Podcast
Questions and Answers
Which of the following is an example of a positive symptom of schizophrenia?
Which of the following is an example of a positive symptom of schizophrenia?
- Asociality
- Avolition
- Hallucinations (correct)
- Alogia
A patient experiencing poverty of speech is exhibiting which type of symptom associated with schizophrenia?
A patient experiencing poverty of speech is exhibiting which type of symptom associated with schizophrenia?
- Affective
- Cognitive
- Positive
- Negative (correct)
What distinguishes negative symptoms of schizophrenia from positive symptoms?
What distinguishes negative symptoms of schizophrenia from positive symptoms?
- Negative symptoms involve a reduction or absence of normal functions. (correct)
- Negative symptoms only appear during the active phase of schizophrenia.
- Negative symptoms are easier to treat with medication.
- Negative symptoms involve an excess or distortion of normal functions.
Which of the following is considered one of the 'five A's' of negative symptoms in schizophrenia?
Which of the following is considered one of the 'five A's' of negative symptoms in schizophrenia?
A patient who has a flat facial expression and speaks in a monotone voice is most likely exhibiting which negative symptom of schizophrenia?
A patient who has a flat facial expression and speaks in a monotone voice is most likely exhibiting which negative symptom of schizophrenia?
Lack of motivation for action is referred to as what in the context of negative symptoms of schizophrenia?
Lack of motivation for action is referred to as what in the context of negative symptoms of schizophrenia?
Which of schizophrenia's phases is characterized by a decline in interest in usual activities and withdrawal from social interactions?
Which of schizophrenia's phases is characterized by a decline in interest in usual activities and withdrawal from social interactions?
During which phase of schizophrenia do both positive and negative symptoms typically manifest?
During which phase of schizophrenia do both positive and negative symptoms typically manifest?
A patient is currently experiencing listlessness and difficulty concentrating after a period of hallucinations and delusions. Which phase of schizophrenia is the patient most likely in?
A patient is currently experiencing listlessness and difficulty concentrating after a period of hallucinations and delusions. Which phase of schizophrenia is the patient most likely in?
Which of the following best describes the 'kindling' phenomenon in the context of schizophrenia?
Which of the following best describes the 'kindling' phenomenon in the context of schizophrenia?
According to the diagnostic criteria for schizophrenia, how long must disturbances in functioning be present to meet requirement?
According to the diagnostic criteria for schizophrenia, how long must disturbances in functioning be present to meet requirement?
Schizophreniform disorder differs from schizophrenia primarily in:
Schizophreniform disorder differs from schizophrenia primarily in:
What is a key diagnostic criterion that differentiates schizoaffective disorder from schizophrenia?
What is a key diagnostic criterion that differentiates schizoaffective disorder from schizophrenia?
Why is early treatment of schizophrenia considered crucial?
Why is early treatment of schizophrenia considered crucial?
What is the primary mechanism of action (MOA) of first-generation antipsychotics (FGAs) in treating schizophrenia?
What is the primary mechanism of action (MOA) of first-generation antipsychotics (FGAs) in treating schizophrenia?
Second-generation antipsychotics (SGAs) are often preferred over first-generation antipsychotics (FGAs) due to:
Second-generation antipsychotics (SGAs) are often preferred over first-generation antipsychotics (FGAs) due to:
What is the significance of 5-HT2A antagonism in the mechanism of action of some second-generation antipsychotics (SGAs)?
What is the significance of 5-HT2A antagonism in the mechanism of action of some second-generation antipsychotics (SGAs)?
According to the information, which medication is generally NOT recommended as a first-line antipsychotic due to its association with significant weight gain?
According to the information, which medication is generally NOT recommended as a first-line antipsychotic due to its association with significant weight gain?
What is a notable side effect associated with Risperidone compared to other second-generation antipsychotics?
What is a notable side effect associated with Risperidone compared to other second-generation antipsychotics?
What is a potential ocular side effect associated with quetiapine (Seroquel)?
What is a potential ocular side effect associated with quetiapine (Seroquel)?
Clozapine is often reserved as a third trial drug because of what potentially dangerous side effect?
Clozapine is often reserved as a third trial drug because of what potentially dangerous side effect?
What monitoring is required with Clozapine?
What monitoring is required with Clozapine?
