Saliva Composition and Modification Quiz

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Questions and Answers

What active process occurs in the ducts as primary saliva is modified?

  • Chloride secretion
  • Sodium absorption (correct)
  • Bicarbonate absorption
  • Potassium absorption

How does the composition of saliva change as it modifies in the ducts?

  • It loses all electrolytes.
  • It becomes more acidic.
  • It remains identical to plasma.
  • It becomes slightly alkaline. (correct)

What drives the passive movement of electrolytes during saliva modification?

  • Temperature changes
  • A pressure gradient
  • Enzymatic reactions
  • An ionic imbalance (correct)

Which of the following ions is actively secreted to balance the charge in saliva?

<p>Bicarbonate (B)</p> Signup and view all the answers

What is the primary source of saliva before modification occurs in the ducts?

<p>Acini (A)</p> Signup and view all the answers

What electrical negativity is created in the salivary ducts due to excess Na+ reabsorption over K+ secretion?

<p>-70 (A)</p> Signup and view all the answers

Which type of reflex is triggered by the presence of food in the mouth?

<p>Simple reflex (D)</p> Signup and view all the answers

What function does the glossopharyngeal nerve (cranial nerve IX) serve?

<p>Stimulates secretion from the parotid gland (B)</p> Signup and view all the answers

What is the role of salivary amylase in saliva?

<p>Digests carbohydrates (C)</p> Signup and view all the answers

Which type of salivary reflex occurs without oral stimulation?

<p>Conditioned reflex (B)</p> Signup and view all the answers

Which cranial nerve is responsible for taste sensation from the posterior one-third of the tongue?

<p>Glossopharyngeal nerve (A)</p> Signup and view all the answers

What happens to chloride ions in the salivary ducts due to electrical negativity?

<p>They are reabsorbed passively (D)</p> Signup and view all the answers

Which glands are stimulated by the facial nerve?

<p>Sublingual and submandibular glands (C)</p> Signup and view all the answers

What is the primary role of the parasympathetic nervous system in salivary gland activity?

<p>To stimulate increased salivary secretion rich in enzymes (C)</p> Signup and view all the answers

Which condition is associated with increased saliva production?

<p>Sour taste stimulation (D)</p> Signup and view all the answers

Which of the following glands secretes Hydrochloric acid?

<p>Oxyntic glands (C)</p> Signup and view all the answers

What is the dominant role of the parasympathetic nervous system in the context of salivary secretion?

<p>To produce a large volume of enzyme-rich saliva (C)</p> Signup and view all the answers

Pepsinogen released by gastric glands is important for which digestive process?

<p>Digestion of proteins (B)</p> Signup and view all the answers

What does the sympathetic nervous system primarily produce in terms of salivary secretion?

<p>Small volumes of saliva rich in mucus (B)</p> Signup and view all the answers

Where is the gastric mucus located primarily?

<p>In the body and fundus regions (B)</p> Signup and view all the answers

Which component is essential for the absorption of Vitamin B12?

<p>Intrinsic factor (B)</p> Signup and view all the answers

The primary function of mucus in gastric secretion is to:

<p>Protect gastric cells from acid damage (D)</p> Signup and view all the answers

Chopping a pencil, which is a rough object, has what effect on saliva production?

<p>It inhibits saliva production (A)</p> Signup and view all the answers

What do parietal cells primarily secrete?

<p>Hydrochloric acid and intrinsic factor (C)</p> Signup and view all the answers

Which cells are primarily responsible for secreting pepsinogen?

<p>Peptic (chief) cells (C)</p> Signup and view all the answers

What is the main purpose of mucus secreted by mucous neck cells?

<p>To prevent the acids from damaging surrounding tissues (D)</p> Signup and view all the answers

What two components are required for the formation of hydrochloric acid (HCl) in the canaliculi?

<p>Water and carbon dioxide (B)</p> Signup and view all the answers

Which mechanism is used to transport hydrogen ions (H⁺) into the canaliculi?

<p>H⁺/K⁺ ATP pump (C)</p> Signup and view all the answers

What happens when carbon dioxide (CO₂) combines with water (H₂O) in the presence of carbonic anhydrase?

<p>It forms carbonic acid (H₂CO₃) (B)</p> Signup and view all the answers

What is the function of the microvilli lining the canaliculi?

<p>To increase surface area for secretion (B)</p> Signup and view all the answers

What is the role of bicarbonate in the gastric system?

<p>To protect cells from acid damage (A)</p> Signup and view all the answers

What is the role of pepsin in the stomach?

<p>To initiate protein digestion (C)</p> Signup and view all the answers

Which cells are responsible for secreting intrinsic factor?

<p>Parietal cells (A)</p> Signup and view all the answers

What condition results from a deficiency of vitamin B12?

