Sedation & Pain Management in ICU Patients

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Questions and Answers

What is the minimum pain score that should trigger pain management using the Behavioral Pain Score (BPS)?

  • 5 (correct)
  • 3
  • 4
  • 6

Which of the following analgesic methods can be used for patients who are awake and cooperative?

  • Intravenous ketamine
  • Intravenous morphine
  • Paracetamol only
  • Patient-controlled analgesia (correct)

When managing sedation, what is the primary aim in terms of patient state?

  • Complete unconsciousness
  • Light sedation (correct)
  • Moderate sedation
  • Deep sedation

Which medication is preferred when additional sedation is required for mechanically ventilated patients?

<p>Non-benzodiazepines (A)</p> Signup and view all the answers

What should be considered when using propofol or dexmedetomidine for sedation?

<p>Patient's haemodynamic status (C)</p> Signup and view all the answers

In which condition is deep sedation particularly indicated?

<p>Post-cardiac arrest care (D)</p> Signup and view all the answers

Which adjunct medication can be considered alongside opioids to manage neuropathic pain?

<p>Gabapentin (D)</p> Signup and view all the answers

When should pain be assessed in ICU patients?

<p>Every 4 hours (D)</p> Signup and view all the answers

What is the recommended pain score threshold for initiating pain management using the Critical Care Pain Observational Tool (CPOT)?

<p>3 (B)</p> Signup and view all the answers

Which of the following is considered a first-line sedative for mechanically ventilated patients?

<p>Fentanyl (C)</p> Signup and view all the answers

What is the correct interval for assessing sedation in ICU patients?

<p>Every 4 hours (D)</p> Signup and view all the answers

Which type of sedatives is preferred over benzodiazepines due to a lower incidence of delirium?

<p>Non-benzodiazepines (A)</p> Signup and view all the answers

In which scenario is deep sedation warranted?

<p>High vasopressors or inotropes administration (C)</p> Signup and view all the answers

What adjunct medication could be used in combination with opioids for neuropathic pain management?

<p>Gabapentin (A)</p> Signup and view all the answers

What is the primary goal of light sedation in ICU patients?

<p>Patient remains awake, calm and comfortable (C)</p> Signup and view all the answers

Which scoring method is not designed for unconscious patients in pain assessment?

<p>Visual Analogue Score (VAS) (C)</p> Signup and view all the answers

What is the lowest pain threshold indicated for administering paracetamol intravenously?

<p>Pain score of 3 (D)</p> Signup and view all the answers

What should be considered when using intravenous midazolam for sedation in unstable patients?

<p>Expected duration of sedation (A)</p> Signup and view all the answers

Flashcards

Pain management in ICU

Using validated pain scales (like BPS, CPOT, VAS) to monitor and assess pain at least every 4 hours, initiating pain management when scores meet thresholds (e.g., BPS ≥ 5).

Pain management mainstay

Opioid-based analgesia is the primary approach for managing pain.

Adjunctive pain relief

Using additional medications (like paracetamol, IV ketamine) alongside opioids to reduce opioid dose and pain severity.

Sedation in ventilated patients

Using analgesia-first sedatives (like morphine or fentanyl), followed by non-benzodiazepines (dexmedetomidine or propofol) if needed to maintain wakefulness and calmness in mechanically ventilated patients.

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Pain assessment frequency

Pain scores should be assessed at least every 4 hours in ICU settings.

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Deep sedation indication

Deep sedation is used for patients needing cerebral protection (head injury), post-cardiac arrest, high vasopressor/inotropes use, or high ventilator settings.

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Sedation goal

Maintain light sedation, where patients are awake, calm, and comfortable during critical care.

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Neuropathic pain treatment

Use gabapentin or carbamazepine along with opioids to manage neuropathic pain such as that from Guillain-Barré syndrome.

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Pain Assessment Tools

Different tools are used for assessing pain in ICU patients. The Behavioral Pain Score (BPS) is used for unresponsive patients, while the Critical Care Pain Observational Tool (CPOT) is used for patients who can't communicate verbally. For conscious patients, the Visual Analogue Score (VAS) is used.

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Pain Thresholds in ICU

Pain management is initiated when the pain score reaches a certain threshold. In ICU, action is taken when the BPS score is ≥ 5, the CPOT score is ≥ 3, or the VAS score is ≥ 3.

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Opioid-Based Analgesia

The primary approach to managing pain in the ICU is opioid-based analgesia. However, it's crucial to consider adjuncts to reduce the opioid dosage and pain severity.

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Adjuncts to Pain Management

These are medications used in addition to opioids to lessen pain and/or reduce the required opioid dosage. Some examples include paracetamol (acetaminophen) for moderate pain and IV ketamine for post-surgical pain.

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Patient-Controlled Analgesia (PCA)

PCA allows patients to self-administer pain medication, enabling them to manage their pain effectively. It's suitable for awake and cooperative patients.

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Pain Management Pre-Procedure

Anaesthetics are administered before procedures that may cause pain, allowing for pre-emptive pain control. This ensures the lowest effective dose is used and the peak effect coincides with the procedure.