Ziprasidone is especially used in which setting?
Ziprasidone is especially used in which setting?
What is a key advantage of using long-acting injectable antipsychotics (LAIs) in the treatment of schizophrenia?
What is a key advantage of using long-acting injectable antipsychotics (LAIs) in the treatment of schizophrenia?
What is post-injection delirium/sedation syndrome, a serious adverse effect sometimes associated with?
What is post-injection delirium/sedation syndrome, a serious adverse effect sometimes associated with?
A patient with schizophrenia is struggling to adhere to their oral medication regimen. Which of the following antipsychotics has a long-acting injectable (LAI) formulation that requires oral supplementation for a few weeks?
A patient with schizophrenia is struggling to adhere to their oral medication regimen. Which of the following antipsychotics has a long-acting injectable (LAI) formulation that requires oral supplementation for a few weeks?
Which medication is considered relatively safe for pregnant women?
Which medication is considered relatively safe for pregnant women?
What is Cognitive Behavioral Therapy in managing Schizophrenia?
What is Cognitive Behavioral Therapy in managing Schizophrenia?
A patient with treatment-resistant schizophrenia (TRS) has failed trials of multiple antipsychotics. What is the next step?
A patient with treatment-resistant schizophrenia (TRS) has failed trials of multiple antipsychotics. What is the next step?
In Treatment-resistant schizophrenia, what are we reviewing history for?
In Treatment-resistant schizophrenia, what are we reviewing history for?
A patient who smokes and requires higher dose because of it, would also get an increased level of clozapine through?
A patient who smokes and requires higher dose because of it, would also get an increased level of clozapine through?
According to the information provided, what is a common sign of Acute Dystonia?
According to the information provided, what is a common sign of Acute Dystonia?
What is a drug used for treatment in patients with Acute Dystonia?
What is a drug used for treatment in patients with Acute Dystonia?
Fidgeting legs, rocking from side to side is a sign of what?
Fidgeting legs, rocking from side to side is a sign of what?
“Pill rolling tremor” is a sign of what?
“Pill rolling tremor” is a sign of what?
According to the material, what symptoms would a patient with Tardive dyskinesia may face?
According to the material, what symptoms would a patient with Tardive dyskinesia may face?
A patient who is stiff, hot and out of it would be suffering from which condition?
A patient who is stiff, hot and out of it would be suffering from which condition?
While a patient has Serotonin Syndrome, what are you most likely going to see in a patient’s reflexes?
While a patient has Serotonin Syndrome, what are you most likely going to see in a patient’s reflexes?
Which is a symptom that is present in Neuroleptic Malignant Syndrome?
Which is a symptom that is present in Neuroleptic Malignant Syndrome?
What would you prescribe to treat patients with Neuroleptic Malignant Syndrome?
What would you prescribe to treat patients with Neuroleptic Malignant Syndrome?
Medications for Schizophrenia require the patient to take everyday for how long to then consider re-assessing?
Medications for Schizophrenia require the patient to take everyday for how long to then consider re-assessing?
What is the rationale behind obtaining pretreatment labs and indices when initiating antipsychotic medication?
What is the rationale behind obtaining pretreatment labs and indices when initiating antipsychotic medication?
What is the primary mechanism by which first-generation antipsychotics (FGAs) exert their therapeutic effect?
What is the primary mechanism by which first-generation antipsychotics (FGAs) exert their therapeutic effect?
Which statement best describes the 'dopamine hypothesis' in relation to antipsychotic action?
Which statement best describes the 'dopamine hypothesis' in relation to antipsychotic action?
How do second-generation antipsychotics (SGAs) theoretically reduce the risk of movement disorders compared to first-generation antipsychotics (FGAs)?
How do second-generation antipsychotics (SGAs) theoretically reduce the risk of movement disorders compared to first-generation antipsychotics (FGAs)?
What effect does stimulation of 5-HT1A receptors have on dopamine and glutamate release, and how could that impact schizophrenia symptoms?
What effect does stimulation of 5-HT1A receptors have on dopamine and glutamate release, and how could that impact schizophrenia symptoms?
Which factor is most important when choosing between antipsychotic medications?
Which factor is most important when choosing between antipsychotic medications?
What is a primary concern associated with initiating olanzapine treatment?
What is a primary concern associated with initiating olanzapine treatment?
