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What percentage of septic shock patients had muscle weakness at hospital discharge?
What is the percentage of control patients with acute disease requiring hospitalization who had not recovered their pre-illness autonomy at 6 months?
What is the mean physical quality-of-life score (PCS) assessed by the MOS SF-36 in control patients at 6 months?
What is the only variable predictive of a poor outcome in septic shock patients at 6 months?
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What is the main cause of lymphedema in patients with septic shock?
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What percentage of patients with septic shock admitted for more than one week develop ICU-acquired weakness and myopathy?
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What is the percentage of septic shock patients who have persistent muscular dysfunction at 6 months?
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What is a potential long-term consequence of septic shock?
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Study Notes
Septic Shock Outcomes
- 79% of septic shock patients experience muscle weakness at hospital discharge.
- At 6 months, 28% of septic shock patients have not recovered their pre-illness autonomy, compared to 15% of controls with acute disease requiring hospitalization.
Quality of Life
- At 6 months, the mean physical quality-of-life score (PCS) assessed by the MOS SF-36 is 48±3 in septic shock patients, compared to 45±5 in ARDS patients and 51±4 in control patients (P=0.009).
Predictors of Poor Outcome
- Self-professed loss of autonomy is the only variable predictive of a poor outcome, with a diagnostic odds ratio of 3.90, 95% CI 1.18–12.83, area under the ROC curve 0.68, 95% CI 0.53–0.83.
Long-term Consequences of Sepsis
- Septic shock has significant long-term consequences, including long-term cognitive impairment, ICU-acquired weakness and myopathy, and considerable pain.
- The incidence of ICU-acquired weakness and myopathy ranges from 25% to 55% of patients with septic shock admitted for more than one week.
- About 25% of patients experience persistent muscular dysfunction.
- Other potential long-term effects of septic shock include drowsiness, anxiety, depression, and symptoms of post-traumatic stress.
- Patients can also develop lymphedema through infections such as acute lymphangitis, often caused by repeated episodes of cellulitis.
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Description
Quiz on the outcomes of septic shock patients, including muscle weakness, recovery, and quality of life at hospital discharge and 6-month follow-up.