<p>Megaloblastic anemia (D)</p> Signup and view all the answers

How does the destruction of parietal cells affect digestion?

<p>It prevents protein digestion due to absence of HCl (C)</p> Signup and view all the answers

What effect does chronic gastritis have on the body’s ability to absorb vitamin B12?

<p>Destroys intrinsic factor-producing cells (B)</p> Signup and view all the answers

G cells in the pyloric glands are responsible for secreting which hormone?

<p>Gastrin (D)</p> Signup and view all the answers

What is the main function of the thick mucus secreted by surface mucous cells?

<p>To lubricate food movement (B)</p> Signup and view all the answers

What is a consequence of achlorhydria?

<p>Inability to properly digest proteins (B)</p> Signup and view all the answers

What happens to folic acid levels when vitamin B12 is deficient?

<p>Increases and accumulates in RBCs (D)</p> Signup and view all the answers

The primary alkalinity of the mucus produced in the pyloric glands serves to:

<p>Prevent direct contact of cells with HCl (D)</p> Signup and view all the answers

Which gland produces the majority of saliva in the human mouth?

<p>Parotid gland (D)</p> Signup and view all the answers

What is the primary function of salivary alpha amylase?

<p>Breakdown of polysaccharides (D)</p> Signup and view all the answers

Which component of saliva plays a role in lubricating food in the mouth?

<p>Mucin (B)</p> Signup and view all the answers

What is the pH range of saliva?

<p>6-7 (A)</p> Signup and view all the answers

Which of the following is NOT a major component of saliva?

<p>Salivary Lipase (B)</p> Signup and view all the answers

Which electrolytes are found in saliva in higher concentrations compared to plasma?

<p>Potassium and Bicarbonate (A)</p> Signup and view all the answers

What role do proline-rich proteins play in saliva?

<p>Enamel protection (B)</p> Signup and view all the answers

The buccal glands primarily secrete which type of saliva?

<p>Mucous only (C)</p> Signup and view all the answers

Which GIT hormone is primarily responsible for stimulating the secretion of gastric juice?

<p>Gastrin (C)</p> Signup and view all the answers

Which factor contributes to the hypotonic nature of saliva?

<p>Low sodium concentration (A)</p> Signup and view all the answers

Which gland is mainly responsible for producing the enzyme amylase in saliva?

<p>Parotid gland (B)</p> Signup and view all the answers

Which type of secretion do submandibular and sublingual glands mainly produce?

<p>Both serous and mucous (A)</p> Signup and view all the answers

What is the primary reason for the antibacterial properties of saliva?

<p>Presence of IgA antibody (C)</p> Signup and view all the answers

What is the daily secretion range of saliva in milliliters?

<p>800-1500ml (A)</p> Signup and view all the answers

Flashcards

Primary Saliva

The initial saliva produced by the acini, the secretory units of salivary glands, is similar in composition to blood plasma.

Acini

These are the tiny, grape-like structures within salivary glands that produce the initial saliva.

Sodium Absorption

As primary saliva travels through the salivary ducts, sodium ions are actively absorbed into the duct cells, making the saliva less like plasma.

Potassium Secretion

Potassium ions are actively secreted from the duct cells into the saliva, further modifying its composition.

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Bicarbonate Secretion

Bicarbonate ions are secreted into the saliva to balance the charge created by sodium and potassium movement, making the saliva slightly alkaline.

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What starts carbohydrate digestion?

Saliva starts breaking down carbs in your mouth thanks to an enzyme called salivary amylase.

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What is one key function of saliva?

Saliva protects your mouth by washing away food debris and harmful substances.

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How does saliva maintain pH balance?

Saliva acts as a buffer, keeping your mouth's pH balanced.

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What allows you to sing and talk?

The movement of your tongue and mouth rely on saliva for lubrication.

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What enzyme breaks down carbs in your mouth?

Saliva contains the enzyme salivary amylase which digests carbohydrates.

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What is a simple salivary reflex?

It's called a simple reflex because it's triggered by direct contact with food in your mouth.

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What is an acquired salivary reflex?

This reflex starts with anticipation! Think about how your mouth waters when you see or smell delicious food.

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What is the role of the Glossopharyngeal nerve (IX) in salivation?

This nerve has two roles: stimulating saliva production from parotid gland and sensing taste from the tongue.

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Salivary glands control

The parasympathetic nervous system is primarily responsible for controlling the salivary glands.

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What inhibits saliva?

Sour taste and rough objects like a pencil can inhibit saliva production.

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Sympathetic and parasympathetic role in saliva

Both the sympathetic and parasympathetic nervous systems stimulate salivary secretion, although the parasympathetic plays a more dominant role.