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Neuropathic Pain Management

For neuropathic pain, such as in Guillain-Barré Syndrome, a combination of opioids, gabapentin or carbamazepine is used to provide effective pain relief.

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Regional Analgesia

Regional pain relief is utilized in selected patients to manage pain in specific areas. For instance, thoracic epidural analgesia might be employed after abdominal aortic aneurysm surgery or rib fractures.

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ICU Sedation Goal

In ICU settings, the goal is to achieve 'light sedation' where patients are awake, calm, and comfortable. This is crucial for facilitating weaning from mechanical ventilation and promoting early mobilization.

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Sedation Assessment in ICU

Sedation levels are assessed every 4 hours to ensure patient comfort and safety. The goal is to maintain a light sedation level while avoiding unnecessary sedation and its associated complications.

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Study Notes

Sedation & Pain Management

  • Light sedation and pain management in ICU patients are crucial to avoid complications and conflicts with other goals, like weaning from mechanical ventilation and early mobilization.
  • The principle is to prioritize analgesia before sedation. Use an analgesic (usually an opioid) first, then a sedative to reach the sedation goal.
  • Aim for minimal sedation unless contraindicated.
  • Titrate analgesic and sedative drugs to a target, using the lowest effective dose.
  • Identify risk factors and implement prevention measures for delirium.
  • Pain, sedation, and delirium should be assessed objectively using validated tools.
  • Use pharmacological and non-pharmacological strategies to manage pain, agitation, and delirium.

Pain Management

  • Use validated pain scales (e.g., Behavioral Pain Score (BPS), Critical Care Pain Observational Tool (CPOT), Visual Analogue Score (VAS)) to monitor pain.
  • Assess pain at least every 4 hours.
  • Initiate pain management when pain scores meet predefined thresholds (e.g., ≥ 5 for BPS, ≥ 3 for CPOT, ≥ 3 for VAS).
  • Opioid-based analgesia is the mainstay of pain management.
  • Consider adjunctive therapies (e.g., paracetamol, IV ketamine) to reduce opioid dose and pain severity.

Patient-Controlled Analgesia (PCA)

  • PCA can be used for awake and cooperative patients.
  • Administer an analgesic prior to a procedure that causes pain, using the lowest effective dose possible and timing the administration to coincide with the procedure's peak effect.
  • Gabapentin or carbamazepine can be combined with opioids to manage neuropathic pain (e.g., Guillain-Barré syndrome).

Regional Analgesia

  • Consider regional analgesia for selected surgical or trauma patients (e.g., thoracic epidural analgesia in post-operative abdominal aortic aneurysm surgery or traumatic rib fractures).

Pharmacological Agents for Pain Management

Drug Bolus Dosage Infusion Dosage Max Dosage Side Effects
IV Fentanyl 0.35 - 0.5 µg/kg 0.5 - 2 µg/kg/h Cumulative in hepatic impairment
IV Morphine 2-4 mg 2-10 mg/h Cumulative in renal and hepatic impairment (avoid if GFR < 20); Ileus with high doses
IV Ketamine 0.1-0.35 mg/kg 0.1-0.5 mg/kg/h Dissociative disorder with higher doses; Hypotension (intravenous); Liver dysfunction
IV/PO Paracetamol 500 mg - 1 gm or 15 mg/kg q6h
PO: 500 mg - 1 gm q6h
4 g/day

Pharmacological Agents for Sedation & Agitation Management

Drug Bolus Dosage Infusion Dosage Max Dosage Side Effects
IV Fentanyl (high dose) 100-200 µg/hr 50-500 µg/hr Cumulative in hepatic impairment
IV Propofol 1% 1-2 mg/kg 50-200 mg/h 4 mg/kg/h Cumulative in hepatic impairment; Fatty liver; Hypotension; Hypertriglyceridemia; Pancreatitis; Propofol infusion syndrome; Infection
IV Midazolam 0.01-0.05 mg/kg 0.02 - 0.1 mg/kg/h Respiratory depression; Hypotension; Delirium; Agitation
IV Dexmedetomidine 0.2-0.7 µg/kg/h 1.5 µg/kg/h Hypotension

Sedation Management

  • Assess sedation every 4 hours.
  • Aim for light sedation with the patient being awake, calm, and comfortable.
  • Use analgesia-first sedatives (morphine or fentanyl) in mechanically ventilated patients.
  • If additional sedatives are required, non-benzodiazepines (propofol or dexmedetomidine) are preferred.
  • Consider adding intravenous midazolam or propofol infusion for deep sedation.
  • Reassess the need for deep sedation and wean sedatives when no longer required.
  • Use dexmedetomidine in patients unable to wean off the ventilator due to agitated delirium.
  • Use benzodiazepines to provide amnesia for procedures or in patients with anxiety, seizures, alcohol withdrawal, or palliation.

Deep Sedation Scenarios

  • Head injury requiring cerebral protection
  • Post-cardiac arrest care
  • Patients on high vasopressors or inotropes
  • Patients on high ventilatory settings
  • Patients in prone position
  • Patients with massive pulmonary hemorrhage
  • Patients with severe bronchial asthma
  • Patients with tetanus
  • Patients on neuromuscular blocking agents

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