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Questions and Answers
Which receptor subtype is responsible for vasoconstriction in blood vessels?
Which receptor subtype is responsible for vasoconstriction in blood vessels?
What is the primary role of 5-HT4 in the gastrointestinal (GI) system?
What is the primary role of 5-HT4 in the gastrointestinal (GI) system?
Which class of drugs are antagonists of 5-HT3 receptors commonly used for?
Which class of drugs are antagonists of 5-HT3 receptors commonly used for?
Which neurotransmitter is synthesized from the amino acid tryptophan?
Which neurotransmitter is synthesized from the amino acid tryptophan?
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What is the rate-limiting step in serotonin synthesis?
What is the rate-limiting step in serotonin synthesis?
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Study Notes
Serotonergic Neurotransmission
- Serotonin, also known as 5-Hydroxytryptamine (5-HT), is a neurotransmitter in the Central Nervous System (CNS)
Location of Serotonergic Neuronal Cell Bodies
- Serotonergic neuronal cell bodies are located in raphe nuclei or midline regions of pons and upper brain stem
Pathways of Serotonergic Neurotransmission
- Descending pathways innervate the spinal cord and modulate pain perception
- Ascending pathways innervate the cortex, cerebellum, substantia nigra, and limbic system, promoting sleep, determining mood, and involvement in mental illness
Serotonin Receptors
- There are multiple serotonin receptor subtypes, including 5-HT1 to 5-HT7, with subtypes
- All serotonin receptors, except 5-HT3, are metabotropic
- 5-HT3 is a ligand-gated ion channel
- 5-HT1A receptors share the same K+ channel as GABAB receptors
Actions of Serotonergic Neurotransmission
- Serotonergic actions can be inhibitory or excitatory, depending on the receptor subtype present
- Inhibition and excitation can occur simultaneously in the same neuron if appropriate receptors are present, making serotonergic actions complex
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Description
Test your knowledge of serotonergic neurotransmission and the pharmacology of the central nervous system with this quiz. Explore topics such as serotonergic neuronal cell bodies, descending pathways, and the treatment of depression, psychosis, and mania.
