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Questions and Answers
Which antiplatelet agent would be appropriate for a patient with a recent thrombotic stroke and no active bleeding?
Which anticoagulant is indicated specifically for persistent or paroxysmal nonvalvular atrial fibrillation?
In the prevention of recurrent ischemic stroke, which medication is noted to be better than warfarin for nonvalvular atrial fibrillation?
For a patient with a hypercoagulable state and intracardiac thrombi, which anticoagulant is appropriately indicated?
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What is the recommended loading dose of Clopidogrel for the prevention of recurrent stroke?
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Study Notes
Secondary Prevention of Ischemic Stroke
- Secondary prevention of ischemic stroke aims to prevent recurrence.
Antiplatelet Agents
- Aspirin is used to prevent recurrent stroke, with a dosage of 75-325 mg/day, unless contraindicated by active bleeding or other conditions.
- Clopidogrel (Plavix®) is an alternative to aspirin, with a loading dose of 300 mg followed by 75 mg/day.
Anticoagulants for Cardioembolic Stroke
- Warfarin (Marevan) is indicated for hypercoagulable states and cardiac sources such as atrial fibrillation (AF) or intracardiac thrombi.
- Dabigatran (Pradaxa®) is used for persistent or paroxysmal nonvalvular AF and is more effective than warfarin.
- Rivaroxaban (Xarelto®) is a factor Xa inhibitor that reduces the risk of stroke and systemic embolism in nonvalvular AF, outperforming warfarin.
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Description
Learn about the medications used to prevent recurrence of ischemic stroke, including antiplatelet agents and anticoagulants, their dosages, and indications.
