action of SGLT2 inhibitors like canagliflozin, dapagliflozin, and empagliflozin?
Which of the following statements best explains the mechanism of action of SGLT2 inhibitors like canagliflozin, dapagliflozin, and empagliflozin?
- They suppress hepatic glucose production, reducing the amount of glucose released into the bloodstream.
- They enhance the sensitivity of peripheral tissues to insulin, promoting glucose utilization and reducing insulin resistance.
- They stimulate insulin secretion from pancreatic beta cells, leading to increased glucose uptake by cells.
- They inhibit the reabsorption of glucose in the proximal convoluted tubule of the kidney, increasing urinary glucose excretion. (correct)
A 62-year-old patient with T2DM and a history of recurrent UTIs is prescribed an SGLT2 inhibitor. Which potential side effect should be closely monitored?
A 62-year-old patient with T2DM and a history of recurrent UTIs is prescribed an SGLT2 inhibitor. Which potential side effect should be closely monitored?
- Metabolic acidosis
- Hypotension
- Hypoglycemia
- Hyperkalemia (correct)
Which patient condition would be considered a contraindication for the use of SGLT2 inhibitors?
Which patient condition would be considered a contraindication for the use of SGLT2 inhibitors?
- Stage 2 hypertension
- Peripheral neuropathy
- History of cardiovascular disease
- Diabetic ketoacidosis (correct)
A patient taking dapagliflozin reports symptoms of increased thirst, frequent urination, and dizziness upon standing. What is the most likely cause of these symptoms?
A patient taking dapagliflozin reports symptoms of increased thirst, frequent urination, and dizziness upon standing. What is the most likely cause of these symptoms?
Which of the following laboratory findings would be most concerning in a patient who is prescribed canagliflozin?
Which of the following laboratory findings would be most concerning in a patient who is prescribed canagliflozin?
A patient with T2DM is started on empagliflozin. Besides monitoring blood glucose, what additional monitoring is crucial?
A patient with T2DM is started on empagliflozin. Besides monitoring blood glucose, what additional monitoring is crucial?
A patient on dapagliflozin develops a UTI. What is the most likely reason for this increased susceptibility?
A patient on dapagliflozin develops a UTI. What is the most likely reason for this increased susceptibility?
A patient with T2DM and moderate renal impairment is considering starting canagliflozin. What is the most appropriate course of action?
A patient with T2DM and moderate renal impairment is considering starting canagliflozin. What is the most appropriate course of action?
A patient who has been taking empagliflozin for 6 months reports feeling lightheaded and dizzy when standing up quickly. What should the healthcare provider assess first?
A patient who has been taking empagliflozin for 6 months reports feeling lightheaded and dizzy when standing up quickly. What should the healthcare provider assess first?
How do SGLT2 inhibitors impact glycemic control in patients with T2DM?
How do SGLT2 inhibitors impact glycemic control in patients with T2DM?
Flashcards
SGLT2 Inhibitors Mechanism
SGLT2 Inhibitors Mechanism
SGLT2 inhibitors increase urinary glucose excretion by reducing glucose reabsorption in the proximal convoluted tubule (PCT).
Examples of SGLT2 Inhibitors
Examples of SGLT2 Inhibitors
Canagliflozin, Dapagliflozin, and Empagliflozin are examples of SGLT2 inhibitors.
SGLT2 Inhibitors Use
SGLT2 Inhibitors Use
SGLT2 inhibitors are indicated for the treatment of type 2 diabetes mellitus (T2DM).
SGLT2 Inhibitors Contraindications
SGLT2 Inhibitors Contraindications
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SGLT2 Inhibitors Side Effects
SGLT2 Inhibitors Side Effects
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Study Notes
- SGLT2 inhibitors are a class of drugs that end in "-gliflozin", including canagliflozin, dapagliflozin, and empagliflozin.
- These medications increase urinary glucose excretion and decrease glucose reabsorption in the proximal convoluted tubule (PCT).
- They treat type 2 diabetes mellitus (T2DM).
- Contraindications include renal failure/dialysis and diabetic ketoacidosis.
- Side effects include increased risk for urinary tract infections (UTIs), hyperkalemia, glucosuria, and dehydration.
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