What side effect is more commonly seen with risperidone compared to other second-generation antipsychotics?
What side effect is more commonly seen with risperidone compared to other second-generation antipsychotics?
Why is routine eye examinations recommended for patients taking quetiapine?
Why is routine eye examinations recommended for patients taking quetiapine?
What is the primary reason clozapine is reserved for use after trials of other antipsychotics have failed?
What is the primary reason clozapine is reserved for use after trials of other antipsychotics have failed?
A patient taking clozapine must be monitored for which severe adverse effect?
A patient taking clozapine must be monitored for which severe adverse effect?
In which clinical situation is ziprasidone most useful due to its formulation?
In which clinical situation is ziprasidone most useful due to its formulation?
What is a primary advantage of using long-acting injectable antipsychotics (LAIs) over oral antipsychotics?
What is a primary advantage of using long-acting injectable antipsychotics (LAIs) over oral antipsychotics?
A patient is being started on olanzapine pamoate (Zyprexa Relprevv) LAI. What serious adverse effect requires monitoring for at least 3 hours post-injection?
A patient is being started on olanzapine pamoate (Zyprexa Relprevv) LAI. What serious adverse effect requires monitoring for at least 3 hours post-injection?
Which long-acting injectable antipsychotic requires oral supplementation for a period after the injection is administered?
Which long-acting injectable antipsychotic requires oral supplementation for a period after the injection is administered?
Which of the following antipsychotics is generally considered to have a relatively safe profile for use during pregnancy?
Which of the following antipsychotics is generally considered to have a relatively safe profile for use during pregnancy?
A patient with schizophrenia is being treated with an antipsychotic, but continues to experience significant cognitive impairment. Which intervention is MOST appropriate to recommend?
A patient with schizophrenia is being treated with an antipsychotic, but continues to experience significant cognitive impairment. Which intervention is MOST appropriate to recommend?
A patient with schizophrenia has not responded to trials of two different antipsychotics at adequate doses and durations. What is the definition of this condition?
A patient with schizophrenia has not responded to trials of two different antipsychotics at adequate doses and durations. What is the definition of this condition?
In a patient with treatment-resistant schizophrenia, which of the following evaluations is most important to perform?
In a patient with treatment-resistant schizophrenia, which of the following evaluations is most important to perform?
A patient who is a smoker has been stabilized on clozapine. If the patient suddenly stops smoking, what potential change in clozapine levels should be anticipated?
A patient who is a smoker has been stabilized on clozapine. If the patient suddenly stops smoking, what potential change in clozapine levels should be anticipated?
Which of the following is a common initial treatment for acute dystonia?
Which of the following is a common initial treatment for acute dystonia?
To best treat patients with Akathisia, which medication should you avoid?
To best treat patients with Akathisia, which medication should you avoid?
Which class has bent forward, stiffness and pill rolling tremor?
Which class has bent forward, stiffness and pill rolling tremor?
Which is the most common symptom patients will face with Tardive Dyskinesia?
Which is the most common symptom patients will face with Tardive Dyskinesia?
Identify the signs and symptoms that is related to Neuroleptic Malignant Syndrome:
Identify the signs and symptoms that is related to Neuroleptic Malignant Syndrome:
In which scenario would Dantrolene be a treatment?
In which scenario would Dantrolene be a treatment?
Before reassessing a patient's medication, how long should an antipsychotic be trailed?
Before reassessing a patient's medication, how long should an antipsychotic be trailed?
According to schizophrenia recovery rates (25% rule), what percentage of patients are dead after 10 years?
According to schizophrenia recovery rates (25% rule), what percentage of patients are dead after 10 years?
What is true in regards to antipsychotics and anticholinergic effects?
What is true in regards to antipsychotics and anticholinergic effects?
Which second-generation antipsychotic reduces risk of EPS?
Which second-generation antipsychotic reduces risk of EPS?
What side effects is more important to consider when taking cariprazine?
What side effects is more important to consider when taking cariprazine?
Which antipsychotic is used in injection form at ERs for acute psychosis?
Which antipsychotic is used in injection form at ERs for acute psychosis?
What does Early Psychosis Intervention Network (EPINET) do?
What does Early Psychosis Intervention Network (EPINET) do?
Which is a non-pharmacologic treatment?
