Seizure Pharmacology

Drugs that inactive sodium channels

A patient presents to your clinic with seizures that originate in the thalamus and then spread to other parts of the cerebral cortex. What medication are you prescribing?

Which types of drugs allow for hyper polarization of the neuron by facilitating GABAa receptor's ability to release Cl- into the post-synaptic cell?

Which drug inhibits the GABA transporter, thus inhibiting the reuptake of GABA from the synaptic cleft and into the pre-synaptic neuron (and thus allowing GABA to remain in the synaptic cleft and exert its depressing effects)

What drugs inhibits GABA metabolism, thus preventing its breakdown and allowing GABA to stay in the synaptic cleft for longer

T or F: Gabapentin and Pregablin are active at GABA A receptors

Which two drugs modulates synaptic transmission by binding to alpha 2 delta 1 subunits on the calcium channels in order to prevent the influx of Ca2+ into the pre-synaptic cell?

The following drug modulates synaptic vesicle activity by binding to the SV2A synaptic protein and thus prevents the release of neurotransmitters into the synaptic cleft

The following drug can be used for focal seizures, generalized tonic seizures, combination seizures, bipolar disorder and migraines

The following drug can be used for focal seizures, generalized tonic seizures and migraines