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Parasympathetic vs. Sympathetic saliva

The parasympathetic nervous system produces more saliva, which is richer in enzymes, while the sympathetic produces smaller amounts of mucus-rich saliva.

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Gastric glands

Gastric glands are a type of tubular gland found in the stomach mucosa.

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What does HCl do?

Hydrochloric acid (HCl) is a strong acid produced by oxyntic glands in the stomach, essential for digestion.

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What is Pepsinogen?

Pepsinogen is an inactive enzyme produced by oxyntic glands, important for protein digestion.

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What is Intrinsic Factor?

Intrinsic factor, produced by oxyntic glands, is a protein essential for the absorption of Vitamin B12.

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Why is mucus in the stomach?

Mucus is secreted by both oxyntic and pyloric glands, protecting the gastric cells from HCl.

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What does Gastrin do?

Gastrin, a hormone produced by pyloric glands, stimulates acid secretion and gastric motility.

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Parietal Cell

A type of cell found in the stomach lining responsible for secreting hydrochloric acid (HCl) and intrinsic factor.

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Intrinsic Factor

A protein secreted by parietal cells into the stomach, essential for the absorption of vitamin B12 in the small intestine.

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Hydrochloric Acid (HCl)

A strong acid produced by parietal cells in the stomach, crucial for digestion and killing bacteria.

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Peptic Cell

A type of cell in the stomach lining that secretes pepsinogen, a precursor to the digestive enzyme pepsin.

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Pepsinogen

An inactive precursor of the enzyme pepsin, secreted by peptic cells in the stomach.

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Mucous Neck Cells

Cells in the stomach lining that secrete mucus, a protective layer that shields the stomach from the corrosive effects of gastric acid.

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Canaliculi

A tiny space within the stomach lining that acts as a channel for the secretion of gastric juices.

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Microvilli

Small hair-like projections that significantly increase the surface area of cells, enabling more efficient secretion of substances.

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Pepsinogen Activation

Pepsinogen, an inactive enzyme, is activated into pepsin in the stomach's acidic environment. Pepsin then further activates other pepsinogen molecules.

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Intrinsic Factor Role

Intrinsic factor, produced by parietal cells in the stomach, facilitates the absorption of vitamin B12 in the ileum (small intestine).

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Vitamin B12 Deficiency

A deficiency in vitamin B12 leads to megaloblastic anemia, a condition where red blood cells are abnormally large and immature.

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Parietal Cell Destruction

Destruction of parietal cells in chronic gastritis can lead to achlorhydria (lack of HCl) and pernicious anemia, due to the inability to produce intrinsic factor.

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Pyloric Gland Function

Pyloric glands in the stomach contain mostly mucous cells that secrete a thick mucus, which lubricates food movement and protects the stomach lining from acidic chyme.

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Gastrin's Role

Gastrin, a hormone secreted by G cells in the pyloric glands, stimulates the production of gastric juice.

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Stomach Mucus Barrier

Mucus secreted by surface mucous cells in the stomach is alkaline, forming a protective barrier against the damaging effects of HCl.

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Protein's Effect on Gastrin

The presence of proteins in the stomach stimulates the release of gastrin, which further enhances the production of gastric juice.

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ECL Cells and Histamine

Enterochromaffin-like cells (ECL cells) in the stomach release histamine, which plays a role in stimulating the release of gastric acid.

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Pepsin and Protein Breakdown

Pepsin, a digestive enzyme, breaks down proteins into smaller polypeptides in the stomach, initiating the process of protein digestion.

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What is Saliva?

Saliva is a mixture of secretions produced by salivary glands, primarily the parotid, submandibular, and sublingual glands. It's slightly alkaline (pH 6-7), and essential for oral health and the initial stages of digestion.

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What is the Parotid Gland?

The parotid glands are the largest salivary glands and predominantly secrete a watery saliva called serous fluid, rich in an enzyme named salivary amylase.

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What are the Submandibular & Sublingual glands?

Submandibular and sublingual glands produce a mix of serous fluid and mucus, a slippery substance that provides lubrication and protection in the mouth.

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What is Salivary Amylase?

Salivary amylase, previously known as ptyalin, is an enzyme found in saliva, primarily produced by the parotid gland. It initiates the breakdown of complex carbohydrates like starch into simpler sugars.

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What are the roles of Saliva?

The primary function of saliva is to lubricate food, aiding in swallowing and speech. It also cleanses the oral cavity, protects teeth, and starts the digestion of carbohydrates.

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How is Saliva Modified?

The salivary glands produce primary saliva, which is similar in composition to blood plasma. However, as it travels through the ducts, there are changes in electrolytes, with sodium being absorbed and potassium secreted.

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What is the Salivary Secretion Process?