Which is a non-pharmacologic treatment?
What causes long-term neuroleptics?
What causes long-term neuroleptics?
What is the treatment for Akinesia?
What is the treatment for Akinesia?
When should a provider avoid 2 treatment options?
When should a provider avoid 2 treatment options?
What is a medication that leads to a hyperkinetic/facial and tongue movement disorder?
What is a medication that leads to a hyperkinetic/facial and tongue movement disorder?
Before diagnosing and treating a patient for Treatment Resistance Schizophrenia, what is important for the practitioner to do?
Before diagnosing and treating a patient for Treatment Resistance Schizophrenia, what is important for the practitioner to do?
Which is an EPS (extrapyramidal symptom)?
Which is an EPS (extrapyramidal symptom)?
What is the primary distinction between positive and negative symptoms of schizophrenia?
What is the primary distinction between positive and negative symptoms of schizophrenia?
Which of the following represents 'avolition' as a negative symptom of schizophrenia?
Which of the following represents 'avolition' as a negative symptom of schizophrenia?
During the prodromal phase of schizophrenia, which of the following behaviors is MOST likely to be observed?
During the prodromal phase of schizophrenia, which of the following behaviors is MOST likely to be observed?
How would you describe the 'kindling' phenomenon observed in individuals with schizophrenia?
How would you describe the 'kindling' phenomenon observed in individuals with schizophrenia?
According to the diagnostic criteria, what is the PRIMARY timeframe in which disturbances in functioning must be present to meet the criteria for schizophrenia?
According to the diagnostic criteria, what is the PRIMARY timeframe in which disturbances in functioning must be present to meet the criteria for schizophrenia?
What is a KEY difference between Schizophreniform disorder and Schizophrenia?
What is a KEY difference between Schizophreniform disorder and Schizophrenia?
How does schizoaffective disorder DISTINCTLY differ from schizophrenia?
How does schizoaffective disorder DISTINCTLY differ from schizophrenia?
Why is early intervention in the treatment of schizophrenia emphasized?
Why is early intervention in the treatment of schizophrenia emphasized?
First-generation antipsychotics (FGAs) primarily target what neurotransmitter receptor?
First-generation antipsychotics (FGAs) primarily target what neurotransmitter receptor?
Why are second-generation antipsychotics (SGAs) often favored over first-generation antipsychotics (FGAs) in clinical practice?
Why are second-generation antipsychotics (SGAs) often favored over first-generation antipsychotics (FGAs) in clinical practice?
What role is 5-HT2A antagonism believed to serve in the mechanism of action of second-generation antipsychotics?
What role is 5-HT2A antagonism believed to serve in the mechanism of action of second-generation antipsychotics?
Why is olanzapine typically NOT recommended as a first-line antipsychotic medication?
Why is olanzapine typically NOT recommended as a first-line antipsychotic medication?
What is a significant adverse effect associated with Risperidone usage, in comparison to other second-generation antipsychotics?
What is a significant adverse effect associated with Risperidone usage, in comparison to other second-generation antipsychotics?
Which of the following potential side effects necessitates routine eye examinations in patients who are on quetiapine?
Which of the following potential side effects necessitates routine eye examinations in patients who are on quetiapine?
Considering its side effect profile, why is clozapine generally reserved as a third-line antipsychotic treatment?
Considering its side effect profile, why is clozapine generally reserved as a third-line antipsychotic treatment?
Which lab value requires continuous monitoring for patients who are prescribed Clozapine?
Which lab value requires continuous monitoring for patients who are prescribed Clozapine?
In what clinical setting is ziprasidone particularly useful due to its available formulation?
In what clinical setting is ziprasidone particularly useful due to its available formulation?
What is a primary advantage of long-acting injectable antipsychotics (LAIs) compared to oral antipsychotics?
What is a primary advantage of long-acting injectable antipsychotics (LAIs) compared to oral antipsychotics?
What potentially serious adverse effect requires monitoring for at least 3 hours post-injection when a patient is administered olanzapine pamoate (Zyprexa Relprevv) LAI?
What potentially serious adverse effect requires monitoring for at least 3 hours post-injection when a patient is administered olanzapine pamoate (Zyprexa Relprevv) LAI?
Which of the long-acting AP formulations requires oral supplementation after the injection is administered?
