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Questions and Answers
During what process do bones increase in size and shift in space?
During what process do bones increase in size and shift in space?
- Osteopenia
- Osteoporosis
- Remodeling
- Modeling (correct)
At what age range is skeletal mass typically maximal?
At what age range is skeletal mass typically maximal?
- 20-25 years
- 35-40 years
- 30-35 years
- 25-30 years (correct)
In which gender does bone mass decline start earlier?
In which gender does bone mass decline start earlier?
- Women, after age 50 years
- Men, after age 40 years
- Women, after age 40 years (correct)
- Men, after age 50 years
What is the definition of osteoporosis provided in the text?
What is the definition of osteoporosis provided in the text?
According to the passage, how often is most of the adult skeleton replaced?
According to the passage, how often is most of the adult skeleton replaced?
Which group is mentioned as being at high risk for osteopenia in peri-menopausal women?
Which group is mentioned as being at high risk for osteopenia in peri-menopausal women?
What is the estimated direct cost of caring for patients with osteoporotic fractures in the United States each year?
What is the estimated direct cost of caring for patients with osteoporotic fractures in the United States each year?
What percentage of fragility fractures occur after age 65 years?
What percentage of fragility fractures occur after age 65 years?
What is the risk of death from complications associated with a hip fracture within the first year of the incident?
What is the risk of death from complications associated with a hip fracture within the first year of the incident?
What percentage of hip fracture patients have lifelong mobility issues, with 25% requiring admission to long-term care?
What percentage of hip fracture patients have lifelong mobility issues, with 25% requiring admission to long-term care?
Which of the following is NOT a risk factor for bone loss?
Which of the following is NOT a risk factor for bone loss?
What percentage of osteoporosis-related fractures in the United States are in women?
What percentage of osteoporosis-related fractures in the United States are in women?
What is the recommended approach to reducing falls risk in older adults with diabetes?
What is the recommended approach to reducing falls risk in older adults with diabetes?
What is the relationship between insulin resistance and bone mass development in young patients?
What is the relationship between insulin resistance and bone mass development in young patients?
What is the relationship between abdominal obesity and bone health?
What is the relationship between abdominal obesity and bone health?
Which ethnic group has the highest hip fracture rates?
Which ethnic group has the highest hip fracture rates?
Which bisphosphonate is the most potent inhibitor of bone resorption?
Which bisphosphonate is the most potent inhibitor of bone resorption?
Which bisphosphonate is known to induce osteoclast apoptosis?
Which bisphosphonate is known to induce osteoclast apoptosis?
Which bisphosphonate has been shown to reduce nonvertebral fractures?
Which bisphosphonate has been shown to reduce nonvertebral fractures?
Which bisphosphonate has the shortest terminal half-life in bone?
Which bisphosphonate has the shortest terminal half-life in bone?
Which bisphosphonate is not recommended for use during breastfeeding?
Which bisphosphonate is not recommended for use during breastfeeding?
Which bisphosphonate has been shown to increase bone mineral density in children with low bone density due to malabsorption syndromes?
Which bisphosphonate has been shown to increase bone mineral density in children with low bone density due to malabsorption syndromes?
Which bisphosphonate is available only for parenteral use?
Which bisphosphonate is available only for parenteral use?
Which bisphosphonate reduces both bone resorption and bone formation?
Which bisphosphonate reduces both bone resorption and bone formation?
Which bisphosphonate has the longest terminal half-life in bone?
Which bisphosphonate has the longest terminal half-life in bone?
Which bisphosphonate is used to prevent heterotopic ossifications or soft tissue calcifications in children?
Which bisphosphonate is used to prevent heterotopic ossifications or soft tissue calcifications in children?
Which of the following bisphosphonate drugs is typically reserved for monthly cancer metastasis prevention and treatment?
Which of the following bisphosphonate drugs is typically reserved for monthly cancer metastasis prevention and treatment?
Which statement is true about the dosing schedule for the intravenous (IV) administration of ibandronate?
Which statement is true about the dosing schedule for the intravenous (IV) administration of ibandronate?
What is the typical dosage schedule for etidronate in the treatment of post-menopausal osteoporosis?
What is the typical dosage schedule for etidronate in the treatment of post-menopausal osteoporosis?
According to the passage, what is the lowest cost bisphosphonate drug?
According to the passage, what is the lowest cost bisphosphonate drug?
Which of the following statements about etidronate is true, according to the passage?
Which of the following statements about etidronate is true, according to the passage?
What is the primary clinical use of bone remodeling drugs shifting towards?
What is the primary clinical use of bone remodeling drugs shifting towards?
What is the dosage schedule mentioned in the passage for zoledronic acid, an IV osteoporosis treatment and fracture prevention medication?
What is the dosage schedule mentioned in the passage for zoledronic acid, an IV osteoporosis treatment and fracture prevention medication?
What condition is associated with altering the balance between bone resorption and formation?
What condition is associated with altering the balance between bone resorption and formation?
What percentage of skeletal mass will be lost in 20 years if bone resorption exceeds formation by 2% per year?
What percentage of skeletal mass will be lost in 20 years if bone resorption exceeds formation by 2% per year?
Which tool estimates the 10-year probability of major bone fractures at the hip, wrist, and shoulder?
