Single carbon metabolism

What is the major carbon source involved in the transfer of single carbon atoms in various biochemical reactions?

Which enzyme catalyzes the reversible reaction transferring the hydroxymethyl group from serine to FH4?

What is produced from deoxyuridine monophosphate (dUMP) by a methylation reaction involving FH4?

In folate deficiency, what type of anemia can develop due to the inability of blood cell precursors to synthesize DNA?

Which vitamin deficiency has been linked to an increased risk of neural tube defects in fetuses?

What molecule is used for the transfer of methyl groups to vitamin B12 in biochemical reactions involving one-carbon atoms?

What is the most oxidized form of FH4?

What is the consequence of primary folate deficiency or secondary B12 deficiency on DNA repair?

Which vitamin is reconjugated to the polyglutamate form within the liver?

Which vitamin participates in the conversion of L-methylmalonyl-CoA to succinyl-CoA?

What is the major form of folate in the blood?

What is the role of SAM in biochemical reactions involving FH4 and vitamin B12?

Which compound does biotin transfer in the carboxylase reaction?

What are the consequences of carbon reduction on FH4?

Which compound carries one-carbon units from serine, glycine, histidine, formaldehyde, and formic acid in biochemical reactions?

Which of the following serve as one-carbon sources for the one-carbon pool carried by FH4?

In which vitamin are one carbon donors transferred to folate at different oxidation states?

What is the main function of FH4 in biochemical reactions involving one-carbon units?

What is the role of biotin in the carboxylase reactions?

Which compound forms a bridge between nitrogen N5 and N10 in the one-carbon pool?

What occurs when the methyl group is formed from FH4?

What is the primary function of folate within the liver?

Which compound is involved in transferring carbon sources to folate at different oxidation states?

What is the consequence of a folate deficiency on blood cell precursors?

Which base is synthesized for DNA synthesis through reactions involving one-carbon transfers?

What is the product of the reaction where deoxyuridine monophosphate (dUMP) is methylated?

What can be a consequence of primary folate deficiency on DNA repair processes?

Which molecule serves as a carrier of one-carbon units from various sources in biochemical reactions?

What is the major carbon source involved in recycling the hydroxymethyl group to tetrahydrofolate (FH4)?

What is the most unusual feature of Vitamin B12's structure?

How does Vitamin B12 react with the 5’-carbon of 5’-deoxyadenosine?

How is ingested Vitamin B12 absorbed if it is bound to proteins?

Which compound must be digested by proteases before Vitamin B12 can bind to intrinsic factor in the small intestine?

What is the function of intrinsic factor in the absorption and transport of Vitamin B12?

What is the consequence of a vitamin B12 deficiency, according to the text?

Which hypothesis is associated with the consequences of vitamin B12 deficiency?

What is the function of vitamin B12 in the body according to the text?

What is the major form of B12 stored in the liver?

Which reaction involves the transfer of a one-carbon group to tetrahydrofolate?

What is the role of transcobalamin II in vitamin B12 metabolism?

What is the consequence of a deficiency in vitamin B12 or a defect in methionine synthase according to the text?

What is the role of choline in one-carbon metabolism as discussed in the text?

What condition leads to the accumulation of homocysteine due to inhibition of its conversion to methionine by the major route?

What effect does a mutation in the enzyme converting N5, N10 methylene FH4 to N5-methyl FH4 have on serum homocysteine levels?

In what situation does homocysteine accumulate in the blood according to the text?

What is a possible outcome of a deficiency in vitamin B6 with regard to serum homocysteine levels?