Which of the long-acting AP formulations requires oral supplementation after the injection is administered?
Which antipsychotic medication is generally considered to have a relatively safer profile for use during pregnancy?
Which antipsychotic medication is generally considered to have a relatively safer profile for use during pregnancy?
In cases where a schizophrenia patient continues to show reduced cognitive impairment, while on an AP medication, what would be the NEXT MOST appropriate recommendation?
In cases where a schizophrenia patient continues to show reduced cognitive impairment, while on an AP medication, what would be the NEXT MOST appropriate recommendation?
Which statement accurately describes "Treatment Resistance Schizophrenia"?
Which statement accurately describes "Treatment Resistance Schizophrenia"?
In a patient with treatment-resistant schizophrenia, what is the MOST important initial step in evaluation?
In a patient with treatment-resistant schizophrenia, what is the MOST important initial step in evaluation?
A patient stable on clozapine quits smoking. What adjustments to medication levels should the provider consider, assuming no other changes?
A patient stable on clozapine quits smoking. What adjustments to medication levels should the provider consider, assuming no other changes?
Which of the following is an appropriate treatment option for acute dystonia?
Which of the following is an appropriate treatment option for acute dystonia?
When using medications to best treat Akathisia, which of these medications should you avoid?
When using medications to best treat Akathisia, which of these medications should you avoid?
A patient comes to your office hunched over, with noticeable stiffness. The patient indicates they are suffering “pill rolling tremors”. Which condition is this patient facing?
A patient comes to your office hunched over, with noticeable stiffness. The patient indicates they are suffering “pill rolling tremors”. Which condition is this patient facing?
What signs and symptoms would a patient who has Tardive Dyskinesia commonly face?
What signs and symptoms would a patient who has Tardive Dyskinesia commonly face?
A patient who is presenting as stiff, hot and confused would be suffering from?
A patient who is presenting as stiff, hot and confused would be suffering from?
While a patient is suffering from Serotonin Syndrome, what are you most likely going to see in a patient’s reflexes?
While a patient is suffering from Serotonin Syndrome, what are you most likely going to see in a patient’s reflexes?
Which of the following treatments is MOST appropriate for a patient experiencing Neuroleptic Malignant Syndrome (NMS)?
Which of the following treatments is MOST appropriate for a patient experiencing Neuroleptic Malignant Syndrome (NMS)?
How long must a medication be trailed to be reconsidered for assessment?
How long must a medication be trailed to be reconsidered for assessment?
Based on the schizophrenia recovery data presented, what percentage of patients are deceased after 10 years?
Based on the schizophrenia recovery data presented, what percentage of patients are deceased after 10 years?
What correlation is MOST accurate regarding the Anticholinergic effects when pertaining to medications for schizophrenia?
What correlation is MOST accurate regarding the Anticholinergic effects when pertaining to medications for schizophrenia?
Due to its indication in injection form, which AP medication is used at some ERs for acute psychosis?
Due to its indication in injection form, which AP medication is used at some ERs for acute psychosis?
What care does EPINET provide?
What care does EPINET provide?
Which option is a non-pharmacologic treatment.
Which option is a non-pharmacologic treatment.
Which medication is MOST related to the risk of hyperkinetic/facial and tongue movements disorder?
Which medication is MOST related to the risk of hyperkinetic/facial and tongue movements disorder?
Prior to diagnosing a patient with Treatment Resistance Schizophrenia, what is IMPORTANT to ascertain by a provider?
Prior to diagnosing a patient with Treatment Resistance Schizophrenia, what is IMPORTANT to ascertain by a provider?
Pertaining to extrapyramidal side effects, which is MOST likely?
Pertaining to extrapyramidal side effects, which is MOST likely?
Flashcards
Delusions
Delusions
False beliefs that are not based in reality
Hallucinations
Hallucinations
Sensory experiences that occur without an external stimulus
Difficulty in abstract thinking
Difficulty in abstract thinking
Difficulty in abstract thinking. Focus on concrete details.