Which tool estimates the 10-year probability of major bone fractures at the hip, wrist, and shoulder?
What is the recommended interval for screenings according to the U.S. Preventive Services Task Force in 2017?
What is the recommended interval for screenings according to the U.S. Preventive Services Task Force in 2017?
How does the FRAX score alone estimate the risk compared to other evaluation tools for osteoporosis?
How does the FRAX score alone estimate the risk compared to other evaluation tools for osteoporosis?
At what age do women have a 23% chance of hip fracture according to Black et al (2017)?
At what age do women have a 23% chance of hip fracture according to Black et al (2017)?
Which statement is true regarding the metabolism of bisphosphonates?
Which statement is true regarding the metabolism of bisphosphonates?
How is the drug that is not distributed to bone typically eliminated from the body?
How is the drug that is not distributed to bone typically eliminated from the body?
For patients with moderate to severe renal impairment, what is the recommendation regarding the use of bisphosphonates?
For patients with moderate to severe renal impairment, what is the recommendation regarding the use of bisphosphonates?
Which of the following is an absolute contraindication for the use of bisphosphonates, according to the text?
Which of the following is an absolute contraindication for the use of bisphosphonates, according to the text?
What is recommended for patients with gastrointestinal disorders when using bisphosphonates?
What is recommended for patients with gastrointestinal disorders when using bisphosphonates?
Which of the following statements is true regarding the risk of severe adverse reactions in the esophagus when taking bisphosphonates?
Which of the following statements is true regarding the risk of severe adverse reactions in the esophagus when taking bisphosphonates?
What is the potential solution marketed for addressing the issues related to adverse reactions in the esophagus?
What is the potential solution marketed for addressing the issues related to adverse reactions in the esophagus?
What is the reason for withholding etidronate from patients with enterocolitis, according to the text?
What is the reason for withholding etidronate from patients with enterocolitis, according to the text?
What is the risk associated with giving high doses of etidronate or prolonged therapy (longer than 6 months) to patients with Paget disease?
What is the risk associated with giving high doses of etidronate or prolonged therapy (longer than 6 months) to patients with Paget disease?
What is the rare form of fracture that is under scrutiny for patients without Paget disease who take bisphosphonates, according to the text?
What is the rare form of fracture that is under scrutiny for patients without Paget disease who take bisphosphonates, according to the text?
Which of the following is a risk factor for osteoporosis that is common among African American women?
Which of the following is a risk factor for osteoporosis that is common among African American women?
According to the passage, which of the following is a reason why Hispanic women have an increased risk of osteoporosis?
According to the passage, which of the following is a reason why Hispanic women have an increased risk of osteoporosis?
What is the primary mechanism by which bisphosphonates help prevent osteoporosis?
What is the primary mechanism by which bisphosphonates help prevent osteoporosis?
Which of the following is a risk factor for osteoporosis that is common among Asian women?
Which of the following is a risk factor for osteoporosis that is common among Asian women?
Which of the following is NOT a risk factor for osteoporosis in men, as described in the passage?
Which of the following is NOT a risk factor for osteoporosis in men, as described in the passage?
What is the role of RANKL in the bone remodeling process?
What is the role of RANKL in the bone remodeling process?
Which of the following medication groups can be used to support bone health, according to the passage?
Which of the following medication groups can be used to support bone health, according to the passage?
What is the primary role of osteoblasts in the bone remodeling cycle?
What is the primary role of osteoblasts in the bone remodeling cycle?
Which of the following is a common risk factor for osteoporosis among both African American and Asian women?
Which of the following is a common risk factor for osteoporosis among both African American and Asian women?
What is the main finding regarding women over 80 years old who took bone medications for more than 10 years?
What is the main finding regarding women over 80 years old who took bone medications for more than 10 years?
What is the impact of taking histamine-2 blocking agents with alendronate?
What is the impact of taking histamine-2 blocking agents with alendronate?
What is the relationship between bisphosphonate use and the risk of GI bleeding?
What is the relationship between bisphosphonate use and the risk of GI bleeding?
What is the relationship between concurrent use of bisphosphonates and other bone-building drugs like estrogens and SERMs?
What is the relationship between concurrent use of bisphosphonates and other bone-building drugs like estrogens and SERMs?
Which of the following bisphosphonates has the best evidence for reducing hip fractures?
Which of the following bisphosphonates has the best evidence for reducing hip fractures?
What is the recommended initial dose of alendronate for the prevention of bone loss?
What is the recommended initial dose of alendronate for the prevention of bone loss?
What is the recommended treatment for patients taking more than 7.5 mg of prednisone or its equivalent for more than 3 weeks?
What is the recommended treatment for patients taking more than 7.5 mg of prednisone or its equivalent for more than 3 weeks?
What is the main concern regarding the use of PTH analogues like teriparatide and abaloparatide?
What is the main concern regarding the use of PTH analogues like teriparatide and abaloparatide?
What is the maximum recommended duration of use for teriparatide (Forteo) or abaloparatide (Tymlos)?
What is the maximum recommended duration of use for teriparatide (Forteo) or abaloparatide (Tymlos)?
What is the effect of using bisphosphonates for more than 4 years?
What is the effect of using bisphosphonates for more than 4 years?
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