Salivary secretion is a two-stage process. The acini, secretory units of salivary glands, produce the primary saliva. Then, as it flows through ducts, modification occurs due to active absorption and secretion of electrolytes.

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How is Salivation Regulated?

The secretion of saliva is controlled by the nervous system. The sight, smell, or even thought of food can stimulate salivary glands (conditioned reflex). This is vital for initiating digestion.

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What Hormones Regulate Gastric Juice Production?

Gastrin, a hormone produced by the stomach, stimulates gastric acid production. Secretin, produced by the duodenum, enhances the secretion of bicarbonate from the pancreas and liver.

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What is Gastric Juice?

Gastric juice is a cocktail of digestive fluids secreted by the stomach. It contains hydrochloric acid (HCl), pepsinogen, and intrinsic factor.

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Why is Hydrochloric Acid Important?

Hydrochloric acid (HCl), a strong acid, is secreted by the stomach and plays a crucial role in activating pepsinogen, killing bacteria, and breaking down food.

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What is the Role of Gastrin?

Gastrin, a hormone primarily produced by the stomach, stimulates gastric acid production and gastric motility. It is released in response to food in the stomach and its release is enhanced by food containing protein.

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What is the Role of Secretin?

Secretin, a hormone produced by the duodenum, plays a crucial role in regulating the secretion of digestive enzymes and bicarbonate from the pancreas and liver. It is released in response to acidic chyme entering the duodenum.

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Study Notes

Saliva and Gastric Secretions

  • Saliva is a mixture of secretions produced by three glands: sublingual, submandibular, and parotid.
  • Daily saliva secretion ranges from 800 to 1500 ml.
  • Saliva pH is between 6-7.
  • Saliva is alkaline in nature.
  • Parotid glands are the largest
  • Buccal glands secrete mucus only.
  • Salivary glands are controlled primarily by the parasympathetic nervous system.
  • Salivary secretion is a two-stage process. The first stage (acini) produces a primary secretion similar in composition to plasma which contains ptyalin, mucus, and extracellular fluid. Second stage (ducts) modifies saliva, through processes of sodium absorption and potassium secretion, thus becoming less similar to plasma and slightly alkaline.
  • Saliva components include water (90%), electrolytes, salivary alpha amylase (ptyalin), lingual lipase, mucin, IgA antibody, antibacterial substances, lysosome, and prolinrich proteins.
  • Saliva functions include taste, oral hygiene, protection, digestion, mastication, swallowing, buffering, singing, and speech.
  • Two types of salivary reflexes include simple (unconditioned) and acquired (conditioned).
  • Unconditioned reflex is triggered by oral stimulation by the presence of food.
  • Conditioned reflex occurs without oral stimulation (thinking, seeing, smelling, or hearing of pleasant food).
  • Salivation factors include sour taste (acids), smooth objects, rough objects, taste/smell of food, and presence of food.
  • Salivation is inhibited by some factors and excited by others.

Gastric Secretions

  • Stomach mucosa has two types of tubular glands: oxyntic (gastric) glands and pyloric glands.
  • Oxyntic (gastric) glands are located on the inside surfaces of the body and fundus (80%).
  • Oxyntic glands secrete hydrochloric acid, pepsinogen, intrinsic factor, and mucus.
  • Pyloric glands are located in the antral portion (20%).
  • Pyloric glands secrete mucus for protection and gastrin.
  • Oxyntic gland is composed of parietal cells, peptic cells (chief cells), and mucous neck cells.
  • Parietal cells secrete hydrochloric acid and intrinsic factor.
  • Peptic cells (chief cells) secrete pepsinogen.
  • Mucous neck cells secrete mucus.
  • Mucus is rich in bicarbonate to prevent acid damage.
  • HCl formation involves combining hydrogen and chloride ions. Hydrogen ions are transported into the canaliculi via the H+/K+ ATP pump (exchanging H+ for K+). Hydroxyl ions combine with CO2 to form bicarbonate (HCO3-), which is released into the interstitial space via chloride-bicarbonate exchange.
  • Gastric secretion has three phases: cephalic, gastric, and intestinal.
  • Cephalic phase occurs before food enters, stimulated by sight, smell, thought, or taste of food.
  • Gastric phase is triggered by food entering the stomach, stimulated by distension, local reflexes, the vagus nerves, and gastrin.
  • Intestinal phase inhibits gastric secretion by reverse enterogastric reflex and hormones like secretin, gastric inhibitory peptide, and cholecystokinin. These hormones act in response to pH<2 (or presence of lipids) in small intestine.
  • Gastrin is a peptide hormone secreted by G cells in the pyloric glands. Gastrin stimulates ECL cells to release histamine which further increases HCl production and secretion.
  • Enterochromaffin-like (ECL) cells are stimulated by gastrin to secrete histamine which is required for HCL production.

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