Affective blunting
Affective blunting
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Avolition
Avolition
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Alogia
Alogia
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Anhedonia
Anhedonia
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Asociality
Asociality
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Schizophrenia Prodromal Phase
Schizophrenia Prodromal Phase
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Schizophrenia Active Phase
Schizophrenia Active Phase
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Schizophrenia Residual Phase
Schizophrenia Residual Phase
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Schizophrenia timeline
Schizophrenia timeline
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Schizophreniform timeline
Schizophreniform timeline
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Schizoaffective Disorder
Schizoaffective Disorder
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Antipsychotics (AP)
Antipsychotics (AP)
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APs Mechanism of Action (MOA)
APs Mechanism of Action (MOA)
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Second Generation Antipsychotics (SGAs)
Second Generation Antipsychotics (SGAs)
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Clozapine (Clozaril)
Clozapine (Clozaril)
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Clozapine REMS
Clozapine REMS
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Risperidone (Risperdal)
Risperidone (Risperdal)
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Aripiprazole (Abilify)
Aripiprazole (Abilify)
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Neuroleptic Malignant Syndrome
Neuroleptic Malignant Syndrome
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Anticholinergics
Anticholinergics
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Akithisia
Akithisia
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Pseudo Parkinson's
Pseudo Parkinson's
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Tardive Dyskinesia (TD)
Tardive Dyskinesia (TD)
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Positive Symptoms
Positive Symptoms
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Negative Symptoms
Negative Symptoms
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Disorganized Speech
Disorganized Speech
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Disorganized Behavior
Disorganized Behavior
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Catatonic Behavior
Catatonic Behavior
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Agitation
Agitation
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Difficulty Concentrating
Difficulty Concentrating
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Emotional Withdrawal
Emotional Withdrawal
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Poor Rapport
Poor Rapport
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Passivity
Passivity
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Apathetic Social Withdrawal
Apathetic Social Withdrawal
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Treatment Significance
Treatment Significance
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Residual Symptoms
Residual Symptoms
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1-6 months
1-6 months
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Two-week psychotic episode
Two-week psychotic episode
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Goals of Treatment
Goals of Treatment
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Psychotic Disorders
Psychotic Disorders
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Treatment Delay
Treatment Delay
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Majority of FEP
Majority of FEP
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Antipsychotic properties
Antipsychotic properties
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Anti-Psychotics
Anti-Psychotics
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Antipsychotics
Antipsychotics
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Theoretical (SGA) decreased
Theoretical (SGA) decreased
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Advantages (SGA)
Advantages (SGA)
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Disadvantages (SGA)
Disadvantages (SGA)
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SGAs
SGAs
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SGAs
SGAs
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PANCE answer
PANCE answer
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Disadvantages (PANCE answer)
Disadvantages (PANCE answer)
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SGAs (Lanzapine)
SGAs (Lanzapine)
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Haldol
Haldol
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Bonus
Bonus
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Added Bonus
Added Bonus
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Treatment nonadherence
Treatment nonadherence
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Side effect
Side effect
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Schizophrenia Hallucinations
Schizophrenia Hallucinations
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Schizophrenia: Communication distortion
Schizophrenia: Communication distortion
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Negative symptom: Blunted affect
Negative symptom: Blunted affect
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Negative symptom: Avolition
Negative symptom: Avolition
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Negative symptom: Alogia
Negative symptom: Alogia
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Negative symptom: Anhedonia
Negative symptom: Anhedonia
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Negative symptom: Asociality
Negative symptom: Asociality
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Schizophrenia Diagnostic Criteria
Schizophrenia Diagnostic Criteria
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Schizophreniform Disorder
Schizophreniform Disorder
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What Increases Relapse?
What Increases Relapse?
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Adherence challenges.
Adherence challenges.
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Clozapine Side Effects
Clozapine Side Effects
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Haldol Mechanism of action
Haldol Mechanism of action
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Risperdal Side Effects
Risperdal Side Effects
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Which SGAs are known for agonist
Which SGAs are known for agonist
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EPS side effects
EPS side effects
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Acute Dystonia
Acute Dystonia
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What blocks symptoms EPS
What blocks symptoms EPS
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NML symptoms
NML symptoms
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Are safe to take while pregnant
Are safe to take while pregnant
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Long-term movements
Long-term movements
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What can you do when TD occurs
What can you do when TD occurs
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Schizophrenia Treatment
Schizophrenia Treatment
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Schizophrenia recovery rates
Schizophrenia recovery rates
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AP Post Treatment Labs and Indices
AP Post Treatment Labs and Indices
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Study Notes
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